ライフサイエンスコーパス: 2',5'-oligoadenylate

1 The human 2', 5'-oligoadenylate (2-5A) synthetases are members of

2 In this study, analysis of 2',5'-Oligoadenylate (2-5A) binding and activation of th

3 The 2',5'-oligoadenylate (2-5A) synthetase (OAS)-RNase L sys

4 Three isoforms of the interferon-inducible 2',5'-oligoadenylate (2-5A) synthetase that require doub

5 ation of the NLRP3 inflammasome involves the 2',5'-oligoadenylate (2-5A) synthetase(OAS)/RNase L syst

6 Upregulation of key components of the 2',5'-oligoadenylate (2-5A) synthetase/RNase L pathway h

7 The IFN-inducible 2',5'-oligoadenylate (2-5A) synthetases (OASs) and ribon

8 The 2',5'-oligoadenylate (2-5A) system is an RNA degradation

9 s a unique oligonucleotide second messenger, 2',5'-oligoadenylate (2-5A), that binds and activates RN

10 RNase L is the 2',5'-oligoadenylate (2-5A)-dependent endoribonuclease t

11 ide against human telomerase RNA linked to a 2',5'-oligoadenylate (2-5A).

12 stant to apoptosis by the RNase L activator, 2',5'-oligoadenylate (2-5A).

13 synthetases that produce 5'-phosphorylated, 2',5'-oligoadenylates (2-5A) from ATP.

14 on sensing double-stranded RNA, OAS produces 2',5'-oligoadenylates (2-5A), which activate RNase L.

15 2'-5' oligoadenylate (2-5 (A)) synthetases are major com

16 Multiple 2'-5' oligoadenylate (2-5A) synthetases are important co

17 RNase L is activated by 5'-phosphorylated, 2'-5' oligoadenylates (2-5A) produced from IFN-inducible

18 of residues 321 to 344 of the 9-2 isozyme of 2'-5'-oligoadenylate (2-5(A)) synthetase causes a loss o

19 2'-5'-Oligoadenylate (2-5(A)) synthetases are a family o

20 is required for transcriptional induction of 2'-5'-oligoadenylate (2-5A) synthetases by interferon (I

21 se-pseudokinase that is activated by unusual 2,'5'-oligoadenylate (2-5A) second messengers and which

22 f the structure-function relationship of the 2'-5' oligoadenylate [2-5 (A)] synthetases has been hamp

23 that germline mutations in the gene encoding 2'-5'-oligoadenylate(2-5A)-dependent RNase L (RNASEL) se

24 hanism of the enzymatic conversion of ATP to 2',5'-oligoadenylates by 2-5A synthetase.

25 These studies demonstrate that 2',5' oligoadenylate covalently linked to antisense (2-5

26 Treatment of human cells with 2',5' oligoadenylate covalently linked to antisense (2-5

27 RNase L, the 2',5' oligoadenylate-dependent ribonuclease, is one of t

28 Ribonuclease L (RNase L), the 2',5'-oligoadenylate-dependent ribonuclease, is one of t

29 2',5'-Oligoadenylate-dependent RNase L functions in the

30 Radiolabeled azido 2'-5'-oligoadenylate dimers were enzymatically synthesiz

31 the 5'-monophosphate moiety, shortening the 2',5'-oligoadenylate domain, and substitution of 3',5'-l

32 e-stranded RNA and catalyze the synthesis of 2'-5' oligoadenylates from ATP.

33 The IFN-gamma response can be blocked by 2',5'-oligoadenylate-linked antisense chimeras against P

34 al product that functions as an inhibitor of 2',5'-oligoadenylate phosphodiesterase (2'-PDE), a key r

35 of Streptomyces sp. SANK 61196 that inhibits 2',5'-oligoadenylate phosphodiesterase (2'-PDE), a key r

36 milarly, direct activation of RNase L with a 2',5'-oligoadenylate resulted in p62(SQSTM1) degradation

37 The 2',5'-oligoadenylate/RNase L system is a virus-activated

38 easuring Stat-1 tyrosine phosphorylation and 2',5'-oligoadenylate synthase and myxovirus resistance g

39 proliferation, apoptosis, and inflammation (2'5'-oligoadenylate synthase, cyclooxygenase-2, and an I

40 we demonstrate that HSV-1 infection inhibits 2'-5' oligoadenylate synthesis in interferon-stimulated

41 o lack of nitric oxide synthase 2 (NOS2) and 2', 5' oligoadenylate synthetase (OAS) 1 induction in re

42 70-fold and myxovirus resistance gene 1 and 2',5' oligoadenylate synthetase mRNA expression (107- an

43 ulated genes myxovirus resistance gene 1 and 2',5' oligoadenylate synthetase.

44 ins dsRNA-activated protein kinase (PKR) and 2',5'-oligoadenylate synthetase (2',5'-OAS) were down-re

45 acokinetics, pharmacodynamic measurements of 2',5'-oligoadenylate synthetase (OAS) activity, and indu

46 2',5'-Oligoadenylate synthetase (OAS) enzymes and RNase-

47 h the wild-type (WT) virus uses to block the 2',5'-oligoadenylate synthetase (OAS)-RNase L (RNase L)

48 ivity, which blocks the interferon inducible 2',5'-oligoadenylate synthetase (OAS)-RNase L pathway to

49 luding Myxovirus resistance protein 2 (Mx2), 2',5'-oligoadenylate synthetase (OAS-1), Virus inhibitor

50 elevation of the IFN-induced antiviral gene 2',5'-oligoadenylate synthetase (OAS1a) but not dsRNA-de

51 Upon interferon activation by dsRNA, 2',5'-oligoadenylate synthetase 1 (OAS1A) is induced; it

52 The upregulation of endogenous IFN-beta and 2',5'-oligoadenylate synthetase 1 mRNA expression was al

53 ted increased expression of interferon-beta, 2',5'-oligoadenylate synthetase 1, interferon-alpha, and

54 activation, as evidenced by upregulation of 2',5'-oligoadenylate synthetase 1.

55 ulation and an IFN-inducible antiviral gene, 2',5'-oligoadenylate synthetase 1a (OAS), were determine

56 The RNase L activity associated with 2',5'-oligoadenylate synthetase is not activated or is b

57 ated Gene 15 (ISG15), Interleukin 16 (IL16), 2',5'-Oligoadenylate Synthetase Like (OASL), and Adhesio

58 ted proteins interferon regulatory factor 1, 2',5'-oligoadenylate synthetase, and double-stranded-RNA

59 randed RNA-dependent protein kinase R (PKR), 2',5'-oligoadenylate synthetase, and Mx1 mRNAs in swine

60 s, including myxovirus resistance protein A, 2',5'-oligoadenylate synthetase, and the IFN-stimulated

61 protein 10, and preferential upregulation of 2',5'-oligoadenylate synthetase, Mx1, and indoleamine 2,

62 novel murine cDNA encoding an ovary-specific 2',5'-oligoadenylate synthetase-like protein, OAS1D, whi

63 kinase (PKR) and the endoribonuclease of the 2',5'-oligoadenylate synthetase-RNase L system (PKR(-/-)

64 clease component of the interferon-regulated 2',5'-oligoadenylate synthetase-RNase L system, demonstr

65 HC class I, IFN regulatory factor-1, MxA and 2',5-oligoadenylate synthetase gene expression, transcri

66 The mRNA for IRF-1, p40, and p69 isoforms of 2'-5' oligoadenylate synthetase (2-5 AS) are detectable,

67 Interferon (IFN)-induced 2'-5' oligoadenylate synthetase (2-5A synthetase)/RNase

68 on, the eIF2alpha protein kinase PKR and the 2'-5' oligoadenylate synthetase (OAS) are both activated

69 Twelve 2'-5' oligoadenylate synthetase (Oas) genes were identif

70 The 2'-5' oligoadenylate synthetase (OAS) locus encodes for

71 influenza virus resistance allele Mx(+) and 2'-5' oligoadenylate synthetase (OAS) proteins was not r

72 d cDNAs, including inhibitor of apoptosis-1, 2'-5' oligoadenylate synthetase (OAS), a 2'-5' OAS-like

73 fter CpG and correlated with serum levels of 2'-5' oligoadenylate synthetase (OAS), a validated inter

74 antiviral interferon-stimulated gene product 2'-5' oligoadenylate synthetase (OAS), and the chemokine

75 h includes conventional poly(A) polymerases, 2'-5' oligoadenylate synthetase (OAS), and yeast Trf4p .

76 nes (ISGs) with antiviral properties such as 2'-5' oligoadenylate synthetase (OAS), stimulated trans-

77 NA-responsive defenses controlled by PKR and 2'-5' oligoadenylate synthetase (OAS), which respectivel

78 hesis mediated by protein kinase R (PKR) and 2'-5' oligoadenylate synthetase (OAS).

79 nd two immunologic surrogates, neopterin and 2'-5' oligoadenylate synthetase (OAS).

80 The importance of the 2'-5' oligoadenylate synthetase (OAS)/RNase L and double

81 We hypothesized that the 2'-5' oligoadenylate synthetase (OAS)/RNase L system, an

82 vidence of concerted evolution of paralogous 2'-5' oligoadenylate synthetase 1 genes was obtained in

83 e Flv locus was previously identified as the 2'-5' oligoadenylate synthetase 1b (Oas1b) gene.

84 , including those coding for MHC I proteins, 2'-5' oligoadenylate synthetase [2'-5'(A)N], and IFN reg

85 IFN-responsive genes OAS and ISG54 (encoding 2'-5' oligoadenylate synthetase and an IFN-stimulated ge

86 We have addressed the evolution of the 2'-5' oligoadenylate synthetase gene family, in the ligh

87 2'-5' oligoadenylate synthetase is stimulated by dsRNA t

88 in the light of both this new member and new 2'-5' oligoadenylate synthetase sequence data from other

89 o-IFN-beta was supported by induction of the 2'-5' oligoadenylate synthetase, an indicator of IFN act

90 trong as that of another IFN-inducible gene, 2'-5' oligoadenylate synthetase, but in contrast to 2'-5

91 ligoadenylate synthetase, but in contrast to 2'-5' oligoadenylate synthetase, TP/PD-ECGF mRNA levels

92 Human 2'-5' oligoadenylate synthetase-1 (OAS1) is central in i

93 Among them, the gene encoding 2'-5' oligoadenylate synthetase-like (OASL) underwent th

94 This protein, which we named p59 2'-5' oligoadenylate synthetase-like protein (p59OASL),

95 Several 2'-5' oligoadenylate synthetase-like proteins, which lac

96 bsence of IFN-stimulated antiviral proteins, 2'-5' oligoadenylate synthetase/RNase L, and dsRNA-depen

97 The interferon-induced enzymes 2'-5'-oligoadenylate synthetase (OAS) and RNase L are ke

98 ation in the gene encoding the 1b isoform of 2'-5'-oligoadenylate synthetase (OAS), a member of the O

99 d IFN-stimulated gene expression (tracked by 2'-5'-oligoadenylate synthetase 1 and myxovirus (influen

100 vels and no significant difference in IFNB1, 2'-5'-oligoadenylate synthetase 1, or myxovirus (influen

101 as well as the effector genes, for example, 2'-5'-oligoadenylate synthetase and myxovirus proteins,

102 lv gene interval including 10 members of the 2'-5'-oligoadenylate synthetase gene family.

103 One 2'-5'-oligoadenylate synthetase gene, Oas1b, was identif

104 This crystal structure of a 2'-5'-oligoadenylate synthetase reveals a structural con

105 ding inflammatory (S100A8/A9/A12, CXCL1, and 2'-5'-oligoadenylate synthetase-like [OASL]) and barrier

106 2'-5'-Oligoadenylate synthetase-like protein (OASL) is a

107 to be conserved among all known isozymes of 2'-5'-oligoadenylate synthetase.

108 ear the amino terminus of the 9-2 isozyme of 2'-5'-oligoadenylate synthetase.

109 ude the demonstration that the gene encoding 2'-5'oligoadenylate synthetase is responsible for murine

110 ms of IL-29 and IFN-alpha induced equivalent 2'5' oligoadenylate synthetase (OAS) and MX1 gene expres

111 d in all animals with increased intrahepatic 2'5' oligoadenylate synthetase 1 (2OAS-1) messenger RNA

112 ed genes for IFN-regulatory factors 1 and 7, 2'5' oligoadenylate synthetase, Mx, and TNF superfamily

113 106 (+/-63.3) pg/ml increase (P < 0.01); and 2'5'-oligoadenylate synthetase (OAS) had a 163 (+/-120.6

114 on of protein kinase R (PKR) and stimulating 2'5'-oligoadenylate synthetase (OAS).

115 ISG noted on the microarrays, such as STAT1, 2'5'-oligoadenylate synthetase 2, and ISG15, also suppor

116 of mRNA for dsRNA-activated protein kinase, 2'5'-oligoadenylate synthetase, and Toll-like receptor 3

117 nown interferon-stimulated genes such as the 2'5'-oligoadenylate synthetase, MX1, IRF-7, and toll-lik

118 Here we report that one of these targets, 2,5 oligoadenylate synthetase (2,5 OAS), is a mediator o

119 Specifically, we demonstrate that 2',5'-oligoadenylate synthetases (2-5AS), RNase L, and d

120 2-5A is produced by interferon-inducible 2',5'-oligoadenylate synthetases (OAS) upon activation b

121 RNA-dependent protein kinase (PKR), but not 2',5'-oligoadenylate synthetases (OAS), in vaginal tissu

122 2'-5' Oligoadenylate synthetases (OAS) are a family of e

123 The 2'-5' oligoadenylate synthetases (OAS) represent a famil

124 The 2'-5' oligoadenylate synthetases form a well conserved f

125 Unlike other RNA polymerases, 2'-5' oligoadenylate synthetases, a family of interferon

126 ed N-terminal domain with the known forms of 2'-5' oligoadenylate synthetases, but differs completely

127 an isozyme of the medium size class of human 2'-5' oligoadenylate synthetases.

128 e genes encoding antiviral proteins, such as 2'-5' oligoadenylate synthetases.

129 The 2'-5'-oligoadenylate synthetases are activated by viral

130 2'-5'-Oligoadenylate synthetases are interferon-induced

131 2'-5'-oligoadenylate synthetases are interferon-induced,

132 te-binding sites of the P69 isozyme of human 2'-5'-oligoadenylate synthetases.

133 Ns2 cleaves 2',5'-oligoadenylate, the product of OAS, to prevent act

134 2H-phosphodiesterase domain that can cleave 2'-5' oligoadenylates, thereby preventing RNase L activa

135 initiate a cellular response by synthesizing 2'-5'-oligoadenylates, which in turn activate RNase L.