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1 was Prox1-positive, CD31-positive and LYVE-1-negative, bearing a different molecular signature from b
2 May and December, 2015, compared with mcr-1-negative isolates from rectal swabs of inpatients (colon
3 hese data, ACA11 overexpression in a t(4;14)-negative MM cell line, MM1.S, demonstrated enhanced reac
4 -1R, externally induced DNA damage in IGF-1R-negative cells caused G1 cell cycle arrest and S phase f
5 isk human epidermal growth factor receptor 2-negative breast cancer compared with the TC6 regimen.
6 145 human epidermal growth factor receptor 2-negative patients younger than 35 years in TEXT, 5-year
8 (Cohen d; Abeta-positive impaired vs. Abeta-negative normal) were evaluated in another phase 2 study
11 here mRNA from PGE2-G response-positive and -negative cell lines was subjected to transcriptome-wide
12 criminating between the cancer-positive and -negative cells, without any amplification step, in less
17 Five of 8 C4d-positive recipients turned C4d-negative in 5-week follow-up biopsies, while another 2 r
21 increase excitation efficacy onto calbindin-negative cells during dopamine inhibition, suggesting th
22 divided into two populations: the calbindin-negative ventral tier, which is vulnerable to neurodegen
23 roduced by 243 isolates and 51 carbapenemase-negative isolates included porin mutants and producers o
24 Due to the highly challenging carbapenemase-negative isolates, specificities were lower than typical
25 ocytic leukaemia (CLL)-phenotype MBL and CD5-negative MBL, as well as differences in absolute monoclo
26 mal abnormalities in Philadelphia chromosome-negative (CCA/Ph(-)) metaphases emerge as patients with
30 Defining the microbial etiology of culture-negative prosthetic joint infection (PJI) can be challen
31 lar-weight isoform of cyclin E (cytoplasmic)-negative) is a reliable prognostic biomarker in ER posit
32 ngs do not support the classification of DIF-negative patients, meeting the clinical criteria for ocu
33 all intent-to-treat minimal residual disease-negative (MRD(-)) remission rate for this phase 1 study
35 in the gene KCNA2, causing either a dominant-negative loss-of-function or a gain-of-function of the v
36 d that the mutated kinase acts in a dominant-negative manner to reduce CaMKIIalpha-WT autophosphoryla
38 monolayers led to the proposal of a dominant-negative trafficking mechanism to explain AE1-associated
39 e, we show that overexpression of a dominant-negative version of DA1 enhances leaf size in a broad ra
40 such effects (gain of function and dominant-negative activity) in lung adenocarcinoma are unclear.
41 e of both pathways by Atg5(-/-) and dominant-negative rab5, ER cholesterol fails to increase when mTO
46 We found that overexpression of dominant-negative (DN) forms of NSF or knockdown of the expressio
47 esized that selective expression of dominant-negative C-terminus-truncated human DISC1 (mutant DISC1)
49 ion and, contrary to their proposed dominant-negative role, did not interfere with the expression of
51 ignaling by RNAi, expression of the dominant-negative Rac1 (Rac1 DN), or the specific Rac1 inhibitor
52 us transcription factors, including a double-negative feedback loop between the microRNA-200 (miR-200
53 h CAL-101 [idelalisib]), interrupts a double-negative feedback loop, enhancing GC-regulated transcrip
54 status (e.g., EGFR-positive [EGFR+] vs. EGFR-negative) was assessed using the Wilcoxon rank-sum test.
58 10 of 11 variants previously reported in ER-negative disease or BRCA1 mutation carrier GWAS and obse
59 and observed consistent associations with ER-negative disease for 105 susceptibility variants identif
61 tly inhibited breast tumor growth in ERalpha-negative mouse xenografts, especially when combined with
62 p are highly effective in inhibiting ERalpha-negative breast cancer due at least in part to epigeneti
64 (PPV3), 30.4% (95% CI: 29.9%, 30.9%); false-negative rate, 4.8 per 1000 (95% CI: 4.6, 5.0); sensitiv
65 ive, true-negative, false-positive and false-negative patients as classified against any reference st
66 true- and false-positive and true- and false-negative results were extracted to fit a cross-tabulatio
67 ems associated with false-positive and false-negative results, inconsistencies and low reactivity of
68 rasitemia, and PfHRP-II tests can give false-negative results when P. falciparum strains do not expre
70 higher analytic sensitivity and lower false-negative rate of HTS improves upon FC for MRD detection
71 test; Cepheid, Sunnyvale, CA) found no false-negative and 4 false-positive cobas Cdiff test results.
74 s significantly lower expressed in PET false-negative cases (5.3-fold change, P < .001) which provide
75 levant number of patients with FDG-PET false-negative MM and a strong association between hexokinase-
78 test reliability, as indicated by the false-negative (FN), false-positive (FP), and fixation loss (F
81 erformance and factors contributing to false-negative results in longitudinal studies, we examined re
83 owever, pfhrp2 gene deletions yielding false-negative RDTs, first reported in South America in 2010,
84 third of metastases < 1.0 cm were (18)F-FET-negative, most likely because of scanner resolution and
85 g cranial computed tomography-positive from -negative cases (AUC = 0.921, 0.923, and 0.646, respectiv
93 regatibacter actinomycetemcomitans is a Gram-negative commensal bacterium of the oral cavity which ha
95 aureus and Streptococcus pyogenes) and gram-negative bacteria (Pseudomonas aeruginosa and Escherichi
96 ty against a panel of Gram-positive and Gram-negative bacteria revealed structure-activity relationsh
100 into the backbone of Gram-positive and Gram-negative bacterial PG utilizing metabolic cell wall recy
101 gram-positive Staphylococcus aureus and gram-negative Pseudomonas aeruginosa (99.3 +/- 1.9% and 88.5
102 Burkholderia cepacia complex (Bcc) are Gram-negative opportunisitic bacteria that are capable of cau
103 dal protein that limits contact between Gram-negative bacteria and the colonic epithelial surface.
104 four bacterial strains, including both Gram-negative and Gram-positive bacteria, showing great poten
107 tal of 210 Bactec bottles demonstrating Gram-negative bacilli were prospectively enrolled for this st
109 e zauPzapA operon is present in diverse Gram-negative bacteria, indicating a common mechanism for Z-r
111 ultidrug resistant bacteria, especially Gram-negative bacteria for which the situation is particularl
112 and showed that HFM increases rat fecal Gram-negative bacteria, elevates lipopolysaccharides (LPS), a
113 exes constitute a primary mechanism for Gram-negative bacteria to expel toxic molecules for survival.
114 e, we chose the pilus protein FimG from Gram-negative bacteria and a disulfide-bonded variant of the
116 otein H-NS is a key global regulator in Gram-negative bacteria and is believed to be a crucial player
118 velopment of resistance particularly in Gram-negative bacteria, illustrates the urgent need for new m
122 timicrobial resistance, particularly in Gram-negative hospital pathogens, which has led to renewed ef
123 ella spp. are facultative intracellular Gram-negative bacteria that cause the zoonotic disease brucel
124 e and human RELMbeta selectively killed Gram-negative bacteria by forming size-selective pores that p
125 fective permeability barrier that makes Gram-negative bacteria inherently resistant to many antibioti
128 tilization of enterobactin permits many Gram-negative bacteria to thrive in environments where low so
131 nalool-IC-NFs inhibited growth of model Gram-negative (E. coli) and Gram-positive (S. aureus) bacteri
133 scriminate between viable and nonviable Gram-negative bacteria to tune the immune response, thereby l
135 rapidly traverse the outer membrane of Gram-negative bacteria and accumulate inside these cells, mak
138 e gene exchange between five species of Gram-negative bacteria, and that the identity of the genetic
139 ad antibiotic resistance, especially of Gram-negative bacteria, has become a severe concern for human
140 r detecting lipopolysaccharide (LPS) of Gram-negative bacteria, was immobilized on both a large area
141 xcellent sensitivity to trace levels of Gram-negative bacteria, while remaining insensitive to both G
145 aratus functions in the injectisomes of gram-negative pathogens to export virulence factors into host
146 olysaccharide, a cell wall component of Gram-negative Proteobacteria and known inducer of lupus in mi
147 he difference in mechanism of action on gram-negative and gram-positive bacteria may be less pronounc
148 Antimicrobial resistance in pathogenic gram-negative bacteria is one of the most pressing challenges
150 Pseudomonas aeruginosa is a pathogenic gram-negative organism that has the ability to cause blinding
151 ibility profiles of clinically relevant Gram-negative bacteria within two hours of antibiotic introdu
152 r the prevention of multidrug-resistant gram-negative bacteria (MDR-GNB) in adult intensive care unit
153 Bcc) are a group of multidrug-resistant gram-negative bacteria rarely reported in patients without cy
156 and export of amyloid protein sequences.Gram-negative bacteria assemble biofilms from amyloid fibres,
161 we have addressed this question in the Gram-negative model bacterium Burkholderia thailandensis E264
162 Bioinformatic screens reveal that these gram-negative bacteria carry genes coding for thiol-disulfide
163 3 ligase (NEL) domain that is unique to Gram-negative pathogens and whose activity is repressed by a
165 a low light dose (0.6 J cm(-2) ) toward Gram-negative bacteria E. coli, making it a remarkably effici
166 am-positive rods and other uncultivable Gram-negative rods, and, rarely, opportunistic microorganisms
167 I secretion (T2S) is one means by which Gram-negative pathogens secrete proteins into the extracellul
170 n monocytes isolated from patients with Gram-negative sepsis compared with healthy control subjects.
173 an epidermal growth factor receptor 2 (HER2)-negative tumors, 82.8% of luminal B-like HER2-positive t
176 ependent data set, 2 of 9 (22.2%) ERBB2/HER2-negative BrCa switched to ERBB2/HER2-positive with 1 BrM
177 ing AGTR1 overexpression in a subset of HER2-negative breast cancers, and they provide a mechanistic
178 HER2 gene amplification and HER2-low or HER2-negative breast cancers following radiotherapy or endocr
180 ly confirmed hormone-receptor-positive, HER2-negative, locally advanced or metastatic breast cancer,
181 patient has hormone receptor-positive, HER2-negative, node-positive breast cancer, the MammaPrint as
183 (HGF-positive, MET-positive) and MKN45 (HGF-negative, MET-positive) and 4 patient-derived xenografts
184 ebo-controlled double-blind study of 162 HIV-negative RV144 vaccine recipients, we evaluated 2 additi
186 or specimens from 23 HIV-positive and 17 HIV-negative patients (29 men and 11 women; mean [SD] age, 5
188 0.008, -0.01 to -0.004; p=0.001) than in HIV-negative people, but the magnitudes of difference were s
189 were detected in both partners in 60% of HIV-negative couples and 96% of HIV-positive couples over 2
191 separate clinical studies of high-risk, HIV-negative persons conducted in Botswana and Thailand.
192 numbers of circulating CD4+ cells in the HIV-negative (HIV-) brain-dead donor (BDD) is not known.
193 overall life expectancies than did their HIV-negative counterparts in the general population [29.1 ye
194 ncerns for nephrotoxicity also extend to HIV-negative individuals using tenofovir disoproxil fumarate
198 ing cT1-2 N1-2b pathologically confirmed HPV-negative OPSCC in 2010 to 2012 were identified using the
199 ted redundancy for NSD family members in HPV-negative HNSCCs and suggest a potential role for impaire
200 ing chromatin regulators is warranted in HPV-negative HNSCCs driven by aberrant H3K36 methylation.
202 all survival rates than do patients with HPV-negative HNSCC, but the mechanisms underlying this pheno
204 racing confirmed that LDB1-depleted, insulin-negative beta cells express NEUROG3 but do not adopt alt
205 dies were performed in PD-L1-positive, PD-L1-negative, and mixed tumor-bearing severe combined immuno
206 with Hirshfeld charges shows that the least-negative Cl discriminates active from nonactive substrat
207 Furthermore, lotus tetragonolobus lectin-negative/p-Creb-positive cyst segments (re)-expressed Nc
208 2(-/-) or Rag2(-/-)gammac(-/-) These lineage-negative CD45(+)/Thy1.2(+) cells are found within the my
209 liferated normally in vitro, whereas lineage-negative progenitors displayed impaired NK-cell differen
210 herapy for AS (58% vs 22%, P < 0.01), margin-negative resection (100% vs 73%, P < 0.01), reconstructi
211 in a subset analysis of patients with margin-negative resection (HR, 0.97; 95% CI, 0.66-1.45; P = .88
212 nalysis of peripheral blood B cells of 30 MC-negative HCV-infected patients and 15 healthy controls r
214 and endocervical cells transfected with miR-negative control, miR-143 or miR-145 were used in cell p
216 Conclusion Our results demonstrate that MRD-negative status surpasses the prognostic value of CR ach
217 Twelve pre-surgical TLE patients (7 MRI-negative) and age-matched healthy volunteers were scanne
219 CLP (NME1 R18Q in an IRF6 and GRHL3 mutation-negative patient with van der Woude syndrome and NME2 G7
223 ariate resolution curve fitting known as non-negative matrix factorization with alternating least-squ
224 were classified as HER2-positive (HER2+) or -negative (HER2-) based on fluorescence in situ hybridiza
226 1) or 3 (cohort 2) cycles of weekly BV; PET-negative patients (Deauville score </=2) proceeded to au
228 g PfHRP2-only RDTs in the presence of PfHRP2-negative parasites caused an increase in prevalence, red
229 cribed in adult Philadelphia chromosome (Ph)-negative B-cell precursor (BCP) acute lymphoblastic leuk
230 Philadelphia chromosome (Ph)-positive or Ph-negative B-cell acute lymphoblastic leukaemia who were d
231 HCM after family screening, 74 FG+/phenotype-negative relatives, and 9 with noncompaction or dilated
235 reated with antimalarials (n = 104), (2) RDT-negative children whose untreated P. falciparum infectio
236 % of RDT-positive (n = 185) and 31.2% of RDT-negative samples (n = 340) were available and selected f
240 re similar among women with hormone receptor-negative disease, although the HRs were substantially sm
241 ormone receptor-positive vs hormone receptor-negative), nodal status (0 vs 1-3 vs or >/=4 positive no
246 evere respiratory syncytial virus/rhinovirus-negative wheezing episode (adjusted OR, 8.0; P = .001),
247 candidate gene sequencing in additional SBDS-negative SDS cases or molecularly undiagnosed IBMFS case
248 trio whole-exome sequencing (WES) in an sbds-negative SDS family and candidate gene sequencing in add
249 n D deficiency is potentially causal of sero-negative RA and provide new insights into the pathogenes
250 ciation study (vGWAS) of six cohorts of sero-negative RA recruited in Europe and the US that were gen
251 The remaining three DSM265-treated, TBS-negative participants of cohort 2 developed transient su
252 rter was stringently repressed in telomerase-negative human cells in a histone deacetylase (HDAC)-dep
254 ion strategies to identify pathogens in test-negative children with CAP and asymptomatic controls.
264 strogen receptor-negative (ER(-)) and triple-negative breast cancer (TNBC), nitric oxide synthase-2 (
265 like tumors (24% v 8%; P < .001), and triple-negative tumors (21% v 6%; P = .08), but not for human e
266 owed a significant difference between triple-negative breast cancer and non-triple-negative breast ca
270 he effects of elevated LDL-C in human triple-negative (MDA-MB-231) and mouse Her2/Neu-overexpressing
272 een reported to be a driving force in triple-negative breast cancer (TNBC), contributing to the maint
273 tially lower level than Akt3/+S472 in triple-negative breast cancer cells, specific ablation of Akt3/
274 of tumor-infiltrating lymphocytes in triple-negative breast cancers and while MEK inhibition can pro
275 yields potent synthetic lethality in triple-negative breast tumors and other aggressive tumors chara
277 by many aggressive cancers, including triple-negative breast cancers (TNBC), to utilize glutamine for
278 le stratification of mesenchymal-like triple-negative breast cancer (TNBC) cells that differ from one
280 Purpose Trop-2, expressed in most triple-negative breast cancers (TNBCs), may be a potential targ
282 triple-negative breast cancer and non-triple-negative breast cancer (P = .009, .003, and .001, respec
283 involvement of ECs in the process of triple-negative breast cancer (TNBC) metastasis has not been ad
285 iew, we describe the heterogeneity of triple-negative disease, focusing on the histologic and molecul
288 er patients, those diagnosed with the triple-negative breast cancer (TNBC) subtype have the worst pro
293 d/allowed calculation of true-positive, true-negative, false-positive and false-negative patients as
295 wn tissue was composed of normal-sized, UCP1-negative unilocular adipocytes, with mitochondrial netwo
297 immunodeficiency virus and hepatitis D virus-negative patients with pretransplant HBV DNA undetectabl
298 are not driven by MCPyV and that such virus-negative MCCs, which can be quite reliably identified by
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