ライフサイエンスコーパス: -seeking

1 ore this directly, we utilized an aggression-seeking task in which male mice self-initiated aggressio

2 MHvl neurons became active during aggression-seeking and that their activity tracked changes in task

3 role in attack, was essential for aggression-seeking.

4 MHvl accelerated moment-to-moment aggression-seeking and intensified future attack.

5 Inactivation of the VMHvl reduced aggression-seeking behavior, whereas optogenetic stimulation of the

6 ote self-initiated or 'voluntary' aggression-seeking when no threat is present.

7 on both voluntary alcohol-intake and alcohol-seeking behaviors.

8 GS6) as a critical regulator of both alcohol-seeking behaviors and the associated cardiac and hepatic

9 r that is associated with compulsive alcohol-seeking behavior.

10 during extinction of cue-conditioned alcohol-seeking behavior.

11 This cue-controlled alcohol-seeking procedure was used to compare the effects of nal

12 star rats, two behavioral models for alcohol-seeking and relapse, respectively.

13 trate the involvement of calpains in alcohol-seeking and relapse and present a rationale for a novel

14 ections between BLA and NAc, mediate alcohol-seeking behaviors.

15 to relapse, the acquisition of a new alcohol-seeking response for an alcohol-associated conditioned r

16 significantly enhanced extinction of alcohol-seeking behavior across multiple extinction sessions, an

17 at contributes to the development of alcohol-seeking behavior following a history of dependence.

18 odel of cue-induced reinstatement of alcohol-seeking behavior in post-dependent Wistar rats and in an

19 l target to facilitate extinction of alcohol-seeking behavior in rats.

20 reduced cue-induced reinstatement of alcohol-seeking behavior.

21 acilitate long-lasting extinction of alcohol-seeking behavior.SIGNIFICANCE STATEMENT Alcohol use diso

22 t- plus cue-induced reinstatement of alcohol-seeking responses.

23 d by stress-induced reinstatement of alcohol-seeking using c-Fos immunohistochemistry.

24 frontal cortex and amygdala regulate alcohol-seeking behaviors differentially, adding to our understa

25 ontributing to increased post-stroke alcohol-seeking and relapse.

26 We hypothesized that alcohol-seeking behavior elicited by a discrete CS that predicte

27 owed that context-induced relapse to alcohol-seeking was attenuated by bilateral microinfusion of var

28 reclinical assay in which relapse to alcohol-seeking was triggered by re-exposure to an alcohol-assoc

29 ) blocked context-induced relapse to alcohol-seeking without affecting the ability to make a port ent

30 ed group showed low attachment and attention-seeking behavior.

31 responses in two taxonomically distant blood-seeking predators, Stable fly and Wolf, while evoking av

32 cell growth and metabolic signaling in bone-seeking breast cancer cells.

33 with doxorubicin (Doxo) and coated with bone-seeking pamidronate (Pam) for the targeted treatment of

34 Using brain-seeking patient-derived melanoma cells and real-time in

35 Radiolabeled cancer-seeking agents, however, undergo degradation, resulting

36 omote improved home-based practices and care-seeking behaviour can have a large impact on maternal an

37 udy maternal mortality risk and causes, care-seeking patterns, and costs within the country.

38 s associated with confounding by health-care-seeking behavior and misclassification of cases.

39 se incidences were corrected for health-care-seeking behaviour and recruitment.

40 substantial subnational differences in care-seeking patterns and service availability.

41 by province, to respond to variances in care-seeking patterns and the capacities of public and privat

42 ds, morbidity, appropriate home care or care-seeking during childhood illnesses.

43 A better understanding of patient care-seeking practices may inform future government action to

44 ocardial infarction symptoms and timely care-seeking behavior are critical to optimize acute medical

45 sess the alignment between tuberculosis care-seeking patterns and the availability of tuberculosis se

46 Cocaine-seeking behaviors were not affected by RO5166017 when mi

47 sity, in 1991 to help us establish a cocaine-seeking procedure.

48 ficantly inhibits cocaine-taking and cocaine-seeking behavior likely by interfering with cocaine bind

49 cocaine self-administration (SA) and cocaine-seeking behavior.

50 a dopamine-dependent manner to drive cocaine-seeking, but not sucrose-seeking, behavior.

51 itability of AcbSh neurons, enhances cocaine-seeking behavior while producing depression-like behavio

52 y involved in learning to extinguish cocaine-seeking behavior in rats.

53 ng the reinstatement of extinguished cocaine-seeking behavior in rats, demonstrating the potential of

54 n reinstated previously extinguished cocaine-seeking behavior in the absence of footshock.

55 Rats were assessed for cocaine-seeking behaviors after either intra-accumbal injections

56 the thalamus (pPVT) participates in cocaine-seeking behavior.

57 extinction sessions showed increased cocaine-seeking behavior.

58 ated subsequent drug context-induced cocaine-seeking behavior, in a memory reactivation-dependent man

59 activation and a test of cue-induced cocaine-seeking behavior.

60 n on subsequent drug context-induced cocaine-seeking behavior.

61 an important role in stress-induced cocaine-seeking behavior.

62 ese brain regions mediate CS-induced cocaine-seeking behavior.

63 c connections, to promote CS-induced cocaine-seeking behavior.

64 A, and CeA, on cue- and drug-induced cocaine-seeking in the rat cocaine reinstatement model.

65 rcinol had no effect on drug-induced cocaine-seeking, but was capable of blocking the initial conditi

66 hell inhibited cue- and drug-induced cocaine-seeking, respectively.

67 d both cue- and drug priming-induced cocaine-seeking.

68 nt drug context-induced instrumental cocaine-seeking behavior.

69 CeA is implicated in compulsive-like cocaine-seeking.

70 f yohimbine-induced reinstatement of cocaine-seeking after intra-CeA SB-334867 (10 nmol) administrati

71 ary for BDNF-mediated suppression of cocaine-seeking and reversal of cocaine-induced dephosphorylatio

72 150 facilitates the reinstatement of cocaine-seeking behavior by amplifying D1DR/PKA-dependent AMPA t

73 isrupted CS-induced reinstatement of cocaine-seeking behavior relative to (i) no optogenetic inhibiti

74 s necessary for the reinstatement of cocaine-seeking behavior, an animal model of drug craving and re

75 IL) contributes to the extinction of cocaine-seeking behavior, but the precise relationship among IL

76 e- and drug-induced reinstatement of cocaine-seeking behavior.

77 arning and the active suppression of cocaine-seeking behavior.

78 mechanisms underlying extinction of cocaine-seeking behavior.

79 e- and drug-induced reinstatement of cocaine-seeking behavior.

80 ability to suppress reinstatement of cocaine-seeking in rats with a cocaine SA history.

81 promote cue-induced reinstatement of cocaine-seeking.

82 prolong responding in extinction of cocaine-seeking.

83 e- and drug-induced reinstatement of cocaine-seeking.

84 s in attenuation of reinstatement of cocaine-seeking.

85 lie contextual stimulus control over cocaine-seeking behavior.

86 uman addiction, including persistent cocaine-seeking and increased reinstatement of cocaine seeking.

87 NorBNI did not induce or potentiate cocaine-seeking behavior induced by OrxA but reversed DynA effec

88 d basolateral amygdala (BLA) promote cocaine-seeking behavior in response to drug-associated conditio

89 lves a new form of learning, reduces cocaine-seeking behavior; however, the molecular mechanisms unde

90 as been shown to negatively regulate cocaine-seeking behavior, but the precise conditions by which vm

91 sure to drug-related cues reinstated cocaine-seeking behavior and increased AMPK and p70s6k phosphory

92 erent subregions regulate relapse to cocaine-seeking behavior in rats.

93 n 5-HT neuron firing, contributes to cocaine-seeking behaviors.

94 verns the prolonged reinstatement to cocaine-seeking observed after cold water swim stress.

95 nner that positively correlated with cocaine-seeking, but not sucrose-seeking, behavior.

96 roduction and loss, as well as dramatic cold-seeking behavior.

97 d found the strongest representation of cold-seeking behavior at the ventral border of the dorsomedia

98 work identifies the neural substrate of cold-seeking behavior in systemic inflammation and expands th

99 is attenuation was due to a blockade of cold-seeking behavior.

100 ted cold seeking.SIGNIFICANCE STATEMENT Cold-seeking behavior is a life-saving response that occurs i

101 Instead, we find that cold-seeking benefits infected animals by increasing their la

102 the autonomic cold defense and for the cold-seeking response to LPS, we studied rats with small ther

103 ested whether an estrogen could augment drug-seeking behavior in response to an ordinarily subthresho

104 from controlled drug use to compulsive drug-seeking habits and relapse to these maladaptive habits.

105 ry, recreational drug use to compulsive drug-seeking habits, neurally underpinned by a transition fro

106 accumbens (NAc) facilitate conditioned drug-seeking behavior and primarily originate from medial pre

107 mories.SIGNIFICANCE STATEMENT Continued drug-seeking behavior, a defining characteristic of cocaine a

108 iction involves an inability to control drug-seeking behavior.

109 We observed decreased drug-seeking behavior on ED1 following 10 mg/kg S-propranolol

110 h the ability of multiple cues to drive drug-seeking behavior after just one reactivation and treatme

111 e ability of a drug-paired cue to drive drug-seeking behavior.

112 Evidence suggests that HCRT may drive drug-seeking through activation of specific brain regions imp

113 CSs intact and able to continue driving drug-seeking behavior.

114 neural subpopulations activated during drug-seeking is to examine their projection targets.

115 Although estrogens can enhance drug-seeking behavior, they do not directly induce reinstatem

116 We modeled flexible drug-seeking behavior in rats by requiring animals to solve d

117 Furthermore, drug-seeking behavior continued to require dopamine neurotran

118 We find that habitual drug-seeking isn't necessary for the development of addiction

119 IA1, a glutamatergic gene implicated in drug-seeking behavior, verified the increased enrichment of l

120 oin self-administration and cue-induced drug-seeking behavior.

121 demonstrated incubation of cue-induced drug-seeking during the initial phase of abstinence, followed

122 eurochemical correlate for a laboratory drug-seeking paradigm that can be administered to treatment-s

123 onal states that instigate and maintain drug-seeking behavior.

124 It is characterized by maladaptive drug-seeking habits that are maintained despite adverse conse

125 To better model drug-seeking behavior in addicts, we first developed a novel

126 rocess consisting of a highly motivated drug-seeking phase that, if successful, is followed by a drug

127 marijuana dependence as reinforcers of drug-seeking and drug-taking behavior.

128 Behavioral manifestations of drug-seeking behavior are causally linked to alterations of s

129 riming- or cue-induced reinstatement of drug-seeking behavior in abstinent subjects (models of relaps

130 n, and cocaine-induced reinstatement of drug-seeking behavior, whereas R-MOD inhibited cocaine-induce

131 also failed to induce reinstatement of drug-seeking behavior.

132 and may have a role in the etiology of drug-seeking behavior.

133 which stress triggers reinstatement of drug-seeking behaviors is particularly pertinent to nicotine.

134 n regions involved in the extinction of drug-seeking behaviors.

135 b) has been implicated in regulation of drug-seeking behaviours through aversion-mediated learning.

136 b) has been implicated in regulation of drug-seeking behaviours through aversion-mediated learning.

137 incentive salience, and development of drug-seeking habits in the binge/intoxication stage involve c

138 ine and stress-induced reinstatement of drug-seeking.

139 in drug-taking and the reinstatement of drug-seeking.

140 stration (SA) underlie reinstatement of drug-seeking.

141 OCT3 mediates corticosterone effects on drug-seeking behavior and establish OCT3 function as an impor

142 or-activating effects of cocaine and on drug-seeking behavior, rats receiving methyl supplementation

143 erative to BDNF's suppressive effect on drug-seeking.

144 h as cocaine or amphetamine can promote drug-seeking and -taking behavior.

145 GR127935 was most effective in reducing drug-seeking on ED1, whereas betaxolol/ICI-118 551 was ineffe

146 .p.) alone were sufficient to reinstate drug-seeking behavior, pretreatment with E2 potentiated reins

147 xt, we describe recent discoveries that drug-seeking is associated with transient synaptic plasticity

148 he DG that could directly contribute to drug-seeking behavior.

149 emories that can precipitate relapse to drug-seeking behavior.

150 nce and METH- or cue-induced relapse to drug-seeking behaviour in mice.

151 ransition from recreational drug use to drug-seeking habits are unknown.

152 ver new therapeutic candidates to treat drug-seeking behavior.

153 osensory behavior: each is important for dry-seeking by hydrated flies and together they underlie moi

154 tal circuitry that acts to prioritize energy-seeking over taste quality.

155 Furthermore, we replicated this entropy-seeking behavior in a control task with no explicit util

156 or cell types in the striatum, during a food-seeking discrimination task.

157 ne (i.e., with no opsin expression) and food-seeking control experiments also failed to produce the s

158 duced food intake, food-motivation, and food-seeking, while blocking endogenous PVT GLP-1R signaling

159 Aergic neurons induced both appetitive (food-seeking) and consummatory (eating) behaviors in vGat-ire

160 ample of this is a dissociation between food-seeking behaviour and metabolic needs, a notoriously dif

161 effects of intra-VTA oleate to decrease food-seeking and DA neuronal activity.

162 uron stimulation is sufficient to drive food-seeking behavior in the continued presence of a competin

163 rgy-dense food, food-related cues drive food-seeking regardless of satiety, an effect that can lead t

164 nfluence motivational states and elicit food-seeking behaviors.

165 The decision to engage in food-seeking behavior depends not only on homeostatic signals

166 factors and orchestrate an increase in food-seeking behavior.

167 als may adapt accordingly by inhibiting food-seeking responses.

168 n a way that may facilitate maladaptive food-seeking behaviors.

169 ht into how the nervous system mediates food-seeking behavior amid oxidative stress and suggest that

170 innervation that mediate noncompulsive food-seeking behavior.

171 ation had no effect on reinstatement of food-seeking behavior induced by cues, a food-prime, or cues+

172 ronal activation both increased operant food-seeking behavior, but only activation of LHA (GABA) neur

173 mus and upstream brain regions organize food-seeking behaviour in mice.

174 of palatable food, as well as palatable food-seeking behavior in a second-order schedule of reinforce

175 be a fundamental determinant of the gradient-seeking capabilities of marine bacteria, and suggest a n

176 d from each study area to investigate health-seeking behaviour in cases of self-reported fever lastin

177 ical costs, which may influence their health-seeking behavior and potentially affect health outcomes.

178 sting for specimen collection and healthcare-seeking practices.

179 In terms of healthcare-seeking behaviour, of 3337/11 192 (30%) students who wer

180 ssed effectiveness and consequences for help-seeking by the odds ratio at follow-up between those rec

181 ractice, so that older persons' hearing help-seeking journey can be facilitated.

182 al health disorders nor did it increase help-seeking.

183 ollowed by tailored advice would modify help-seeking behaviour.

184 acute symptoms (e.g., self-mutilation, help-seeking suicide attempts) of borderline personality diso

185 ication Test (AUDIT), and self-reported help-seeking from clinical and welfare providers comparing th

186 low-up between those receiving tailored help-seeking advice and those who received general mental hea

187 creening group, which received tailored help-seeking advice, or the control group, which received gen

188 Participants were help-seeking individuals identified as being at ultra-high ri

189 ily understood in the context of animal host-seeking.

190 During host-seeking, AaegTRPA1(-/-) mutants failed to avoid stimuli

191 nfective juveniles (IJs) of EPNs employ host-seeking behaviors to locate suitable hosts for infection

192 aria vectors make use of visual cues in host-seeking.

193 that have been implicated in mediating host-seeking by adult females but are not known to activate A

194 taxis is likely critical for mosquitoes host-seeking in a complex thermal environment in which humans

195 picaridin provided against noninfected, host-seeking females of the southern house mosquito, Culex qu

196 pite the fact that our knowledge of the host-seeking behaviour of filariasis infected mosquitoes is l

197 thin a minimal promoter in skin/inflammation-seeking effector memory T cells.

198 ts provide evidence that such an information-seeking motive may also underpin infants' demonstrated p

199 results delineate a circuit for information-seeking decisions and suggest a neural basis for curiosi

200 ntly dampened seasonal cycles in information-seeking behavior.

201 early stage in the hierarchy of information-seeking decisions, before evaluation is complete.

202 d seasonal cycles in chicken pox information-seeking behavior to VZV vaccine-induced reduction of sea

203 We (i) report robust seasonal information-seeking behavior for chicken pox using Google data from

204 We studied information-seeking during a university lockdown following an active

205 rovement is necessary to induce intervention-seeking behavior.

206 Stressed job-seeking unemployed community adults (n = 35) were random

207 perirhinal DPFE infusions did not alter meth-seeking in the presence of meth cues.

208 PFE infusions into perirhinal cortex on meth-seeking under two different test conditions.

209 rated flies and together they underlie moist-seeking by dehydrated flies.

210 inil (S-MOD) on nicotine-taking and nicotine-seeking behavior, and mechanisms underlying such actions

211 icotine nor reinstated extinguished nicotine-seeking behavior.

212 Nontreatment-seeking, daily cannabis smokers were randomized to recei

213 and ratings of 'good effect' in nontreatment-seeking daily cannabis smokers.

214 led laboratory study of IBUD in nontreatment-seeking individuals with current (ie, past month) mild-t

215 Novelty-seeking tendencies in adolescents may promote innovation

216 e a longitudinal design to track 144 novelty-seeking adolescents at age 14 and 16 to determine whethe

217 c disorders associated with abnormal novelty-seeking behaviors.

218 High novelty-seeking temperament was robustly associated with increas

219 responses to anticipated rewards in novelty-seeking adolescents may increase vulnerability to future

220 sorimotor gating deficits, increased novelty-seeking and reduced fear extinction.

221 ion in the NAcSh directly influences novelty-seeking exploratory behavior and facilitates self-admini

222 was an association of rs2235749 with novelty-seeking trait and a strong genotype-dose association wit

223 night-time lighting exhibited natural refuge-seeking behaviour less often compared to control animals

224 Reward-seeking behavior is fundamental to survival, but suppres

225 Initiating a reward-seeking behavior involves deciding on an action, how fas

226 ns in the regulation of emotional and reward-seeking behaviors; thus, dysfunctional interactions betw

227 These interactions break reward-seeking habits, a putative factor in multiple psychopath

228 high-effort cost behavior, but not by reward-seeking behavior.

229 oned responses and control compulsive reward-seeking behavior.

230 striatal neurons promotes conditioned reward-seeking behaviour after learning, while activity in cort

231 tal circuitry can dynamically control reward-seeking behaviour through the opposing activities of pro

232 late to the timing of a visually cued reward-seeking behavior.

233 mportance of the VP in context-driven reward-seeking behavior.

234 ctivity of VP neurons in a cue-driven reward-seeking task previously shown to require neural activity

235 t probability, suggesting that during reward-seeking actions, risk of punishment diminishes VTA-drive

236 resentation of punishment risk during reward-seeking behavior.

237 anonical GABA co-release and enhances reward-seeking behaviour measured by optical self-stimulation.

238 in/hypocretin system is important for reward-seeking behaviors, however less is known about its funct

239 esulting in the increase of impulsive reward-seeking behaviors that are often observed during puberty

240 cally connected regions implicated in reward-seeking and aversive behaviors.

241 rontal cortex have been implicated in reward-seeking and fear-related responses, but how information

242 escents are notorious for engaging in reward-seeking behaviors, a tendency attributed to heightened a

243 l reward-predictive cues can motivate reward-seeking behaviors.

244 Motivated reward-seeking behaviours are governed by dopaminergic ventral

245 by which mPFC modulates expression of reward-seeking behavior, by regulating the dynamical interactio

246 a conserved role in the regulation of reward-seeking behavior, providing cellular and anatomical iden

247 triggered reward representations over reward-seeking decisions as assayed by Pavlovian-to-instrumenta

248 (VTA) plays a key role in regulating reward-seeking behaviors.

249 rmation may be a key component of the reward-seeking behaviours in behavioural variant frontotemporal

250 ry predictive information about timed reward-seeking actions, thus elucidating a behavioral role for

251 ortical structures that contribute to reward-seeking behaviours, such as the ventral striatum and mid

252 Uncovering brain circuits underlying reward-seeking is an important step toward understanding the ci

253 osted anticipation significantly drives risk-seeking behaviors, most pertinently in gambling.

254 hat chronic sleep restriction increases risk-seeking, whereas this was not observed after acute sleep

255 ss biases people to make risk-averse or risk-seeking decisions, respectively.

256 to increased and subjectively unnoticed risk-seeking.

257 circuitry necessary for context-driven salt-seeking behavior is unknown.

258 This salt-seeking behavior is also observed when the animal is pre

259 OrxA reinstated cocaine- and SCM-seeking behavior, with a greater effect in cocaine anima

260 This coincided with a sensation-seeking and low-anxiety phenotype.

261 behavioral type (adaptive groups; sensation-seeking vs. extraverted/emotionally stable).

262 sed resilience for others, in high sensation-seeking individuals.

263 ividuals at risk often show a high sensation-seeking/low-anxiety behavioural phenotype.

264 icity, maternal educational level, sensation-seeking tendency, parental cigarette smoking, and cigare

265 s addiction, for which high or low sensation-seeking personality has been identified as a risk factor

266 es high-risk personality traits of sensation-seeking/low anxiety associated with enhanced alcohol con

267 Shelter-seeking behavior was decreased by dilbit and conventiona

268 Further understanding of stimulation-seeking behavior may shed light on the etiology of psych

269 and how this varies according to stimulation-seeking preference.

270 nduced reinstatement of cocaine- and sucrose-seeking in prelimbic cortex (PL), infralimbic cortex (IL

271 er to drive cocaine-seeking, but not sucrose-seeking, behavior.

272 elated with cocaine-seeking, but not sucrose-seeking, behavior.

273 t food, cue-induced reinstatement of sucrose-seeking, and motivation to work for sucrose were employe

274 o reduced context-induced relapse to sucrose-seeking, but only at the 2.5 mg/kg dose.

275 hat moderate stress increased social support-seeking behavior in rat cagemates and facilitated long-t

276 Treatment-seeking CD outpatients (N=29) underwent functional magne

277 Treatment-seeking smokers (N = 69; 30 slow metabolizers and 39 nor

278 In study 1, treatment-seeking smokers (n = 81) completed an IC task during fun

279 A sample of 101 treatment-seeking adolescents (mean age, 15.9 years) at clinical h

280 oss interaction contexts (n = 42), treatment-seeking patients with panic disorder with agoraphobia (n

281 ard-related brain activation among treatment-seeking individuals with AUDs, and indicate that smoking

282 gonally in their voice-hearing and treatment-seeking statuses.

283 istic framework reflecting complex treatment-seeking pathways.

284 pulation, and it influences dental treatment-seeking behavior and oral and systemic health.

285 ical symptoms, malaria microscopy, treatment-seeking behavior, and compliance with referral advice we

286 Participants were non-treatment-seeking alcohol-dependent heavy-drinking individuals.

287 -two currently heavy-drinking, non-treatment-seeking alcohol-dependent males were recruited.

288 Participants included 56 non-treatment-seeking cocaine users (CUs) (52 with cocaine dependence

289 Subjects included 64 non-treatment-seeking cocaine users (NTSCUs) and 67 healthy control su

290 Ninety-four non-treatment-seeking individuals with AUD were genotyped for these po

291 suppress opioid withdrawal in non-treatment-seeking individuals with OUD.

292 Non-treatment-seeking opioid-dependent male volunteers (n=11) underwen

293 sue biopsies collected from 97 non-treatment-seeking volunteers based on reflux and smoking status.

294 a stratified random sample of non-treatment-seeking young adults recruited from Victoria, Australia,

295 Non-treatment-seeking, healthy cannabis smokers (n=31; 17M, 14 F) comp

296 ntermediate or secondary outcomes (treatment-seeking, identification of at-risk individuals, antidepr

297 radigm that can be administered to treatment-seeking and abstaining drug-addicted individuals.

298 One hundred and fifty-two treatment-seeking individuals with alcohol dependence, half presel

299 Participants were treatment-seeking patients with principal diagnoses of social anxi

300 participate in the mediation of uncertainty-seeking actions, whereas uncertainty-related enhancement