ライフサイエンスコーパス: 4-phenylbutyrate

1 us administration of the molecular chaperone 4-phenylbutyrate.

2 sobutyl-1-methylxanthine, 2) BPDZ 154, or 3) 4-phenylbutyrate.

3 In vitro, chaperone drugs, such as 4-phenylbutyrate (4-PB), have been shown to partially co

4 tive effect of the chemical chaperone sodium 4-phenylbutyrate (4-PBA) on mutant UMOD maturation.

5 previously shown that the chemical chaperone 4-phenylbutyrate (4-PBA) promotes the maturation of ABCC

6 Treatment of mice with 4-phenylbutyrate (4-PBA), a chemical chaperon and a pote

7 chaperones tauroursodeoxycholate (TUDCA) and 4-phenylbutyrate (4-PBA), as well as the iron chelator c

8 ion process using the proteostasis regulator 4-phenylbutyrate (4-PBA), which we show targets COPII pr

9 ization for rescue by the chemical chaperone 4-phenylbutyrate (4-PBA).

10 ine (NAC, a blocker of oxidative stress) and 4-phenylbutyrate (4-PBA, a blocker of endoplasmic reticu

11 ules include histone deacetylase inhibitors, 4-phenylbutyrate (4PBA) and trichostatin A, and two smal

12 Sodium 4-phenylbutyrate (4PBA) corrects trafficking of DeltaF50

13 Sodium 4-phenylbutyrate (4PBA) improves the intracellular traff

14 T mutation with a chemical chaperone, sodium 4-phenylbutyrate (4PBA), reduces ER stress/UPR and impro

15 A chemical corrector, 4-phenylbutyrate (4PBA), restored LGI1(E383A) folding an

16 at a known transcriptional regulator, sodium 4-phenylbutyrate (4PBA), will enable a greater fraction

17 ter treatment of PBD fibroblasts with sodium 4-phenylbutyrate, a human peroxisome proliferator, there

18 t that a low temperature eye mask and sodium 4-phenylbutyrate, a United States Food and Drug Administ

19 mbinations of protein repair agents, such as 4-phenylbutyrate and genistein, may be necessary to rest

20 Sodium 4-phenylbutyrate and glycerol displayed a significant sy

21 In contrast, sodium 4-phenylbutyrate and probenecid, the latter a uricosuric

22 The chemical chaperones sodium 4-phenylbutyrate and tauroursodeoxycholic acid were foun

23 of two different chemical chaperones, sodium 4-phenylbutyrate and tauroursodeoxycholic acid, both wit

24 tion were mimicked by HDAC inhibitors sodium 4-phenylbutyrate and trichostatin A (TSA).

25 The ER stress inhibitor, 4-phenylbutyrate, blocked CITED2 knockdown-induced apopt

26 Importantly, we found that sodium 4-phenylbutyrate (Buphenyl(R)), a drug used to treat ure

27 Sodium 4-phenylbutyrate (Buphenyl, 4PBA) is a new FDA approved

28 Furthermore, we show that 4-phenylbutyrate can rescue the enamel phenotype in affe

29 ose cells with the chemical chaperone sodium 4-phenylbutyrate could partially restore trafficking of

30 e of VCP, MLN-273 (proteasome inhibitor), or 4-phenylbutyrate (histone deacetylase inhibitor).

31 The chemical chaperon, 4-phenylbutyrate, increased the mutant solubility, reduc

32 l, and the transcriptional regulator, sodium 4-phenylbutyrate, inhibit the constitutively activated i

33 hat induce peroxisome proliferation, such as 4-phenylbutyrate, may have therapeutic potential in the

34 Further, lowering ER stress by 4-phenylbutyrate mitigated the enhanced immune stimulati

35 ed that administration of chemical chaperone 4-phenylbutyrate or genetic inhibition of ATF4 successfu

36 feeding Drosophila throughout adulthood with 4-phenylbutyrate (PBA) can significantly increase lifesp

37 known to suppress ER stress signaling, like 4-phenylbutyrate (PBA) or tauroursodeoxycholic acid, wil

38 s to determine whether topical ocular sodium 4-phenylbutyrate (PBA) treatment rescues glaucoma phenot

39 Systemic administration of sodium 4-phenylbutyrate (PBA), a chemical chaperone, increased

40 ent with chemical chaperones, such as sodium 4-phenylbutyrate (PBA), reduces protein aggregation in n

41 chaperones tauroursodeoxycholate (TUDCA) and 4-phenylbutyrate (PBA), which facilitate protein folding

42 reduction of ER stress in the TM with sodium 4-phenylbutyrate prevented dexamethasone-induced ocular

43 In addition, glycerol and sodium 4-phenylbutyrate reduced the amount of Hsc70 expressed i

44 Treatment with 4-phenylbutyrate resulted in remarkable amelioration of

45 Colchicine and sodium 4-phenylbutyrate reverse these processes and could poten

46 uced UPR/ER stress by the chemical chaperone 4-phenylbutyrate significantly alleviated astrocyte-medi

47 ndent on IRE1b and to be inhibited by sodium 4-phenylbutyrate, suggesting that heat-induced autophagy

48 Colchicine and sodium 4-phenylbutyrate treatment increased secretion of THP fr

49 We show that 4-phenylbutyrate treatment of cells from both X-ALD pati

50 demonstrate the in vivo efficacy of dietary 4-phenylbutyrate treatment through its production of a s

51 After 4-phenylbutyrate treatment, an increase in transcription

52 ked by treatment with the chemical chaperone 4-phenylbutyrate, uncovering the involvement of ER stres

53 chaperones (thapsigargin, glycerol or sodium 4-phenylbutyrate), we demonstrated a marked increase in