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3 rease in the load of antimony-sensitive and -resistant parasites, thus confirming that Wnt5a signalin
5 ion pathways leading to Fv3-susceptible and -resistant amphibian Mphi populations and defines the mol
9 a National Action Plan to Combat Antibiotic-Resistant Bacteria to curb the rise of "superbugs," bact
16 mechanism, (c) the fitness of the antibiotic-resistant mutant bacteria as a function of drug concentr
19 rate nosocomial acquisition of antimicrobial-resistant sequence type 156 (ST156) serotype 9V S. pneum
20 high burden of community-onset antimicrobial-resistant infection among patients with acute febrile il
24 ion of the wildtype allele of wag31 in APYS1-resistant M. tuberculosis was dominant and restored susc
27 Co-expression of cathepsin B and cathepsin B-resistant mutant LFABP in McA-RH7777 cells resulted in a
29 splayed M2 polarization, whereas bevacizumab-resistant xenografts transduced to upregulate MIF exhibi
30 erally regarded as safe to consume, are bile-resistant and can plausibly be modified to produce a pan
31 4 + anti-PD-1) was ineffective against BRAFi-resistant melanomas, the addition of MDSC depletion/bloc
38 d when 9 patients with blaOXA-232 carbapenem-resistant K. pneumoniae infections were identified at a
41 -carbapenemase-producing (non-CP) carbapenem-resistant isolates, and carbapenem-susceptible isolates.
42 ate the predation of an important carbapenem-resistant human pathogen, Klebsiella pneumoniae, by B. b
45 ly detect carbapenemase-producing carbapenem-resistant Enterobacteriaceae (CP-CRE) is an important el
51 PC tumors compared to primary and castration-resistant prostate cancers, and its expression is negati
53 inical CRPC, orthotopically grown castration-resistant VCaP (CR-VCaP) xenografts express high levels
56 ents who have advanced metastatic castration-resistant prostate cancer (mCRPC) and are receiving (223
57 rpose In patients with metastatic castration-resistant prostate cancer (mCRPC), overall survival (OS)
59 y are an unmet need in metastatic castration-resistant prostate cancer clinical research and practice
60 hich 266 patients with metastatic castration-resistant prostate cancer were treated with placebo alon
61 al benefit in men with metastatic castration-resistant prostate cancer with the addition of custirsen
62 ith chemotherapy-naive metastatic castration-resistant prostate cancer without visceral metastases.
65 tate cancer either in the form of castration-resistant prostate cancer (CRPC) or transdifferentiated
72 nsmission of cefixime-sensitive and cefixime-resistant strains of Neisseria gonorrhoeae in MSM in Eng
74 herapeutic applications against chemotherapy-resistant AML.Significance: These findings reveal a mito
75 ition sensitized p53-defective, chemotherapy-resistant CLL cells to clinically achievable doses of HR
78 rthermore, we showed that acquired cisplatin-resistant ovarian cancer cells expressed high levels of
79 A showed photocytotoxicity against cisplatin-resistant A2780Cis human ovarian cancer cells (IC50 74 m
81 growth of subcutaneously implanted cisplatin-resistant human ovarian cancer cells in athymic nude mic
83 served increased susceptibility of cisplatin-resistant cells to NK cell cytotoxicity when neutralizin
84 etracycline-, erythromycin-, and clindamycin-resistant ST first identified in Minnesota, which is con
85 ism that distinguishes CoB-sensitive and CoB-resistant T cell populations to reduce the risk of CoBRR
88 R)-active, porous, conductive, and corrosion-resistant nitride Ni3 FeN is used as a support for oxyge
89 their correlation with renitence and damage-resistant nature, we termed these structures "renitence
92 ity of protein markers to select for disease-resistant hygienic behavior in the European honey bee (A
94 cerns exist regarding the emergence of drug -resistant variants and subsequent treatment failure.
98 2D culture where MDA-MB-231 attained a drug-resistant tumor-initiating phenotype indicated by increa
101 products that have bioactivity against drug-resistant pathogens in order to assess their drug potent
104 of chimeric capsids from wild-type and drug-resistant core proteins was susceptible to multiple caps
107 The recent increase in extensively drug-resistant bacterial pathogens and the associated increas
108 s of 20 downstream cases of extensively drug-resistant tuberculosis with almost identical sequencing
109 South African patients with extensively drug-resistant tuberculosis, or resistance beyond extensively
110 losis, or resistance beyond extensively drug-resistant tuberculosis, were followed up over a period o
111 er of multidrug-resistant and extremely drug-resistant strains is a significant reason for concern.
113 ents who underwent epilepsy surgery for drug-resistant seizures in 36 centers from 12 European countr
114 nosa is an opportunistic and frequently drug-resistant pulmonary pathogen especially in cystic fibros
116 ts infected with wild-type and/or multi-drug-resistant HIV-1 variants, that the newly generated P2-Cr
118 ess flexible, target gatekeeper mutated drug-resistant EGFR-L858R/T790M, and covalently alkylate Cys7
120 is critical to address the emergence of drug-resistant cancers, but direct screening of all possible
121 apy ultimately enables the emergence of drug-resistant clones, limiting the long-term effectiveness o
123 t care by providing faster detection of drug-resistant infecting strains and to help inform therapeut
124 few ways forward through the morass of drug-resistant infectious disease and should be fully explore
125 tely predict the clinical prevalence of drug-resistant mutations is a key step toward generating more
126 % of drug-sensitive patients and 83% of drug-resistant patients, it is necessary to develop a better
130 BET bromodomain inhibition resensitizes drug-resistant tumors to Enz by selectively impairing the GR
131 sispecies and the pre-existence of some drug-resistant variants in the liver, which are not necessari
132 ellent inhibition of cell growth in the drug-resistant cell line H1975, without significantly affecti
136 er trial, children and adolescents with drug-resistant epilepsy who had undergone epilepsy surgery ha
139 ctive in postmenopausal women with endocrine-resistant, hormone receptor-positive and HER2-negative a
140 r (R)-9bMS-sensitized naive and enzalutamide-resistant prostate cancer cells and reduced AR and AR-V7
142 -TKI therapy, and in the generated erlotinib-resistant HCC827 (HCC827/ER) cells than in HCC827 cells.
144 ), blaNDM-1 (r = 0.934, p = 0.009), and ESBL-resistant bacteria (r = 0.913, p = 0.010) levels across
145 NA is periodically anchored to an extraction-resistant protein structure, via matrix attachment regio
146 beta-synuclein (betaS) is essentially fibril-resistant under cytoplasmic physiological conditions.
148 fficile infections caused by fluoroquinolone-resistant and fluoroquinolone-susceptible isolates was e
149 treatment of the problematic fluoroquinolone-resistant MRSA, VRE, and S. pneumoniae, and the possibil
150 osate sensitive A tuberculatus In glyphosate-resistant plants, a cluster of EPSPS genes on the perice
152 es higher antitumor activity against hormone-resistant prostate cancer cells (DU145) relative to trip
157 reat promise as high load bearing and impact-resistant materials due to a unique layered deformation
161 ctant protein-1 and VCAM-1 levels in insulin-resistant LMCs indicated activation of inflammatory mech
170 antly in Kenya and Ethiopia, whereas the MAb-resistant subgenotype D4.2 MeVs were isolated predominan
171 Following PCV13 introduction, dual macrolide-resistant IPD decreased 74.1% (incidence 0.32/100000 in
173 ate vaccine (PCV7) in 2000 reduced macrolide-resistant invasive pneumococcal disease (MR-IPD) due to
174 e childhood onset epilepsies with medication-resistant seizures and poor developmental outcomes.
175 with 15-PGDH inhibitor + PGE2 or metabolism-resistant dimethyl-PGE2 resulted in preterm cervical rip
178 pervirulent, community-acquired, methicillin-resistant Staphylococcus aureus (CA-MRSA) with specific
180 interest including MDROs such as methicillin-resistant S. aureus, extended-spectrum beta-lactamase-pr
185 Infection control practices for methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-res
186 the detection of mecC-harboring methicillin-resistant S. aureus (MRSA), which failed to identify fro
187 ere only significantly higher in methicillin-resistant Staphylococcus aureus (OR, 2.80; 95% CI, 1.65-
188 xtended-spectrum beta-lactamase, methicillin-resistant S. aureus, and carbapenem-resistant strains wa
190 ulates the cost-effectiveness of methicillin-resistant S aureus prevention strategies and recommends
192 sequencing epidemic lineages of methicillin-resistant Staphylococcus aureus (MRSA) over sensitive is
194 innate immune response to treat methicillin-resistant S. aureus infection in immunodeficient patient
198 acquisition and infection due to meticillin-resistant Staphylococcus aureus, vancomycin-resistant en
199 T OF EARLY ACTIVATION TAGGED 1 (TOE1)-miR172-resistant (35S::TOE1(R) ) and mutant (flowering locus T-
201 of fosfomycin was performed on 649 multidrug-resistant E. coli clinical isolates collected between 20
202 sector contributed 87% of acquired multidrug-resistant tuberculosis, related to irregular adherence;
204 icrobial activity observed against multidrug-resistant strains of Pseudomonas aeruginosa and Acinetob
206 t Staphylococcus aureus (MRSA) and multidrug-resistant Acinetobacter baumannii (MDR-AB) were assessed
211 uced selective pressures favouring multidrug-resistant epidemic ribotypes and was associated with sub
212 CRISPR-Cas systems are absent from multidrug-resistant (MDR) Enterococcus faecalis, which only posses
214 obacterium tuberculosis, including multidrug-resistant strains, and some species of nontuberculous my
215 world, and the increased number of multidrug-resistant and extremely drug-resistant strains is a sign
216 f strategies for the prevention of multidrug-resistant gram-negative bacteria (MDR-GNB) in adult inte
217 pacia complex (Bcc) are a group of multidrug-resistant gram-negative bacteria rarely reported in pati
221 primary analysis, the incidence of multidrug-resistant tuberculosis in 2024 would be 3.3 (95% uncerta
224 iotic resistance, and particularly multidrug-resistant profiles, is certainly of paramount relevance,
225 testing (AFST) of the potentially multidrug-resistant pathogen Candida glabrata against anidulafungi
226 t tuberculosis is more common than multidrug-resistant tuberculosis, it has been much less studied.
227 ith the worldwide emergence of the multidrug-resistant species Candida auris, identification of Candi
232 ily member YES1 was amplified in osimertinib-resistant EGFR-mutant tumor cells, the effects of which
233 e constitutively up-regulated in oxaliplatin-resistant HCT116 (HCT116-OxR) cells and that gammaH2AX,
234 caspase-3 and cleavage of HuR in paclitaxel-resistant oral cancer cells, both in vitro and in vivo.
236 her analyses extending to differentially PAH-resistant subpopulations showed organismal level bioener
237 h to May 2016 and 7 previously determined PB-resistant E. cloacae isolates from JMI Laboratories.
238 31 penicillin-susceptible and 31 penicillin-resistant strains, were retrospectively reviewed to eval
240 severe, presenting in infancy with pharmaco-resistant seizures; are often accompanied by debilitatin
241 acement in the oocyte with a phosphorylation-resistant form of GNU, which promotes PNG-GNU complex fo
242 ifferential distribution between piperaquine-resistant and piperaquine-sensitive parasite lines.
243 ning both proteinase K (PK)-sensitive and PK-resistant PrP(Sc) and samples containing only the PK-res
246 Patients and Methods Patients with platinum-resistant epithelial ovarian, fallopian tube, or primary
248 ice with inducible expression of proteolytic-resistant alpha1C Prevention of C-terminal cleavage did
251 Xpert MTB/RIF (Xpert) detects rifampicin-resistant tuberculosis (RR-tuberculosis), enabling physi
253 f H3K9me3 and H3K27me3 domains in sonication-resistant heterochromatin (srHC) versus euchromatin.
254 enerated two functionally distinct sorafenib-resistant human Huh-7 HCC cell lines in order to identif
257 g airway inflammation and identify a steroid-resistant cascade of Wnt5a, Tgm2, and LTs, which might r
258 significantly suppressed RSV-induced steroid-resistant airway hyperresponsiveness and airway inflamma
259 essential roles in the generation of steroid-resistant inflammation and AHR secondary to allergen- an
261 ta responses in experimental severe, steroid-resistant asthma were examined using a highly selective
263 roduction of IFN-gamma and IL-27 was steroid-resistant, and neutralization of IFN-gamma or IL-27 sign
264 usillum and transgenic yeast, and its stress-resistant ability was stronger than that of the yeast mb
265 icated that OxyR1-activated oxidative stress-resistant genes were highly expressed in oxyR2 mutants e
266 NA and protein, along with elevated tartrate-resistant acid phosphatase-positive (TRAP+) OCs and alve
268 ts for breast cancer fail to address therapy-resistant cancer stem-like cells that have been characte
271 t cancer cells in a high mesenchymal therapy-resistant cell state are dependent on the lipid hydroper
273 n 46.7% (7/15) of the patients with EGFR-TKI-resistant NSCLC, suggesting that the NGS-based ctDNA ass
274 dvanced EGFR-TKI-naive NSCLC and 15 EGFR-TKI-resistant patients to identify somatic SNVs, small indel
277 and shRNA-mediated HOTAIR knockdown in TRAIL-resistant PANC-1 cells sensitized them to TRAIL-induced
281 and neuromodulatory approaches in treatment-resistant cases provides alternatives for patients whose
283 ty in patients with progressive or treatment-resistant NSCLC, providing a rationale for further studi
284 ptom severity levels by recruiting treatment-resistant patients currently showed low symptom severity
285 alyzed the primary tumor, the sole treatment-resistant metastasis, and germline tissue to explore mec
288 tality rate among individuals with treatment-resistant schizophrenia not treated with clozapine compa
290 ncept, wild-type (ATCC 29212) and vancomycin-resistant Enterococcus cells were incubated at five diff
291 -resistant Staphylococcus aureus, vancomycin-resistant enterococci, C difficile, and multidrug-resist
293 biotics and with the emergence of vancomycin-resistant pathogens (VRSA and VRE), the studies pave the
294 ycin resistance is conferred upon vancomycin-resistant enterococci (VRE) through the replacement of p
295 ive bacteria (high priority) were vancomycin-resistant Enterococcus faecium and meticillin-resistant
296 ult in intestinal domination with vancomycin-resistant Enterococcus (VRE), leading to bloodstream inf
299 bidopsis has been used as a source for virus-resistant genes that derive from alterations in essentia
300 vo genome and plastome assemblies for a wilt-resistant South African accession of Mentha longifolia (
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