ライフサイエンスコーパス: 201Tl

1 201Tl and MIBI planar imaging yield the same high specif

2 201Tl and MIBI scans were obtained in 54 patients with n

3 201Tl imaging has been widely used for postinfarction ri

4 201Tl scintigrams were reviewed blindly, and each segmen

5 201Tl single-photon emission computed tomography viabili

6 201Tl single-photon emission computed tomography, 99mTc

7 201Tl SPECT/CT imaging permits serial, regional quantifi

8 compared myocardial uptake of thallium-201 (201Tl) at rest with rest technetium-99m (99mTc) sestamib

9 the intravenous injection of 111 MBq (3mCi) 201Tl and at 1 hr postinjection of 925 MBq (25 mCi) 99mT

10 as 76% by counting all studies with abnormal 201Tl uptake, but it increased to 100% when the retentio

11 rdial ischemia was quantified with adenosine 201Tl tomography (SPECT) performed 4.5+/-2.9 days after

12 on curves recorded for 131I-albumin, 42K and 201Tl from the coronary sinus outflow following injectio

13 s lymphoma) patients underwent both 67Ga and 201Tl scintigraphy.

14 hat realistically models the attenuation and 201Tl uptake distributions in different organs of the up

15 redicted maximum heart rate, the Doppler and 201Tl imaging data agreed in 46 of 52 stenoses (agreemen

16 and/or cardiac death, echocardiographic and 201Tl parameters were the only predictive variables.

17 riables and exercise, echocardiographic, and 201Tl tomographic parameters were studied in 248 patient

18 uated for CAD, exercise echocardiography and 201Tl combined with ECG variables provide comparable pro

19 he accuracy of exercise echocardiography and 201Tl single photon emission computed tomography (SPECT)

20 rate, several 111In compounds, 131I-MIBG and 201Tl-thallous chloride, periods of 12-44 days are estim

21 ith [123I]metaiodobenzylguanidine (MIBG) and 201Tl, respectively.

22 Comparable MRI and 201Tl basal and midventricular short-axis images were su

23 In protocol 1, 2-hour NOET and 201Tl stenotic-to-normal tissue activity ratios were sim

24 In protocol 1 (n=10), NOET and 201Tl were injected during low flow in the left anterior

25 mibi, 99mTc-tetrofosmin and 99mTcN-NOET) and 201Tl in a canine model of myocardial ischemia with phar

26 calculated by well counting postmortem, and 201Tl and 99mTc-tetrofosmin defect magnitudes were deter

27 d MMP-targeted radiotracer (99mTc-RP805) and 201Tl demonstrated favorable biodistribution and clearan

28 Relationships between 99mTc-sestamibi and 201Tl RRFs and microsphere RRFs were curvilinear, platea

29 ionuclide SPECT imaging (99mTc-sestamibi and 201Tl).

30 detection rate between 99mTc-tetrofosmin and 201Tl but with smaller defect magnitudes for 99mTc-tetro

31 of a major branch of the circumflex artery, 201Tl and either tetrofosmin or sestamibi were injected

32 of a major branch of the circumflex artery, 201Tl and Q12 were injected intravenously.

33 Nitrate-augmented 201Tl reinjection significantly, albeit modestly, improv

34 ggest that administration of nitrates before 201Tl reinjection enhances the detection of reversible m

35 The difference between 201Tl and 67Ga sensitivity in patients with low-grade ly

36 The overall results were the same for both 201Tl and MIBI imaging, with a sensitivity of 19 of 36 (

37 e intracoronary Doppler ultrasound with both 201Tl imaging and coronary angiography.

38 After confirmation of LAD occlusion by 201Tl scintigraphy, a mixture of 99mTc glucarate (15.7 +

39 owing hyperenhancement were judged viable by 201Tl and may have represented an admixture of scar tiss

40 4 of 36 (67%) patients with residual cancer; 201Tl detected tumor sites in 13 of 24 (54%) of these pa

41 stigates the feasibility of routine clinical 201Tl gated perfusion SPECT (gated Tl), and compares qua

42 The aim was to compare 201Tl (thallium) single photon emission CT (SPECT), 99mT

43 Conversely, 201Tl sensitivity was 100%, respectively, for patients a

44 to 3 weeks after MI in regions of decreased 201Tl perfusion.

45 High-dose ouabain decreased 201Tl Enet at 3 min and 99-Tc-Q12 Enet at 10 and 15 min.

46 in these defects for initial 201Tl, delayed 201Tl and 99mTc-sestamibi was 62.5 +/- 2.7%, 63.1 +/- 7.

47 Early and delayed 201Tl uptake ratios were obtained for patients with posi

48 Early and delayed 201Tl uptake ratios were obtained for the positive studi

49 estamibi with initial rest 201Tl and delayed 201Tl uptake.

50 e reduction in viability, defined as delayed 201Tl uptake < 50%.

51 d reduction in viability, defined as delayed 201Tl uptake < or = 75% and > or = 5%, or a severe reduc

52 or initial 201Tl, 38.3 +/- 12.2% for delayed 201Tl and 42.7 +/- 14.2% for 99mTc-sestamibi defects in

53 for initial 201Tl, 42.9 +/- 8.6% for delayed 201Tl and 44.5 +/- 11.3% for 99mTc-sestamibi defects.

54 for initial 201Tl, 67.0 +/- 9.1% for delayed 201Tl and 67.7 +/- 12.4% for 99mTc-sestamibi defects.

55 ignificantly different than that for delayed 201Tl but was significantly greater than initial 201Tl u

56 but not significantly different than delayed 201Tl uptake in these severe defects.

57 s much time-dependent redistribution as does 201Tl, it has been considered suboptimal for the detecti

58 LAD:LCx flow ratios were similar during 201Tl and 99mTc-tetrofosmin injections (0.48 +/- 0.04 ve

59 In the presence of abnormal early 201Tl uptake, it is essential to perform delayed imaging

60 the latter are dobutamine echocardiography, 201Tl isotope studies, and positron image tomography.

61 Quantitative gated tomography, using either 201Tl or 99mTc tracers, has a good correlation with echo

62 ocardiography with exercise ECG and exercise 201Tl SPECT with exercise ECG.

63 coronary Doppler ultrasound and had exercise 201Tl testing within a 1-week period.

64 for acute myocardial infarction had exercise 201Tl tomography and coronary angiography before hospita

65 Quantitative exercise 201Tl tomography provides important incremental, long-te

66 ho underwent simultaneous treadmill exercise 201Tl SPECT and echocardiography.

67 For the model with exercise 201Tl SPECT, the strongest predictor was ischemic perfus

68 Final 201Tl activity (0.66 +/- 0.04) was significantly higher

69 teen patients (52 segments) had severe fixed 201Tl defects.

70 -to-LCx activity ratios were 0.37+/-0.04 for 201Tl and 0.67+/-0.05 for 99mTc-tetrofosmin (P<.01).

71 slope of the curve normalized by average for 201Tl (0.83) was greater than those for the 99mTc tracer

72 Revised radiation dosimetry estimates for 201Tl-thallous chloride have been developed using new da

73 image defects were significantly greater for 201Tl than for 99mTc-tetrofosmin in both groups.

74 y myocardial viability as has been noted for 201Tl and sestamibi, we analyzed the initial and delayed

75 myocardial viability, as has been noted for 201Tl and sestamibi, we analyzed the initial and delayed

76 of tetrofosmin was similar to that noted for 201Tl, but after 1 hour of tracer circulation, the tetro

77 3-dimensional quantitation of perfusion from 201Tl and 99mTc-sestamibi images is feasible and reprodu

78 iability can be quantified in a single gated 201Tl study.

79 With clinical imaging, greater 201Tl attenuation and redistribution may lessen this adv

80 nted with focal lesions on CT and/or MRI had 201Tl brain SPECT studies (early and delayed image sets)

81 Hybrid 201Tl SPECT/CT imaging was performed in pigs (n=8) at ba

82 schemia with dipyridamole induced hyperemia, 201Tl shows a more ideal relationship between tracer upt

83 of poststress or rest/redistribution images, 201Tl or 99mTc tracers.

84 ients had 11 foci of significantly increased 201Tl uptake in regions of corresponding CT/MRI lesions.

85 patients had foci of significantly increased 201Tl uptake on the early images in regions of correspon

86 percent uptake was 38.9 +/- 7.3% for initial 201Tl, 38.3 +/- 12.2% for delayed 201Tl and 42.7 +/- 14.

87 percent uptake was 37.0 +/- 8.5% for initial 201Tl, 42.9 +/- 8.6% for delayed 201Tl and 44.5 +/- 11.3

88 percent uptake was 61.6 +/- 5.2% for initial 201Tl, 67.0 +/- 9.1% for delayed 201Tl and 67.7 +/- 12.4

89 percent uptake in these defects for initial 201Tl, delayed 201Tl and 99mTc-sestamibi was 62.5 +/- 2.

90 uptake was significantly higher than initial 201Tl uptake, but not significantly different than delay

91 l but was significantly greater than initial 201Tl uptake.

92 A 36-yr-old man with AIDS exhibited intense 201Tl uptake (lesion-to-brain uptake ratio 5.38) in a br

93 As was seen for mild 201Tl redistribution defects, 99mTc-sestamibi uptake was

94 Between 3 and 15 min, 201Tl Enet was decreasing by a rate of 2% per minute whi

95 Neither 201Tl or 67Ga is dependable in the evaluation of low-gra

96 Twenty patients showed no 201Tl uptake in the regions of CT/MRI lesions.

97 Of nine patients with no 201Tl uptake in regions of CT/MRI lesions, two had biops

98 The absence of 201Tl uptake on early images at the site of a CT/MRI abn

99 lt testes from intravenous administration of 201Tl-thallous chloride.

100 y quantitative and qualitative assessment of 201Tl scans showed persistent, systematically greater MR

101 The Emax of 201Tl was greater than 99mTc-Q12 Emax (0.73 +/- 0.01 and

102 oma is low and gastrointestinal excretion of 201Tl is poorly controlled.

103 Tl study results, and the retention index of 201Tl was calculated.

104 for recovery of function, whereas indexes of 201Tl scintigraphy are in general more sensitive and les

105 lactating mother was administered 111 MBq of 201Tl for a brain scan.

106 -yr-old from an administration of 111 MBq of 201Tl to the mother ranged from 0.90 mSv to 0.00072 mSv,

107 After 30 min, 37 MBq (1 mCi) of 201Tl and microspheres were injected and initial and 2-h

108 hat may be encountered in the preparation of 201Tl-thallous chloride are shown to range from a fracti

109 defined arteriogenesis and quantification of 201Tl perfusion.

110 over a period of three days, and the rate of 201Tl secretion was determined.

111 ocol in which they received a reinjection of 201Tl (1.0 mCi) 5 minutes after either placebo or 0.8 mg

112 stic imaging, including the evolving role of 201Tl, 99mTc-MIBI (methoxyisobutylisonitrile), and newer

113 The overall sensitivity of 201Tl brain SPECT was 100%, and specificity was 90%.

114 The overall sensitivity of 201Tl brain SPECT was 96%.

115 , as well as to determine the sensitivity of 201Tl uptake in both Hodgkin's and non-Hodgkin's lymphom

116 retention index increases the specificity of 201Tl brain SPECT in human immunodeficiency virus patien

117 ction (Emax) and net extraction (Enet(t)) of 201Tl and 99mTc-Q12 over 15 min during control perfusion

118 Furthermore, newer techniques of 201Tl imaging, such as reinjection and nitrate-enhanced

119 m-tetrofosmin uptake was compared to that of 201Tl in the setting of low flow and systolic dysfunctio

120 cess for 99mTc-Q12 is different from that of 201Tl.

121 At 3 min of perfusion, 201Tl Enet was greater than 99mTc-Q12 Enet (0.40 +/- 0.0

122 egative serum Tg levels, 6 had true-positive 201Tl and 5 had true-positive MIBI scans.

123 ios were obtained for patients with positive 201Tl study results, and the retention index of 201Tl wa

124 40% who underwent preoperative quantitative 201Tl scintigraphy before coronary bypass surgery were a

125 For each anatomy, realistic 201Tl projection data were simulated for a 180 degrees a

126 tients who underwent exercise-redistribution 201Tl single photon emission computed tomography (SPECT)

127 mpared MRI findings with rest-redistribution 201Tl imaging and dobutamine echocardiography.

128 ted with nonviability by rest-redistribution 201Tl scintigraphy and dobutamine echocardiography, part

129 crograms.kg-1.min-1) and rest-redistribution 201Tl tomography 1 day before revascularization.

130 ography and quantitative rest-redistribution 201Tl tomography in the prediction of recovery of functi

131 Conclusion: Ouabain reduced 201Tl Emax but not 99mTc-Q12 Emax.

132 Relative 201Tl retention (ischemic/nonischemic) was reduced immed

133 +/- 2% underwent early and 3-h delayed rest 201Tl SPECT, rest 99mTc-sestamibi SPECT and two-dimensio

134 Nitrate-enhanced rest 201Tl imaging detected reversible defects in 68 patients

135 uch as reinjection and nitrate-enhanced rest 201Tl imaging, have been shown to improve the detection

136 d on a separate day by nitrate-enhanced rest 201Tl study.

137 e further classified as fixed or having rest 201Tl redistribution.

138 to compare 99mTc-sestamibi with initial rest 201Tl and delayed 201Tl uptake.

139 201Tl defect count ratio on the initial rest 201Tl scan (0.57 +/- 0.03 versus 0.56 +/- 0.02, p = ns),

140 re developed for separate, dual-isotope rest 201Tl-exercise 99mTc-sestamibi SPECT in 36 patients with

141 s) had severe redistribution defects on rest 201Tl imaging.

142 d mild redistribution defects on serial rest 201Tl imaging.

143 Before revascularization, resting 201Tl uptake was similar in segments demonstrating bipha

144 We conclude that resting 201Tl scintigraphy may be useful in preoperative risk st

145 After revascularization, 201Tl uptake increased only in segments that showed a bi

146 t to our present observations of significant 201Tl redistribution and some changes in sestamibi distr

147 he three-dimensional MCAT phantom simulating 201Tl uptake in the upper torso and the SIMSET Monte Car

148 Attenuated SPECT 201Tl emission data were simulated from a mid-ventricula

149 clinical significance of dipyridamole SPECT 201Tl scintigraphy, we examined the relationships betwee

150 r descending coronary artery (LAD) stenoses, 201Tl and 99mTc-tetrofosmin were administered during ade

151 rve < 1.7 predicted the presence of a stress 201Tl defect in 56 of 67 stenoses (agreement=84%; kappa=

152 sence of exercise-induced ischemia on stress 201Tl imaging, and coronary angiography does not reliabl

153 en compared to itself in lymphoma subgroups, 201Tl was found to be statistically more avid for low-gr

154 - 0.02, p = ns), but significantly less than 201Tl defect count ratio at 2 hr (0.57 +/- 0.03 versus 0

155 Tc-sestamibi uptake at rest may be less than 201Tl uptake, thereby underestimating the extent of viab

156 underestimated the flow disparity more than 201Tl.

157 processes and longer cellular retention than 201Tl for rapid and sustained cardiac imaging to differe

158 The 201Tl activity ratio was 0.58+/-0.04, compared with 0.81

159 The 201Tl retention index in patients with lymphomas (1.18 +

160 The 201Tl retention index in patients with lymphomas was sig

161 The 201Tl retention index is useful in differentiating CNS l

162 did not reliably predict the results of the 201Tl stress test (kappa=0.21; agreement=57% to 63%).

163 Four weeks postocclusion, postmortem tissue 201Tl activity was measured by gamma counting, and immun

164 ake after injection at rest is comparable to 201Tl uptake after injection at rest in patients with se

165 y nonavid for low-grade lymphoma compared to 201Tl and is statistically inferior in detecting low-gra

166 smin image defect count ratio was similar to 201Tl defect count ratio on the initial rest 201Tl scan

167 rdial imaging agent with kinetics similar to 201Tl in experimental models, permitting redistribution

168 cal lesions on CT or MRI, or both, underwent 201Tl brain SPECT shortly after admission and before a C

169 underwent a nuclear medicine procedure using 201Tl.

170 on computed tomography imaging studies using 201Tl at rest and 99mTc-sestamibi after adenosine stress

171 No significant differences were found when 201Tl and 67Ga were compared in the intermediate, high o

172 This study sought to assess whether 201Tl brain SPECT can significantly reduce the time requ

173 rpose of this study was to determine whether 201Tl retention in focal intracranial lesions can help d

174 ry disease diagnosis over that achieved with 201Tl imaging, particularly when this technique is combi

175 der resting conditions (83% concordance with 201Tl in both cases).

176 tification of left ventricular function with 201Tl was possible and as reliable as gated SPECT with 9

177 le-photon-emission CT perfusion imaging with 201Tl or one of the new 99mTc-labeled perfusion agents,

178 from 28 patients (56 studies) injected with 201Tl-thallous chloride at peak exercise.

179 99mTc-methoxyisobutyl isonitrile (MIBI) with 201Tl scintigraphy for the detection of residual thyroid

180 ith adenosine stress is better resolved with 201Tl than with 99mTc-tetrofosmin and may be explained b

181 The correlation between gated SPECT with 201Tl and gated SPECT with 99mTc-sestamibi was: r = 0.93

182 cellent correlation between gated SPECT with 201Tl and gated SPECT with 99mTc-sestamibi.

183 to determine if myocardial gated SPECT with 201Tl was possible and reliable to quantify left ventric

184 ardium and to compare 99mTc-tetrofosmin with 201Tl uptake during adenosine-induced vasodilatation in