ライフサイエンスコーパス: 5-HT(1B) receptor

1 mera (Chi22) that only weakly coupled to the 5-HT1B receptor.

2 agamma and Sf9 cell membranes containing the 5-HT1B receptor.

3 one of the serotonin-receptor subtypes, the 5-HT1B receptor.

4 whereas they are relatively unbiased at the 5-HT1B receptor.

5 ludes several ion channels and the serotonin 5-HT1B receptor.

6 region does not show any coupling ability to 5-HT1B receptors.

7 velopment and by signaling and expression of 5-HT1B receptors.

8 serotonin transporter, as well as 5-HT1A and 5-HT1B receptors.

9 because several neuron types in VTA express 5-HT1B receptors.

10 ween Galphai1 and the 5-hydroxytryptamine1B (5-HT1B) receptor.

11 asic, functionally active antagonists of the 5-HT(1B) receptor.

12 excitation probably through 5-HT1A (and not 5-HT1B) receptors.

13 100,635, consistent with the involvement of 5-HT(1B) receptors.

14 ses GABAergic inhibition through presynaptic 5-HT1B receptors; (2) 5-HT decreases the firing of palli

15 resses GABAergic inhibition probably through 5-HT1B receptors; (2) in the external pallidal segment,

16 2+) entry, and we have now demonstrated that 5-HT(1B) receptors (5-HT(1B)Rs) liberate Gbetagamma to i

17 agonist, partial agonist, and antagonist) on 5-HT1B receptor (5-HT1BR) occupancy and the associated h

18 ts suggest that nigral 5-HT, via presynaptic 5-HT1B receptor activation, gates the excitatory STN-->S

19 fects of serotonin1B [5-hydroxytryptamine1B (5-HT1B)] receptor activation on cocaine reinforcement we

20 ryptamine), and L-694,247, and the selective 5-HT(1B) receptor agonist CP 93,129 produced concentrati

21 Results showed that neonatal treatment with 5-HT(1B) receptor agonist robustly impaired sexual behav

22 Systemic administration of the 5-HT(1B) receptor agonist TFMPP attenuated the inhibitor

23 n of 5-nonyloxytriptamine (NNT), a selective 5-HT(1B) receptor agonist, affects TCA organization in r

24 N-(3-Trifluoromethylphenyl)piperazine, a 5-HT(1B) receptor agonist, potently inhibited 5-HT(1A) r

25 s inhibitory 5-HT effect was mimicked by the 5-HT1B receptor agonist CP93129 and blocked by the 5-HT1

26 the administration to wild-type mice of the 5-HT1B receptor agonist RU24969 results in a striatal in

27 e mice, CP-93,129 (1.4 mumol/kg), a specific 5-HT1B receptor agonist, had no effect in knockout mice.

28 usion of CP 93129 (20, 40, and 80 microM), a 5-HT1B receptor agonist, increased extracellular DA conc

29 uoromethyl)phenyl]-piperazine HCl (TFMPP), a 5-HT1B receptor agonist, reduced in a dose-related manne

30 that intra-tegmental infusion of CP 94253, a 5-HT1B receptor agonist, significantly prolonged the eff

31 The 5-HT1B receptor agonists 5-methoxy-3-1,2,3,6-tetrahydro-

32 phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reaction

33 Finally, the 5-HT1B receptor agonists that blocked synaptic transmiss

34 conducted to determine whether activation of 5-HT(1B) receptors also alters photic regulation of noct

35 Overexpression of 5-HT1B receptors also shifted the dose-response curve fo

36 The rat 5-HT1B receptor (also referred to as the 5-HT1D beta rec

37 two markers of serotonin neurotransmission, 5-HT(1B) receptors and serotonin reuptake sites, which a

38 H]paroxetine, selective radioligands for the 5-HT(1B) receptors and the serotonin reuptake sites, res

39 of Galphai1 increase agonist binding to the 5-HT1B receptor and receptor stimulation of GTPgammaS bi

40 Furthermore, although both 5-HT1B receptor and serotonin transporters are found in

41 n pulmonary hypertension and explain how the 5-HT1B receptor and SERT are codependent in regulating S

42 Gi1 can interact with the 5-HT1B receptor and stabilize a high affinity agonist bi

43 tatin anorectic response may be modulated by 5-HT1B receptors and that a neuronal pathway from the am

44 ffinity (Ki = 17 nM) at its species homolog, 5-HT1B receptors, and at a mutant 5-HT1D beta receptor (

45 by intra-tegmental infusion of SB 216641 (a 5-HT(1B) receptor antagonist), but not BRL 15572 (a 5-HT

46 is effect was blocked by pretreatment with a 5-HT(1B) receptor antagonist, indicating that the behavi

47 Finally, the 5-HT1B receptor antagonist NAS-181 increased the STN-tri

48 Co-infusion of the 5-HT1B receptor antagonist SB 216641 (10 microM), but no

49 in the discovery of novel, de novo designed, 5-HT(1B) receptor antagonists that lack a basic moiety a

50 microscopic immunocytochemical analysis with 5-HT1B receptor antibodies and whole-cell patch-clamp re

51 Although 5-HT(1B) receptors are believed to be expressed on nerve

52 In these neurons, 5-HT1B receptors are expressed presynaptically, and thei

53 5-HT1B receptors are inhibitory GPCRs located on the pre

54 e of abnormal stimulation of 5-HT(1A) and/or 5-HT(1B) receptors as a result of increased synaptic ava

55 p11 increases localization of 5-HT1B receptors at the cell surface.

56 suggest that blockade and activation of VTA 5-HT1B receptors attenuates and potentiates the neuroche

57 , may cause or contribute to the increase in 5-HT(1B) receptor binding in the SCN in middle aged anim

58 5-HT(1B) receptor binding sites ([125I]cyanopindolol) we

59 pharmacological interventions to interrogate 5-HT1B receptor binding and function and determined bloo

60 s in serotonergic neurotransmission increase 5-HT(1B) receptors but decrease serotonin reuptake sites

61 dicate that the agonist action of NNT at the 5-HT(1B) receptor causes TCA disorganization in rat barr

62 usion and examined for 5-HT afferents to and 5-HT1B receptor-containing neuronal puncta and somata in

63 s in vivo and demonstrate that activation of 5-HT1B receptors contributes to the cellular responses e

64 ng sequence in Galphat either permitted full 5-HT1B receptor coupling to the chimera (Chi24) or only

65 ions within Chi22 (K300Q and L304E) restored 5-HT1B receptor coupling, and again the effects of the t

66 tagonistic drug characteristics and on local 5-HT1B receptor density.

67 In the ventral midbrain, 5-HT(1B) receptor-dependent inhibition of gamma-aminobut

68 th the structure of the 5-HT2B receptor, the 5-HT1B receptor displays a 3 angstrom outward shift at t

69 nity shift of 5-HT1A receptors compared with 5-HT1B receptors (EC50 values of 6.4 and 12.0 nM, respec

70 Simultaneous activation of 5-HT1A and 5-HT1B receptors effectively blocks L-DOPA-induced dyski

71 amic NPY, alpha-MSH, and serotonin receptor (5-HT(1B)-receptor) enhancing FI.

72 The 5-HT1A and 5-HT1B receptors exhibited both high- and low-affinity s

73 escending 5-HT neurons and to be mediated by 5-HT1B receptors expressed by AADC cells.

74 In conclusion, these studies indicate that 5-HT(1B) receptor function can be assessed using agonist

75 n (5-HT) turnover and deficient 5-HT(1A) and 5-HT(1B) receptor function in brain regions regulating e

76 These results indicate that 5-HT(1B) receptors function as autoreceptors and heteror

77 Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates cert

78 rinergic receptor-mediated inhibition of CHO/5-HT1B receptor function was blocked when 5-HT2A recepto

79 ion of 5-HT2A receptors had no effect on CHO/5-HT1B receptor function, although 5-HT2A receptor-media

80 Null mutant mice lacking the 5-HT1B receptor gene (5-HT1B-/-) have been developed tha

81 arch has focused on the 5-HT1A receptor, the 5-HT1B receptor has a lesser known role in modulating em

82 ing emotional behaviour and the 5-HT(1A) and 5-HT(1B) receptors have been shown to have distinct role

83 5-HT(1B)-receptor immunoreactivity decreased 13% only in

84 5-HT1B receptor immunostaining was observed associated w

85 investigate the localisation of 5-HT(1A) and 5-HT(1B) receptors in CeA projection neurones identified

86 Due to postsynaptic 5-HT(1B) receptors in DRN terminal fields, it has not pr

87 y underscores the role played by presynaptic 5-HT(1B) receptors in mediating the effects of cocaine o

88 sent investigation to assess the function of 5-HT(1B) receptors in the modulation of synaptic transmi

89 an induce pulmonary vasoconstriction via the 5-HT1B receptor in man.

90 Here we show that serotonin 5-HT1B receptors in cholecystokinin (CCK) inhibitory int

91 as designed to assess the involvement of VTA 5-HT1B receptors in mediating the stimulatory effects of

92 Thus, increased expression of 5-HT1B receptors in NAcc efferents, probably in the term

93 viral-mediated gene transfer to overexpress 5-HT1B receptors in NAcc projections to VTA.

94 GFP injection induced elevated expression of 5-HT1B receptors in neuronal fibers in VTA and increased

95 by examining the subcellular localization of 5-HT1B receptors in the mouse SCN using electron microsc

96 For example, serotonin actions at 5-HT1B receptors in the ventral tegmental area (VTA) mod

97 als in SNr, indicating a primary role of the 5-HT1B receptors in these axon terminals.

98 that cocaine acts as an indirect agonist of 5-HT1B receptors in vivo and demonstrate that activation

99 receptor antagonist, GR127935, to antagonize 5-HT1B receptors in vivo.

100 The results suggest that activation of VTA 5-HT1B receptors increases mesolimbic DA neuron activiti

101 gic inputs that are inhibited by presynaptic 5-HT1B receptors; inhibition of excitatory synapses onto

102 s, whereas serotonin (5-HT) acting through a 5-HT1B receptor inhibits aggressive responding.

103 serotonin 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] interacts with p11.

104 results thus demonstrate that stimulation of 5-HT1B receptors is required for fenfluramine-induced an

105 To test the hypothesis that stimulation of 5-HT1B receptors is required for the anorectic effect of

106 ts are in opposition to recent findings with 5-HT1B receptor knock-out mice and may have important on

107 in inhibiting light-induced phase shifts in 5-HT1B receptor knock-out mice.

108 induced phase shifts was also examined using 5-HT1B receptor knock-out mice.

109 The 5-HT(1B) receptor knockout mouse was used in the present

110 nes retrogradely-labelled with CTb expressed 5-HT(1B) receptor-like immunoreactivity, whereas fewer (

111 alterations in 5-HT afferent innervation and 5-HT1B receptor localization were observed throughout th

112 clock through the activation of presynaptic 5-HT(1B) receptors located on retinal terminals in the s

113 s as a result of activation of 5-HT1A and/or 5-HT1B receptors located on presynaptic terminals.

114 he circadian system by acting at presynaptic 5-HT1B receptors located on retinal axons in the SCN.

115 ctively, and support the suggestion that VTA 5-HT(1B) receptors may be involved in part in mediating

116 he lack of 5-HT2A mediated regulation of CHO/5-HT1B receptors may be due to activation of a third pat

117 reductions found in this study suggest that 5-HT1B receptors may contribute to the etiology or expre

118 5-HT1A agonist (8-OH-DPAT), indicating that 5-HT1B receptors mediate the inhibition of EPSCs.

119 residues within this domain are critical for 5-HT1B receptor-mediated G protein activation.

120 n SNr GABA neurons, indicating a presynaptic 5-HT1B receptor-mediated inhibition of glutamate release

121 ay be associated, at least in part, with the 5-HT1B receptor-mediated inhibition of VTA GABA release.

122 5-HT1B receptor-mediated presynaptic inhibition has been

123 ells, 5-hydroxytryptamine (5-HT)1B-like (CHO/5-HT1B) receptor-mediated inhibition of forskolin-stimul

124 ences aggressive behavior, a distinct set of 5-HT1B receptors modulates impulsive behavior during adu

125 as, with bLRs having greater 5-HT1A, but not 5-HT1B, receptor mRNA levels in the septum, hippocampus

126 nterpretation that activation of presynaptic 5-HT(1B) receptors on retinal terminals in the SCN atten

127 One possibility is that 5-HT1B receptors on the terminals of GABAergic projectio

128 Our results suggest that the 5-HT1B receptor participates in the regulation of ethano

129 diates 5-HT2C receptor regulation of the CHO/5-HT1B receptor pathway.

130 hiothepin >>> yohimbine, consistent with rat 5-HT(1B) receptor pharmacology.

131 ronal circuits and particularly 5-HT(1A) and 5-HT(1B) receptors play a prominent role in the regulati

132 idence suggests that 5-hydroxytriptamine-1B (5-HT1B) receptors play a role in modifying ethanol's rei

133 The 5-HT(1B) receptor, present on TCAs during the first post

134 ion and find that serotonin (5-HT) activates 5-HT(1b) receptors resulting in a long-term depression (

135 its to membranes expressing either 5-HT1A or 5-HT1B receptors shifted the majority of the receptors t

136 h serotonin receptor 1B (5-HTR1B), modulates 5-HT1B receptor signal transduction, and is required for

137 stochemical study, using NPY, alpha-MSH, and 5-HT(1B)-receptor-specific antibodies and slides assesse

138 the behavioral consequences of mCPP-induced 5-HT(1B) receptor stimulation are unmasked in animals de

139 Together, these findings indicate that 5-HT1B receptor stimulation facilitates the reinforcing

140 odulating signaling through 5-HT4 as well as 5-HT1B receptors supports the concept that this protein

141 ity requires activation of nucleus accumbens 5-HT1B receptors, the blockade of which prevents social

142 ncrease serotonergic receptor functions (eg, 5-HT(1B) receptors), these data support the need for fur

143 act in concert to mediate the ability of the 5-HT1B receptor to couple specifically to inhibitory G p

144 of the ability of the 5-hydroxytryptamine1B (5-HT1B) receptor to discriminate between G protein heter

145 bilities of the Galphat/Galphai1 chimeras to 5-HT1B receptors using high affinity agonist binding and

146 Functional coupling to 5-HT1B receptors was assessed by 1) [35S]GTPgammaS bindi

147 e contribution of the 5-hydroxytryptamine1B (5-HT1B) receptor, we studied the induction of the immedi

148 retrogradely-labelled neurones positive for 5-HT(1B) receptor were present in both lateral and media

149 tly into DRN using stereotaxic procedure, HA-5-HT(1B) receptors were expressed in serotonergic neuron

150 rcing effects and voluntary intake, and that 5-HT1B receptors within the ventral tegmental area (VTA)

151 dy was designed to assess the involvement of 5-HT1B receptors within the ventral tegmental area (VTA)