ライフサイエンスコーパス: 2-deoxyribose

1 ions whereupon it was partially converted to 2-deoxyribose.

2 lso increased by thymidine phosphorylase and 2-deoxyribose.

3 lase and subsequent extracellular release of 2-deoxyribose.

4 rmits this enzyme to distinguish ribose from 2'-deoxyribose.

5 -0.07, G; 0.03, C; 0.20, T) and the isolated 2-deoxyribose (-0.38) at the same level of theory.

6 nd ribose 1-phosphate (or 2'-deoxyuridine to 2'-deoxyribose 1-phosphate).

7 arsenate with thymidine to form thymine and 2-deoxyribose 1-arsenate, which rapidly decomposes to 2-

8 forming thymine and the chemically unstable 2-deoxyribose 1-arsenate.

9 purine ribonucleosides to the free bases and 2-deoxyribose 1-phosphate.

10 nucleosides to the free base and ribose (or 2'-deoxyribose) 1-phosphate.

11 midine were duplicated by the TP metabolite, 2-deoxyribose-1-phosphate (dR-1-P), and 10-fold more pot

12 more potently by its subsequent metabolite, 2-deoxyribose (2dR).

13 e five-carbon phosphorylated monosaccharide, 2-deoxyribose 5-phosphate (2dR5P), as an alternate subst

14 uctose 1,6-bisphosphate (F16BP) aldolase and 2-deoxyribose 5-phosphate (dR5P) aldolase (DERA).

15 ncised by AP endonuclease, resulting in a 5' 2-deoxyribose 5-phosphate (i.e. dRP lyase activity).

16 non-natural nucleoside, 5-cyclohexylindolyl-2'-deoxyribose (5-CHInd), behaves as a P-gp inhibitor.

17 igher binding affinity of 5-phenyl-1-indolyl-2'-deoxyribose-5'-triphosphate and suggests that the pol

18 eviously demonstrated that 5-nitro-1-indolyl-2'-deoxyribose-5'-triphosphate, a nonnatural nucleobase

19 damage, because Pol lambda has intrinsic 5',2'-deoxyribose-5-phosphate lyase activity.

20 activities, including DNA polymerase and 5',2'-deoxyribose-5-phosphate lyase.

21 olution structures of wild-type and mutant d-2-deoxyribose-5-phosphate (DRP) aldolase complexes with

22 of the bacterial (Escherichia coli) class I 2-deoxyribose-5-phosphate aldolase (DERA) has been deter

23 Removal of 2-deoxyribose-5-phosphate as 4-hydroxy-2-pentenal-5-phos

24 phodiesterase (dRpase) activity that removes 2-deoxyribose-5-phosphate at an incised 5' apurinic/apyr

25 te moiety of the downstream strand by the 5'-2-deoxyribose-5-phosphate lyase activity of either DNA p

26 bda, but not pol mu, pol IV has intrinsic 5'-2-deoxyribose-5-phosphate lyase activity.

27 The mechanism of the 5'-2-deoxyribose-5-phosphate lyase reaction catalyzed by ma

28 s demonstrate that although this 5'-terminal 2-deoxyribose-5-phosphate mimic does not affect the fide

29 ng a 1,2-dideoxyribose-5-phosphate moiety, a 2-deoxyribose-5-phosphate mimic, we measured the incorpo

30 cision repair, the excision of a 5'-terminal 2-deoxyribose-5-phosphate moiety of the downstream stran

31 Yet the effects of this 5'-terminal 2-deoxyribose-5-phosphate moiety on the polymerase activ

32 ascent 3' base pair and to be inhibited when 2-deoxyribose-5-phosphate, rather than phosphate, consti

33 beta-pol was covalently cross-linked to a 5'-2-deoxyribose-5-phosphate-containing DNA substrate by so

34 ng components of thymidine phosphorylase and 2-deoxyribose action.

35 putative cross-link remnant 9b composed of a 2-deoxyribose adduct attached to the exocyclic N(2)-amin

36 Here, a stabilized 2'-fluoro-2'-deoxyribose analog of N(2),3-epsilonG was used to qua

37 cleavage of the glycosidic bond between the 2'-deoxyribose and base, corresponding to B[a]PDE adduct

38 4.7 muM), which contain one or two 2'-fluoro-2'-deoxyriboses and/or bis-phosphorothioate linkages, ar

39 bose 1-arsenate, which rapidly decomposes to 2-deoxyribose and inorganic arsenate.

40 times more active than PBN as assessed using 2-deoxyribose and p-nitrosodimethylaniline as substrates

41 2-deoxyribonolactone (L) and 2-deoxyribose (AP) are abasic sites that are produced by

42 The 8,5'-cyclopurine-2'-deoxyriboses are suspected to play a role in the etio

43 ced stability, reactivity, and solubility of 2-deoxyribose as compared to ribose.

44 ng blocks using readily available O-1-methyl-2-deoxyribose as starting material.

45 assembly, because an siRNA strand bearing a 2'-deoxyribose at this position can inhibit the cognate

46 Further, thymidine phosphorylase and 2-deoxyribose, but not VEGF, increased the association o

47 yl radical attack on the C1', C3' and C4' of 2-deoxyribose can give rise to epimeric 2-deoxyribose le

48 very base is the same, -0.28 with the sum of 2-deoxyribose charges being positive, +0.28.

49 The latter was used as a model for the 2-deoxyribose component of DNA.

50 t-handed helix with all nucleotides in anti, 2'-deoxyribose conformations within the C2'-endo/C1'-exo

51 has been crystallized with a cationic 1-aza-2'-deoxyribose-containing DNA that mimics the ultimate t

52 However, the complexity of nucleobase and 2-deoxyribose damage caused by strong oxidants such as i

53 depyrimidination of dT yielding thymine and 2-deoxyribose (dRib).

54 dic bond provide nucleobase and/or ribose or 2'-deoxyribose fragment ions and fragments thereof.

55 Compounds containing 2-deoxyribose gave higher levels of methylglyoxal than t

56 erevisiae revealed that the model lesion and 2-deoxyribose have distinct in vivo effects.

57 The oxidation of 2-deoxyribose in DNA has emerged as a critical determina

58 erminant of hydroxyl radical reactivity with 2-deoxyribose in DNA, but the large differences between

59 Thymidine phosphorylase and 2-deoxyribose-induced focal adhesion kinase phosphorylat

60 we present mechanistic studies revealing the 2'-deoxyribose isomerization and subsequent deglycosylat

61 nthraniloyl modification at the 3'-OH of the 2'-deoxyribose leads to ligands (mant-deoxy-ATP [dATP],

62 Owing to the instability of 2-deoxyribose lesions (AP), a chemically stable tetrahyd

63 ' of 2-deoxyribose can give rise to epimeric 2-deoxyribose lesions, for which the in vivo occurrence

64 The mechanisms by which 2-deoxyribose might mediate thymidine phosphorylase-indu

65 nd from entering holo-RISC; in contrast, the 2'-deoxyribose-modified strand has enhanced activity in

66 . scavengers suggesting that OH* cleaved the 2'-deoxyribose moiety in the DNA to produce base propena

67 identified a series of modifications of the 2'-deoxyribose moiety of DNA arising from the exposure o

68 e original methodology's neutral loss of the 2'-deoxyribose moiety to allow for the detection of all

69 Using duplex 2'-deoxyribose oligonucleotides containing an abasic (AP

70 direct effect of thymidine phosphorylase and 2-deoxyribose on signaling pathways associated with endo

71 unted to 40% and 35%, respectively, of total 2-deoxyribose oxidation as measured by a plasmid nicking

72 Further, the well-defined 2-deoxyribose oxidation chemistry of the enediyne antibi

73 The proportions of the various 2-deoxyribose oxidation products generated by gamma-radi

74 for the rigorous quantification of two major 2-deoxyribose oxidation products: the 2-deoxyribonolacto

75 2-deoxyribonolactone at 7% and 24% of total 2-deoxyribose oxidation, respectively, with frequencies

76 ponding to [(B[a]Ptriol+phosphate)-H]- and [(2'-deoxyribose+phosphate+B[a]Ptriol)-H]-, respectively.

77 Es) are believed to involve the formation of 2-deoxyribose radicals.

78 p participates in a tight interaction with a 2'-deoxyribose residue of the 5'-terminal G of a neighbo

79 oup was introduced at the 5' position of the 2'-deoxyribose residue of thymidine or at a correspondin

80 emnant 6 in which the anomeric carbon of the 2-deoxyribose residue was connected to the exocyclic N(6

81 tely associated with the conformation of the 2'-deoxyribose ring is the value of the C-N torsion angl

82 conformational preferences of HSV-tk for the 2'-deoxyribose ring.

83 e show that both thymidine phosphorylase and 2-deoxyribose stimulated the formation of focal adhesion

84 2'-Deoxyribose substitution leads to folding with reduce

85 Thermodynamic effects of 2'-deoxyribose substitutions of loop nucleotides were ex

86 hio modification preorganizes the ribose and 2'-deoxyribose sugars for a C3'-endo conformation, and s

87 the source of selectivity in silyl-protected 2-deoxyribose systems.

88 esizing several unique 5-substituted indolyl 2'-deoxyribose triphosphates and defining their kinetic

89 The 2-chloro pharmacophore, rather than the 2'-deoxyribose was responsible for the reduced 2CdA upta

90 e (BCNA) 6-pentylphenylfuro[2,3-d]pyrimidine-2'-deoxyribose was synthesized using carbocyclic 2'-deox

91 determine the properties of combinations of 2-deoxyribose with each of the isolated DNA bases for bo