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1                      We have used 20 capsule-switched variants of strain TIGR4 to investigate whether
2        Median FH binding was high in capsule-switched mutant strains expressing more invasive serotyp
3  wild-type serotype 3 strain and the capsule-switched mutant behaved similarly, whereas in the lungs
4 e 3 strain was virulent, whereas the capsule-switched mutant was avirulent.
5 neutrophil association for the TIGR4 capsule-switched strains.
6                                      A chain-switched Fab fragment containing the M77 Fd fragment and
7                                        Class-switched and nonswitched GC B cells emerged contemporane
8                                        Class-switched anti-RNP autoantibody-producing cells were also
9                                        Class-switched memory B cells showed: accumulation of FAS-muta
10 with a lentiviral construct encoding a class-switched anti-HIV IgA (b12-IgA) into the humanized bone
11 st be exquisitely controlled because a class-switched B cell cannot revert back to the parent isotype
12 onal germinal center activity and of a class-switched memory B-cell compartment.
13 mma H chains, which is indicative of a class-switched response.
14 vo and isolated 24 h later initiated a class-switched, Ag-specific Ab response in naive animals.
15                          High-affinity class-switched Abs and memory B cells are products of the germ
16 ant mice fail to produce high-affinity class-switched antibodies and generate memory B and long-lived
17 response, which produces high affinity class-switched antibody made by long-lived plasma cells.
18 specific GC B cells, and high-affinity class-switched antibody production.
19  in B cells that express high-affinity class-switched IgG.
20 ined by the formation of high-affinity class-switched memory B cells and long-lived antibody-secretin
21 on and the generation of high-affinity class-switched plasma and memory B cells.
22 responses that generate high-affinity, class-switched Ab in vivo.
23  However, the number of high-affinity, class-switched Ab-forming cells was severely decreased in the
24 nduce B cells secreting high-affinity, class-switched antibodies during germinal center (GC) reaction
25 s for the generation of high-affinity, class-switched antibodies during T cell-dependent antibody res
26 bited the production of high-affinity, class-switched antibodies, but not the production of low-affin
27 or B cell production of high-affinity, class-switched antibodies.
28 ial in the induction of high-affinity, class-switched antibodies.
29 orting the induction of high-affinity, class-switched antibody responses, long-lived plasma cells, an
30  (Tfh) cells potentiate high-affinity, class-switched antibody responses, the predominant correlate o
31 excessive production of high-affinity, class-switched autoantibodies and to the high incidence of B c
32  IgG, but not IgM secretion by already class-switched B cells.
33                               Although class-switched virus-specific Abs were initially generated in
34                Both CD8(+) T cells and class-switched Ab responses have been detected from patients w
35  provide help for germinal centers and class-switched Ab responses.
36 e, B cell-deficient, Ab-deficient, and class-switched Ab-deficient mice with attenuated Salmonella an
37  proliferation markers (Ki-67(+)), and class-switched B cells (IgG(+)); and (5) both TNFRSF17 mRNA an
38  cytidine deaminase was expressed, and class-switched B cells were present.
39 d numbers of marginal zone B cells and class-switched cells, and were associated with decreased antib
40 ronment essential for GC formation and class-switched Ig responses.
41    This may imply that CD4 T cells and class-switched IgG antibodies are more relevant for generating
42 oted homeostatic production of IgM and class-switched IgG antibodies to microbial capsular polysaccha
43 +) B cells, including IgM(+) naive and class-switched IgG memory B cells, with a concomitant increase
44  Numbers of total memory (CD27(+)) and class-switched memory B cells (IgM(-)) were significantly redu
45 d circulating natural killer cells and class-switched memory B cells were reduced.
46  molecule expression between naive and class-switched memory B cells, indicating their potential to i
47 ive, mature CD5(+), IgM(+) memory, and class-switched memory B cells.
48 erse compartment of IgM(+)(IgD(+)) and class-switched memory B cells.
49 s-associated, somatically mutated, and class-switched pathogenic autoantibodies are generated in spon
50  in germinal center B cells as well as class-switched high-affinity Ab-secreting cells.
51  (healthy donors) MHC-II expression as class-switched memory B cells and intermediate costimulatory m
52 ng T cells and significantly augmented class-switched HSV-specific antibody responses compared with t
53 etic mechanisms, valproic acid blunted class-switched and hypermutated T-dependent and T-independent
54 systemic autoimmunity characterized by class-switched anti-nuclear Abs.
55  memory compartments, characterized by class-switched IgG and high-affinity Abs, are the basis for su
56 in the immunoglobulin (Ig)D(-)CD27(+) (class-switched) memory B-cell compartment that normally arises
57 of somatic mutations in CD19+IgD-CD27+ class-switched memory B cells in RV-specific memory B cells, s
58  ligand gene, do not have a classical, class-switched memory B-cell population (IgD(-) CD27(+)).
59                           In contrast, class-switched antibodies specific to S. aureus are common, im
60 tingly, in the absence of conventional class-switched memory B cells, the circulating EBV load was co
61              In addition, it decreased class-switched and hypermutated autoantibodies, ameliorated di
62              Frequencies of AF DENV(+) class-switched memory B cells (IgD(-)CD27(+) CD19(+) cells) re
63  high titers of specific IgM and early class-switched antibodies.
64 lipopolysaccharide effectively elicits class-switched NP-specific IgG3 and IgG2b in mice.
65 e hypothesized that clonally expanded, class-switched IgG4-positive B cells and plasma cells could be
66  germinal centers and is necessary for class-switched Ab responses.
67 iple MHC disparities, cognate help for class-switched alloantibody may also be provided by CD4 T cell
68 te activity, and provision of help for class-switched antibody responses.
69 ive repertoire are apparent mainly for class-switched B cells and not for IgM germinal center, IgM me
70 response to different stimuli than for class-switched memory cell development.
71 spontaneous germinal center formation, class-switched autoantibodies, renal histopathology, and early
72  t1/2 of pre-established Ag-induced Ig class-switched and IgM-positive memory B cells over 402 d.
73        By showing dysregulation of IgD class-switched B cells and 'IgD-armed' basophils in autoinflam
74 ion to enhancing mucosal immunity, IgD class-switched B cells enter the circulation to 'arm' basophil
75 ing the recall response by CD27(+) IgG class-switched human memory B cells, total IgG secreted is a f
76 ii) germinal-center B cells, and (iii) class-switched B cells.
77 irment in production of immunoglobulin class-switched antibodies, which is possibly contributed to by
78 rexpressing MiR-210 exhibited impaired class-switched Ab responses, a finding confirmed in wild-type
79 at Sox2 may regulate AID expression in class-switched B cells to suppress genomic instability associa
80 gs are considered to largely reside in class-switched CD27(+) cells.
81 ciated with a significant reduction in class-switched IgG, and anti-nucleosomal IgG-secreting B cells
82 ic failure and the severe reduction in class-switched memory B cells, while gathering longitudinal la
83  2 anti-parasite mechanisms, including class-switched antibodies, activated leukocytes and innate def
84 assumes multiple cell fates, including class-switched B cells, antibody-secreting plasma cells, and m
85 om infants who survived RSV infection, class-switched antiviral and antinucleosomal antibodies were d
86 c B1a cells, which differentiated into class-switched CD138(+) IgG-secreting B1a cells.
87 to promote B cell differentiation into class-switched plasmablasts and led to downregulation of chemo
88 tiation of WASp-deficient B cells into class-switched plasmablasts in vitro, suggesting that WASp-dep
89            In addition, anti-P. murina class-switched Abs were increased in BL/6 Stat4(-/-) mice, but
90 ge B-cell clones, especially among non-class-switched memory B cells.
91 hat are essential for the synthesis of class-switched Ab.
92  Ab formation, decreases production of class-switched Abs targeting nonnuclear Ags, and limits system
93 1), are critical for the generation of class-switched and hypermutated (mature) Ab and autoantibody r
94         Greater apoptotic depletion of class-switched and IgM memory cells was associated with phosph
95 magglutinin leads to the production of class-switched anti-MOG antibodies, dependent on the presence
96 ponse that increases the generation of class-switched antibodies and the frequency of somatic hypermu
97  the events that lead to production of class-switched antibodies during T. gondii infection have not
98 ght be useful to enhance production of class-switched antibodies following vaccination.
99                          Expression of class-switched antibodies from Ara h 2-positive cells confirms
100                          The titers of class-switched antibodies in immunized CD4 T-cell- and MHC cla
101 ter reaction and for the production of class-switched antibodies in response to thymus-independent an
102                           Secretion of class-switched antibodies requires additional stimulation by B
103 s naive B cells, higher frequencies of class-switched antibodies were detected in cocultures of CXCR5
104                      The production of class-switched antibodies, particularly immunoglobulin (Ig) G1
105 licular CD4 T cells, and production of class-switched antibody, together with expansion of B1 B cells
106 c infections through the generation of class-switched antibody-secreting cells (ASCs) in germinal cen
107                    Complete absence of class-switched B cells was a sensitive predictor of AID defici
108 I compound AZD8055 increased titers of class-switched high-affinity antibodies to a hapten-protein co
109 rminal center formation, production of class-switched Ig, and development of memory B cells.
110 ro and produced high concentrations of class-switched IgG2b and IgG2c, including anti-RNA antibodies.
111 e observed reductions in expression of class-switched isotypes in OCA-B-/- mice may be due in part to
112 ediated recombination, the tracking of class-switched memory B and plasma cells in vivo.
113  lymphopenia, decreased frequencies of class-switched memory B cells and hypogammaglobulinemia due to
114 er of iNKT cells and the percentage of class-switched memory B cells and propensity to lymphoprolifer
115 us toxin, whereas the proliferation of class-switched memory B cells is suppressed by Stichodactyla h
116  controls revealed that frequencies of class-switched memory B cells were increased in the patients,
117 uencies ranging from 0.01% to 0.11% of class-switched memory B cells.
118 nal center and ensure replenishment of class-switched memory CD27(+) B cells from Ag-experienced prec
119 ry repertoire is distinct from that of class-switched memory.
120 ficient mice by blocking production of class-switched pathogenic IgG autoantibodies.
121 nted the age-dependent accumulation of class-switched resting memory B cells.
122 esponses, especially the generation of class-switched, antigen-specific antibody responses.
123 es the T cell-dependent development of class-switched, autoreactive memory B cells and plasma cells/p
124 diseases are marked by the presence of class-switched, high-affinity autoantibodies with pathogenic p
125 ith B cells but lacking secreted Ab or class-switched Ab had little deficiency in resistance to Salmo
126 -transgenic mice spontaneously produce class-switched autoantibodies ex vivo.
127 inii-specific IgM, but did not produce class-switched IgG or IgA.
128 munoglobulin were activated, producing class-switched autoantibody in vivo despite the apparently nor
129 r CD40 expression on B cells producing class-switched Ig in response to a T-dependent Ag.
130 B cells to generate GCs and productive class-switched antibody responses.
131 h the periphery and produce protective class-switched Abs after Borrelia burgdorferi infection.
132                 In contrast, quiescent class-switched memory B cells express high levels of Kv1.3 ( a
133                             The rapid, class-switched amAb response indicates that B cells in female
134 e without memory T cells recapitulated class-switched recall alloantibody responses.
135 o those patients with severely reduced class-switched memory B cells and an elevated level of CD21(lo
136 ted with recurrent infections, reduced class-switched memory B cells, and hypogammaglobulinemia.
137 D8alpha(-) DCs in mice leads to robust class-switched antibody (Ab) responses to a T cell-dependent (
138 cripts, and reduced titers of secreted class-switched IgG1, IgG3, and IgA antibodies, without alterat
139 ed with a rapid decline in Ag-specific class-switched Ab.
140 nhanced production of antigen-specific class-switched antibodies in vivo.
141 n reported to produce antigen-specific class-switched human antibodies, with some demonstrating neutr
142 ell as increased levels of Ag-specific class-switched Ig production following immunization with OVA t
143 sequencing of the BCR from E2-specific class-switched memory B cells sorted from two independent part
144                           HCV-specific class-switched memory B cells were detected in 3 out of 7 part
145                  Here we report strong class-switched, high avidity humoral immune responses elicited
146 oproliferative disease (XLP) lack such class-switched memory B cells but are highly susceptible to EB
147              Our data demonstrate that class-switched MBC can respond to variants of the original pat
148      In this study, we showed that the class-switched IgG autoantibody response in MRL/Fas(lpr/lpr) a
149 /CDR3 sequences from those seen in the class-switched response to oxazolone that we have also analyze
150                            High titer, class-switched autoantibodies are a hallmark of systemic lupus
151       Epithelial cells (ECs) transport class-switched immunoglobulin G (IgG) and IgA antibodies acros
152 production of Ag-specific IgM, whereas class-switched isotypes are decreased by approximately 80-90%
153  surface models to derive the electric-field-switched low-symmetry structures of new TTF- and PMDI-ba
154 rrelation (HETCOR) experiment with frequency-switched Lee-Goldburg (FSLG) irradiation is performed on
155 enon of passively Q-switched ~3 mum and gain-switched ~2 mum pulses in a shared cavity was demonstrat
156 arget a segment of membrane IgE on human IgE-switched B cells that is not present in serum IgE.
157 erstanding of the origin and fate of the IgE-switched B cell has been markedly improved by studies in
158           The immediate precursor of the IgE-switched B cell is either a relatively naive nonswitched
159 ely naive nonswitched B cell or a mature IgG-switched B cell.
160          In normal mice, self-reactive IgG2a-switched B cells were deleted, leading to the selective
161               Phospholipase A2-specific IgG4-switched memory B cells expanded after bee venom exposur
162                                      Isotype-switched B cells were only detected in the peritoneum.
163 st immune responses, T helper type 1 isotype-switched antibodies, and gamma interferon (IFN-gamma)-se
164 plasma cells secreting high-affinity isotype-switched Abs in mice immunized with T cell-dependent Ags
165 te the development of high-affinity, isotype-switched Abs, and immunological memory; consequently, ma
166 er (GC) reactions and high affinity, isotype-switched antibody responses.
167 e dominant pathway of high-affinity, isotype-switched autoantibody production in the MRL/MpJ-Fas(lpr)
168 uction of high-titer, high-affinity, isotype-switched IgG autoantibodies directed against nucleic aci
169                   The genes were all isotype-switched and somatically mutated.
170 noclonal antibody (MAb) 9d8 (2a), an isotype-switched variant of the immunoglobulin G3 (IgG3) MAb 9d8
171 major IgMD-expressing subsets and an isotype-switched variant, each developing from distinct B-cell p
172 fic flow sorting express mutated and isotype-switched antibodies.
173  and B220(+) lymphocytes, IgM(+) and isotype-switched IgG(+) and IgA(+) B cells, antigen presenting c
174 CPS is able to induce potent IgM and isotype-switched IgGs in mice and pigs, yielding functional acti
175 rminal center B cells, more antibody isotype-switched germinal center B cells, more memory B cells, a
176                            In blood, isotype-switched B cells constitute the major viral reservoir.
177 d by CD138(-) IgD(-) IgM(+) B cells, isotype-switched CD138(-) IgD(-) IgM(-) memory B cells (B(mem)),
178        Human memory B cells comprise isotype-switched and nonswitched cells with both subsets display
179 ulation of memory B cells containing isotype-switched (IgG and IgA) and IgM-only cells and lacking ex
180    We propose that germline-encoded, isotype-switched B cells in newborn piglets differentiate to Ab-
181 erated B memory cells that expressed isotype-switched immunoglobulins (swIg) or retained IgM.
182              Interestingly, the F240 isotype-switched variants IgG3 and IgG4, also expressed in CHO c
183         These data reveal a role for isotype-switched antibodies in promoting basophil expansion and
184      We have found a unique role for isotype-switched antibodies in promoting helminth-induced basoph
185 switch recombination (CSR) generates isotype-switched Abs with distinct effector functions.
186 e earliest Ag-driven events in human isotype-switched, IgG-expressing MBCs and compare them with thos
187 ansfer of variable region-identical, isotype-switched, LPS-specific, murine immunoglobulin M (IgM) an
188 l for immunoglobulin (Ig) G1 and IgE isotype-switched antibody responses.
189 as not affected by the deficiency in isotype-switched antibodies, suggesting a direct effect on basop
190 68 latency is predominantly found in isotype-switched memory B cells.
191 onses, we found a marked decrease in isotype-switched, A. fumigatus-specific antibodies in sera of mi
192 F59 was highly effective in inducing isotype-switched IgG antibodies and long-term protective immune
193  the differentiation of B cells into isotype-switched B cells and plasma cells.
194 tially maintained in the long-lived, isotype-switched CD40(+) B cells.
195 ignant tumor of somatically mutated, isotype-switched plasma cells (PC), usually arises from a common
196   First, we examined circulating non-isotype-switched (IgD(+)CD27(+)) memory cells, a population that
197 d is preceded by accumulation of non-isotype-switched IgD(+) and IgM(+) B cells.
198 notypes characteristic of naive, non-isotype-switched, memory (Bmem) cells and antibody-secreting cel
199 imately, the quality and quantity of isotype-switched Abs produced in Icos(-/-) mice declined over ti
200 abaudi AS infection or production of isotype-switched Abs, but it is necessary for maintenance of a s
201 a cell development, and secretion of isotype-switched anti-Id Abs.
202 -dependent, as was the production of isotype-switched anti-Sm/RNP autoantibodies.
203 le as helper cells for production of isotype-switched antibodies.
204 ggesting that defective apoptosis of isotype-switched autoreactive B cells is central to Fas mutation
205                  The life history of isotype-switched B cells is unclear, in part, because of an inab
206 intained in two different subsets of isotype-switched B cells, germinal center and memory B cells.
207  from the circulating compartment of isotype-switched B cells.
208  a driving force for accumulation of isotype-switched B(mem) and ASC.
209 out and we also raise the subject of isotype-switched CLL, which, despite its rarity, contributes int
210 e follicle and for the generation of isotype-switched IgG autoantibodies.
211 etected only very low frequencies of isotype-switched IgG-secreting cells in mouse spleens, until at
212 body sequences by deep sequencing of isotype-switched memory B cells or in IgG antibodies elicited ag
213 equired to inhibit the production of isotype-switched pathogenic Abs and the evolution of joint infla
214 ls, GC reactions, and development of isotype-switched, flu-specific antibody responses.
215 A (miR)-155 for normal production of isotype-switched, high-affinity antibodies and for a memory resp
216  plasma cells, but down-regulated on isotype-switched plasma cells in vivo.
217 fferentiated directly into IgM(+) or isotype-switched (sw) Ig(+) memory B cells in a GC-independent f
218 e IFN-gamma-producing CD4 T cells or isotype-switched Salmonella-specific Ab responses.
219 dent antigens, eliciting protective, isotype-switched antibodies in the absence of conventional TCR a
220 nd to be highly effective in raising isotype-switched IgG antibodies to a T-dependent influenza virus
221 Cs) are long-lived sources of rapid, isotype-switched secondary antibody-forming cell (AFC) responses
222        These cells engendered rapid, isotype-switched secondary plasmablast responses upon restimulat
223 rminal center (GC) B cell reactions, isotype-switched Ab responses, parasite control, and host surviv
224  located in both cycling and resting isotype-switched B cells.
225 not production, of parasite-specific isotype-switched Abs.
226 DCs was dependent on virus-specific, isotype-switched antibodies (Abs) that facilitated the capture a
227 ayed accumulation of virus-specific, isotype-switched ASC requires CD19-dependent GC formation in CLN
228 results in the generation of strong, isotype-switched antibody responses, which are protective.
229             Here we demonstrate that isotype-switched plasma cells expressed major histocompatibility
230 ost by preferentially colonizing the isotype-switched (IgD(-)CD27(+)) memory B-cell pool.
231 -TT conjugate vaccine conform to the isotype-switched (IgG(+)CD27(+)) rather than the IgM memory (IgM
232 VH sequences similar to those of the isotype-switched plasma cell.
233 ells ranging from early-activated to isotype-switched differentiation stages is both temporally and s
234 nstrated a steady ratio of IgM(+) to isotype-switched GC B cells and a persistent population of GC B
235  tumors are rare variants of typical isotype-switched multiple myeloma with a similar disease outcome
236 e immediately before that of typical isotype-switched myeloma.
237                              Whereas isotype-switched memory had the highest viral loads by quantitat
238 ardtii has been shown to be a directly light-switched cation-selective ion channel, which employs 11-
239                  Low-affinity FcgammaR locus-switched mice represent an unprecedented model of cognat
240                                      The NBD-switched complexes, T1MT2C/T2MT1C, TAP1/T2MT1C, and TAP2
241 +)CD27(+) cells (commonly referred to as non-switched memory) in infected cord blood cell cultures, a
242 icited larger LAN and LPC amplitude than non-switched words.
243                                     Platform-switched implants showed greater crestal bone preservati
244 alatal/lingual implant position; 2) platform-switched abutments; 3) flapless approach; 4) bone grafts
245 hic bone changes around customized, platform-switched abutments placed according to the "one-abutment
246  crestal bone preservation than non-platform-switched implants.
247 ral blood mononuclear cells (PBMCs) with PLY-switched strains and assessed dendritic cell and CD4(+)
248                             These polymerase-switched strains initially grow very slowly, but subsequ
249   We particularly show that electrically pre-switched devices in low-resistive states comprise reduce
250                                            Q-switched operation at 1480 nm and 1840 nm is achieved wi
251                                          A Q-switched Nd:YAG laser at 355 nm was used to ablate a hig
252 hly focused nanosecond laser pulses from a Q-switched Nd:YAG laser at lambda = 532 nm to generate cav
253 sing focused laser pulses of 532 nm from a Q-switched Nd:YAG laser.
254                We have demonstrated that a Q-switched neodymium:yttrium-aluminum-garnet dermatology l
255  diagnosis of CALM and were treated with a Q-switched or picosecond laser.
256 ied by modulating the magnetization, and a Q-switched pulse output with a pulse width of 5 ns and pea
257        We have proposed and demonstrated a Q-switched Thulium doped fibre laser (TDFL) with a 'Yin-Ya
258 eveloped a photoacoustic probe that uses a Q-switched, frequency-doubled Nd:YAG (neodymium, yttrium,
259 produced using a single laser pulse from a Q-switched, frequency-quadrupled Nd:YAG laser that was mod
260 from a nanotube polymer composite SA based Q-switched Thulium doped fibre laser.
261 by residents (41 of 52 [79%]), followed by Q-switched Nd:YAG (30 of 52 [58%]).
262 een investigated using a frequency doubled Q-switched (10 Hz) Nd:YAG laser at 532 nm.
263 ptic Q-switch, we demonstrate an efficient Q-switched laser with a repetition rate of 200 kHz.
264 e of an inexpensive, small, and "turn-key" Q-switched 532-nm Nd:YAG laser as a source for nonlinear,
265  (Yb) and an erbium (Er)-doped fiber laser Q-switched by a solution processed, optically uniform, few
266 e picosecond laser, Q-switched ruby laser, Q-switched alexandrite laser, or Q-switched 1064-nm Nd:YAG
267  with 755-nm alexandrite picosecond laser, Q-switched ruby laser, Q-switched alexandrite laser, or Q-
268 t repetition rate achieved so far in a LGS Q-switched laser and it can provide a practical Q-switched
269  lifetime as the gain medium, a stable LGS Q-switched laser was designed with average output power of
270     A 10-mm cavity length magnetooptically Q-switched Nd:GdVO4 laser was demonstrated using a single-
271 by laser, Q-switched alexandrite laser, or Q-switched 1064-nm Nd:YAG laser.
272 ees well with the experiments of passively Q-switched lasers using Ti3 CN at wavelengths of 1558 and
273 se experiments is a diode-pumped passively Q-switched microchip laser operating at 266 nm.
274  techniques, a new phenomenon of passively Q-switched ~3 mum and gain-switched ~2 mum pulses in a sha
275 tched laser and it can provide a practical Q-switched laser with a tunable high repetition rates for
276                    Previously, we reported Q-switched lasers incorporating rare-earth substituted iro
277 is LRD technique utilizes an Er:YAG rotary Q-switched laser with an output wavelength of lambda = 2.9
278 ed laser cavities, we obtain self-starting Q-switched pulses with microsecond duration and kilohertz
279 al-band fiber ring laser with synchronized Q-switched pulses at wavelengths of 1480 nm and 1840 nm, a
280 he most extensively studied device was the Q-switched Nd:YAG laser, which has shown promising results
281 ecorded in the range of 200-975nm by using Q-switched Nd:YAG laser at 532nm (4ns, 10Hz) attached to e
282                           Clinicians using Q-switched or picosecond lasers to treat CALMs can use mor
283 switching strategy known as the Sequentially-Switched Delay Line (SSDL) is proposed.
284 l and functional characterization of subtype-switched Epa1 variants shows that specificity is governe
285 ncreased frequency of CD19+IgD+CD27+ unclass-switched memory B cells and a low frequency of somatic m

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