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1 lase) and sterol 12alpha-hydroxylase/CYP8B1 (12alpha-hydroxylase).
2 ceptor, oxysterol 7alpha-hydroxylase, sterol-12alpha-hydroxylase, and hepatic bile acid transporters
3                                       Sterol 12alpha-hydroxylase catalyzes the synthesis of cholic ac
4 esterol 7alpha-hydroxylase (Cyp 7a1), sterol 12alpha-hydroxylase (Cyp 8b1), and the intestinal bile a
5 BA composition, in part by regulating the BA 12alpha-hydroxylase CYP8B1.
6 effects of the level of expression of sterol 12alpha-hydroxylase (CYP8b1) and cholesterol 7alpha-hydr
7                                       Sterol 12alpha-hydroxylase (CYP8B1) is required for cholic acid
8                                       Sterol 12alpha-hydroxylase (CYP8b1) is required for the biosynt
9 terol 7alpha-hydroxylase (Cyp7a1) and sterol 12alpha-hydroxylase (Cyp8b1) partly through inducing sma
10 d bile acid homeostasis, notably cholesterol 12alpha-hydroxylase (CYP8B1), which was strongly reexpre
11 sterol 7alpha-hydroxylase (CYP7A1) or sterol 12alpha-hydroxylase (CYP8B1).
12 terol-7alpha-hydroxylase (CYP7A1) and sterol 12alpha-hydroxylase (CYP8b1).
13  chain fatty acids-like 3, Elovl3 and sterol 12alpha-hydroxylase, Cyp8b1, by enhancing their expressi
14                                   The sterol 12alpha-hydroxylase/CYP8B1 (12alpha-hydroxylase) promote
15               One of these enzymes is sterol 12alpha-hydroxylase/CYP8B1 (12alpha-hydroxylase), the sp
16 ylase/CYP7A1 (7alpha-hydroxylase) and sterol 12alpha-hydroxylase/CYP8B1 (12alpha-hydroxylase).
17                                       Sterol 12alpha-hydroxylase/CYP8b1 is the specific enzyme requir
18 on times still resulted in lower 7alpha- and 12alpha-hydroxylase expression, but unchanged SHP expres
19 ic cholesterol 7alpha-hydroxylase and sterol 12alpha-hydroxylase expression.
20  the FTF-mediated suppression of 7alpha- and 12alpha-hydroxylase expression.
21                     Disruption of the sterol 12alpha-hydroxylase gene (Cyp8b1) in mice prevents the s
22            Targeted disruption of the sterol 12alpha-hydroxylase gene (Cyp8b1) results in complete ab
23                            Expression of the 12alpha-hydroxylase gene is tightly down-regulated by hy
24 e bile acid biosynthetic pathway, the sterol 12alpha-hydroxylase gene.
25  10-fold lower expression of the 7alpha- and 12alpha-hydroxylase genes and up to 8-fold higher SHP ex
26    This higher expression of the 7alpha- and 12alpha-hydroxylase genes resulted in a 33% higher bile
27  heterozygous FTF knockout mice, 7alpha- and 12alpha-hydroxylase genes were expressed at 5-7-fold hig
28 n transcription factor (FTF) is required for 12alpha-hydroxylase promoter activity and bile acid-medi
29  DNA elements that are required for both the 12alpha-hydroxylase promoter activity and bile acid-medi
30 NF-4 is the factor involved in regulation of 12alpha-hydroxylase promoter activity by bile acids thro
31 e short heterodimer partner (SHP) suppresses 12alpha-hydroxylase promoter activity via an interaction
32 pha-hydroxylase promoter and is required for 12alpha-hydroxylase promoter activity.
33  not involved in SHP-mediated suppression of 12alpha-hydroxylase promoter activity.
34        Mutation of these elements suppresses 12alpha-hydroxylase promoter activity.
35 ear factor-4 (HNF-4) binds and activates the 12alpha-hydroxylase promoter and is required for 12alpha
36 isplaces FTF binding to its sites within the 12alpha-hydroxylase promoter.
37 n a non-liver cell line activates the sterol 12alpha-hydroxylase promoter.
38       The sterol 12alpha-hydroxylase/CYP8B1 (12alpha-hydroxylase) promoter is also down-regulated by
39  the C-36-mediated regulation of 7alpha- and 12alpha-hydroxylase promoters mapped to the alpha1-fetop
40 NF-4 recognition site within the 7alpha- and 12alpha-hydroxylase promoters, which can otherwise be oc
41 nzymes is sterol 12alpha-hydroxylase/CYP8B1 (12alpha-hydroxylase), the specific enzyme required for c
42 on factor (FTF) are activators of 7alpha-and 12alpha-hydroxylase transcription and that the small het
43  which results in suppression of 7alpha- and 12alpha-hydroxylase transcription.
44 n of bile acid-mediated regulation of sterol 12alpha-hydroxylase transcription.

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