ライフサイエンスコーパス: 1S,3R-ACPD

1 3R-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD).

2 2 inside neurones diminished the response to 1S,3R-ACPD.

3 ed the size of the inward current induced by 1S,3R-ACPD.

4 onductance, closely resembling the effect of 1S,3R-ACPD.

5 enous AMPA was not significantly affected by 1S,3R-ACPD.

6 because 4-AP occluded any further actions of 1S,3R-ACPD.

7 septal injection of the metabotropic agonist 1S,3R-ACPD.

8 shold Ca2+ currents were also suppressed by (1S,3R)-ACPD.

9 mGluR research have made use of the agonist (1S,3R)-ACPD.

10 eurons mimicked the postsynaptic effects of (1S, 3R)-ACPD.

11 nocyclopentane-trans-1,3-dicarboxylic acid [(1S, 3R)-ACPD, 0.5 nmol/side] and amphetamine (AMPH, 6.8

12 S,3R)-1-aminocyclopentane-1,3-dicarboxylate (1S,3R)-ACPD, 1), was found to possess relatively high af

13 The 1S,3R-ACPD (100-900 nmol) induced death of striatal neur

14 R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) (100 microM) is suppression of I(D) by accel

15 studies of ABHxD-I (6a), ABHD-VI, LY354740, (1S,3R)-ACPD, (1S, 3S)-ACPD, and l-glutamate, we conclude

16 )-1-aminocyclopentane-1,3-decarboxylic acid (1S,3R-ACPD; 200 microM), quisqualate (10 microM) and (2S

17 The 1S,3R-ACPD (50-200 microM)-induced inward current was as

18 nonselective group I/group II mGluR agonist (1S,3R)-ACPD ((-)-9 ED50 = 19 mg/kg, (-)-10 ED50 = 14 mg/

19 In contrast, application of 1S,3R-ACPD, a mixed agonist at group I and group II mGlu

20 (1S,3R)-ACPD also depolarized trigeminal motoneurons and

21 e tested, the metabotropic glutamate agonist 1S,3R-ACPD also activated inwardly rectifying Ba2+-sensi

22 )-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD), an agonist for metabotropic glutamate recep

23 The postsynaptic effects of (1S,3R)-ACPD and repetitive stimulation were both antagon

24 ve to 100-200 microM 4-AP was accelerated by 1S,3R-ACPD, and because 4-AP occluded any further action

25 ponse to the local application of serotonin, 1S,3R-ACPD, and CCK8S, and a rapid depolarization follow

26 dy, we investigated whether these actions of 1S,3R-ACPD are attributable to the release of calcium fr

27 Interestingly, 1S,3R-ACPD attenuated internucleosomal DNA fragmentation

28 and require extracellular Ca2+, but that the 1S,3R-ACPD current may depend on Ca2+ influx via voltage

29 )-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) depolarized all neurones tested by activatio

30 (1S,3R)-ACPD depressed excitatory transmission to trigemi

31 Moreover, Ba2+, occluded 1S,3R-ACPD effects.

32 The 1S,3R-ACPD exchange current requires extracellular Ca2+

33 1-amino-1,3-cyclopentane-dicarboxylic acid [(1S,3R)-ACPD], group I/II antagonist (+/-)-alpha-methyl-4

34 of the alpha,alpha-dialkyl-alpha-amino acid (1S,3R)-ACPD has been achieved using an alkylidene carben

35 -1-amino-1, 3-cyclopentanedicarboxylic acid (1S,3R-ACPD) has multiple actions on phrenic motoneurons

36 ent with the hypothesis that quisqualate and 1S,3R-ACPD in Ba2+ and Cs+ solution activate a Na(+)-Ca2

37 1S,3R-ACPD induced internucleosomal DNA fragmentation of

38 Intraseptal injection of 1S,3R-ACPD induced the expression of Fos-like, Jun B-lik

39 (S)-MCPG blocked (1S,3R)-ACPD-induced IPSC suppression and markedly reduce

40 Many other similarities between DSI and the (1S,3R)-ACPD-induced suppression of IPSCs also were found

41 The 1S,3R-ACPD-induced current was reduced by the heavy meta

42 a S inside neurones irreversibly blocked the 1S,3R-ACPD-induced current whilst photolysis of caged GT

43 These data suggest that the quisqualate- and 1S,3R-ACPD-induced currents are mediated through a rise

44 In the presence of Ba2+, Iacpd and the 1S,3R-ACPD-induced decrease of membrane conductance were

45 urrent evoked by baclofen (10 microM) or the 1S,3R-ACPD-induced inward current associated with decrea

46 The quisqualate- and 1S,3R-ACPD-induced inward currents were reduced in Ca(2+

47 100 mM choline reduced the quisqualate- and 1S,3R-ACPD-induced inward currents, results consistent w

48 These results suggest that 1S,3R-ACPD-induced reduction of inspiratory synaptic cur

49 However, in Ba2+ and Cs+, the 1S,3R-ACPD inward current amplitude was enhanced and was

50 ate-induced current was not altered, but the 1S,3R-ACPD inward current was blocked.

51 Thus, elevation of [Ca2+]i, during firing by 1S,3R-ACPD is likely attributable to enhancement of calc

52 )-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) on synaptic transmission and excitability of

53 crease in locomotor activity in response to (1S, 3R)-ACPD or AMPH when these were microinjected into

54 We found that 1S,3R-ACPD reduced the frequency but not the amplitude o

55 1-aminocyclopentane-1S,3R-dicarboxylic acid (1S,3R-ACPD) results in contralateral rotation with delay

56 -1-aminocyclopentane-1, 3-dicarboxylic acid (1S,3R-ACPD), suggesting they are not mediated via group

57 tivated an inward current more potently than 1S,3R-ACPD, suggesting that this current is preferential

58 )-1-aminocyclopentane-1,3-dicarboxylic acid (1S, 3R-ACPD), the group I mGlu receptor selective agonis

59 ion allowed the synthesis of the amino acid (1S,3R)-ACPD to be completed.

60 abotropic glutamate receptor (mGluR) agonist 1S,3R ACPD was used to stimulate PI turnover and to dete

61 Rotation induced by DHPG or 1S,3R-ACPD was attenuated by group I antagonists, but no

62 Rotation induced by DHPG or 1S,3R-ACPD was attenuated by pretreatment with antagonis

63 nternucleosomal DNA fragmentation induced by 1S,3R-ACPD was attenuated by the protein synthesis inhib

64 The inward current elicited by 1S,3R-ACPD was unaffected by K+ channel blockade with ex

65 Furthermore, the effects of 1S,3R-ACPD were inhibited by the metabotropic antagonist

66 The effects of 1S,3R-ACPD were mimicked by the group I metabotropic ago

67 The effects of 1S,3R-ACPD were multiple, including reduction of inspira

68 R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) were characterized in the basolateral nucleu

69 )-1-amino-1,3-cyclopentanedicarboxylic acid (1S,3R-ACPD), were studied alone and together with N-meth