ライフサイエンスコーパス: 15-lipoxygenase

1 lles in rabbit reticulocytes is initiated by 15-lipoxygenase.

2 yl-end first" as has been proposed for human 15-lipoxygenase.

3 he binding of fatty acid substrates in human 15-lipoxygenase.

4 described to date to bind to a derivative of 15-lipoxygenase.

5 and DPAn-3 proved to be good substrates for 15-lipoxygenase.

6 y, these enzymes have been referred to as 12/15-lipoxygenases.

7 compared with the previously reported human 15S-lipoxygenase.

8 e identity to the known human 5S-, 12S-, and 15S-lipoxygenases.

9 % identity to the known human 5S-, 12S-, and 15S-lipoxygenases.

10 icosatetraenoic acid (15(S)-HETE), the major 15-lipoxygenase 1 (15-LO1) metabolite of arachidonic aci

11 To examine for the expression of 15-lipoxygenase 1 (15-LOX1) and 15-LOX2 in human retinal

12 in vitro, adenovirus-mediated expression of 15-lipoxygenase 1 (15-Lox1) enhanced BI-induced EGFR, Sr

13 To understand the role of human 15-lipoxygenase 1 (15-LOX1) in vascular wall remodeling,

14 Epithelial 15-lipoxygenase 1 (15LO1) and activated ERK are increase

15 of human platelet-type 12- and reticulocyte 15-lipoxygenase-1 (12-hLO and 15-hLO) using structure-ba

16 lipoxygenase (12-hLO) and human reticulocyte 15-lipoxygenase-1 (15-hLO) were tested with arachidonic

17 Human reticulocyte 15-lipoxygenase-1 (15-hLO-1) and human platelet 12-lipox

18 Human reticulocyte 15-lipoxygenase-1 (15-hLO-1), which catalyzes the dioxyg

19 Human colon tumors have elevated levels of 15-lipoxygenase-1 (15-LO-1), suggesting that 15-LO-1 may

20 uman prostate tumors have elevated levels of 15-lipoxygenase-1 (15-LOX-1) and data suggest that 15-LO

21 can induce in these cells the expression of 15-lipoxygenase-1 (15-LOX-1) and in so doing up-regulate

22 us studies, we have found that expression of 15-lipoxygenase-1 (15-LOX-1) and its main product, 13-S-

23 15-Lipoxygenase-1 (15-LOX-1) contributes significantly t

24 n tumorigenesis, is linked to down-regulated 15-lipoxygenase-1 (15-LOX-1) expression in colorectal ca

25 induce apoptosis in these cells by restoring 15-lipoxygenase-1 (15-LOX-1) expression.

26 15-Lipoxygenase-1 (15-LOX-1) is transcriptionally silenc

27 ienoic acid (13-S-HODE), the main product of 15-lipoxygenase-1 (15-LOX-1) metabolism of linoleic acid

28 Transcriptional silencing of 15-lipoxygenase-1 (15-LOX-1) promotes tumorigenesis.

29 We previously found that (a) 15-lipoxygenase-1 (15-LOX-1) protein and its product 13-

30 15-Lipoxygenase-1 (15-LOX-1), which is crucial to produc

31 ithelial cells (HAECs) and determine whether 15-lipoxygenase-1 (15LO1) binding with phosphatidylethan

32 Human 15-lipoxygenase-1 (h-15-LOX-1) is a mammalian lipoxygena

33 Endogenously generated metabolites of 15-lipoxygenase-1 also inhibit thioredoxin reductase in

34 a mechanistic link between the induction of 15-lipoxygenase-1 by a HDAC inhibitor and apoptosis in c

35 Conditional, highly selective induction of 15-lipoxygenase-1 caused an inhibition of ribonucleotide

36 The expression of 15-lipoxygenase-1 correlates with suberoylanilide hydrox

37 ide hydroxamic acid induce the expression of 15-lipoxygenase-1 in human colorectal cancer cells.

38 Here we report that several metabolites of 15-lipoxygenase-1 inhibit purified thioredoxin reductase

39 ite of linoleic acid formed by the action of 15-lipoxygenase-1 is 13(S)-hydroxy-cis-9, trans-11-octad

40 These results demonstrate that 15-lipoxygenase-1 is activated by oxidative stress in AR

41 s, suggesting that the increased activity of 15-lipoxygenase-1 is due to activation of pre-existing p

42 The influences of 15-lipoxygenase-1 on (1)inflammation, cell growth, and s

43 with inhibition of thioredoxin reductase via 15-lipoxygenase-1 overexpression.

44 or the deficient cells showed an increase in 15-lipoxygenase-1 protein content after 16 h of oxidativ

45 Furthermore, specific inhibition of 15-lipoxygenase-1 significantly reduced the suberoylanil

46 cid, a metastable hydroperoxide generated by 15-lipoxygenase-1, and 4-hydroxy-2-nonenal, its non-enzy

47 lipid hydroperoxide metabolites of 5-, 12-, 15-lipoxygenase-1, and cyclooxygenase-2 oxidize the 2-Cy

48 receptor, 5-lipoxygenase-activating protein, 15-lipoxygenase-1, prostaglandin D2, and proinflammatory

49 Recently, 15-lipoxygenase-1, the enzyme that converts arachidonic

50 The 15-lipoxygenase-1-deficient cells exhibited 30% of the p

51 thermore, when ataxin-1 82Q was expressed in 15-lipoxygenase-1-deficient cells, apoptosis was greatly

52 hanisms by which HDAC inhibitors up-regulate 15-lipoxygenase-1.

53 cell line using short hairpin RNA to target 15-lipoxygenase-1.

54 The enzyme 12/15 lipoxygenase (12/15LO) has been implicated in the oxi

55 ucose increases production of endothelial 12/15 lipoxygenase (12/15LO) products in vitro.

56 The 12/15 lipoxygenase (12/15LOX) enzyme is increased in pathol

57 e recently reported that mouse macrophage 12/15-lipoxygenase (12/15-LO) activity promotes F-actin for

58 ases (Noxes) nor mitochondria, but rather 12/15-lipoxygenase (12/15-LO) are pivotal ROS sources invol

59 nstrate that mice deficient in the enzyme 12/15-lipoxygenase (12/15-LO) develop a myeloproliferative

60 The 12/15-lipoxygenase (12/15-LO) enzyme is upregulated in the

61 in WT mice high fat diet feeding induced 12/15-lipoxygenase (12/15-LO) expression in the endothelium

62 It was reported recently that 12/15-lipoxygenase (12/15-LO) expression is increased in hi

63 The enzyme 12/15-lipoxygenase (12/15-LO) has been implicated in the ox

64 Recently, we discovered a novel role for 12/15-lipoxygenase (12/15-LO) in mediating IL-12p40 express

65 The enzyme 12/15-lipoxygenase (12/15-LO) introduces peroxyl groups in

66 12/15-Lipoxygenase (12/15-LO) is an enzyme widely distribut

67 convincing body of evidence suggests that 12/15-lipoxygenase (12/15-LO) plays a role in atheroscleros

68 12/15-Lipoxygenase (12/15-LO) produces 15-hydroxyeicosatetr

69 We have shown that the 12/15-lipoxygenase (12/15-LO) product 12S-hydroxyeicosatetr

70 Mice lacking leukocyte type 12/15-lipoxygenase (12/15-LO) show reduced atherosclerosis

71 12/15-lipoxygenase (12/15-LO), one of a family of fatty aci

72 PPARgamma) ligands by inducing macrophage 12/15-lipoxygenase (12/15-LO).

73 a and its natural ligand-producing enzyme 12/15-lipoxygenase (12/15-LOX) in IL-4-treated cells.

74 lerosis, here we investigated the role of 12/15-lipoxygenase (12/15-LOX) in TF expression.

75 e experiments, cells were pretreated with 12/15-lipoxygenase (12/15-LOX) inhibitor cinnamyl-3,4-dihyd

76 12/15-Lipoxygenase (12/15-LOX) is induced in beta-cells and

77 Either 90 nM recombinant Sema3A, or the 12/15-lipoxygenase (12/15-LOX) metabolites 12-HETE and 12-H

78 12/15-Lipoxygenase (12/15-LOX) plays a pathogenic role in a

79 hat it is produced by a pathway involving 12/15-lipoxygenase (12/15-LOX), and that S. enterica serova

80 drug target between species, such as with 12/15-lipoxygenase (12/15-LOX), which contributes to ischem

81 We recently discovered that 12/15-lipoxygenase (12/15-LOX), which oxidizes unsaturated

82 Our results further demonstrate that 12/15-lipoxygenase (12/15-LOX)-derived, but not cyclooxygen

83 Herein, we establish a critical role for 12/15-lipoxygenase (12/15-LOX)-mediated unsaturated fatty a

84 The 12/15-lipoxygenase (12/15LO) enzyme is widely distributed w

85 12/15-Lipoxygenase (12/15LO) plays a role in the pathogenes

86 The 12/15-lipoxygenases (12/15-LOX) catalyze the stereo-specifi

87 A human 15-lipoxygenase (15-HLO) assay has been employed to disc

88 The selective inhibition of human 15-lipoxygenase (15-hLO) could serve as a promising ther

89 Human reticulocyte 15-lipoxygenase (15-hLO-1) and epithelial 15-lipoxygenas

90 te 15-lipoxygenase (15-hLO-1) and epithelial 15-lipoxygenase (15-hLO-2) have been implicated in a num

91 ment of atherosclerosis, an oxidative enzyme 15-lipoxygenase (15-LO) and a scavenger receptor CD36.

92 1 and Stat3 is required for the induction of 15-lipoxygenase (15-LO) expression by IL-13.

93 green fluorescent 5-lipoxygenase (5-LO) and 15-lipoxygenase (15-LO) fusion proteins were expressed i

94 The human 15-lipoxygenase (15-LO) gene was transfected into rat ki

95 ion of LDL increases its atherogenicity, and 15-lipoxygenase (15-LO) has been implicated in the proce

96 es that is capable of inducing expression of 15-lipoxygenase (15-LO) in primary human monocytes.

97 IL-13 induces profound expression of 15-lipoxygenase (15-LO) in primary human monocytes.

98 ave evidence that subacute hypoxia activates 15-lipoxygenase (15-LO) in small PAs of neonatal rabbits

99 d the expression of cyclooxygenase (Cox) and 15-lipoxygenase (15-LO) in the human colorectal carcinom

100 The enzyme 15-lipoxygenase (15-LO) participates in the dioxygenatio

101 onic acid (AA) is metabolized by endothelial 15-lipoxygenase (15-LO) to several vasodilatory eicosano

102 ion of several proteins is induced including 15-lipoxygenase (15-LO), a lipid-peroxidating enzyme and

103 3 induction of M2 gene expression, including 15-lipoxygenase (15-LO).

104 15-lipoxygenase (15-LOX) and lipoxin A(4) receptors (ALX

105 of purified soybean and rabbit reticulocyte 15-lipoxygenase (15-LOX) and PA317 cells transfected wit

106 The cornea expresses 15-lipoxygenase (15-LOX) and receptors for lipoxin A(4)

107 vious studies have suggested that activating 15-lipoxygenase (15-LOX) is a promising strategy to inte

108 The expression of 15-lipoxygenase (15-LOX) peaks in reticulocytes immediat

109 15-Lipoxygenase (15-LOX)-2 is expressed in benign prosta

110 reported the induction of reticulocyte type 15-lipoxygenase (15-Lox-1) in a human colorectal carcino

111 nsaturated phosphatidylethanolamines (PE) by 15-lipoxygenases (15-LO) that normally use free polyunsa

112 15-Lipoxygenase 2 (15-LOX2) is a recently cloned human l

113 15-Lipoxygenase 2 (15-LOX2), a lipid-peroxidizing enzyme

114 Several pieces of evidence implicate 15-lipoxygenase 2 (15-LOX2), a molecule with a restricte

115 s project, we studied the gene regulation of 15-lipoxygenase 2 (15-LOX2), the most abundant arachidon

116 15-Lipoxygenase 2 (15-LOX2), the most abundant arachidon

117 Expression of 15-lipoxygenase 2 was increased in epithelium from patie

118 elationship exists between the expression of 15-lipoxygenase-2 (15-LOX-2) and peroxisome proliferator

119 The enzyme 15-lipoxygenase-2 (15-LOX-2) is highly expressed in larg

120 anced eicosanoid production via an activated 15-lipoxygenase-2 (15-LOX2) pathway.

121 EGCs expressed 15-lipoxygenase-2 and produced high levels of 15-HETE, w

122 Thus, the strongest 15-lipoxygenase-2 expression is in the androgen regulate

123 15-Lipoxygenase-2 has a limited tissue distribution in e

124 Strong 15-lipoxygenase-2 immunostaining was also observed in se

125 Meibomian glands were uniformly negative for 15-lipoxygenase-2 in all cases examined (n = 9), and seb

126 Strong uniform 15-lipoxygenase-2 in situ hybridization (n = 6) and immu

127 This compares with the prostate, in which 15-lipoxygenase-2 is expressed in differentiated prostat

128 exhibited 30% of the protein expression, and 15-lipoxygenase-2 remained unchanged, as compared with a

129 In this study the distribution of 15-lipoxygenase-2 was characterized in human skin using

130 The product of 15-lipoxygenase-2, 15-hydroxyeicosatetraenoic acid, may

131 Human 15S-lipoxygenase-2 (15-LOX-2) is a recently identified l

132 ipoxygenase (8-LOX) and its human homologue, 15S-lipoxygenase-2 (15-LOX-2), share 78% identity in ami

133 Inhibition of 15-lipoxygenase activity reduced PD1n-3 DPA and augmente

134 of VCAM-1 on endothelium, mucin production, 15-lipoxygenase activity, and Th2 lymphocyte stimulation

135 15-diHETE, indicating that T. gondii carries 15-lipoxygenase activity.

136 urable 5-lipoxygenase protein or 5-, 12-, or 15-lipoxygenase activity.

137 2 yielded a chimeric enzyme with exclusively 15S-lipoxygenase activity.

138 one peroxidase 4 (GPX4) and arachidonic acid 15-lipoxygenase (ALOX15) are antagonizing enzymes in the

139 sted the potential of targeting arachidonate 15-lipoxygenase (ALOX15) in treating alcoholic liver dis

140 d with the expression levels of arachidonate 15-lipoxygenase (ALOX15), and SAT1-induced ferroptosis i

141 L-4 with elevated expression of arachidonate 15-lipoxygenase (ALOX15).

142 termined that the gene encoding arachidonate 15-lipoxygenase (Alox15/15-LO) is essential for the surv

143 of Stat3 with DNA and maximal expression of 15-lipoxygenase, an important regulator of inflammation

144 ogenesis by in vivo delivery of the gene for 15-lipoxygenase, an oxidizing enzyme present in atherosc

145 This effect was shown to involve 12/15 lipoxygenase and activation of peroxisome-proliferato

146 pe mice displayed increased sciatic nerve 12/15-lipoxygenase and 12(S)-hydroxyeicosatetraenoic acid l

147 zymes of arachidonate metabolism, namely, 12/15-lipoxygenase and cyclooxygenase-2.

148 eases (>1.5-fold expression) in arachidonate 15-lipoxygenase and gamma-glutamyltransferase transcript

149 foam cell differentiation markers including 15-lipoxygenase and lectin-type oxidized LDL receptor-1

150 he ribonucleases) together with arachidonate-15-lipoxygenase and protease inhibitor plasminogen activ

151 o show that inhibitors of enzymes such as 12/15-lipoxygenase and the cyclooxygenases that produce kno

152 activates the RhoA/Rho kinase/CPI-17 via 12/15-lipoxygenases and thereby contributes to diabetes-ass

153 Inhibition of lipoxygenases, particularly 15-lipoxygenase, and cyclooxygenases, but not cytochrome

154 s derived from the COX-2, cytochrome P450, 5/15-lipoxygenase, and non-enzymatic oxidative pathways we

155 vating AMPK abolished cellular production of 15-lipoxygenase arachidonic acid metabolites in IL-4-sti

156 With the combination of 15-lipoxygenase, arachidonic acid, and aortic homogenate

157 This study establishes inhibition of 12/15-lipoxygenase as a viable strategy for first-line stro

158 In vitro, the purified rabbit reticulocyte 15-lipoxygenase binds and permeabilizes organellar membr

159 pathogen as well as exogenously administered 15-lipoxygenase can interact with host biosynthetic circ

160 and determination of the in vivo role of 12/15-lipoxygenase-catalyzed oxidation of LDL in atherogene

161 The mRNAs in question encode 15-lipoxygenase, ceruloplasmin, and histones.

162 he amino acid sequence has 78% identity to a 15S-lipoxygenase cloned recently from human skin and app

163 ncreased in the ischemic mouse brain, and 12/15-lipoxygenase colocalized with a marker for oxidized l

164 12/15-Lipoxygenase deficiency in this strain led to approxi

165 12/15-lipoxygenase deficiency prevented or alleviated diabe

166 E-deficient mice with 1) global leukocyte 12/15-lipoxygenase deficiency, 2) normal enzyme expression,

167 While studying 12/15-lipoxygenase-deficient macrophages in culture, we dis

168 Additionally, 12/15-lipoxygenase-deficient macrophages, which are unable

169 P < 0.006), whereas retinas from diabetic 12/15-lipoxygenase-deficient mice had significantly less le

170 e observation that bone marrow cells from 12/15-lipoxygenase-deficient mice retain sensitivity to IL-

171 mice, 5-lipoxygenase-deficient mice, and 12/15-lipoxygenase-deficient mice were assessed 1) after 9

172 and streptozotocin-diabetic wild-type and 12/15-lipoxygenase-deficient mice were maintained for 14 to

173 Thus, 12/15-lipoxygenase-deficient mice will be useful for the st

174 d and 17.2-fold in diabetic wild-type and 12/15-lipoxygenase-deficient mice, respectively.

175 in 5-lipoxygenase-deficient mice, but not 12/15-lipoxygenase-deficient mice.

176 5-lipoxygenase-deficient mice, but not in 12/15-lipoxygenase-deficient mice.

177 mice by repressing an interleukin-1- and 12/15-lipoxygenase-dependent neutrophil recruitment cascade

178 oagulant phospholipid surface enriched in 12/15-lipoxygenase-derived hydroxyeicosatetraenoic acid-pho

179 ovided by site-directed mutagenesis of human 15-lipoxygenase, despite the low amino acid sequence ide

180 s mouse DRG neurons lacking expression of 12/15-lipoxygenase display protection of axons in this cont

181 both support an antiatherogenic role for 12/15-lipoxygenase downstream actions.

182 We showed previously that deletion of the 12/15-lipoxygenase enzyme (12/15-LO, Alox15 gene) in NOD mi

183 L-12LO is highly related to human and rabbit 15-lipoxygenases, enzymes that have been implicated in t

184 Together, these results indicate that 15-lipoxygenase expressed by a pathogen as well as exoge

185 ed (P < 0.001, n = 12) when compared with 12/15-lipoxygenase-expressing controls (apo E-/-/L-12LO+/+)

186 studies demonstrated that the IL-13-induced 15-lipoxygenase expression in primary human monocytes is

187 Results from these indicate that 12/15-lipoxygenase expression protects mice against atheros

188 and 15-hLO, based on the structure of rabbit 15-lipoxygenase, for in silico screening of a large comp

189 12/15-lipoxygenase gene deficiency did not affect weight ga

190 Administration of plant 15-lipoxygenase generated endogenous LXA4 and mimicked t

191 Human 15-lipoxygenase (h15-LO) is present on chromosome 17p13.

192 Pharmacological and genetic inhibition of 12/15-lipoxygenases has effects on high glucose-induced CPI

193 e of the mouse 8S-lipoxygenase and its human 15S-lipoxygenase homologue.

194 These include Fc epsilonRII (CD23), 15-lipoxygenase, IL-1 receptor antagonist (IL-1ra), and

195 provide in vivo evidence for the role of 12/15-lipoxygenase in atherogenesis and demonstrate diminis

196 eceptor (LDL-R) deficiency has implicated 12/15-lipoxygenase in atherogenesis.

197 to explore other potential mechanisms for 12/15-lipoxygenase in atherosclerosis using apolipoprotein

198 This study evaluated the role for 12/15-lipoxygenase in diabetic large and small fiber periph

199 eted gene disruption or overexpression of 12/15-lipoxygenase in mice on the genetic background of apo

200 been shown to inhibit induction of CD23 and 15-lipoxygenase in monocytes; however, the effects of IF

201 e findings reveal a physiological role of 12/15-lipoxygenase in the generation of endogenous ligands

202 The data support indirectly a role for 12/15-lipoxygenase in the oxidative modification of low den

203 The combined data indicate a role for 12/15-lipoxygenase in the pathogenesis of atherosclerosis a

204 e overexpression of murine leukocyte-type 12/15-lipoxygenase in VSMCs increased the levels of cell-as

205 Reciprocally, stable overexpression of 12/15-lipoxygenase increased AT1R expression in cultured me

206 arrel/catalytic domain chimeras with 12- and 15-lipoxygenase indicated that only the N-terminal domai

207 his CO increased phagocytosis was blocked by 15-lipoxygenase inhibition, and SPM stimulated phagocyto

208 f endpoints for future clinical trials of 12/15-lipoxygenase inhibitors.

209 These data demonstrate that 15-lipoxygenase is capable of disrupting the pH gradient

210 ere was no correlation between expression of 15-lipoxygenase isozymes or their products and tumor gro

211 esangial cells and glomeruli derived from 12/15-lipoxygenase knockout mice compared with control mice

212 utoantibodies to oxidized LDL epitopes in 12/15-lipoxygenase knockout mice crossbred with atheroscler

213 e, we demonstrate that ectopic expression of 15-lipoxygenase leads to the collapse of the mitochondri

214 4 and IL-13 are the only known activators of 15-lipoxygenase (LO) expression in cultured macrophages.

215 We have now evaluated 15-lipoxygenase (LO)-1-mediated arachidonic acid (AA) me

216 xidation in vivo is its modification with 12/15-lipoxygenase (LO).

217 synthesis is blocked with an inhibitor of 12/15-lipoxygenase (LO).

218 Products of arachidonate 15-lipoxygenases (LO) types I and II display both benefi

219 differentiation: translational silencing of 15-lipoxygenase (Lox) mRNA and stabilization of alpha-gl

220 n D1 (NPD1) are lipid autacoids formed by 12/15-lipoxygenase (LOX) pathways that exhibit anti-inflamm

221 Two prominent enzymes, 12/15-lipoxygenase (LOX), which generates antiinflammatory

222 Transcriptional suppression of 15-lipoxygenase (LOX)-1 (15-LOX-1) helps enable human co

223 There are two human 15-lipoxygenases (LOX), 15-LOX-1 and -2, which convert a

224 oid formed from sequential actions of 5- and 15-lipoxygenases (LOX), facilitate resolution of inflamm

225 A novel inhibitor of 12/15-lipoxygenase, LOXBlock-1, protected neuronal HT22 cel

226 12/15-Lipoxygenases (LOXs) in monocytes and macrophages gen

227 gnaling elicits anti-inflammatory responses, 15-lipoxygenase may either support or inhibit inflammato

228 erefore, oxidized lipids generated by the 12/15-lipoxygenase-mediated metabolism of arachidonic acid

229 he coordinate induction of PPAR-gamma and 12/15-lipoxygenase mediates interleukin-4-dependent transcr

230 Here, we determined that 12/15-lipoxygenase-meditated (12/15-LO-mediated) enzymatic

231 enzyme that at least partly accounts for the 15S-lipoxygenase metabolism of arachidonic acid in certa

232 Pretreatment with the 15-lipoxygenase metabolite, 15(S)-hydroxyeicosatetraenoi

233 athogenic phase of the infection, whereas 12/15-lipoxygenase metabolites were associated with the res

234 cis-element in the 3'-untranslated region of 15-lipoxygenase mRNA that is known to bind hnRNP E1 also

235 Retinal ganglion cell axons from 12/15-lipoxygenase-null mice were similarly protected from

236 ion also results from genetic deletion of 12/15-lipoxygenase or inhibiting its activity with nordihyd

237 12/15-Lipoxygenase or p47phox deficiency resulted in attenu

238 ALOX15 (12/15-lipoxygenase) orthologs have been implicated in matur

239 The human 12/15-lipoxygenase orthologue, ALOX12, is expressed in cavi

240 ine and poly(ADP-ribose) accumulation and 12/15-lipoxygenase overexpression in peripheral nerve and d

241 yme expression, or 3) macrophage-specific 12/15-lipoxygenase overexpression.

242 results suggest that drugs targeting the 12/15-lipoxygenase pathway merit investigation as a therapy

243 The 12/15-lipoxygenase pathway of arachidonate metabolism and i

244 support for a novel mechanism linking the 12/15-lipoxygenase pathway to a known immunomodulatory Th1

245 AA is also metabolized via the 15-lipoxygenase pathway, predominantly to 15-hydroxyeico

246 iments show a range of responses with the 12/15-lipoxygenase pathways in atherosclerosis.

247 with Alox15 knockout mice confirmed that 12/15-lipoxygenase plays a role in skeletal development.

248 on in murine peritonitis, demonstrating that 15-lipoxygenase possesses antiinflammatory properties.

249 of DHA, DPAn-3, and DPAn-6 with 5-, 12-, and 15-lipoxygenases produced oxylipins, which were identifi

250 ed rat mesangial cells, we found that the 12/15-lipoxygenase product 12(S)-hydroxyeicosatetraenoic ac

251 xy-LTB4, the cysteinyl leukotriene LTC4, the 15-lipoxygenase product 15(S)-HETE, or the lipoxygenase

252 duct migrated on reverse-phase HPLC with the 15-lipoxygenase product, 15-hydroxy-eicosa-trienoic acid

253 One paradigm concerns regulation of 15-lipoxygenase production during reticulocyte maturatio

254 Temporal control of 15-lipoxygenase production in reticulocytes is often cit

255 15-Lipoxygenase proved to be the most efficient enzyme o

256 action products obtained from the DPAn-6 and 15-lipoxygenase reaction.

257 In vivo, modified siRNA targeting 12/15-lipoxygenase reduced glomerular AT1R expression in a

258 However, it is unclear whether 12/15-lipoxygenase regulates expression of AT1R.

259 subunit 1) and ALOX15 (encoding arachidonate 15-lipoxygenase), show significant association with IL-6

260 15-Lipoxygenase-silenced cells also displayed an exacerb

261 NPD1 selectively and potently rescued 15-lipoxygenase-silenced cells from oxidative stress-ind

262 achidonic acid, [U-14C]arachidonic acid plus 15-lipoxygenase (soybean lipoxidase), or [U-14C]15-hydro

263 angiotensin II induced greater levels of 12/15-lipoxygenase, TGF-beta1, and fibronectin (FN) in AT1R

264 metabolizing enzymes cyclooxygenase-2 and 12/15-lipoxygenase that generate inflammatory lipids.

265 and arachidonic acids, respectively, by a 12/15-lipoxygenase that is upregulated by the TH2-derived c

266 tochondrial pH was observed with a mutant of 15-lipoxygenase that lacks enzymatic activity.

267 eal injections of 15-HETE or an inhibitor of 15-lipoxygenase (the enzyme that produces 15-HETE); colo

268 gest that arachidonic acid is metabolized by 15-lipoxygenase to 15-HPETE, which undergoes an enzymati

269 nolenic acid, it is transformed by epidermal 15-lipoxygenase to mainly 13-hydroxyoctadecadienoic acid

270 For instance, epidermal 15-lipoxygenase transforms dihomo-gamma-linolenic acid (

271 by blockage of a key SPM biosynthesis enzyme 15-lipoxygenase type 1.

272 In conclusion, whereas 12/15-lipoxygenase up-regulation provides an important cont

273 Here we show that the activity of 12/15-lipoxygenase was increased in the ischemic mouse brai

274 of AT1R protein expression decreased when 12/15-lipoxygenase was knocked down with specific short hai

275 The mechanism postulated for 15-lipoxygenase was pieced together in vitro and has nev

276 biosynthesis, cytosolic phospholipase A2 and 15-lipoxygenase, was altered in AD hippocampus.

277 lipoxygenase pathways (5-lipoxygenase and 12/15-lipoxygenase), which are important enzymes for specia

278 Up-regulation of 12/15-lipoxygenase, which converts arachidonic acid to 12(S

279 te- macrophages and eosinophils also express 15-lipoxygenase, which converts arachidonic acid to 15(S

280 e KSHV miRNA cluster probably targets enzyme 15-lipoxygenase, which is involved in lipoxin A4 synthes

281 atures contrast with the previously reported 15S-lipoxygenase, which oxygenates arachidonic acid main

282 rachidonate-binding to mammalian 5-, 12- and 15-lipoxygenases, would appear to be true also for linol