ライフサイエンスコーパス: 20S proteasome

1 l region is essential for degradation by the 20S proteasome.

2 ydrolysis by stimulating gate opening in the 20S proteasome.

3 the in vitro degradation of CTA1 by the core 20S proteasome.

4 calmodulin that initiate degradation by the 20S proteasome.

5 postulate a duplication of Anbu created the 20S proteasome.

6 a noncompetitive and reversible inhibitor of 20S proteasome.

7 protein phosphatase and was degraded by the 20S proteasome.

8 te with susceptibility to degradation by the 20S proteasome.

9 direct interaction between nicotine and the 20S proteasome.

10 of proteasomes using an antibody against the 20S proteasome.

11 ct the intrinsic proteolytic activity of the 20S proteasome.

12 rotected it from in vitro degradation by the 20S proteasome.

13 biquitin-independent degradation by the core 20S proteasome.

14 hanneling of ubiquitylated substrates to the 20S proteasome.

15 construction of the Thermoplasma acidophilum 20S proteasome.

16 o stimulate the trypsin-like activity of the 20S proteasome.

17 ors of the chymotrypsin-like activity of the 20S proteasome.

18 a ubiquitin-independent fashion by the core 20S proteasome.

19 are toxic to cells bearing mutations in the 20S proteasome.

20 ics as measured by percent inhibition of the 20S proteasome.

21 the entry of ubiquitinated proteins into the 20S proteasome.

22 organizing complex (MTOC) and its associated 20S proteasome.

23 esolvable products upon addition of purified 20S proteasome.

24 distribution resembling the MTOC-associated 20S proteasome.

25 beta-ring in comparison with one-half of the 20S proteasome.

26 ion with, and subsequent degradation by, the 20S proteasome.

27 tly reduced their rate of degradation by the 20S proteasome.

28 . volcanii synthesizes more than one type of 20S proteasome.

29 lates in the presence of an inhibitor of the 20S proteasome.

30 heximide or lactacystin, an inhibitor of the 20S proteasome.

31 inhibited chymotrypsin-like activity of the 20S proteasome.

32 nd abundant barrel-shaped complex called the 20S proteasome.

33 as regulators and subunits of the mammalian 20S proteasome.

34 t on the basis of the structure of the yeast 20S proteasome.

35 at least three components of the 26S but not 20S proteasome.

36 ine protease with structural similarity to a 20S proteasome.

37 ls of ubiquitin, Hsp70, PA700, PA28, and the 20S proteasome.

38 product eponemycin, selectively targets the 20S proteasome.

39 cted by the binding of a single PA700 to the 20S proteasome.

40 g of the beta prosubunits or assembly of the 20S proteasome.

41 y of the inhibitors complexed with the yeast 20S proteasome.

42 anism that requires only 19S AAA ATPases and 20S proteasome.

43 ocking of the 19S regulatory particle to the 20S proteasome.

44 biquitin-independent FOS degradation via the 20S proteasome.

45 wo of the six active sites of the eukaryotic 20S proteasome.

46 h as papain and calpain as well as the human 20S proteasome.

47 reading of chymotrypsin-like activity of the 20S proteasome.

48 nd cellular assays, but does not inhibit the 20S proteasome.

49 t with and "wobble" on top of the heptameric 20S proteasome.

50 hsp90, directing CXCR4 to degradation by the 20S proteasome.

51 can be degraded in a cell-free system by the 20S proteasome.

52 mers that differ in shape from both HslV and 20S proteasomes.

53 bind to and be degraded in vitro by purified 20S proteasomes.

54 (T-L), and caspase-like (C-L) activities of 20S proteasomes.

55 n of precursor peptides with highly purified 20S proteasomes.

56 sequester various components of the 19S and 20S proteasomes.

57 nd the subsequent final maturation to active 20S proteasomes.

58 ndent degradation of beta-casein by archaeal 20S proteasomes.

59 erence in caspase-like activity for purified 20S proteasomes.

60 s, 26S proteasome disassembly, and a rise in 20S proteasomes.

61 eta-subunit (Anbu) is homologous to HslV and 20S proteasomes.

62 associate with 'singly capped' 26S (i.e. 19S-20S) proteasomes.

63 eased incorporation of inducible subunits in 20S proteasomes; (2) enhanced 20S sensitivity to PKA act

64 The core of this large protease is the 20S proteasome, a barrel-shaped structure made of a stac

65 d of two relatively stable subparticles, the 20S proteasome, a hollow cylindrical structure which con

66 urofilaments in midbrain of KO mice, whereas 20S proteasome activities were decreased, which could po

67 There was no effect of GW610742 on 20S proteasome activity and mRNA expression, or the musc

68 TUNEL assays, C9 immunohistochemistry, and 20S proteasome activity assays were also performed.

69 Moreover, 20S proteasome activity in the diaphragm was elevated in

70 If 20S proteasome activity is inhibited, ubiquitinated prot

71 Inhibition of 20S proteasome activity seemed to be dose dependent.

72 Reversible inhibition of 20S proteasome activity was dose dependent and best fit

73 20S proteasome activity was not affected by heat.

74 A significant increase in 20S proteasome activity was observed with unloading, in

75 Diaphragm 20S proteasome activity was slightly increased in both v

76 bits both 19S proteasome-associated DUBs and 20S proteasome activity with a mechanism distinct from t

77 20S and 19S proteasome subunit abundance and 20S proteasome activity, were significantly decreased by

78 This dose correlates with 70% inhibition of 20S proteasome activity.

79 on of oxidized proteins and up-regulation of 20S proteasome activity.

80 were evaluated by measurement of whole blood 20S proteasome activity.

81 ne (SNAP), at all concentrations, suppressed 20S proteasome activity.

82 n along with elevated (p < 0.05) calpain and 20S proteasome activity.

83 was evaluated by measurement of whole blood 20S proteasome activity.

84 o juxtanuclear aggresomes, without affecting 20S proteasome activity.

85 of PI31 drastically reduces its affinity for 20S proteasome alpha subunits to relieve 20S repression

86 in M. smegmatis cells already lacking intact 20S proteasome alpha- and beta-subunit genes (called prc

87 These data suggest that interaction with a 20S proteasome alpha-subunit is a critical determinant o

88 PACE was used successfully to identify human 20S proteasome alpha-subunit PSMA7 mRNA as the cellular

89 lification of cDNA ends) revealed that human 20S proteasome alpha-subunit PSMA7 mRNA was a target RNA

90 in, caspase-3, and proteasome, expression of 20S-proteasome alpha subunits, E2 conjugases, E3 ligases

91 a missense mutation in the gene encoding the 20S proteasome alpha2 subunit.

92 y inhibits the activity of a purified rabbit 20S proteasome and 26S proteasome in intact highly metas

93 In mammalian cells, the 20S proteasome and a specific type of vacuolar autophagy

94 es one CDC48 protein that interacts with the 20S proteasome and activates the degradation of model su

95 s a homohexameric structure that resembles a 20S proteasome and binds to single-stranded RNA and DNA.

96 nuclear aggregates which colocalize with the 20S proteasome and endogenous HDJ-2/HSDJ.

97 alinispora tropica, is a potent inhibitor of 20S proteasome and exhibits therapeutic potential agains

98 translocated into the central chamber of the 20S proteasome and hydrolyzed to polypeptide products of

99 ing of p369-377 was not detected by purified 20S proteasome and immunoproteasome, indicating that tum

100 MuRF-1, multiple but not all subunits of the 20S proteasome and its 19S regulator, and cathepsin L.

101 fficient for assembly of 26S proteasome from 20S proteasome and PA700/19S subcomplexes and for protea

102 he cell regulates the ratio of the different 20S proteasome and PAN proteins to modulate the structur

103 se, gamma-secretase, ribosome-EF-Tu complex, 20S proteasome and RNA polymerase III, we illustrate how

104 ron-induced complex that associates with the 20S proteasome and stimulates breakdown of small peptide

105 ediated stress leads to up-regulation of the 20S proteasome and suppression of ubiquitinylation activ

106 al activity revealed that p63 is degraded by 20S proteasome and that this degradation is significantl

107 sistent with the biological functions of the 20S proteasome and the CUGBP1-eIF2 complexes, the stabil

108 activities by 40% and 70%, respectively, in 20S proteasomes and caused rapid degradation of some of

109 of a prokaryote which produces two separate 20S proteasomes and suggests that there may be distinct

110 e of ATP in proteolysis, we studied archaeal 20S proteasomes and the PAN (proteasome-activating nucle

111 complex comprises a catalytic core particle (20S proteasome) and a regulatory particle (19S regulator

112 ng affinity by inserting into pockets on the 20S proteasome, and PA26 activation loops induce conform

113 magnitude less than that of the Rhodococcus 20S proteasome, and unlike eukaryotic and archaeal prote

114 ient delivery of substrate proteins into the 20S proteasomes, and depletion of key components of the

115 noprecipitation reveals that E1A, S8 and the 20S proteasome are recruited to both Ad early region gen

116 architecture and enzymatic properties of the 20S proteasome are relatively well understood.

117 20S proteasomes are large, multicatalytic proteases that

118 Our results demonstrate that 20S proteasomes are required for growth.

119 asome, suggesting that at least two separate 20S proteasomes are synthesized.

120 released/mg/min, were obtained for purified 20S proteasomes as well as crude heart and liver samples

121 activity may arise from the accumulation of 20S proteasome assembly intermediates or from qualitativ

122 Eukaryotic 20S proteasome assembly remains poorly understood.

123 locus, UMP1, encodes a chaperone involved in 20S proteasome assembly.

124 dependent proteases have been characterized: 20S proteasomes associated with proteasome-activating nu

125 itination or the proteolytic activity of the 20S proteasome, because ubiquitinated proteins and the p

126 edundant catalytically active mutants of the 20S proteasome beta-subunit, reminiscent of PSMB5 mutati

127 determine the structure of the P. falciparum 20S proteasome bound to the inhibitor using cryo-electro

128 AP-43) was attacked by purified reticulocyte 20S proteasome but not by the 26S proteasome.

129 a-annulus) that is blocked in the unliganded 20S proteasome by amino-terminal sequences of alpha-subu

130 ein Cdc48/p97, functions in concert with the 20S proteasome by unfolding substrates and passing them

131 nonenal) and increased proteolytic activity (20S proteasome, calpain-1, and caspase-3).

132 ry molecular target of VR23 was beta2 of the 20S proteasome catalytic subunit.

133 eatment with bortezomib, an inhibitor of the 20S proteasome, caused a dose-dependent increase in hD4R

134 r ATP-dependent protein breakdown by the PAN-20S proteasome complex (K(m) approximately 300-500 micro

135 directly binds to the C8alpha subunit of the 20S proteasome complex and that by competing for binding

136 he beta-subunit (PSMB4 N3, 24.36 kDa) of the 20S proteasome complex were identified as LPS-binding pr

137 to elucidate the function and regulation of 20S proteasome complexes in the heart.

138 The dissociation of 20S proteasome components requires the molecular chapero

139 A 20S proteasome, composed of alpha(1) and beta subunits a

140 The 20S proteasome comprises a dyad-symmetric stack of four

141 assays using purified REGgamma, p21, and the 20S proteasome confirm that REGgamma directly mediates d

142 enhanced the peptidase activity of purified 20S proteasome containing the proteasome activator PA28

143 Although synthesis of 20S proteasomes containing either alpha1 or alpha2 could

144 In eukaryotes, the 20S proteasome contains two chymotrypsin-like, two tryps

145 Here we present the structure of the human 20S proteasome core bound to a substrate analogue inhibi

146 wever, the mutant protein is degraded by the 20S proteasome core leading to loss-of-function pathogen

147 The 20S proteasome core particle (20S CP) plays an integral

148 to a collection of complexes centered on the 20S proteasome core particle (20S CP), a complex of 28 s

149 The 20S proteasome core particle (CP), a barrel-like structu

150 on transfer NMR spectroscopy focusing on the 20S proteasome core particle from Thermoplasma acidophil

151 The 20S proteasome core particle is a molecular machine that

152 beta2c, beta5c (assembled into constitutive 20S proteasome core particles), beta1i, beta2i, beta5i (

153 2 and Cim5 (another of the ATPases), but not 20S proteasome core proteins, to the promoters of these

154 at is bound to either end of the cylindrical 20S proteasome core.

155 tial gene encoding the beta-7 subunit of the 20S proteasome core.

156 the beta1 protein relative to beta2 into the 20S proteasome (core particle [CP]) increased with incre

157 A fully active 20S proteasome could be assembled in vitro with purified

158 3) apparently associate with the ends of the 20S proteasome cylinder.

159 The present studies show that 20S proteasomes degrade p53.

160 We show that 20S proteasome digestion of ameloblastin in vitro genera

161 on and immunoblot analysis demonstrated that 20S proteasomes directly interacted and degraded C/EBPal

162 ions in Rpt4 and 6-but not components of the 20S proteasome-disrupt telomeric gene silencing.

163 nt evidence that during aggresome clearance, 20S proteasomes dissociate from protein aggregates, whil

164 We show that the 20S proteasome endoproteolytically cleaves the fully syn

165 Here we report that the 20S proteasome endoproteolytically cleaves the translati

166 e eukaryotic kingdom, as mammalian and yeast 20S proteasomes exhibit the same target specificity.

167 us mitochondrial proteases and the cytosolic 20S proteasome exhibited different substrate specificiti

168 Eukaryotic 26S and 20S proteasomes failed to cut within stretches of 9-29Q

169 ese findings suggest that targeting REGgamma-20S proteasome for cancer therapy may be applicable to h

170 The barrel-like architecture of 20S proteasomes, formed by the stacking of four heptamer

171 The 20S proteasome from the methanoarchaeon Methanosarcina t

172 The 20S proteasome functions in protein degradation in eukar

173 ing of trypsin-like activity of the purified 20S proteasome gave the lowest reading of chymotrypsin-l

174 The REG-20S proteasome, however, only degrades short peptides.

175 ts the CT-like activity of a purified rabbit 20S proteasome (IC(50) = 1.85 micromol/L) and cellular 2

176 the chymotrypsin-like activity of a purified 20S proteasome (IC(50) = 2.5 micromol/L) and human prost

177 motrypsin-like activity of a purified rabbit 20S proteasome (IC50=4.5 microM) and 26S proteasome in h

178 (UCHL5 and USP14), without effecting on the 20S proteasome; (ii) NiPT selectively induces proteasome

179 t PolH is recruited by Pirh2 and degraded by 20S proteasome in a ubiquitin-independent manner.

180 he steroid receptor coactivator SRC-3 by the 20S proteasome in an ATP- and ubiquitin-independent mann

181 he steroid receptor coactivator SRC-3 by the 20S proteasome in an ATP- and ubiquitin-independent mann

182 ognition of oxidized calmodulin (CaM) by the 20S proteasome in complex with Hsp90 was identified usin

183 report the crystal structure of the archaeal 20S proteasome in complex with the C-terminus of the arc

184 demonstrate distinct roles for APIS and the 20S proteasome in E1A-dependent transactivation.

185 inds to p21, MDM2, and the C8 subunit of the 20S proteasome in G(1) phase and facilitates proteasomal

186 ibited the chymotrypsin-like activity of the 20S proteasome in vitro, leading to a significant accumu

187 F protein could be degraded directly by the 20S proteasome in vitro, we propose that the full-length

188 -rich region (GRR) is completely degraded by 20S proteasome in vitro.

189 21WAF1/CIP1 was degraded rapidly by purified 20S proteasomes in a manner that was dependent on the C8

190 late the composition and subunit topology of 20S proteasomes in the cell.

191 that utilizes its HbYX motifs to bind mature 20S proteasomes in vitro and that the Pba1-Pba2 HbYX mot

192 romoter activity of the PSMB5 subunit of the 20S proteasome increased with either Nrf2 overexpression

193 ch identified amino acids required for human 20S proteasome inhibiting activity.

194 istribution at steady state, and analysis of 20S proteasome inhibition and markers of the unfolded pr

195 PD studies revealed PS-341 induced 20S proteasome inhibition in a time-dependent manner, an

196 dose and toxicity profile, and the extent of 20S proteasome inhibition obtained.

197 -pyrrolidinone (8), the gamma-lactam core of 20S proteasome inhibitor (-)-salinosporamide A (marizomi

198 essed FLIL33, reversed by treatment with the 20S proteasome inhibitor bortezomib.

199 echanism distinct from that of the classical 20S proteasome inhibitor bortezomib.

200 ( 1 (NPI-0052)) is a potent, monochlorinated 20S proteasome inhibitor in clinical trials for the trea

201 41) was licensed in 2003 as a first-in-class 20S proteasome inhibitor indicated for treatment of mult

202 b is an investigational, orally bioavailable 20S proteasome inhibitor.

203 site sensitivity of multiple myeloma (MM) to 20S proteasome inhibitors, such as carfilzomib.

204 how that Rb, MDM2, and the C8 subunit of the 20S proteasome interact in vitro and in vivo and that MD

205 ere we show that the C8 alpha-subunit of the 20S proteasome interacts with the C-terminus of p21WAF1/

206 eat shock cognate protein 70 (Hsc70) and the 20S proteasome into virus-induced chaperone-enriched (VI

207 The 20S proteasome is a dynamic enzyme and its activity vari

208 The 20S proteasome is a large multisubunit assembly that per

209 The 20S proteasome is a self-compartmentalized protease whic

210 The 20S proteasome is also recruited to CR3 independently of

211 The 20S proteasome is an essential, 28-subunit protease that

212 indicate that the proteolysis of Pah1 by the 20S proteasome is controlled by its phosphorylation stat

213 The 20S proteasome is made up of four stacked heptameric rin

214 st that the lack of processing seen with the 20S proteasome is not an artefact arising from the way i

215 Proteolytic activity of the 20S proteasome is regulated by activators that govern su

216 Protein degradation in the 20S proteasome is regulated in eukaryotes by the 19S ATP

217 d transport of SOCS-1 to the MTOC-associated 20S proteasome is required to regulate SOCS-1 protein le

218 t the subunit arrangement of the Arabidopsis 20S proteasome is similar if not identical to that recen

219 The proteolytic activity of the eukaryotic 20S proteasome is stimulated by a multisubunit activator

220 together, these results demonstrate that the 20S proteasome is structurally and functionally conserve

221 The 20S proteasome is the proteolytic complex in eukaryotes

222 Biogenesis of the 20S proteasome is tightly regulated.

223 t demonstration that the function of cardiac 20S proteasomes is modulated by associating partners and

224 se results demonstrate that the RP, like the 20S proteasome, is functionally and structurally conserv

225 ow that Rpn11/POH1, a DUB enzyme upstream of 20S proteasome, is more highly expressed in patient MM c

226 2, and beta) that assemble into at least two 20S proteasome isoforms.

227 lysis of mammalian lysates, we find that the 20S proteasome, latent in peptide hydrolysis, specifical

228 Fourthly, we detected a rise in 20S proteasome levels and activity.

229 20S proteasome levels in blood were assayed at baseline

230 ulated the chymotrypsin-like activity of the 20S proteasome: lower concentrations enhanced proteasome

231 n of proteasome activator 28 (PA28) with the 20S proteasome may play a role in antigen processing.

232 genes, which encode the beta subunits of the 20S proteasome, may affect proteasome function, assembly

233 Furthermore, 20S proteasome mRNA and protein were higher in patients

234 ory particle of the proteasome, but not in a 20S proteasome mutant.

235 pleted supernatant by addition of a purified 20S proteasome or proteasome-enriched fraction.

236 g deubiquitylating (DUB) enzymes upstream of 20S proteasome overcomes proteasome inhibitor resistance

237 which enhances the activity of the REGgamma-20S proteasome pathway and contributes to mutant p53 gai

238 53/TGF-beta signalling inhibits the REGgamma-20S proteasome pathway by repressing REGgamma expression

239 een p53/TGF-beta signalling and the REGgamma-20S proteasome pathway, and provides insight into the RE

240 an effective therapeutic strategy, and both 20S proteasome peptidases and 19S deubiquitinases (DUBs)

241 rofoundly impact the proteolytic function of 20S proteasomes: phosphorylation of 20S complexes enhanc

242 te that the beta1 subunit in the P. furiosus 20S proteasome plays a thermostabilizing role and influe

243 The 20S proteasome preferentially degrades specific substrat

244 ivity of both crude 20S and 26S and purified 20S proteasome preparations from rat liver as well as pr

245 cin, a potent and selective inhibitor of the 20S proteasome, prevented geranylgeranyl-enhanced degrad

246 The eukaryotic 20S proteasome proteolytic core structure comprises 14 d

247 says using purified REGgamma, SRC-3, and the 20S proteasome reinforce these conclusions and demonstra

248 he M. jannaschii as well as related archaeal 20S proteasomes require a nucleotidase complex such as P

249 ocking of the 19S regulatory particle to the 20S proteasome requires functional Rpt subunit ATPase ac

250 encoding the beta6 and beta2 subunits of the 20S proteasome, respectively.

251 l electrophoresis assessed docking of 19S to 20S proteasome revealing 3 proteasome populations (20S,

252 Aggregated beta-PrP reduced the 20S proteasome's basal peptidase activity, and the enhan

253 th D7 symmetry, the Thermoplasma acidophilum 20S proteasome, showing clear side-chain density.

254 With purification of the 20S, proteasome specific activity was equivalent between

255 d to specific catalytic beta subunits of the 20S proteasome stimulated bone formation in bone organ c

256 type protein that assemble into at least two 20S proteasome subtypes.

257 e expression of phytoene desaturase (PDS), a 20S proteasome subunit (PB7) or Mg-protoporphyrin chelat

258 rtezomib and MG132) and depletion of 19S and 20S proteasome subunits (PSMD4, PSMD14, and PSMB3) inhib

259 of total ubiquitinated proteins and 19S and 20S proteasome subunits are evident in both low-grade an

260 n-dedicated 19S base complex is lacking, and 20S proteasome subunits have been shown to associate wit

261 e, methionine sulfoxide reductase A, and the 20S proteasome subunits PSMB5 and alphabeta.

262 myeloma cells were found to occur within the 20S proteasome subunits, MCL1, RRM1, USP8, and CKAP5.

263 lpha2, and beta) which are classified in the 20S proteasome superfamily.

264 ture of the 700 kDa Thermoplasma acidophilum 20S proteasome (T20S), determined at 2.8 A resolution by

265 two- to threefold increase in content of the 20S proteasome that was due to a corresponding increase

266 ucture in which, under basal conditions, the 20S proteasome, the PA700 and PA28 (700- and 180-kD prot

267 Two 20S proteasomes, the alpha1-beta and alpha1-alpha2-beta

268 e alpha1 and beta proteins alone form active 20S proteasomes; the role of alpha2, however, is not cle

269 ion of bFGF and trypsin-like activity of the 20S proteasome, thereby resulting in the degradation of

270 14 different subunits that make up the yeast 20S proteasome, three have proteolytic active sites: Doa

271 Peptide products probably exit the 20S proteasome through the same opening.

272 e for targeting DUB enzyme Rpn11 upstream of 20S proteasome to enhance cytotoxicity and overcome prot

273 was shown to associate transiently with the 20S proteasome upon binding of ATP or ATPgammaS, but not

274 The beta5 subunit of the 20S proteasome was characterized as target by X-ray crys

275 The degradation of Pah1 by the 20S proteasome was dependent on time and proteasome conc

276 However, the 20S proteasome was not inhibited when the gate in the al

277 In addition, the M. jannaschii 20S proteasome was purified as a 700-kDa complex by in v

278 n artefact arising from the way in which the 20S proteasome was purified.

279 the archaebacterium Thermoplasma Acidophilum 20S proteasome was selected for mechanistic studies in t

280 phorylated alpha7 subunit (serine250) of the 20S proteasome was significantly less (P=0.011) by almos

281 oteasome complexes in the heart, among which 20S proteasomes were found to contain cylinder-shaped st

282 arkedly decreased, while major components of 20S proteasomes were increased.

283 Functionally viable murine cardiac 20S proteasomes were purified.

284 ted proteins and the peptidase activities of 20S proteasomes were significantly increased rather than

285 complex and coordinating its degradation by 20S proteasome when RNAPII is persistently stalled by th

286 it RPN6 induced recruitment of only PA200 to 20S proteasomes, whereas PA28gamma was not mobilized.

287 ded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes.

288 ermine the architecture of an archaeal Cdc48 20S proteasome, which we stabilized by site-specific cro

289 a-inducible catalytic subunits of vertebrate 20S proteasomes, which can replace constitutive catalyti

290 The concomitant rise in 20S proteasomes, which seem to degrade proteins in an un

291 teasome-inhibitory activity against purified 20S proteasome, while 2 demonstrated superior inhibitory

292 eaved exclusively at the Leu-Ala bond by the 20S proteasome with a kc/Km value of 13 000 M-1 s-1.

293 the chymotrypsin-like activity of the yeast 20S proteasome with an IC50 of 5.9 nM and the human cons

294 number of high-resolution structures of the 20S proteasome with and without inhibitors have emerged

295 Inhibition of proteolytic activity of the 20S proteasome with specific inhibitors prevents cleavag

296 inhibits the 3 proteolytic activities of the 20S proteasome with specificity distinct from bortezomib

297 we report the co-crystal structure of yeast 20S proteasome with the 11S regulator from Trypanosoma b

298 rmore, structural and function defects in 26/20S proteasomes with accumulation and aggregation of pot

299 Cleavage analyses of 20S proteasomes with natural or synthetic substrates all

300 Breakdown of ovalbumin by the 26S and 20S proteasomes yielded the immunodominant peptide SIINF