ライフサイエンスコーパス: 3-hydroxy-3-methylglutaryl-CoA reductase

1 ation of the cholesterol biosynthetic enzyme 3-hydroxy-3-methylglutaryl CoA reductase.

2 ccelerating sterol-stimulated degradation of 3-hydroxy-3-methylglutaryl CoA reductase.

3 specific effect is through the inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase.

4 ontrol point in cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA reductase.

5 yme regulating the mevalonate (MVA) pathway, 3-Hydroxy-3-Methylglutaryl CoA Reductase 1 (HMGR1), inte

6 Dietary cholesterol suppressed hepatic 3-hydroxy-3-methylglutaryl CoA reductase activity, stimu

7 her reduced by 84% with empagliflozin, while 3-hydroxy-3-methylglutaryl-CoA reductase activity and to

8 ound ( approximately 20-fold) decrease in ER 3-hydroxy-3-methylglutaryl-CoA reductase activity in vit

9 cholesterol are associated with decreases in 3-hydroxy-3-methylglutaryl-CoA reductase and increases i

10 is (3-hydroxy-3-methylglutaryl CoA synthase, 3-hydroxy-3-methylglutaryl CoA reductase), and fatty aci

11 imvastatin and pravastatin are inhibitors of 3-hydroxy-3-methylglutaryl CoA reductase, and are used a

12 e synthase, farnesyl-pyrophosphate synthase, 3-hydroxy-3-methylglutaryl-CoA reductase, and low densit

13 er, leptin treatment reduced the activity of 3-hydroxy-3-methylglutaryl-CoA reductase, but it did not

14 endoplasmic reticulum (ER)-localized enzyme 3-hydroxy-3-methylglutaryl CoA reductase catalyzes a rat

15 The endoplasmic reticulum (ER) enzyme, 3-hydroxy-3-methylglutaryl-CoA reductase, catalyzes the

16 y mevalonic acid, a downstream metabolite of 3-hydroxy-3-methylglutaryl CoA reductase, confirming tha

17 th SREBP-1 and -2 increased on promoters for 3-hydroxy-3-methylglutaryl-CoA reductase, fatty-acid syn

18 f the sterol regulatory element (SRE) of the 3-hydroxy-3-methylglutaryl-CoA reductase gene.

19 rols accelerate degradation of the ER enzyme 3-hydroxy-3-methylglutaryl CoA reductase (HMG CoA reduct

20 on of the cholesterol synthesis pathway with 3-hydroxy-3-methylglutaryl CoA reductase (HMG-CoA reduct

21 rol-sensing domains in three other proteins: 3-hydroxy-3-methylglutaryl CoA reductase (HMG-CoA reduct

22 The degradation rate of 3-hydroxy-3-methylglutaryl CoA reductase (HMG-R), a key

23 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-R), a key

24 gulated endoplasmic reticulum degradation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-R).

25 MAD3 encodes 3-hydroxy-3-methylglutaryl CoA reductase (HMG1), which f

26 owever, the normal yeast ER membrane protein 3-hydroxy-3-methylglutaryl-CoA reductase (Hmg2p) undergo

27 es, including fatty acid synthase (FASN) and 3-hydroxy-3-methylglutaryl CoA reductase (HMGCR).

28 atoma cell lines, SUGP1 knockdown stimulated 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) alterna

29 nti-signal recognition protein (SRP) or anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) antibod

30 lone and in combination with variants in the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) gene.

31 iological studies report that utilization of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) inhibit

32 3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is the

33 se in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the in

34 latory element binding factor 2 (Srebf2) and 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr).

35 The enzymes 3-hydroxy-3-methylglutaryl CoA reductase (HMGR) and C24-

36 cascade appears to control the expression of 3-hydroxy-3-methylglutaryl CoA reductase (HMGR) and l-ph

37 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) catalyze

38 The enzyme 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) catalyze

39 The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) enzyme c

40 doplasmic reticulum (ER) and the activity of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) imbedded

41 with compromised proteasomal degradation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) or defic

42 Hepatic 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) protein

43 t, through feedback-regulated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR).

44 biosynthesis of isoprenoids is catalysed by 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR).

45 We hypothesized that statins, inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase, inhibit cardia

46 organ cultured for 7 days with lovastatin, a 3-hydroxy-3-methylglutaryl CoA reductase inhibitor, deve

47 n in an MMP-dependent manner and whether the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorv

48 e investigated the effects of simvastatin, a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor, on h

49 Inhibition of isoprenoid synthesis with the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor, simv

50 Furthermore, we show that the 3-hydroxy-3-methylglutaryl-CoA-reductase inhibitor mevas

51 , (cyclooxygenase-2 inhibitor), and statins (3-hydroxy-3-methylglutaryl CoA reductase inhibitors) inh

52 The statins, 3-hydroxy-3-methylglutaryl CoA reductase inhibitors, hav

53 ter overnight (or longer) treatment with the 3-hydroxy-3-methylglutaryl CoA reductase inhibitors, the

54 ation of Pyk2 in response to Ang II by using 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors and

55 nthesis and suggest a novel direct effect of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors on t

56 The use of statins, 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors that

57 In addition, our results indicate that 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, a c

58 ng drugs that selectively inhibit the enzyme 3-hydroxy-3-methylglutaryl CoA reductase, leading to dec

59 syl transferase (squalene synthase), but not 3-hydroxy-3-methylglutaryl-CoA reductase or farnesyl dip

60 The endoplasmic reticulum enzyme 3-hydroxy-3-methylglutaryl-CoA reductase produces mevalo

61 mmediate metabolic product of the acetyl CoA/3-hydroxy-3-methylglutaryl CoA reductase reaction.

62 ticulum-associated degradation of the enzyme 3-hydroxy-3-methylglutaryl-CoA reductase represents one

63 Inhibitors of 3-hydroxy-3-methylglutaryl CoA reductase (statins) reduc

64 ins includes pharmacologic inhibitors of the 3-hydroxy-3-methylglutaryl-CoA reductase that are potent

65 Inhibition of 3-hydroxy-3-methylglutaryl CoA reductase, the rate-limit

66 ins; and the cholesterol biosynthetic enzyme 3-hydroxy-3-methylglutaryl CoA reductase, thus inducing