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2 the past year abiraterone acetate, a CYP17 (17alpha-hydroxylase/17, 20 lyase) inhibitor, received US
3 in, we cloned and examined the expression of 17alpha-hydroxylase/17,20 lyase (CYP17), the enzyme that
4 o discover potent and specific inhibitors of 17alpha-hydroxylase/17,20-lyase (CYP17), the key enzyme
6 rectly interacts with bovine cytochrome P450 17alpha-hydroxylase/17,20-lyase (P450c17) and donates el
8 Disabling mutations in CYP17 cause combined 17alpha-hydroxylase/17,20-lyase deficiency, but rare mis
10 om) and both activities of P450c17 (K(I) for 17alpha-hydroxylase, 8.4 +/- 0.6 microm; K(I) for 17,20-
11 ase activities of Xenopus CYP17 exceeded the 17alpha-hydroxylase activities in both the Delta4 and De
12 haromyces cerevisiae, mutation E305G retains 17alpha-hydroxylase activities, converting pregnenolone
13 >85% with RNA interference had no effect on 17alpha-hydroxylase activity but reduced 17,20 lyase act
14 0 and SB203580 inhibited 17,20 lyase but not 17alpha-hydroxylase activity in human adrenocortical HCI
15 duction of cytochrome c, oxidation of NADPH, 17alpha-hydroxylase activity of P450c17, and 17,20 lyase
17 - and Fpr-Fld-supported P450c17 progesterone 17alpha-hydroxylase activity while in contrast 17alpha-O
18 ne and 17-hydroxyprogesterone, respectively (17alpha-hydroxylase activity), followed by conversion of
19 cytochrome c, oxidation of NADPH, support of 17alpha-hydroxylase activity, and support of 17,20 lyase
23 d dehydrogenase type II (3betaHSDII) and the 17alpha-hydroxylase and 17,20-lyase activities of cytoch
24 in Saccharomyces cerevisiae and analyzed the 17alpha-hydroxylase and 17,20-lyase activities of the re
25 such compounds selectively inhibited CYP17A1 17alpha-hydroxylase and 17,20-lyase activities with IC50
26 with P450c17 increases the Vmax of both the 17alpha-hydroxylase and 17,20-lyase reactions 5-fold; co
27 ytochrome P450c17 (CYP17) catalyzes both the 17alpha-hydroxylase and 17,20-lyase reactions in human s
30 atalyses two key steroid reactions involving 17alpha-hydroxylase and C(17,20)-lyase in the androgen b
32 and synthesized a number of cytochrome P450 17alpha-hydroxylase-C17,20-lyase (P450c17) inhibitors wi
33 ial for their synthesis, especially P450c17 (17alpha-hydroxylase/c17,20 lyase), are expressed in a de
34 at in addition to being potent inhibitors of 17alpha-hydroxylase/C17,20-lyase and/or 5alpha-reductase
35 ivatives of androstene were shown to inhibit 17alpha-hydroxylase/C17,20-lyase with potencies 2-20-fol
37 mes of the androgen biosynthetic pathway are 17alpha-hydroxylase/C17,20-lyase, which regulates an ear
40 c acid and GATA6 increased the expression of 17alpha-hydroxylase, providing a functional link between
41 cytochrome P450 (P450c17) catalyzes both the 17alpha-hydroxylase reaction required to produce cortiso
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