ライフサイエンスコーパス: 2',3'-dideoxycytidine

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1 s associated with 2'-C-cyano-2',3'-didehydro-2',3'-dideoxycytidine.

2 been approved for human use: azidothymidine; 2'3'-dideoxycytidine; 2'3'-dideoxyinosine; 2', 3'-didehy

3 aturated series, L-3'-fluoro-2',3'-didehydro-2',3'-dideoxycytidine 24 and 5-fluorocytidine 26 showed

4 S-octadecyl-2-O-palmitoyl-1-thioglycerol (2) 2',3'-dideoxycytidine 5'-diphosphate-rac-1-S-octadecyl-2

5 methoxyphenyl ether, the target 4'-C-ethynyl-2',3'-dideoxycytidine analogue (rac-1h) was obtained aft

6 presence of reverse transcriptase inhibitors 2',3'-dideoxycytidine and a tetrahydroimidazo[4,5,1-jk](

7 esia caused by HIV/AIDS antiretroviral [ddC (2',3'-dideoxycytidine)] and anticancer (oxaliplatin) che

8 In contrast, 2',3'-dideoxyinosine, 2',3'-dideoxycytidine, and 3'-azidothymidine, which are

9 the anti-human immunodeficiency virus agent 2',3'-dideoxycytidine (approximately 6-fold) and the ant

10 mately 20% of normal levels by treating with 2',3'-dideoxycytidine (ddC) and subsequently allowed rec

11 2',3'-dideoxycytidine (ddC) is a synthetic pyrimidine nu

12 are modified cytosine analogs, Zalcitabine (2',3'-dideoxycytidine (ddC)) and Lamivudine (beta-d-(+)-

13 ',3'-didehydro-2',3'-dideoxythymidine (D4T), 2',3'-dideoxycytidine (ddC), (-)-beta-L-2',3'-dideoxy-3'

14 ells to the mtDNA depletion caused by beta-d-2',3'-dideoxycytidine (ddC), 2',3'-didehydro-2',3'-dideo

15 include D-nucleoside analogs such as beta-D-2',3'-dideoxycytidine (ddC), beta-2'-fluoro-5-methyl-ara

16 ditionally exhibited low-level resistance to 2',3'-dideoxycytidine (ddC).

17 athway activity, we used a nucleoside analog 2'3'-dideoxycytidine (ddC), which is phosphorylated to t

18 dideoxy-5-fluorocytidine (beta-L-FddCTP) and 2', 3'-dideoxycytidine (ddCTP), on DNA strand elongation

19 reducing resistance to tenofovir, abacavir, 2',3'-dideoxycytidine, dideoxyinosine, and stavudine.

20 eta-l-2',3'-dideoxy-3'-thiocytidine > beta-d-2',3'-dideoxycytidine > beta-d-2',2'-difluorodeoxycytidi

21 y-2', 3'-didehydro-5-fluorocytidine > beta-l-2',3'-dideoxycytidine > beta-l-2',3'-dideoxy-3'-thiocyti

22 lls and an 82-fold increase in the IC(50) to 2',3'-dideoxycytidine in Jurkat cells.

23 exhibited antinociception in a zalcitabine (2'-3'-dideoxycytidine) model of AIDS therapy-induced and

24 The L-enantiomers of 5-fluoro-2',3'-dideoxycytidine monophosphate and triphosphate had

25 side reverse transcriptase inhibitor (NRTI), 2',3'-dideoxycytidine or 2',3'-dideoxyinosine, mtDNA dep

26 '-azidothymidine therapy in combination with 2',3'-dideoxycytidine or 2',3'-dideoxyinosine.

27 sphorylated to the activated antimetabolite, 2'3'-dideoxycytidine triphosphate by cytoplasmic nucleos

28 mbination therapy with zidovudine (AZT) plus 2',3'-dideoxycytidine was found to regain sensitivity to

29 uoro-2',3'-dideoxy-3'-thiacytidine) and ddC (2',3'-dideoxycytidine) were added to the cultures beginn

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