ライフサイエンスコーパス: -substituted

1 ntanes, 1,6-disubstituted diamantanes, and 1-substituted adamantane ammonium ions by direct and compe

2 er ZnI2 as catalyst for the preparation of 1-substituted or CdI2 for the synthesis of 1,3-disubstitue

3 High regioselectivity was observed with 1-substituted and 1,2-disubstituted butadienes.

4 2-Substituted 3-aroylquinolin-4(1H)-ones, prepared through

5 2-Substituted indolines are resolved (s=2.6-19) using an a

6 yield of 51-99% when cyclopropanes with a 2-substituted alkenyl group as a donor underwent isomeriza

7 l alkynes with simple allyl phosphates and 2-substituted allyl phosphates is described.

8 structures of N-substituted pyridones and 2-substituted pyridines.

9 -free approach for the synthesis of 3-aryl-2-substituted quinolines and 4-arylacridines has been deve

10 es with "opposite" chiralities of the endo-2-substituted-5,6-norbornene skeleton, can be prepared usi

11 ting species and the chirality of the endo-2-substituted-5,6-norbornene skeleton.

12 A and B are two enantiomerically pure endo-2-substituted-5,6-norbornenes with "opposite" chiralities

13 hdrawing groups are well tolerated to form 2-substituted dihydroquinolines and dihydroisoquinolines.

14 r to attack C2 of the intermediate to form 2-substituted pyridines.

15 rious nucleophiles, giving access to 4-[N-(2-substituted)piperazin-1-yl]-5H-1,2,3-dithiazoles in mode

16 and proton chemical shifts in a variety of 2-substituted 1-(methyl-d)piperidines.

17 e parent allyl group as well as a range of 2-substituted allylic fragments.

18 )4] forms enone products with a variety of 2-substituted cyclic enamides and 3,4-dihyro-2H-pyrans.

19 ion states and facilitate the formation of 2-substituted pyridines.

20 lar double carboalumination of unactivated 2-substituted 1,5-dienes, which provides efficient and dir

21 Various 2-substituted benzimidazoles are obtained in moderate to g

22 a reactions of the bromoporphyrins yielded 2-substituted or 2,12-disubstituted porphyrins with red-sh

23 ormational analysis suggested that trans-3''-substituted trioxolanes would exhibit Fe(II) reactivity

24 atalysis leading to sp-, sp(2) -, and sp(3) -substituted arrays.

25 that the most active compounds were the N(3)-substituted uracil derivatives containing 6-(4-bromophen

26 One property of chemical bonding renders 1,3-substituted allenes chiral, making them attractive targe

27 hodology allows for the preparation of 1,2,3-substituted borocyclopropanes in high yields and diaster

28 oration of a series of biphenyl-N-[4-[4-(2,3-substituted-phenyl)piperazine-1-yl]alkyl]carbamates, a n

29 A variety of optically active 3-substituted 3,4-dihydroisocoumarins were obtained in exc

30 reoselective synthesis of optically active 3-substituted piperidines via ring expansion reaction.

31 l substitution reaction sequence to afford 3-substituted 4-enone moieties.

32 4- and 1,2-addition reactions of allyl and 3-substituted allylsilanes to indolizidine and quinolizidi

33 Enantiopure 2-methyl-3-substituted tetrahydrofurans are key precursors of sever

34 is strategy, finding that incorporation of 3-substituted azetidine groups allows rational tuning of t

35 regioselectivity of the hydroarylation of 3-substituted phenyl propargyl ethers catalyzed by cationi

36 A decarboxylative cross-coupling of 3-substituted picolinic acids with (hetero)aryl halides is

37 ation, -arylation, and -heteroarylation of 3-substituted pyrazoles have been achieved using K2CO3-DMS

38 c study of the N-substitution reactions of 3-substituted pyrazoles under basic conditions has been un

39 In this study inspired by previous work on 3-substituted Asp analogues, we designed and synthesized a

40 An efficient, metal-free approach to 3-substituted 3-hydroxyoxindole by DBU-mediated highly dia

41 We report a dual probe system based on 4'-substituted biphenyl-2-carboxylic acids (BPAs) for analy

42 preparation of a small library of novel 1,4-substituted triazoles with AR antagonistic activity.

43 We found that 2,4-substituted triazole ureas with a biphenylmethanol group

44 of 2-iodo enol esters leading to 4- and 3,4-substituted isocoumarins was accomplished selectively at

45 roups cis to each other is observed with a 4-substituted 3-nitroindole.

46 The reported alkyl 2-cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrahy-dropyrimidine-5-car

47 -deazapurine ribonucleosides (derived from 4-substituted thieno[2',3':4,5]pyrrolo[2,3-d]pyrimidines a

48 developed by catalytic desymmetrization of 4-substituted cyclohexanones with O-arylhydroxylamines and

49 Optimization of 4-substituted indazoles yielded two compounds, 27 and 48,

50 A series of 4-substituted N-alkoxypiperidines were prepared and studie

51 dy, we investigated a systematic series of 4-substituted-2-pyridylquinazolines in terms of their inhi

52 des, under palladium catalysis, to produce 4-substituted homopropargyl alcohols and 5-en-3-yn-1-ols,

53 )-5-substituted oxazoles and their related 4-substituted-5-(3',4',5'-trimethoxyphenyl) regioisomeric

54 ized by a change in the orientation of the 4-substituted TEMPO derivatives with the increasing substi

55 ort the synthesis and evaluation of novel 5'-substituted amiloride derivatives as hA2AAR allosteric a

56 hich offer flexible entry to a range of C(5)-substituted cotinine variants.

57 5-Substituted-2-ethoxy-1,3,4-oxadiazoles were conveniently

58 ar heteroannulation of newly synthesized 4,5-substituted 3-amino- or 3-hydroxy 2-functionalized thiop

59 A few of the 4,5-substituted 3-amino/hydroxy-2-stryrylthiophenes (or 2-ac

60 eazaadenine and -7-deazaguanine as well as 5-substituted uracil and cytosine 2'-deoxyribonucleosides

61 -1-(trimethylsilyloxy)-1-propene result in 5-substituted-1,3-cyclohexadienes after removal of the met

62 Many 5-substituted and 2,5-disubstituted tetrazoles are excelle

63 broad activity profile in the synthesis of 5-substituted tryptophans.

64 In this study, 5-substituted phenyl ether-linked aminoquinolines and deri

65 ple 2-methyl-4-(3',4',5'-trimethoxyphenyl)-5-substituted oxazoles and their related 4-substituted-5-(

66 It was found that the linear 6,6''-substituted ditopic motif (L(3)) would be directed by th

67 Structural determinants of affinity of N(6)-substituted-5'-C-(ethyltetrazol-2-yl)adenosine and 2-chl

68 All N(6)-substituted-5'-C-(ethyltetrazol-2-yl)adenosine derivativ

69 P), we previously identified a series of 4,6-substituted 2-aminopyrimidines that associate with this

70 s could be further transformed into chiral 6-substituted 5,6-dihydrophenanthridines as important stru

71 New HPs, including 6-substituted analogues, demonstrate potent antibacterial

72 complexes, which forms a mixture of 5- and 7-substituted 2H-chromenes.

73 s of hybrid compounds incorporating 6- and 7-substituted coumarins (carbonic anhydrase, CA inhibitors

74 substituents as well the first examples of 7-substituted analogues of this scaffold.

75 nical candidate, this structurally related 7-substituted 2-nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazin

76 led in a facile manner to yield diverse C(8)-substituted 2,1-borazaronaphthalenes.

77 es of pyrazolo[1,5-a]quinazoline 3- and/or 8-substituted as 5-deaza analogues of previous reported py

78 tuents outperform the corresponding acceptor-substituted systems.

79 n of global gene-knockout, single-amino-acid-substituted, as well as floxed mice that can be used for

80 Herein, we report on boronic acid-substituted stilbenes that limit TTR amyloidosis in vitr

81 ternary stereogenic center with an aliphatic-substituted allylic electrophile is disclosed.

82 -5-ene (TBD) to yield a well-defined, alkene-substituted degradable polymer, which was used as a comm

83 readily generate the bicyclic alkyl-/alkenyl-substituted stannylenes, ArSn(norbornyl) (2a or 2b) and

84 reactions were accomplished with an alkenyl-substituted pyrimidine, pyrazine, thiazole, quinoxaline,

85 In contrast, the N-5-alkyl-substituted analogues, and notably the n-butyl-arylamide

86 -, heteroaryl-, alkenyl-, alkynyl- and alkyl-substituted allylic phosphates may thus be converted to

87 substrates (e.g., aryl-, benzyl-, and alkyl-substituted allylic sulfides) and alpha-diazo esters.

88 Interestingly, aryl-substituted and alkyl-substituted alpha-diketones produced different products:

89 hioamides with aryl-, heteroaryl-, and alkyl-substituted dioxazolones under the Cp*Co(III) -catalyzed

90 alenediimide motifs thus far, branched alkyl-substituted PIID[2F]T polymers are particularly promisin

91 ioselective means for the synthesis of alkyl-substituted aziridines.

92 rs a direct route for the synthesis of alkyl-substituted chiral aziridines from achiral starting mate

93 Treatment of the alkyne-substituted dipyrrin with BF3.OEt2 and NEt3 revealed the

94 ing-opening polymerization (ROP) of an allyl-substituted caprolactone monomer was carried out using t

95 ed the conformation of three chiral N(alpha)-substituted, N(beta)-Boc protected alpha-hydrazinoacetam

96 ective alkylation step proceeds via an alpha-substituted malonate-imidazolidinone enolate in its Z-co

97 Homobenzylic aldehydes and alpha-substituted homobenzylic aldehydes were cleaved to benzy

98 onalized terminal styrenes, as well as alpha-substituted and beta-substituted styrenes.

99 , and tosylates from the corresponding alpha-substituted methyl iodides.

100 The use of enantioenriched alpha-substituted benzylamines gave the corresponding secondar

101 e kinetics of a series of reactions of alpha-substituted carbanions with reference electrophiles to e

102 atalyzed dynamic kinetic resolution of alpha-substituted cyclohexanones has been performed and yields

103 To provide alpha-substituted piperazines for early stage medicinal chemis

104 It was found that the reaction with alpha-substituted five- to seven-membered cyclic amines procee

105 tions that the tau torsion of the meta-amino-substituted BDI systems leads to a zwitterionic twisted

106 ides a new synthetic route to valuable amino-substituted phosphiranes and phosphirenes, respectively.

107 derivatives have also been discovered: anion-substituted compounds where the complex borohydride anio

108 or whether the reaction involves an argento-substituted allylic cation.

109 substituted thioureayl alanines and aromatic-substituted amino tetrazolyl alanines were successfully

110 Thus, a variety of aliphatic- and aromatic-substituted thioureayl alanines and aromatic-substituted

111 Aryl-substituted bis(imino)pyridine iron and cobalt dihalide

112 ioselective coupling protocol between 3-aryl-substituted-1,1-diphenyl-2-azaallyl derivatives and viny

113 found to be general for both alkyl- and aryl-substituted enones, providing the corresponding 4-oxopip

114 f two readily available partners, gamma-aryl-substituted alkynoates and alcohols, under mild conditio

115 Interestingly, aryl-substituted and alkyl-substituted alpha-diketones produc

116 allows the construction of a variety of aryl-substituted imidazo[2,1-b]benzothiazoles, -[2,1-b]thiazo

117 s, the rate enhancements in a series of aryl-substituted methylenecyclopropanes correlate with sigma(

118 diene products bearing either alkyl- or aryl-substituted benzylic stereocenters are afforded in excel

119 A series of racemic aryl-substituted phenylalanines was synthesized and evaluated

120 e rates of the reactions of the arylsulfonyl-substituted carbanions carrying alpha-chloro and alpha-b

121 Despite the fact that ASF-substituted GF cookies had inferior sensory attributes c

122 e to yndiamides, a novel class of double aza-substituted alkyne, has been established by the copper(I

123 shift (deltaNA) of the five different azine-substituted 1,2,4-triazole ligands employed, L(azine) =

124 on-carbon triple bond activation of benzylic-substituted propargyl alcohols by a seleniranium ion, an

125 rt an intramolecular cyclization of benzylic-substituted propargyl alcohols promoted by iron(III) chl

126 ne was reacted with aldehydes to access beta-substituted alpha-fluoroalkenyl pyrrolidines in one step

127 )ethanone gives a mixture of alpha- and beta-substituted products in a ratio of 1:3.

128 renes, as well as alpha-substituted and beta-substituted styrenes.

129 ion between 2-mercaptobenzaldehydes and beta-substituted vinyl PT-sulfones has been realized for the

130 ed as nucleophiles for the synthesis of beta-substituted carbonyl derivatives.

131 s an optical indicator composed of a bismuth-substituted yttrium iron garnet thin film, and visualize

132 The resulting BN-substituted contorted polycyclic aromatic hydrocarbons s

133 most-favorable pathway involves a rare boryl-substituted carbocation.

134 racterization of the crystal packing of a Br-substituted Biginelli-like derivative, while computation

135 sformation of a longer polyynes to butadiyne-substituted thiophene.

136 The tert-butyl-substituted analogue, Cp*U(NTol)2((t)Bu-(Mes)PDI(Me)) (3

137 compared to that in the analogous tert-butyl-substituted array 1b.

138 transformation provides a new approach to C-substituted unsaturated morpholine derivatives that are

139 C3-substituted indoles and carbazoles react with alpha-aryl

140 Upon deprotonation of the NH group, a C6F5-substituted formazan undergoes facile cyclization as a r

141 Hydroperoxy, hydroxyl and carbonyl-substituted CPA derivatives were tentatively identified

142 Readily available beta-carbonyl-substituted aldehydes are shown to be exceptional substr

143 Both the trehalose- and carboxybetaine-substituted pCL were further investigated with regard to

144 When incorporated into mRNA, the CCl2-substituted dinucleotide most efficiently promoted cap-d

145 tion initiation factor 4E (eIF4E), with CCl2-substituted analogues having the highest affinity.

146 tively, the regioselective assembly of 3-CF3-substituted pyrazoles can be performed via two-step one-

147 olvents (DMSO), the formation of their 5-CF3-substituted isomers was preferentially observed.

148 c elaboration to produce, for example, a CF3-substituted 2-oxa-4,7-diazabicyclo[3.3.0]octan-3-one sys

149 yloxiranes, which are precursors to many CF3-substituted tertiary alcohols.

150 A broad range of CF3-substituted arenes is efficiently converted into unsymme

151 phate-unmodified and previously reported CH2-substituted caps.

152 tion-null T53A DAT relative to WT and charge-substituted T53D DATs, consistent with functions related

153 When starting from 7-chloro-substituted 2,3,4-benzothiadiazepine 2,2-dioxide, the fo

154 transfer of both P and Cl atoms from chloro-substituted dibenzo-7lambda(3) -phosphanorbornadiene.

155 quinolines by selective metalation of chloro-substituted quinolines with metal amides followed by rea

156 ween the product distributions of the chloro-substituted and the thiadiazolo-fused derivatives.

157 reactive sites were consumed by chlorine, Cl-substituted functional groups (Cl-DOM) are reacting with

158 involves intermediates that contain a copper-substituted stereogenic carbon centre.

159 investigation of structural evolutions of Cu-substituted Co3 O4 supplemented by first-principles calc

160 Of the cysteine-substituted residues, interaction of a proposed pore-lin

161 thoxy-1-vinylcyclopropane, whereas deuterium-substituted 1-methoxycyclopropyl-d3-methylcarbene underg

162 substituents, halides, isolated mono- and di-substituted double bonds, esters, silyl ethers, and sily

163 two equivalents of HN(NO2 )2 afforded the di-substituted borate anion consisting of two isomers, one

164 ure and slightly higher activity than the di-substituted flavone on the ring A.

165 ene (NHC) to form an isolable N-dicarbollide-substituted NHC dianion.

166 n characterization of 3,7- and 2,6-dithienyl-substituted NBA molecules and corresponding isomeric NBA

167 Donor-substituted diazo reagents, generated in situ from sulfo

168 reactivity previously requiring strong donor-substituted alkynes such as ynamides.

169 gashira coupling, led to the tethered enoate-substituted furans 14 and 19.

170 anism in which chain extension with fluorine-substituted extender units switches largely to an acyl c

171 leading to a first generation of fluoroalkyl-substituted quinoline tau binding ligands with suboptima

172 or enantioselective synthesis of fluoroalkyl-substituted Z-homoallylic tertiary alcohols has been dev

173 Group IV and V framework-substituted zeolites have been used for olefin epoxidati

174 cks, we examined high-pressure frozen/freeze-substituted alfalfa root cap cells with electron microsc

175 tly with temperature, forming mixtures of Ga-substituted In2O3 and In-substituted beta-Ga2O3 with dif

176 e-derived aminophenol and a Z- or an E-gamma-substituted boronic acid pinacol ester.

177 elective rhodium-catalyzed reaction of gamma-substituted enoldiazoacetamide with nitrosobenzene produ

178 This method opens a rapid access to gamma-substituted propyl-1,1-diesters, ketoesters, cyanoesters

179 e(mu-P)2 GeL2 ] 4 and bis(germyliumylidenyl)-substituted diphosphene [(L2 Ge-P=P-GeL2 )] 5 could also

180 Halo-substituted ruthenium carbene complexes decompose rapidl

181 yl-, alkenyl-, alkynyl-, aryl- or heteroaryl-substituted trifluoromethyl ketones can be used.

182 lorins, heterocarbaporphyrinoids, heteroatom-substituted confused porphyrins, and so on.

183 of an incredibly diverse array of heteroatom-substituted products.

184 BMS-816336 (6n-2), a hydroxy-substituted adamantyl acetamide, has been identified as

185 ical evaluation of novel C9- and C11-hydroxy-substituted hexahydrocannabinol (HHC) and tetrahydrocann

186 nd synthesized a collection of novel hydroxy-substituted heteroarylpiperazines and heteroarylhomopipe

187 ST-active tetra(carboxamide) and/or hydroxyl-substituted bisphosphonate ligands.

188 ming mixtures of Ga-substituted In2O3 and In-substituted beta-Ga2O3 with different degrees of substit

189 Moreover, we showed that all other indole-substituted analogs of Trp undergo methylation at varyin

190 2 and H2 capture capacities of the Li(+)-ion-substituted CD-MOF have been shown to exceed the highest

191 pirocin P, which contains a 7-hydroxy-6-keto-substituted THP, from a DeltamupP strain and chemical co

192 e units, 15 elastin-like units, and 1 lysine-substituted elastin-like unit) with GAG GM-0111, we crea

193 rapid way to prepare a large variety of meso-substituted porphyrins from only one precursor.

194 ons of various methodologies leading to meso-substituted corroles.

195 or phosphites in the same pot produces meta-substituted anilines in good yields.

196 The meta-substituted benyzlsulfonamides can be readily transforme

197 atures a C3-symmetric ligand motif with meta-substituted phenyl spacers, which enables the host to in

198 selectively and fully deuterated syn methyl-substituted Criegee intermediates under atmospheric cond

199 The methyl-substituted spiroazetidine ring systems were accessed us

200 iation/alkylation chemistry while the methyl-substituted spiropyrrolidines were synthesized by 1,4-ad

201 BH3 THF with K[N(NO2 )2 ](-) produced a mono-substituted [BH3 N(NO2 )2 ](-) anion, which contains a B

202 he kinetics of the reactions of monoacceptor-substituted ethylenes (H2C horizontal lineCH-Acc, 1) and

203 e-light irradiation, typical mono- and multi-substituted aromatic olefins could be converted into ket

204 d to both symmetric and unsymmetric N,N',N''-substituted derivatives.

205 to attack C8 of intermediate 4a, affording N-substituted pyridones, while phenylmethanamine, 2-phenyl

206 etween potassium selenocyanate (KSeCN) and N-substituted ortho-halobenzamides to form 2-alkyl-1,2-ben

207 Antimicrobial N-substituted glycine (peptoid) oligomers ("ampetoids") ar

208 Readily available N-substituted amides or their requisite carboxylic acids o

209 e conformational heterogeneity of backbone N-substituted peptides limits their ability to adopt stabl

210 by the microwave-assisted reaction between N-substituted 5-aminopyrazoles 1 and 3-(3-oxo-2-benzofuran

211 Both N-substituted and N-unsubstituted alpha-amino acids, dipep

212 gical profiling of natural product-derived N-substituted 2,4-dodecadienamides as a selective endocann

213 A series of N-substituted (2-phenylcyclopropyl)methylamines were desig

214 uctive cleavage enables the preparation of N-substituted cis 5-amino-3-hydroxypiperidines from a read

215 Peptoids that are oligomers of N-substituted glycines represent a class of peptide mimics

216 A highly functionalized variety of N-substituted pyridine-fused chromeno and pyrano derivativ

217 fford prevalent heterocyclic structures of N-substituted pyridones and 2-substituted pyridines.

218 We report a series of N-substituted THQ analogues that incorporate various carbo

219 ives that only differ in the length of the N-substituted glycol chain.

220 h by simple grinding of 1-haloalkynes with N-substituted pyrroles and potassium carbonate which playe

221 s of 1,3-disiloxanediols, including naphthyl-substituted and unsymmetrical siloxanes, has been quanti

222 lo[3,2-c]isoquinolin-5-amines, the first NH2-substituted derivatives of 1H-pyrrolo[3,2-c]isoquinoline

223 of acetyl coenzyme A synthase using a nickel-substituted azurin protein (NiAz).

224 substitution in the complete series of nitro-substituted octaethylporphyrins.

225 on of a partial positive charge on the nitro-substituted carbon in both transition state and product

226 Nitrogen-substituted isocyanates (N-isocyanates) are rare amphote

227 ry amines as nucleophiles to afford nitrogen-substituted benzo[b][1,6]naphythyridines while primary a

228 he imidazole ring-fragmented lesion, N(5)-NM-substituted formamidopyrimidine (NM-Fapy-dG).

229 a preference to degrade substituted and non-substituted polycyclic aromatic hydrocarbons.

230 gonists that introduce a bicyclic nortropine-substituted benzothiazole carboxylic acid moiety onto a

231 Nonstabilized alpha-O-substituted tertiary organolithium species are difficult

232 For the significantly larger hepta-O-substituted system the assignment particularly benefits

233 es, four tetra-O-substituted and one hepta-O-substituted, have been resolved by enantioselective HPLC

234 om comparison of rotational barriers on N-(o-substituted aryl)thiazoline-2-thione atropisomers.

235 five chiral resorcin[4]arenes, four tetra-O-substituted and one hepta-O-substituted, have been resol

236 For the four tetra-O-substituted resorcin[4]arenes, the ECD exciton couplet a

237 locyanine fused in peripheral positions octa-substituted with alkyl linked carbazole has been prepare

238 ertaken to determine the influence of ortho'-substituted nucleophilic groups (OH, NH2, or NHR) on the

239 nic esters and a N-activator to afford ortho-substituted benzylic boronic esters with formal 1,1'-ben

240 ues is achieved from readily available ortho-substituted phenols.

241 even with sterically encumbered doubly ortho-substituted substrates.

242 For ortho-substituted phenols, initial incorporation of a benzotri

243 cantly higher yields were achieved for ortho-substituted substrates than para ones, probably due to t

244 The synthetic strategy starting from ortho-substituted benzene units to construct five-membered rin

245 to allowing atropisomerism in hindered ortho-substituted phenylcyclohexanes.

246 Non-ortho-substituted boronic acids result in "flat" complexes.

247 molecular 1,3-dipolar cycloaddition of ortho-substituted 1,1,1-trifluoromethylstyrene-derived nitrone

248 which function as ready precursors of ortho-substituted 8-aryl BODIPY derivatives by reaction with b

249 adienes are also formed in the case of ortho-substituted arylalkynes by a metathesis-type process.

250 on of the association constant (Ka) of ortho-substituted boronic acids in solution showed that Ka for

251 rapping of the benzylic cations by the ortho-substituted oxygen and nitrogen nucleophilic groups.

252 The results showed that when ortho-substituted nucleophilic groups such as OH and NHR are p

253 direct irradiation of diphenyl sulfide and p-substituted thioanisoles in the presence of oxygen was i

254 hree-step synthesis sequence starting from p-substituted acetophenones.

255 t of corresponding SF5- or CF3-acetates of p-substituted cinnamyl alcohols with triethylamine followe

256 folds endowed at the C6 position with a para-substituted phenethyl side chain, which could be exploit

257 The rate of oxidation of meta- and para-substituted benzylic alcohols by either 1 or 5 displays

258 arylanilines that contain flanking meta/para-substituted aromatic rings adjacent to the central anili

259 In the case of para-substituted phenols, after reaction of a dilithio phenol

260 rotein family catalyze the oxidation of para-substituted phenols.

261 of VAO and related enzymes that oxidize para-substituted phenols.

262 alkylation has also been achieved using para-substituted phenoxypyrimidine and 3 mol equiv of the dia

263 Evaluation of various para-substituted benzenesulfonamides defined a substituent ef

264 Amphiphilic arrays containing PEG-substituted BODIPY and chlorins or bacteriochlorins were

265 A simple method for accessing perfluoroalkyl-substituted enones is described applying a four-componen

266 tocol for direct synthesis of perfluoroalkyl-substituted enones is reported.

267 cess readily extends to other perfluoroalkyl-substituted alkenes.

268 We report here the synthesis of 7-phenoxy-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-di

269 protocol for the synthesis of certain phenyl-substituted carboxylic acids from 2-phenylcycloalkanones

270 n an increase in the concentration of phenyl-substituted dihomooxacalix[4]arene bidentate urea, volta

271 New Si-phenyl-substituted silacyclohexanes and 3-silatetrahydropyrans

272 91/6-31G(d,p)) on terminal and phenylethynyl-substituted 5,6-diethynylquinoxaline and 6,7-diethynylqu

273 tibacterial activity of three phenylthiazole-substituted aminoguanidines.

274 Nazarov cyclization of the beta-(propenoyl)-substituted ring C forms the isocyclic ring (E).

275 tortion in the premartensite phase of 10% Pt-substituted Ni2MnGa.

276 ent enantioselective synthesis of quaternary-substituted thiazolines through the organo-catalyzed hal

277 the corresponding C-N coupled products, N-R-substituted carbazoles, in 82-98% yield.

278 s are difficult to generate, and the alpha-S-substituted analogues are configurationally unstable.

279 erentially occurred as nanogoethite or Al/Si-substituted goethite.

280 um ylides 3, sulfonium ylide 4, and sulfonyl-substituted chloromethyl anion 5.

281 riles enabled the direct synthesis of sulfur-substituted benzo[b][1,6]naphthyridines via multiple bon

282 ivity in the hydrogenation of tri- and tetra-substituted alkenes with TON > 8000 for the hydrogenatio

283 e used for synthesis of di-, tri-, and tetra-substituted allenes.

284 ides incorporating contiguous tri- and tetra-substituted centers.

285 g accompanied by CH2 extrusion yielded tetra-substituted sulfamidates with an aminomethyl group.

286 be observed at room temperature for thienyl-substituted phenazines without any heavy metals ( Ratzke

287 In this work, the thienyl-substituted phenazines are investigated in more detail b

288 eoselective nucleophile attack for 2,3-trans-substituted five-membered ring oxocarbenium ions is stro

289 A tri-substituted borate was tentatively identified by NMR in

290 eaction mixture generated mono-, di- and tri-substituted sugar complexes and their hydrolysis product

291 building blocks and 1,1-bis(trifluoromethyl)-substituted alkenes can be prepared under ambient condit

292 Trifluoromethyl-substituted cyclopropanes are an attractive family of bu

293 higher-energy (Z) isomers of trifluoromethyl-substituted alkenes through cross-metathesis reactions w

294 ical precursors, an array of trifluoromethyl-substituted alkenes undergoes radical defluorinative alk

295 the asymmetric synthesis of trifluoromethyl-substituted cyclopropanes by means of myoglobin-catalyze

296 e synthesis of the requisite trifluoromethyl-substituted alkene starting materials.

297 atalyzed reactions of beta-triisopropylsilyl-substituted enoldiazo compounds with sulfur ylides.

298 readily accessible meso-(2-aminophenyl) tris-substituted platform.

299 ansformation, yielding both alkyl- and vinyl-substituted boronate esters containing chiral tetrahydro

300 6 literature ligands, known as bpp(X,Y) [X,Y-substituted 2,6-(pyrazol-1-yl)pyridines], which have pro