ライフサイエンスコーパス: 3' end

1 conserved structure and an RNA bridge to the 3' end.

2 significantly lower SSM density than at the 3' end.

3 which is the nuclease cleaving the pre-mRNA 3' end.

4 have multiple Helitron 5' ends, but a single 3' end.

5 oprotein L via a CANACA motif located in its 3' end.

6 a long-distance RNA-RNA connection with the 3' end.

7 eavage just 2 nts downstream of the 16S rRNA 3' end.

8 ring translation and proceeds from the 5' to 3' end.

9 h increased levels of CPA factors at the HIV 3' end.

10 se RNAs is an accessible, protein-free 5' or 3' end.

11 nded RNAs with at least one adenosine at the 3' end.

12 acylated (charged) with an amino acid at its 3' end.

13 e density which increases from the 5' to the 3' end.

14 the aptamer around its target from 5'-end to 3'-end.

15 used for a single-nucleotide labeling of the 3'-end.

16 re unit at the 5'-end, and a quencher at the 3'-end.

17 ting is independent of the intactness of its 3'-end.

18 g different transcript isoforms with altered 3' ends.

19 ature piRNA length are then trimmed at their 3' ends.

20 long terminal repeats (LTRs), at its 5' and 3' ends.

21 nd Hen1 define a mechanism to modulate piRNA 3' ends.

22 posing activities in the biogenesis of piRNA 3' ends.

23 ar permutations, which reposition the 5' and 3' ends.

24 x with two regions of RNAIII near the 5' and 3' ends.

25 t is attached to the pseudoknot at the 5' or 3' ends.

26 epitope tag to facilitate detection at their 3' ends.

27 y factor involved in the processing of snRNA 3' ends.

28 is the primary polymerase that extends both 3' ends.

29 y stable RNAs due to the lack of free 5' and 3' ends.

30 ic abundance of transcripts with alternative 3' ends.

31 ers with shared seed sequences but divergent 3'-ends.

32 ial use of exons and previously unidentified 3' ends across development, new primary microRNAs and te

33 echanism that generates mRNAs with different 3'-ends, allowing them to interact with different sets o

34 ntergenic region between the prophage at the 3' end and the bacterial gene.

35 The 3' end and the hairpin structure of the nascent RNA prom

36 that recognize ncRNAs with accessible 5' or 3' ends and/or increase the availability of these ends.

37 of this ssDNA oligomer, particularly at the 3'-end and facilitates base unstacking along the entire

38 5' monophosphate, lack a poly(A) tail at the 3' end, and contain no introns; these features distingui

39 g 2-5 nucleotide long RNA oligomers from the 3' end, and longer RNA substrates from the 5' end.

40 ing the enzyme strand with a quencher at the 3' end, and the DNA substrate strand with a fluorophore

41 scripts with uridylated or multiply modified 3' ends, and genes possessing multiple 3'-untranslated r

42 nucleotide additions and deletions at 5' and 3' ends; and nucleotide substitutions.

43 The identity and abundance of the 3' ends are determined by high-throughput sequencing, wh

44 st mammalian genes produce transcripts whose 3' ends are processed at multiple alternative positions

45 sing random hexamer primers, which minimizes 3' end bias; reverse transcription proceeds until it is

46 ne mRNAs not only are degraded from both the 3' end but also from the 5' end, likely after decapping.

47 Histone pre-mRNAs are cleaved at the 3' end by a complex that contains U7 snRNP, the FLICE-as

48 ten having the same 5' ends but differing in 3' ends by 1-nt steps.

49 and the antitoxin gene sr5 overlap at their 3' ends by 112 bp.

50 nger RNAs (pre-mRNAs) are processed at their 3' ends by the 1-megadalton multiprotein cleavage and p

51 her nucleic acid fragment was labeled at the 3'-end by a dansyl molecule prone to be included into th

52 However, the 3'-end can be bypassed by the transposase, resulting in

53 ely regulates MALAT1 levels by promoting the 3' end cleavage and maturation of MALAT1 RNA.

54 Depletion of TALAM1 leads to defects in the 3' end cleavage reaction and compromises cellular accumu

55 r, the DSP1 complex does not affect pre-mRNA 3' end cleavage, suggesting that plants may use differen

56 we report a unique spliceosome-mediated TER 3'-end cleavage mechanism in Neurospora crassa that is d

57 I profiling reveals a role for Integrator in 3'-end cleavage of eRNA primary transcripts leading to t

58 structure explains how Pno1 coordinates the 3'end cleavage of the 18S rRNA by Nob1 and how the late

59 ain nonnative nucleotides resulting from the 3' end created by the ribozyme and the 5' end created fr

60 Using specialized 3' end deep sequencing methods, we undertook a comprehen

61 xosome complex and cellular RNAs en route to 3' end degradation.

62 tion by cotransfection of 5'-end-deleted and 3'-end-deleted and replication-deficient genomes.

63 Identification of the intron's 3' end depends upon sequence elements that define the br

64 TL has 16 nucleotides of the 3' end duplicated at the 5' end and a 3' end produced by

65 leads to DNA damage at the primer terminus (3-end) during the succeeding insertion event.

66 el to determine whether or not targeting key 3' end elements involved in mRNA processing using antise

67 We conclude that targeting key functional 3' end elements involved in pre-mRNA to mRNA maturation

68 iogenesis of the majority of snRNAs involves 3' end endonucleolytic cleavage of the nascent transcrip

69 e, it only displaces Rpa from the 5' but not 3' end, explaining how Rpa regulates cleavage polarity.

70 ells with reduced levels of TOE1 accumulated 3'-end-extended pre-snRNAs, and the immunoisolated TOE1

71 its relationship to 5' end resection and/or 3' end extension is poorly understood.

72 mmed piwi-interacting RNA intermediates with 3' end extension, leading to severe reduction of mature

73 otidyl-transferase properties that match the 3' end features of dormant cytoplasmic mRNAs.

74 A 3'-end-focused library approach cannot detect differenti

75 This preference for adenine at the reactive 3' end for both Mos1 and Mboumar-9 may be a general feat

76 that in mammalian cells, the formation of a 3' end for noncoding RNAs can be a complex process gover

77 ndergo cleavage and polyadenylation at their 3'-end for maturation.

78 ' end) and T oligo (carrying a T-tail at the 3' end), for efficient ligation to target DNA and subseq

79 esults reveal an unanticipated role for mRNA 3' end formation factors in global promotion of alternat

80 Unexpectedly, we find that two mRNA 3' end formation factors, cleavage and polyadenylation s

81 RNAPII) transcription is associated with RNA 3' end formation.

82 lation specificity factor (CPSF) complex for 3'-end formation of mRNA, but it still has no clear func

83 PA sites are found, indicating a unique mRNA 3'-end formation regulation during gametophyte developme

84 or how PAS sequences are recognized for mRNA 3'-end formation.

85 Defects in mRNA 3'end formation have been described to alter transcripti

86 on maps of the human heart and show that the 3'end formation of mRNA is dynamic in heart failure, sug

87 N-terminal La module binds and protects the 3' end from degradation, but the structural and function

88 e, we tested the compatibility of the U6atac 3' end from phylogenetically distant species in a human

89 se activity that cleaves the single-stranded 3'-end from tRNAs that contain guanine discriminator nuc

90 This remarkable divergence from canonical 3'-end gap filling is consistent with data on end-joinin

91 rupture first, followed by unfolding of the 3'-end hairpin (Iright harpoon over left harpoonF).

92 (CRS overlapping) enhancer RNAs and extended 3' ends have significantly increased expression levels o

93 xoN excises nucleotide mismatches at the RNA 3'-end in vitro, and its inactivation in vivo jeopardize

94 primer for reverse transcription of HIV; the 3' end is complementary to the primer-binding site on HI

95 For pre-miRNAs where the 3' end is further recessed into the stem (as in 3' trimm

96 uses one of the poly(A) sites to define its 3'-end, is a common regulatory mechanism in eukaryotic g

97 riptional addition of uridyl residues to RNA 3' ends, leading in some cases to altered stability.

98 Using genome-wide 3' end-mapping on an engineered Bacillus subtilis NusA d

99 four additional proteins, to catalyze snRNA 3' end maturation in Arabidopsis.

100 G 1 (DSP1) is an essential protein for snRNA 3' end maturation in Arabidopsis.

101 te here for the first time that proline tRNA 3' end maturation in Escherichia coli employs a one-step

102 entifies a complex responsible for the snRNA 3' end maturation in plants and uncovers a previously un

103 by poly(A) polymerase (PAP) is important for 3' end maturation of almost all eukaryotic mRNAs.

104 munoisolated TOE1 complex was sufficient for 3'-end maturation of snRNAs.

105 tions, we show that PARN is required for the 3'-end maturation of the telomerase RNA component (TERC)

106 ignificantly weaker effect is observed for a 3'-end modification.

107 undergo internal changes by RNA editing and 3' end modifications.

108 s is not affected by loss of known small RNA 3'-end modifying enzymes, and may result from modificati

109 sing events such as alternative splicing and 3 end mRNA processing.

110 zyme which functions in the last step of the 3' end mRNA decay pathway.

111 non-templated addition of nucleotides to the 3' end, namely tailing, was found to associate with the

112 roRNA maternal loading and sequence-specific 3' end nontemplate oligoadenylation of maternally deposi

113 s mismatched, BH bending can promote the RNA 3'-end nucleotide into a frayed state that further leads

114 regions encompassing nucleotides 5-44 at the 3 end of mature 18S rRNA.

115 The xRRM binds the 3' end of 7SK RNA at the top of stem-loop 4 (SL4) and in

116 ined by the U-rich element juxtaposed to the 3' end of a 5'-ACACCC-3' motif.

117 es to initiate DNA synthesis directly at the 3' end of a DNA strand while simultaneously attaching a

118 dependently of trigger location at the 5' or 3' end of a gene.

119 n be preconjugated via an amino group at the 3' end of a synthetic DNA molecule, so that the 5' end p

120 h can form a stabilizing triple helix at the 3' end of an RNA.

121 med between exons 1-9 of SND1 and exons 2 to 3' end of BRAF.

122 134 kb-long first intron, splicing joins the 3' end of exon 1 to successive points within intron 1 we

123 ed exons and retained introns and toward the 3' end of expressed genes.

124 ' end processing factors, is enriched at the 3' end of genes, and binds RNA motifs downstream from cl

125 diction of poly(A) sites helps to define the 3' end of genes, which is important for gene annotation

126 The HGE starts from the 3' end of intron 19 and extends into intron 22, possesse

127 rection with slow recovery and TC-NER at the 3' end of long genes.

128 es cleavage and poly(A) tail addition at the 3' end of mRNAs at the polyadenylation site (PAS).

129 leotide triphosphates (biotin-NTPs) into the 3' end of nascent RNA.

130 nrdB(S) shared >99% identity to 3' end of nrdB(L) and had no active site.

131 stance between the 5' G-dC base pair and the 3' end of RNA fluctuates over a three-nucleotide width.

132 The 3' end of Schizosaccharomyces pombe telomerase RNA (SpTE

133 phenotype is due to an insertion within the 3' end of secA, which results in the production of a C-t

134 ce [SD]) and a complementary sequence in the 3' end of the 16S rRNA (anti-Shine-Dalgarno sequence [aS

135 A similar phenotype was found at the 3' end of the 16S rRNA, and the primary 4.5S rRNA transc

136 ssociation, Cas9 asymmetrically releases the 3' end of the cleaved DNA strand that is not complementa

137 tisense transcription initiation site at the 3' end of the coding sequence.

138 rom nucleotides 889 to 1289 encompassing the 3' end of the delta protein-coding gene.

139 programmed +1 ribosomal frameshifting at the 3' end of the first of two partially overlapping ORFs.

140 to enhance antisense transcription from the 3' end of the GAL10 coding sequence.

141 tion of H3K36me3, preferentially towards the 3' end of the gene body, accompanied by a reduction in g

142 RLuc constructs with introns near the 5' or 3' end of the gene.

143 s Ser-5 at the promoter and Ser-2 toward the 3' end of the gene.

144 er and Bur1/Ctk1 phosphorylates Ser-2 at the 3' end of the genes.

145 The stem-loop at the 3' end of the genome interacts extensively with the matu

146 7 inhibits synthesis of transcripts from the 3' end of the genome to a greater extent than those from

147 Mismatches near the 3' end of the initiating DNA strand have a small effect,

148 ied PABPN1-dependent ALYREF binding near the 3' end of the mRNA.

149 ification of cDNA ends (RACE), we mapped the 3' end of the N and NSs mRNAs, showing that the mRNAs te

150 We show that the 3' end of the N mRNA terminates upstream of a 5'-GCCAGCC

151 ntering an MNase-resistant nucleosome at the 3' end of the NFR.

152 and the elongated poly-thymidine tail at the 3' end of the ODN.

153 uding the stem-loop structure (5'SL6) at the 3' end of the promoter.

154 We also report that four to six bases at the 3' end of the short CRISPR RNA (crRNA) used to program C

155 occurs opposite the second nucleotide at the 3' end of the template.

156 efficiently blocked Nun cross-linking to the 3' end of the transcript, whereas the highly homologous

157 For all variants examined, the 3' end of the transcripts mapped to the same downstream

158 adjacent 18-bp sequence which comprises the 3' end of the tRNA-Pro gene corresponding to the TPsiC l

159 y after the nonstructural proteins or at the 3' end of the viral coding sequences.

160 otide cytosine/cytosine/adenine (CCA) to the 3' end of transfer RNAs (tRNAs) is essential for transla

161 on to introduce an electrophilic site at the 3' end of tRNA analogues.

162 which binds adjacent to the telestem at the 3' end of U6, provides a comparable rate enhancement.

163 a unique peak-pair pattern indicating 5' and 3' ends of ArgR-binding region.

164 n-templated nucleotides were observed at the 3' ends of both miRNAs and endogenous siRNAs from wild-t

165 d ribonucleoprotein complex that extends the 3' ends of chromosomes to counteract telomere shortening

166 al activity redistributes the complex to the 3' ends of convergently oriented gene pairs.

167 telomeres), which prevents shortening of the 3' ends of DNA with each cell division.

168 of the GU and AG dinucleotides at the 5' and 3' ends of introns and provides insight into the catalyt

169 ingle-stranded telomere DNA repeats onto the 3' ends of linear chromosomes using an integral telomera

170 e is an RNA-protein complex that extends the 3' ends of linear chromosomes, using a unique telomerase

171 The poly(A) extension on the 3' ends of magnetically isolated miRNA targets facilitat

172 um tuberculosis functions to both define the 3' ends of mRNAs and silence substantial fragments of th

173 The 3' ends of nascent RNAs are captured through barcode lin

174 nt siRNAs primarily correspond to the 5' or 3' ends of P4R2 RNAs, suggesting a model whereby siRNAs

175 The 5' and 3' ends of RNA harbour crucial information for gene regu

176 m the underrepresentation of both the 5' and 3' ends of RNAs, which can be attributed to second-stran

177 t data in support of spliceosomes generating 3' ends of telomerase RNAs in other fungi.

178 Inspection of the 5' and 3' ends of the dodecamers also supplies new information

179 results in a spurious polyadenylation of the 3' ends of the mitochondrial (mt-) rRNA and mt-tRNA.

180 ng DNA-chromatin loops connecting the 5' and 3' ends of the repaired gene.

181 Both the 5' and the 3' ends of the RNA cross-link Nun, implying that Nun con

182 ats, with the breakpoint located near 5' and 3' ends of the spike (S) protein gene.

183 dentify insertion sites from both the 5' and 3' ends of the transposon, providing an inbuilt level of

184 e diverse accessory proteins, encoded in the 3' ends of their genomes, that often act as host cell an

185 s; (iii) the terminators associated with the 3' ends of TUCs tend to be Rho-independent terminators,

186 dels GTP.EF-Tu.aa-tRNA complexes to free the 3'-end of aa-tRNA for entry into the nuclease active sit

187 overlapping the site that interacts with the 3'-end of aminoacyl-tRNA (aa-tRNA).

188 ral product which acts as an analogue of the 3'-end of aminoacyl-tRNA and terminates protein synthesi

189 diesterase resulted from modification of the 3'-end of an ON with either (R)- or (S)-C5'-Me nucleotid

190 The 3'-end of cleaved RNA(3'-rA) consists of 2',3'-cyclic ph

191 NGS can then be used to sequence the 3'-end of each message to build a cell-specific transcri

192 in a well-defined 7-kb region bounded by the 3'-end of exon 1 and the adjacent region of intron 1 of

193 RNA synthesis resumed fully at the 3'-end of genes after a 24 h recovery in wild-type fibro

194 I as an enzyme which selectively digests the 3'-end of single stranded DNA (ssDNA).

195 as an enzyme which specifically degrades the 3'-end of single-stranded DNA (ssDNA).

196 III amplification was used to hydrolyze the 3'-end of the dsDNA after the recognition of target AFB1

197 ation, selective nucleotides included at the 3'-end of the PCR primers result in additional genome re

198 ymerase repetitively adds nucleotides to the 3'-end of the RNA, a pyrophosphate ion is generated afte

199 ruplexes via a cytosine-rich region near the 3'-end of the RNA.

200 U binds to an adenosine-rich region near the 3'-end of the RNA.

201 ently discovered CDK12 appears to act at the 3'-end of the transcription unit and has been identified

202 A hairpin close to the 3'-end of the transposon functions as a transposition te

203 data are consistent with a model whereby the 3'-end of the tRNA remains free to sample different posi

204 ract most directly and specifically near the 3'-end of these ssDNA oligomers, thus defining the polar

205 ps are dynamic structures that juxtapose the 3'-ends of genes with their promoters.

206 terminants of NNS termination, we mapped the 3'-ends of NNS-terminated transcripts genome-wide.

207 mination were shown previously to define the 3'-ends of Okazaki fragments synthesized by Pol delta du

208 ically hybridized and ligated to the 5'- and 3'-ends of target RNAs, respectively, by T4 RNA ligase 2

209 nal variation to a 78 kb region spanning the 3'end of MLH1 and the 5'end of the neighboring LRRFIP2,

210 ugh allowing ribosomes to translate into the 3-end of mRNAs.

211 thway in the nanopore, either from the 5' to 3' end or in the reverse direction, can be controlled by

212 ut do not significantly affect the 5' TAGGGT 3'-ending overhangs, indicating that telomerase-mediated

213 in vivo, leading to the discovery that miRNA 3'-end pairing is a general determinant of AGO binding s

214 CC line complication, and a composite of all 3 end points.

215 Many eukaryotic genes undergo alternative 3'-end poly(A)-site selection producing transcript isofo

216 1 promotes intron excision in the context of 3'-end polyadenylation but not when bound to internal A-

217 rocess governed by the activities of various 3'-end polymerases and exonucleases.

218 We show that the 3'-end polyuridine sequence of viral and cellular RNA po

219 Exportin-t (Xpot) transports mature 5'- and 3'-end processed tRNA from the nucleus to the cytoplasm

220 sing how alternative promoters, splicing and 3' end processing add, remove, or remodel functional mot

221 eolytic cleavage plays a crucial role in the 3' end processing and cellular accumulation of MALAT1, a

222 PARN mutations lead to incomplete 3' end processing and increased destruction of nascent T

223 st to snRNA 3' end processing, HVS pre-miRNA 3' end processing by Integrator can be uncoupled from tr

224 own subunits of the cleavage factor I (CFIm) 3' end processing complex; however, CPSF6 could particip

225 e in pre-mRNA splicing and regulation of RNA 3' end processing events.

226 NA maturation by binding the cellular CPSF30 3' end processing factor and/or suppressing the activati

227 We found that Seb1 associates with 3' end processing factors, is enriched at the 3' end of

228 levels affected the recruitment of conserved 3' end processing factors, our findings indicate that th

229 mRNA 3' end processing is an essential step in gene expressio

230 These effects impaired 3' end processing of c-FOS transcripts.

231 wn and rescue experiments confirmed that the 3' end processing of HVS pre-miRNAs also depends on Inte

232 In budding yeast, the 3' end processing of mRNA and the coupled termination of

233 eiotropic developmental defects, impairs the 3' end processing of snRNAs, increases the levels of snR

234 bservation that the spliceosome functions in 3' end processing raised questions about the evolutionar

235 tegrator complex, which recognizes the snRNA 3' end processing signal (3' box), generates the 5' ends

236 F6), a cellular protein involved in pre-mRNA 3' end processing that binds HIV-1 capsid and connects H

237 cient histone mRNA biosynthesis and coupling 3' end processing with transcription termination.

238 Surprisingly, in contrast to snRNA 3' end processing, HVS pre-miRNA 3' end processing by In

239 llular lncRNAs that display RNase P-mediated 3' end processing.

240 cision between alternative modes of pre-mRNA 3' end processing.

241 ) generate circular RNAs predominately after 3' end processing.

242 nserved role for spliceosomes functioning in 3' end processing.

243 buildup of mRNAs near transcription sites in 3'-end processing and chromosome segregation mutants, an

244 uncovers a previously unidentified role for 3'-end processing and transcription termination machiner

245 RNase Z(L) is a highly conserved tRNA 3'-end processing endoribonuclease.

246 or Pab2, we show that reduced expression of 3'-end processing factors lengthens 3' UTR, with Pcf11 h

247 The mechanism for TER 3'-end processing is highly divergent among different or

248 3'-end processing of MVC mRNAs at (pA)p is critical for

249 nuclease activity, which is required for the 3'-end processing of non-polyadenylated, RNAPII-dependen

250 complex (INT) has important functions in the 3'-end processing of noncoding RNAs, including the uridi

251 , we demonstrated that CAGE-seq also detects 3'-end processing of pre-miRNAs on Drosha cleavage site

252 sibility that mRNA structures facilitate the 3'-end processing of thousands of human mRNAs by juxtapo

253 s showed increased read-through of the snRNA 3'-end processing signal, leading to continuation of tra

254 CYC1 promoter with either proximal or distal 3'-end processing sites, resulting in the synthesis of s

255 lease Dhp1/Rat1/Xrn2, which couples pre-mRNA 3'-end processing to transcription termination, to promo

256 n chromatin remodeling, actin assembly, mRNA 3'-end processing, gene looping and mRNA decay, but they

257 typical CNA isoform generated by alternative 3'-end processing, whose divergent C terminus shares the

258 was linked to regulation of Aldh1a3 pre-mRNA 3'-end processing.

259 AP target mRNA specificity and regulation of 3'-end processing.

260 og of CPSF-73, the endonuclease for pre-mRNA 3'-end processing.

261 ent polyadenylation, to help coordinate mRNA 3'-end processing.

262 tion is crucial for the role of INT in snRNA 3'-end processing.

263 of the 3' end duplicated at the 5' end and a 3' end produced by self-cleavage of a delta ribozyme.

264 cur: distortions in solvent-exposed seed and 3'-end regions are less likely to produce steric clashes

265 ic regions, especially common in the 5'- and 3'-end regions of annotated genes.

266 d to be more prevalent within these extended 3'-end regions than within PAS-upstream regions and inde

267 lutely conserved sequence motif CCA at their 3'-ends, representing the site of aminoacylation.

268 ae Sae2 can function with MRX to initiate 5'-3' end resection and also plays an important role in att

269 homologous recombination by inhibiting 5' to 3' end resection, independent of Mec1 and Tel1 inhibitio

270 effect is attributable to a single appended 3'-end residue, is dependent upon its single-stranded na

271 h a fluorophore and a quencher at the 5' and 3' ends, respectively.

272 ine dinucleotide (74% and 66% at the 5'- and 3'-end, respectively) under 254 nm.

273 nd 8% of S sugar conformation at its 5'- and 3'-end, respectively.

274 tecture of the CTD in complex with Rtt103, a 3'-end RNA-processing and transcription termination fact

275 We used 3'end RNA sequencing (e3'-Seq) to directly measure globa

276 in mammals, consists of 12 Mg(2+)-dependent 3'-end RNases with substrate specificity that is mostly

277 ng) and their resection to generate invasive 3'-end single-stranded DNA (resection).

278 mL/min/1.73 m(2) and 25% decrease in eGFR), (3) end-stage renal disease, and (4) rate of kidney funct

279 at degrade RNA either from the 5' end to the 3' end, such as XRN4, or in the opposite direction by th

280 uridylation, and guanylation of U6 and Y RNA 3' ends, suggesting that in mammalian cells, the formati

281 By contrast, mRNA isoforms with 3' ends that lie within annotated 5'-UTRs were overrepre

282 number of mRNA isoforms with polyadenylated 3' ends that map to 5'-untranslated regions (UTRs), intr

283 n contrast, we find that RelE yields precise 3'-ends that for the first time reveal reading frame in

284 e quadruplex-forming scaffolds linked at the 3' end to a telomeric duplex sequence and annealed to a

285 cing libraries, which are sequenced from the 3' end to provide high-resolution positional information

286 a long-range lever to precisely direct tRNA 3' end to the other protein subunit for aminoacylation i

287 cording to our results, the proximity of the 3' end to the ribosomal recruitment site of the mRNA cou

288 Here we utilize an engineered RNA with two 3' ends to obtain a crystal structure of an 11-subunit n

289 eam of its 5'-end to 10 kb downstream of its 3'-end to determine SOX9 interaction site.

290 sing poly(A) pulldown stranded RNA-seq and a 3' end transcript counting method we characterise tempor

291 This is associated with decreased 3' end uridylation of the miRNA.

292 but also observe significant alterations in 3' end usage across orthologs.

293 ve synthesis of telomere repeat DNA at their 3'-ends, using an integral telomerase RNA (TER) and telo

294 followed by the stronger G-quadruplex at the 3'-end via various intermediates.

295 nked by 3C(pro) cleavage sites at the 5' and 3' ends, was found in the 2C/3A junction region of the v

296 Through deep sequencing of 3' ends, we provide evidence that PARN can also deadenyl

297 r fluorescence intensity than those near the 3' end when the dye was tagged at the 5' end of the prob

298 ation to degrade all DNA strands with a free 3' end, which would nevertheless preserve closed circula

299 ve a well-defined 5' end and a more flexible 3' end with the possibility of 3' tailing events, such a

300 RNAs with 3' ends within protein-coding regions and introns were l