ライフサイエンスコーパス: -step

1 , respectively) compared with those with a 1-step DRSS improvement, no change, or worsening (37.9%, 3

2 ients treated with ranibizumab experienced 1-step or more improvement in DRSS from baseline to month

3 3-step improvement, >/=2-step improvement, 1-step improvement, and no DRSS change, respectively) comp

4 THP offers the prospect of rapid, simple, 1-step, room-temperature syringe-and-vial radiolabeling of

5 s higher in solution, the efficacy of the 10-step pathway measured by conversion of glucose to lactat

6 esis of the limonoid andirolide N using a 12-step sequence from commercially available materials.

7 Integrating the described 12-step process should prove valuable for improving how ear

8 Here we report a chemoenzymatic 14-step, one-pot synthesis that can be used to generate (13

9 for a 2-step decrease in VH demonstrated a 2-step decrease (40% in Group 1 and 46.1% in Group 2).

10 5% of patients who had the potential for a 2-step decrease in VH demonstrated a 2-step decrease (40%

11 Here we apply a 2-step machine learning framework for quantitative imaging

12 ls for these candidates were measured in a 2-step manner in a screening cohort and a validation cohor

13 uctures, and senescent cells, as well as a 2-step pancreatic clamping with a [U-(13)C]palmitate infus

14 r preference as an IV method, we propose a 2-step procedure with which to estimate a valid treatment

15 re identified, and QMs were developed in a 2-step review process.

16 arylation product may be accomplished by a 2-step sequence involving an acidic hydrolysis of the meth

17 a standard inverse-variance meta-analysis (2-step analysis).

18 From 2-step testing, all glutamate dehydrogenase (GDH)-positive

19 Improvement was defined by a >/=2-step decrease of both anterior chamber and vitreous haze

20 present between baseline DRSS score and >/=2-step DRSS score improvement at week 100 for DME patients

21 influence of select baseline factors on >/=2-step DRSS score improvement by logistic regression in an

22 h worse BCVA or thicker CST experienced >/=2-step DRSS score improvement compared with those with bet

23 ly factor significantly associated with >/=2-step DRSS score improvement in all treatment groups at w

24 Proportion of patients with >/=2-step improvement in DRSS score from baseline at week 100

25 had no impact on the ability to achieve >/=2-step improvement in DRSS score.

26 11.2 letters for >/=3-step improvement, >/=2-step improvement, 1-step improvement, and no DRSS change

27 s or more was more common in patients with 2-step or 3-step or more DRSS improvement (51.9% and 44.6%

28 We implemented a 3-step analysis strategy in 3 data sets: the Epidemiologic

29 This strategy has also resulted in a 3-step synthesis of dehydroherbarin from a 3-methallylnaph

30 .1, +14.2, +11.3, and +11.2 letters for >/=3-step improvement, >/=2-step improvement, 1-step improvem

31 We recently reported a novel 3-step pretargeted radioimmunotherapy (PRIT) strategy base

32 was more common in patients with 2-step or 3-step or more DRSS improvement (51.9% and 44.6%, respecti

33 he patient-parent dyads received a simple, 3-step instruction sheet on how best to take photographs u

34 Input images underwent a 4-step automated image segmentation process consisting of

35 A short, 5-step total synthesis of (+/-)-3-demethoxyerythratidinone

36 predicts that a 1-point difference on this 5-step scale would be detectable with 12 subjects in each

37 The resulting 6-step synthesis of the carbocyclic core of the berkeleyon

38 Here we provide a step-by-step GIG protocol that includes procedures for (i) prote

39 for most experimental scientists, a step-by-step guide was provided, by which users can easily get t

40 Here, we present a step-by-step guideline for the procedure by providing examples o

41 We give step-by-step instructions for using TMLE to estimate the average

42 ning microscopy and provide detailed step-by-step instructions to re-building the device, including a

43 other related studies to dissect the step-by-step intricacies of this complex process, provide our cu

44 Each subject reported a step-by-step mapped account of where and with whom they traveled

45 dynamics simulations to monitor the step-by-step movement of DNA through different mutations of alph

46 erformance results from the distinct step-by-step photon-transport charging mechanism and the increas

47 protocol, we present the optimized, step-by-step procedure for generating reproducible SERRS nanopar

48 This protocol describes step-by-step procedures for CSF sample preparation for the analy

49 The protocol includes step-by-step procedures for sample collection and processing, li

50 This protocol describes step-by-step procedures for tissue preparation, permeabilization

51 is to provide food businesses with a step-by-step tool for calculating nutrient content of foods for

52 We also added scripts and a step-by-step tutorial for visualizing each dataset at the single

53 animal models and provide extensive, step-by-step tutorials that demonstrate how to fit such models i

54 In experiment 1, a double-step paradigm quantified the ability to modify convergen

55 ry strategy may potentially be used for dual-step targeted therapy.

56 In this work, we present an eight-step route to 5-hydroxymethylcytidine (hm(5)rC) phosphor

57 ynthetic studies that led to the final eight-step synthesis of dehaloperophoramidine.

58 The overall yield of the eight-step sequence was 60 %.

59 can be considered as an evidence-based first-step approach in treating symptoms of depression.

60 cted this initial dip, suggesting that first-step decision dynamics depend on additive integration of

61 dicted by the HLCA and PEI models, the first-step decision dynamics were initially biased toward the

62 MA complexes (Y = I(-) , F(-) ) in the first-step deposition, followed by intercalating with FAI to c

63 S Biology by Ono et al. finds that the first-step mutations selected in yeast populations evolving in

64 ynthesis of 3-propanaldehydes through a five-step process in 11-67% yield from aldehydes.

65 ghly popular ProTide system relies on a four-step enzymatic and chemical process to liberate the corr

66 discuss the results in the context of a four-step mechanism for HCCS, whereby HCCS mutants such as E1

67 In this review, a four-step model is described for the receptor-mediated cell m

68 A four-step protocol for the synthesis of pyrazolo[1,5-a]pyrazi

69 s was elaborated to 12-epi-mutilin by a four-step sequence (39% overall).

70 A four-step, resource-stratified implementation strategy was us

71 d pharmaceuticals, as demonstrated by a four-step, telescoped synthesis of measles therapeutic, AS-13

72 can be used consecutively in three- and four-step iterative homologation processes, without interveni

73 ted from bovine serum by an established four-step purification procedure.

74 yields in a multicatalytic metal-free, four-step one-pot cascade reaction under mild, yet robust, co

75 series has been synthesized in a simple four-step sequence.

76 This four-step process involves three cycloadditions and electrocy

77 before inhalation into a new potential host-steps influenced by ambient conditions and crowding and

78 ealed a complex community that fluctuated in-step with the groundwater community and responded to DO.

79 esign of acoustic devices and provides a key-step towards realizing spatial sound modulators.

80 tethered to microtubule-ends through a multi-step end-on conversion process.

81 ylation and kinase activity serve as a multi-step mechanism to coordinate cell motility during migrat

82 Here we characterise a multi-step phosphorelay signal transduction pathway consisting

83 Cancer metastases arise from a multi-step process that requires metastasizing tumor cells to

84 ng an in vitro system, we now define a multi-step process whereby the kinase LOK specifically phospho

85 Skin carcinogenesis is known to be a multi-step process with several stages along its malignant evo

86 We established a multi-step protocol involving protein immobilization, sialic a

87 in continuous-flow systems are common, multi-step transformations are more valuable.

88 A complete multi-step formation mechanism is proposed for the tribofilm o

89 neck cancer surgery is often a complex multi-step procedure that includes major resections, vasculari

90 Expression of mtDNA entails multi-step maturation of precursor RNA.

91 Utilizing this methodology, multi-step continuous-flow systems have improved the syntheses

92 s reports utilized approaches based on multi-step ferroelectric switching with multiple ferroelectric

93 Most current approaches rely on multi-step ligations with low yields and incomplete products.

94 n of filtering combined with single or multi-step linking term chains is carried out on all articles

95 nd labeled standards using an original multi-step strategy, then we developed and validated a UPLC-MS

96 sensors and their fabrication requires multi-step lithographic processes.

97 described, and it shows that tethered, multi-step biological pathways can be reconstituted in hybrid

98 Thus, the multi-step nature of Rho-dependent termination may facilitate

99 However, the role of SIRT1 in the multi-step process leading to transformation and/or tumorigene

100 onstitute an attractive alternative to multi-step protocols, with major recent progress through the e

101 usly from solution via a single- or multiple-step process.

102 beta-cell function was measured with a nine-step hyperglycemic clamp before and 48 h and 14 days aft

103 phene-based electrochemical biosensor for on-step, sensitive and low cost detection of beta-lactoglob

104 bulk carbon nitride, was fabricated by a one-step approach.

105 tify the levels of the two bacteria in a one-step assay, without the need for DNA extraction or ampli

106 carbon onions have been synthesized by a one-step carbonization of metal-organic-framework ZIF-67.

107 ic wettability are synthesized through a one-step compartmentalized growth of a mesoporous organosili

108 In contrast, we developed a one-step design strategy using phylogenetic analysis and Ros

109 of DNA as a scaffolding material with a one-step lithographic process, we demonstrate the patterning

110 FAU-type zeolite, HOU-3, prepared via a one-step organic-free synthesis route.

111 We have developed a one-step procedure to a variety of chiral lipophilic and con

112 A one-step QuEChERS-based approach to extraction and cleanup h

113 st agent (perfluoropentane, PFP) using a one-step sonoporation method to create ELTSLs and ENTSLs, wh

114 We designed and developed a one-step synthesis of 5-amino-4-carboxamidothiazoles 1 by an

115 A one-step synthesis of a nanographene propeller with a D3-sym

116 osanoic acids caused a transition from a one-step to two-step process.

117 This study proposed a one-step wood modification method by combining the depositio

118 Here, we developed a one-step, cost-effective route to produce a novel biocompati

119 of the device, which could be used as a one-step, portable, disposable, low-cost, simple, instrument

120 c table, their compounds, or alloys by a one-step, scalable, low-cost, and eco-friendly process.

121 Thus, oligolysine-PEG is a one-step, structure-independent approach that provides low-c

122 This method achieves one-step, redox-neutral synthesis of catechols with diverse

123 f BMP and PG species was developed after one-step methylation of lipid extracts in combination with h

124 nsposon Analysis in Yeast (SATAY) allows one-step mapping of all genetic loci in which transposons ca

125 lternative approach for an automated and one-step enzyme-linked immunosorbent assay (ELISA).

126 his study reports a room-temperature and one-step synthesis technique that leads to large-scale and l

127 oated onto a screen-printed electrode by one-step electrodeposition and used to conjugate the HA oval

128 articles (Tyr-Au NPs) were fabricated by one-step reduction of Au(3+) ion using Tyr as a reducing and

129 ide range from 20 to 1000 nm followed by one-step thermal activation.

130 e potential to be used for point-of-care one-step detection of norovirus in clinical samples.

131 GaN layers that are obtained by a facile one-step electrochemical etching method without any extra pr

132 2O3@ZSM-5 core@shell catalyst active for one-step conversion of synthesis gas to dimethyl ether (DME)

133 Here we describe an IP-free one-step method that enables stable genome integration into

134 The new one-step QuEChERS strategy was compared to other methodologi

135 A novel one-step synthesis of anthraquinones and chloro anthraquinon

136 e artificial throat has the advantage of one-step fabrication, high efficiency, excellent flexibility

137 Herein, we demonstrate an easy operating one-step and low-cost way to synthesize egg-derived heteroat

138 s practical and scalable method provides one-step synthetic access to primary anilines and phenols at

139 Subsequently, a simple one-step protocol was established for the purification and i

140 In this paper, we report a simple one-step synthesis of well-dispersed amorphous cobalt hydrox

141 Here, the one-step direct synthesis of 2D Mo2 C-on-graphene film by mo

142 This novel approach enables the one-step formation of CsPbI3/PEDOT composite, which could be

143 mine moieties were synthesized using the one-step microwave pyrolysis of citric acid in the presence

144 symmetry restricted to be two-fold, the one-step sharp magnetization reversal is realized and giant

145 The one-step spin-coating process of perovskites is investigated

146 This methodology was adapted for the one-step synthesis of a series of clinically active topoisom

147 A general asymmetric route for the one-step synthesis of chiral beta-branched amides is reporte

148 This one-step "signal on" biosensor takes 20min for the sensitive

149 n is another practical advantage of this one-step protocol.

150 We demonstrated its utility with one-step HHH purification of a wide range of traditionally c

151 on additive integration of competing second-step choices.

152 Single-step production from a Good Manufacturing Practice cold

153 into liquid fuels and chemicals in a single-step catalytic process that bypasses the production of s

154 duced on wheat bran was purified by a single-step chromatographic procedure.

155 rd fabrication, generally requiring a single-step lithography, and the possibility of vertical integr

156 on factors, we previously developed a single-step method to generate glutamatergic neurons from human

157 Using this method, a single-step separation factor up to 261 was obtained for the se

158 surface charges were developed via a single-step spinning process without any post-treatment.

159 minerals and could be exploited for a single-step synthesis of van der Waals heterostructures, as an

160 oxide nanoparticles (MNPs) through a single-step synthetic route involving the simultaneous nanopart

161 portunity to tailor dosage forms in a single-step with minimal excipients and operations.

162 lenes has been discovered that allows single-step access to 3-functionalized indoles that usually req

163 Although single-step transformations in continuous-flow systems are comm

164 The direct and single-step conversion of benzene, ethylene, and a Cu(II) oxida

165 cal peats, by applying either a large single-step (10 degrees C within a day) or a slow ramping (0.1

166 From our extensive experience of single-step and multistep continuous flow synthesis, we also de

167 It also permits single-step deposition of films of unprecedented thickness via

168 teral flow devices, using a scalable, single-step, weaving-based manufacturing approach.

169 In cytosensors fabrication simple single-step procedure was used which includes coating pencil gr

170 Here we report that single-step codelivery of CRISPR/Cpf1 ribonucleoproteins with s

171 promising approach to sensors for the single-step measurement of specific proteins and peptides.

172 Through single-step solid-state reactions, a series of novel bichalcoge

173 monodomain magnetoelectric state with single-step switching is desirable.

174 sted of a self-help booklet describing a six-step graded exercise programme that would take roughly 1

175 A general six-step approach to alkyl 2-oxo-2,3,6,7-tetrahydro-1H-1,3-d

176 velopment of an efficient, high yielding six-step convergent synthesis of the semisynthetic alkaloid

177 crystal structures of 1 and 3a reveal stair-step infinite chains whereby adjacent dimer-of-trimer un

178 silience Assessment (IRA) framework: a three-step analytical process to assess resilience and constru

179 A three-step approach using the developed soil-bacterium compati

180 PKR activation occurs in a three-step cascade.

181 In this study, we propose a three-step maxdenominator reweighted sparse representation cla

182 rx2 by urate hydroperoxide occurs by a three-step mechanism, where the peroxide reversibly associates

183 We propose a three-step model for TULP3/TUB-mediated ciliary trafficking, i

184 fication of proteins is catalysed in a three-step pathway.

185 s for ray-finned fishes and designed a three-step pipeline for multilocus DNA barcoding.

186 With the observations, we built a three-step prediction model, namely RPI-Bind, for the identifi

187 The new receptor was synthesized in a three-step process, and was investigated for its anion binding

188 We applied a three-step process, starting with a comparative analysis of th

189 A three-step protocol is shown to be effective for removal of 99

190 A three-step reaction sequence has been developed to prepare a v

191 lic oxaphospholenes were prepared in a three-step sequence from chiral pool terpenoid ketones.

192 thesized in 58-66% overall yield, by a three-step synthesis sequence starting from p-substituted acet

193 This transformation enables a concise, three-step synthesis of the natural products phenopyrrozin and

194 us Zn(II)-MOF (1) displays distinctive three-step hysteretic breathing behavior under ethane gas pres

195 An efficient three-step synthesis of a series of fused bicyclic s-[1,2,4]tr

196 ng reactions could be fit to a minimal three-step 'bind-open-lock' model in which the clamp loader bi

197 This three-step method efficiently recovered bound p-XSC by more th

198 one- (1.(H2O,EtOH)), two- (1.3H2O) and three-stepped (1.

199 -lactams, are also prepared in two- to three-steps from the versatile 2-hydroxy-5,6,7,7a-tetrahydro-3

200 eraction in eczema was conducted using a two-step approach, which included as a first step, a biologi

201 ing all available evidence, we propose a two-step assembly strategy for +ssRNA viruses: step I, acqui

202 Our scheme is based on a two-step calculation in which a linear-response TDDFT calcul

203 catalyst was created, that can perform a two-step cascade reaction.

204 A two-step catalytic mechanism was extrapolated: the catalyst

205 g chromatids from the cleavage site in a two-step cell elongation and demonstrate the role of myosin

206 is of uniform single-layer WS2 film by a two-step chemical vapor deposition (CVD) method followed by

207 Willebrand factor is activated through a two-step conformational transition: first, elongation from c

208 FA-PVSK films are processed via a two-step deposition process, known to provide high efficienc

209 A two-step enzymatic approach to reduce immuno-reactivity of w

210 A sample preparation method using a two-step extraction was developed for use with UV and/or tan

211 demanding computing, we also proposed a two-step fast screening algorithm for more efficient genome-

212 Specifically, we have implemented a two-step fragmentation process in the inject flatapole devic

213 A two-step growth approach along with a gradual variation in G

214 nd NW density revealed the efficacy of a two-step growth temperature sequence (initiating the growth

215 In addition, a two-step hierarchical linear regression model showed that si

216 ized by tRNA-dependent mechanism using a two-step indirect pathway, where O-phosphoseryl-tRNA synthet

217 A two-step integrated protocol creates a more rapid autoinduct

218 Using 1 in a two-step integrated protocol yields a rapid, sensitive, and

219 Collectively, these data indicate a two-step kinase activation process in which the IRAK4 kinase

220 al-semiconductor junctions in MoTe2 in a two-step lithographic synthesis.

221 ing to high-affinity spots, suggesting a two-step mechanism for SSB diffusion.

222 at single-molecule resolution revealed a two-step mechanism in which FtsY initially contacts membrane

223 sed Pol II states, these data identify a two-step mechanism of Hox-driven transcription, with M1BP bi

224 A two-step mechanism was elucidated through detailed kinetic a

225 6 nM), and both complexes bind through a two-step mechanism with a slow isomerization phase after the

226 uctural variant (SV) analyses revealed a two-step mechanism, a complex rearrangement followed by gene

227 n processes, this reaction proceeds by a two-step mechanistic sequence involving initial in situ gene

228 We used a two-step Mendelian randomization approach to assess whether

229 We exploited a two-step multienzymatic stereoselective cascade reduction of

230 icles, crystallization instead follows a two-step pathway that begins with the creation of disordered

231 We propose a two-step pipeline to initially assess for a treatment effect

232 Through the use of a two-step procedure consisting of a tandem alkene insertion-S

233 mplates is generally carried out using a two-step procedure involving registering a population of ima

234 For this study, a two-step procedure was employed.

235 rChiA modeling was performed by a two-step procedure, using the Swiss-Model server and Modelle

236 CDIs) and -coronenediimides (TCDIs) by a two-step process from a perylenediimide (PDI) precursor.

237 ce 5' end-dependent RNA degradation is a two-step process in E. coli involving gamma-phosphate remova

238 show that strand photodissociation is a two-step process involving light-activated cis-trans isomeri

239 Nitrification is a two-step process linking the reduced and oxidized sides of t

240 nctional theory calculations to unveil a two-step process mediated by an orbital localized on the cor

241 Here, we report a two-step process where a large design space is divided into

242 that cYY binding to CYP121 proceeds in a two-step process, and EPR spectroscopy indicates that the bi

243 s that the DAM program is activated in a two-step process.

244 into the bicyclic iridoid scaffold in a two-step reduction-cyclization sequence.

245 ly disentangle these models, we design a two-step reward-based decision paradigm and implement it in

246 remodified with MnO2 nanoparticles via a two-step sequential adsorption under careful temperature and

247 The conjugates were prepared through a two-step sequential click approach with a combination of oxi

248 ansposon mutagenesis strategy based on a two-step Sleeping Beauty (SB) forward genetic screen to iden

249 A two-step synthetic scheme is developed to allow control of c

250 strong non-flowable gels which showed a two-step yielding behavior during strain-sweep rheology, ind

251 se gradients in copper vacancies using a two-step, diffusion-assisted spray pyrolysis process.

252 A two-step, one-flask reaction of pyrrole and pentafluorobenza

253 The reaction proceeds via a two-step, one-pot process and requires 2-8 mole % of 3,3'-Ph

254 ions by restriction enzyme targeting and two-step proximity ligation.

255 The basic two-step terminal differentiation model of the medullary thy

256 -aryl-3-sulfonylchromans is described by two-step routes: (i) NH4OAc mediated Knoevenagel condensatio

257 ernary (GeTe)1-2x(GeSe)x(GeS)x system by two-step strategies.

258 Following our canonical two-step assembly protocol, polyU RNAs ranging in length fro

259 ldehyde thus demonstrating a consecutive two-step process.

260 A diastereoselective two-step strategy for the synthesis of densely functionalize

261 oline have been synthesized via a direct two-step alkylation method.

262 myosin heavy chain polymerization during two-step surimi gelation (different setting temperatures/tim

263 An efficient two-step procedure "imine formation/azirine-carbenoid coupli

264 responses are derived for two-electron, two-step homogeneous electrocatalytic reactions in the total

265 This approach enables two-step assembly of a molecular 819 knot featuring eight no

266 A mild and facile two-step process was employed to convert the inkjet-printed

267 ency of metal oxides, such as ceria, for two-step thermochemical water splitting cycles.

268 he thermodynamic efficiency of ceria for two-step thermochemical water splitting.

269 hich goes from the classical Cu-mediated two-step transport in this system to a direct coherent tunne

270 diazatetracenes are prepared using a new two-step sequence.

271 hosphorylation occurs via a noncanonical two-step mechanism in which 1) the cyclin-dependent kinase a

272 We present a novel two-step computational approach for identification of master

273 A novel two-step surface modification method that includes atomic la

274 lyubiquitin chain assembly by an ordered two-step mechanism requiring two dynamically linked E2 appro

275 e aldehyde precursors required a one-pot two-step approach, without isolation of the bicyclic acetal

276 Herein, we present the one-pot two-step procedure for the synthesis of a set of pyrazolo[3,

277 This one-pot, two-step process occurs in minutes and enables the synthesis

278 (2+) cation occurs readily in a one-pot, two-step stoichiometric reaction at room temperature to form

279 We have developed a rapid two-step synthesis of substituted 3-azabicyclo[3.2.0]heptane

280 By employing repeated two-step oxygen (O2) plasma treatment processes with 35 days

281 om the studies, we uncover a sequential, two-step mechanism of cellular reprogramming in which repres

282 process as well as the high-temperature two-step process.

283 The sensitivity and specificity of the two-step algorithm compared to results with real-time PCR we

284 genase and gluconate kinase catalyze the two-step conversion of glucose into the pentose phosphate pa

285 The two-step diagnostic algorithm utilizing microscopy as a conf

286 lergenic milk protein products using the two-step enzymatic modification method involving thermolysin

287 The two-step fabrication consists of printing a silver electrode

288 Herein, the two-step fabrication of the first inkjet-printed sulfide-sel

289 ilitate the consecutive reactions of the two-step indirect pathway of Cys-tRNA(Cys) synthesis (tRNA-d

290 Our results show that the two-step lipid-binding mechanism uncouples the membrane asso

291 The two-step meta-analysis did not reveal evidence of heterogene

292 oline utilization A (PutA) catalyzes the two-step oxidation of proline to glutamate using separate pr

293 The two-step process has been achieved at 1,300 degrees C/900 de

294 The two-step task allows distinguishing between these mechanisms

295 al magnetic resonance imaging during the two-step task.

296 This two-step approach leads to GO with a high yield (>70 wt %),

297 Using this two-step procedure we evaluated all rare variants in two AD

298 s caused a transition from a one-step to two-step process.

299 al details that select for direct versus two-step processes is unknown.

300 bstituted pyrazoles can be performed via two-step one-pot procedure.