ライフサイエンスコーパス: 5-HT

1 5-HT and cholecystokinin (CCK) induced dose-dependent in

2 5-HT immunoreactivity had nearly complete overlap with P

3 5-HT is an important pro-kinetic agent in the colon.

4 5-HT neurons in the dorsal raphe nucleus (DRN) often fir

5 5-HT receptor antagonists and agonists were given as dru

6 on by autocrine signalling through the SER-7 5-HT receptor.

7 Using genetic tools, we characterize a 5-HT neuron subtype defined by expression of Tachykinin1

8 on of Slc6a4 or treatment with Fluoxetine, a 5-HT reuptake inhibitor, restored normal breathing.

9 Here, we characterize in mice a 5-HT neuron subtype identified by expression of Tac1 and

10 Surprisingly, adult 5-HT deficiency did not affect anxiety-like behavior, bu

11 ing this technique, we discovered that adult 5-HT deficiency led to a novel compound phenotype consis

12 cal small optic lobe (SOL) calpain 2 d after 5-HT treatment or paired stimuli did not disrupt the mai

13 Soon after 5-HT treatment or paired stimuli, however, blocking clas

14 droxyl group and lipid headgroups and allows 5-HT to intercept reactive oxygen species, preventing me

15 Although 5-HT enhances odor-evoked responses of antennal lobe pro

16 l, are likely subserved by differences among 5-HT neuron subtypes at the cellular and molecular level

17 attenuates the ability of glucose to amplify 5-HT effects.

18 bute to drug seeking via beta-adrenergic and 5-HT neurotransmission in DH.

19 Both inward currents and 5-HT release were inhibited by Piezo2 small interfering

20 express TH2 and TPH1 and contain both DA and 5-HT, a dual neurotransmitter phenotype hitherto undescr

21 he expression of synthetic enzymes of DA and 5-HT, respectively, tyrosine hydroxylase (TH) and trypto

22 evations in brain extracellular dopamine and 5-HT in vivo.

23 st time between SK channel dysregulation and 5-HT neuron activity in a lifelong stress paradigm, sugg

24 annel NaV1.3 for electrical excitability and 5-HT release.

25 yed differential modulation by glutamate and 5-HT.

26 It is well known that 5-HT and 5-HT transporter (5-HTT) play important roles in the pul

27 ver, the underlying mechanism between OT and 5-HT remains unclear.

28 oreceptors, and thus DRNshort right arrowNAc 5-HT neuronal activity, in the etiology and vulnerabilit

29 n of 5-HT synthesis from the adult ascending 5-HT system.

30 a TRPV4 antagonist significantly attenuated 5-HT-evoked scratching in vivo.

31 d blood 5-HT levels, linking integrin beta3, 5-HT, and ASD risk.

32 tic acid [DTPA]-gadolinium or indium 111-bis-5-HT-DTPA, respectively).

33 lts, we investigated the effects of blocking 5-HT and beta-adrenoceptor transmission in DH on drug se

34 Blood 5-HT levels were dynamic across pregnancy and were incre

35 n a subgroup of patients with elevated blood 5-HT levels, linking integrin beta3, 5-HT, and ASD risk.

36 nction, as well as elevated peripheral blood 5-HT levels.

37 avbeta3 receptors that influence whole-blood 5-HT levels and may influence the risk for autism spectr

38 ed order, and we observe that the early-born 5-HT(+) neurons are generated in Ascl1(-/-) mutants, des

39 n subtype with the potential to release both 5-HT and substance P is necessary for normal respiratory

40 neuroendocrine dopamine release through both 5-HT-dependent and -independent actions, providing a mec

41 f methods to target specifically adult brain 5-HT synthesis.

42 These effects were mediated by 5-HT because they were blocked by antagonists of 5-HT2A

43 females in prooestrus, an effect mediated by 5-HT in the colonic mucosa and by 5-HT3 receptors.

44 We examined whether alterations in colonic 5-HT signalling underlie age-related changes in faecal o

45 In comparison, 5-HT-evoked inhibitory responses in the AOB arose due to

46 of mucosal enterochromaffin cells containing 5-HT changes with the oestrous cycle in mice.

47 of Piezo2 by force leads to inward currents, 5-HT release and an increase in mucosal secretion.

48 creased microglia cell numbers and decreased 5-HT immunoreactivity in the nucleus of the solitary tra

49 rsal part of the BNST (dBNST) receives dense 5-HT innervation, whether and how 5-HT in the dBNST norm

50 ing ChIs from the vSt by acting on different 5-HT receptor isoforms.

51 Differential 5-HT neuromodulation of MCs across the MOB and AOB could

52 ubstitution (SERT Met172) without disrupting 5-HT recognition or uptake.

53 DH receives strong inputs from LC-NE and DR 5-HT neurons.

54 hrine (LC-NE) and dorsal raphe serotonin (DR 5-HT) systems.

55 onosynaptic, glutamatergic drive to both DRN 5-HT and GABA neurons and that this architecture was con

56 d that activating dorsal raphe nucleus (DRN) 5-HT neurons induced a strong suppression of spontaneous

57 ergistic activation of alphaIIbbeta3 by dual 5-HT/ADP stimulation.

58 efining a subset of SIDS cases with elevated 5-HT.

59 otonergic signaling by increasing endogenous 5-HT.

60 nd motivation but the function of endogenous 5-HT remains controversial.

61 knockout mice exhibited significantly fewer 5-HT-evoked scratching bouts compared with wild-type mic

62 comes showed a high correlation for the five 5-HT targets and this enabled us to transform the atlas

63 d the sensitivity and stability required for 5-HT measurements from intestinal tissue.

64 sory systems, suggesting a possible role for 5-HT in perceptual inference.

65 Although there is much support for 5-HT transporter (SERT) antagonism as a basis of antidep

66 h decreased placenta and embryonic forebrain 5-HT levels at E14.5.

67 s offspring placental 5-HT levels, forebrain 5-HT levels, and neurodevelopment.

68 nal SERT Ala56 genotype effects on forebrain 5-HT levels were accompanied by a broadening of 5-HT-sen

69 stage-specific switch in Pet-1 targets from 5-HT synthesis genes to transmitter receptor genes requi

70 t stabilize inward-open conformations (e.g., 5-HT, ibogaine) increased phosphorylation.

71 Thirty-one percent (19/61) of SIDS cases had 5-HT levels greater than 2 SDs above the mean of the con

72 nsory stimuli, but little is known about how 5-HT affects sensory processing, especially on this time

73 ives dense 5-HT innervation, whether and how 5-HT in the dBNST normally modulates anxiety remains unc

74 Serotonin (5-hydroxytriptamine; 5-HT) is implicated in a variety of brain functions incl

75 nover and expression of 5-hydroxytryptamine (5-HT) 2A (5-HT2A) and 5-HT2C serotonin receptors in the

76 ch re-uptakes excessive 5-hydroxytryptamine (5-HT) from effective location to terminate its physiolog

77 Serotonin or 5-hydroxytryptamine (5-HT) has been shown to be essential in lots of physiolo

78 tropic and metabotropic 5-hydroxytryptamine (5-HT) receptors are expressed on whisker Abeta-afferent

79 ensory neuron 2 d after 5-hydroxytryptamine (5-HT) treatment reversed persistent nonassociative LTF.

80 d to reduced serotonin (5-hydroxytryptamine (5-HT)) blood levels that paralleled a mild bleeding phen

81 Serotonin, or 5-hydroxytryptamine (5-HT), plays a key role in the central nervous system an

82 uptake and recycling of 5-hydroxytryptamine (5-HT; serotonin) after its exocytotic release during neu

83 is well recognized that 5-hydroxytryptamine (5-HT; serotonin) plays a central role in depression, our

84 Serotonin (5-hydroxytryptamine, 5-HT) and brain-derived neurotrophic factor (BDNF) are t

85 rmalities in serotonin (5-hydroxytryptamine, 5-HT) in regions of the brainstem critical in homeostati

86 Serotonin (5-hydroxytryptamine, 5-HT) is a well-known neurotransmitter that is involved

87 The serotonin (5-hydroxytryptamine, 5-HT) system modulates many important brain functions an

88 y map of the serotonin (5-hydroxytryptamine, 5-HT) system.

89 contents of serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter involved in both sleep-wake an

90 f the body's serotonin (5-hydroxytryptamine, 5-HT).

91 all systemic serotonin (5-hydroxytryptamine; 5-HT), which is an important neurotransmitter and endocr

92 Taken together, our results identify 5-HT as a potent inhibitor of lipid peroxidation and off

93 specific alterations of crucially important 5-HT-dependent neurogenic processes.

94 Regio-specific changes in 5-HT overflow were observed with age, where increases in

95 l studies revealed a significant decrease in 5-HT synapses in the midbrain, accompanied by decreases

96 w were observed with age, where increases in 5-HT overflow were observed in the distal colon due to a

97 ctivity of 5-HT Transporter (SERT/Slc6a4) in 5-HT neurons leading to an increase of 5-HT uptake.

98 satiety-signaling peptide YY 3-36 increased 5-HT turnover in the LH and ameliorated the ppDIO-induce

99 Jejunum mucosal pressure increased 5-HT release and short-circuit current via submucosal 5-

100 ommon SERT variant (Ala56) in mice increases 5-HT clearance and causes ASD-like behaviors.

101 including autoreceptors that act to inhibit 5-HT release.

102 s selectively decreased while, for instance, 5-HT(+) neurons, which previously were believed to be As

103 g seeking during initial abstinence involves 5-HT and beta-adrenergic signaling in female DH, but onl

104 of 5-HT1A autoreceptors, which would lessen 5-HT neuron firing, contributes to cocaine-seeking behav

105 Low 5-HT in the placenta persisted, but forebrain levels nor

106 e primary monoamine oxidase that metabolizes 5-HT in C. elegans, and we also found that grk-2 loss-of

107 trate that these ionotropic and metabotropic 5-HT receptors have a synergistic effect that is critica

108 Here we show that, in mice, 5-HT depolarizes cholinergic interneurons (ChIs) of the

109 Early in gestation, before midbrain 5-HT projections have reached the cortex, peripheral sou

110 f 5-HT predominate, and E18.5, when midbrain 5-HT projections have reached the forebrain.

111 siological mechanisms through which midbrain 5-HT neurons modulate amygdala circuits could be pivotal

112 In the MOB, 5-HT elicited three types of responses in 93% of 180 cel

113 ese results demonstrate that GRK-2 modulates 5-HT metabolism by regulating AMX-2 function and that 5-

114 patterns for functional maturation of mouse 5-HT neurons.

115 Age increased mucosal 5-HT availability and TNF-alpha expression and decreased

116 The release of mucosal 5-HT occurred oral to the fecal pellet and was linked to

117 Monitoring of mucosal 5-HT overflow has been achieved to date using microelect

118 ession are an important regulator of mucosal 5-HT signalling and pellet output and water content in o

119 resemble those seen in mice lacking neuronal 5-HT.

120 his effect was mediated by glutamate and not 5-HT because it was abolished by ionotropic glutamate re

121 HFD attenuated the response to CCK, but not 5-HT.

122 how that 5-HT from the dorsal raphe nucleus (5-HT(DRN)) enhances fear and anxiety and activates a sub

123 Approximately 90% of 5-HT-sensitive dorsal root ganglion neurons were immunor

124 iological recordings assessed the ability of 5-HT to increase anterior gastric vagal afferent nerve (

125 mitotic precursors to control acquisition of 5-HT transmitter identity.

126 oaches to study the effects of activation of 5-HT axons in the basal nucleus of the amygdala (BA).

127 e impact of phasic optogenetic activation of 5-HT neurons in mice over time scales from seconds to we

128 dominance was associated with activation of 5-HT neurons within the dorsal raphe in females and acti

129 Thus, HIF-1-mediated activation of 5-HT signalling promotes axon regeneration by activating

130 ogenetics, we demonstrate that activation of 5-HT terminals in the dBNST reduces anxiety in a highly

131 show an increased expression and activity of 5-HT Transporter (SERT/Slc6a4) in 5-HT neurons leading t

132 The addition of 5-HT or inhibition of 5-HT metabolism also rescued the e

133 study therefore provides a detailed atlas of 5-HT receptor expression within a well-characterized neu

134 T levels were accompanied by a broadening of 5-HT-sensitive thalamocortical axon projections.

135 molecular level, the antioxidant capacity of 5-HT and its interaction with lipid membranes.

136 nuclei contained a moderate concentration of 5-HT fibers, whereas caudal regions of Me as well as the

137 ei contained a sparse/light concentration of 5-HT fibers.

138 clei contained a very dense concentration of 5-HT fibers; 2) of the cortical pallial nuclei, the ante

139 udally contained a moderate concentration of 5-HT fibers; and 3) of the subpallial nuclei, the anteri

140 uld be revised to incorporate the concept of 5-HT/glutamate cotransmission.

141 ignificantly upregulated, and the content of 5-HT was decreased which negatively correlated with the

142 suggest that theories on the contribution of 5-HT neurons to amygdala function should be revised to i

143 table and sensitive for ex vivo detection of 5-HT, and no differences in the fecal pellet velocity wa

144 ribe the complete pattern of distribution of 5-HT fibers to the amygdala (proper) and to the extended

145 ucibly achieves near-complete elimination of 5-HT synthesis from the adult ascending 5-HT system.

146 bitory balance governing the excitability of 5-HT neurons.

147 te ultimately to the core coding features of 5-HT neurons.

148 itecture and increased spontaneous firing of 5-HT neurons.

149 s have shown nonpharmacological functions of 5-HT linked to its chemical properties.

150 4) in 5-HT neurons leading to an increase of 5-HT uptake.

151 ity through parallel effects, independent of 5-HT transmission.

152 ysis revealed that optogenetic inhibition of 5-HT inputs into the dBNST increases anxiety in a less a

153 The addition of 5-HT or inhibition of 5-HT metabolism also rescued the egg laying defect.

154 vented the increased extracellular levels of 5-HT in the BLA typically produced by IS.

155 ASB was sensitive to physiological levels of 5-HT modification, and that OT does not act directly on

156 in these mice, and that the localization of 5-HT transporters to specific compartments within the sy

157 et-1, during which it promotes maturation of 5-HT neuron excitability.

158 ctories of genes necessary for maturation of 5-HT neuron excitability.

159 ons, which prevented postnatal maturation of 5-HT neuron passive and active intrinsic membrane proper

160 tilized to conduct multisite measurements of 5-HT overflow from the entire colon.

161 or genes required for afferent modulation of 5-HT neuron excitability.

162 y and depression are mediated by a number of 5-HT receptors, including autoreceptors that act to inhi

163 rous cycle-dependent change in the number of 5-HT-containing EC cells in the colonic mucosa.

164 chemistry was used to quantify the number of 5-HT-expressing enterochromaffin (EC) cells.

165 whole, the BST contained moderate numbers of 5-HT fibers, spread fairly uniformly throughout BST.

166 nderstand these underevaluated properties of 5-HT, we combined biochemical, biophysical, and molecula

167 Our studies identify a complex regulation of 5-HT homeostasis and behaviors by integrin alphavbeta3,

168 SK2 and SK3 channels in normal regulation of 5-HT neuronal excitability.

169 ion, is critical for appropriate reuptake of 5-HT.

170 ryonic day E14.5, when peripheral sources of 5-HT predominate, and E18.5, when midbrain 5-HT projecti

171 bserved following optogenetic stimulation of 5-HT inputs into the dBNST.

172 Optical stimulation of 5-HT terminals at higher frequencies (10-20 Hz) evoked b

173 Optical stimulation of 5-HT terminals at low frequencies (</=1 Hz) evoked a sho

174 Furthermore, optical stimulation of 5-HT terminals did not evoke glutamate release onto BA p

175 G2, which is implicated in transamidation of 5-HT to Rac1) are observed in the mouse prefrontal corte

176 s PTSD may be more effective with the use of 5-HT-targeted drugs in females and AVP-targeted drugs in

177 tical synapses, compared with its effects on 5-HT responses, a measure of cortical-cortical responses

178 -adrenergic signaling in female DH, but only 5-HT signaling in male DH.

179 at, no previous report has described overall 5-HT projections to the amygdala in the rat.

180 suggesting that altered maternal or placenta 5-HT system function could impact the developing embryo.

181 al SERT function impacts offspring placental 5-HT levels, forebrain 5-HT levels, and neurodevelopment

182 the-art techniques, we show that presynaptic 5-HT function is altered in these mice, and that the loc

183 urthermore, insulin stimulation up-regulated 5-HT uptake rates of GDM-platelets as it does in the con

184 ls, but it was also important for regulating 5-HT release by these cells.

185 insight into the genetic network regulating 5-HT neurotransmission in the CNS that is also associate

186 We found that 5-HT neurons co-release 5-HT and glutamate onto BA neurons in a cell-type-specif

187 The EC cell model released 5-HT in response to stretch, and had Piezo2 mRNA and pro

188 of sour (acidic) tastants and this released 5-HT activates 5-HT3 receptors on the gustatory nerves.

189 ensor, and it is well known that it releases 5-HT in response to mechanical forces.

190 , in vivo atlas of four of the human brain's 5-HT receptors (5-HT1A, 5-HT1B, 5-HT2A, and 5-HT4) and t

191 is dependent on activation of serotonergic (5-HT) dorsal raphe nucleus (DRN) neurons that project to

192 As is well recognized, serotonergic (5-HT) fibers distribute widely throughout the forebrain,

193 Serotonin (5-HT) is a crucial neuromodulator linked to many psychia

194 Serotonin (5-HT) is a crucial neuromodulator, yet its role in behav

195 Serotonin (5-HT) is associated with mood and motivation but the fun

196 Serotonin (5-HT) neurons located in the raphe nuclei modulate a wid

197 Serotonin (5-HT) neurons project from the raphe nuclei throughout t

198 itis elegans, the biogenic amines serotonin (5-HT) and octopamine regulate a number of food-related b

199 at the interaction between OT and serotonin (5-HT) is critical for several aspects of social behavior

200 oamines such as dopamine (DA) and serotonin (5-HT) occur in the periventricular zones of the hypothal

201 ed antidepressant medications are serotonin (5-HT) selective reuptake inhibitors (SSRIs).

202 ical evidence has implicated both serotonin (5-HT) 2C and 2A receptors as potential mechanisms for me

203 hat in addition to inducing brain serotonin (5-HT) synthesis and reuptake, the Pet-1 ETS (E26 transfo

204 ociated with changes in brainstem serotonin (5-HT) expression and whether it can be prevented by the

205 The modulation of the amygdala by serotonin (5-HT) is important for emotional regulation and is impli

206 la56 variant have altered central serotonin (5-HT) system function, as well as elevated peripheral bl

207 mmunohistochemically demonstrable serotonin (5-HT) was 30% greater in female mice during oestrus than

208 During typical development, serotonin (5-HT) synthesized in the placenta from maternal l-trypto

209 ctor is continuously expressed in serotonin (5-HT) neurons and initially acts in postmitotic precurso

210 ceptor, OCTR-1, and a 5-HT1A-like serotonin (5-HT) receptor, SER-4, that involves a complex interacti

211 widely distributed CNS modulator, serotonin (5-HT), for its ability to modulate the biophysical prope

212 the relationship between mucosal serotonin (5-HT) and colonic motility, however contradictory studie

213 modulated by the neurotransmitter serotonin (5-HT).

214 reuptake of the neurotransmitter, serotonin (5-HT; 5-hydroxytryptamine), into cells by the 5-HT trans

215 fective and contain low levels of serotonin (5-HT) and high levels of the 5-HT metabolite 5-hydroxyin

216 omy induces ectopic expression of serotonin (5-HT) in axotomized non-serotonergic neurons via HIF-1,

217 ammation, the fundamental role of serotonin (5-HT) in enteric neuroimmune mechanisms, and future pers

218 Release of serotonin (5-HT) is thought to have an important role in the increa

219 eletion disturbs the migration of serotonin (5-HT) neuronal precursors, leading to altered global ser

220 The effects of serotonin (5-HT) on anxiety and depression are mediated by a number

221 turation and the translocation of serotonin (5-HT) transporter, SERT to the plasma membrane of the tr

222 The preferential serotonin (5-HT) 2A/1A receptor agonist, psilocybin (Psi), reduces

223 ng cells, Type III cells, release serotonin (5-HT) in response to the presence of sour (acidic) tasta

224 These compounds include selective serotonin (5-HT)2C receptor antagonists, a 5-HT4 receptor agonist,

225 tor nuclei.SIGNIFICANCE STATEMENT Serotonin (5-HT) neurons modulate physiological processes and behav

226 A dopaminergic marker (TH), serotonin (5-HT) or GABA do not co-localize with Galphat-S-ir neuro

227 The serotonin (5-HT) system and the amygdala are key regulators of emot

228 e integrin beta3 subunit with the serotonin (5-HT) system, likely via its modulation of the 5-HT tran

229 functional coding variants of the serotonin (5-HT) transporter (SERT, encoded by SLC6A4) have been id

230 d by chemical signaling, of which serotonin (5-HT) is a key transmitter.

231 of the SERT Met172 model for isolating SERT/5-HT contributions of drug actions in vivo.

232 Serum 5-HT, adjusted for postconceptional age, was significant

233 orter promoter region polymorphism and serum 5-HT level.

234 High serum 5-HT may serve as a potential forensic biomarker in auto

235 DS is associated with an alteration in serum 5-HT levels.

236 These fast glutamate- and slow 5-HT-mediated responses often coexisted in the same neur

237 To do so, 5-HT was added to red blood cells and lipid membranes be

238 expression patterns in maturing flow-sorted 5-HT neurons and the temporal requirements for Pet-1 in

239 Specifically, 5-HT(DRN) projections to the BNST, via actions at 5-HT2C

240 Here, we study 5-HT inputs into the bed nucleus of the stria terminalis

241 eached the cortex, peripheral sources supply 5-HT to the forebrain, suggesting that altered maternal

242 A TRPV4 antagonist significantly suppressed 5-HT-evoked responses in dorsal root ganglion cells from

243 Components of the 5-HT signalling system (5-HT, 5-HIAA, SERT) and TNF-alpha expression were examin

244 parallel partitions of the olfactory system, 5-HT largely elicited MC excitation in the MOB while it

245 part because of a lack of methods to target 5-HT synthesis specifically in the adult brain.

246 xia-inducible transcription factor, and that 5-HT subsequently promotes axon regeneration by autocrin

247 Our results demonstrate that 5-HT acts as a potent antioxidant and binds with a super

248 We find that 5-HT signaling is required for animals to assume food-ap

249 scan in humans, we have recently found that 5-HT 1A receptor (5-HT1AR) function is modified after in

250 We found that 5-HT neurons co-release 5-HT and glutamate onto BA neuro

251 We found that 5-HT predominantly hyperpolarizes dBNST neurons, reducin

252 In the present study, we found that 5-HT treatment increases BDNF receptor, TrkB (tropomyosi

253 ecreased SERT activity support the idea that 5-HT signaling regulates enteric neuronal development an

254 These results indicate that 5-HT-induced itch is linked to TRPV4.

255 It is well known that 5-HT and 5-HT transporter (5-HTT) play important roles i

256 Indeed, it was reported that 5-HT may, on the one hand, bind lipid membranes and, on

257 dized lipids converge to further reveal that 5-HT contributes to the termination of lipid peroxidatio

258 These data reveal that 5-HT release in the dBNST modulates anxiety-like behavio

259 uantitative behavioral imaging, we show that 5-HT and octopamine jointly influence locomotor activity

260 Here we show that 5-HT from the dorsal raphe nucleus (5-HT(DRN)) enhances

261 le-cell patch-clamp recordings, we show that 5-HT hyperpolarizes and abolishes phasic discharge in ra

262 We show that 5-HT locates at the hydrophobic-hydrophilic interface, b

263 factor for depressive illness, we show that 5-HT neurons in the dorsal raphe nucleus are less respon

264 We show that 5-HT produced by the ADF neurons acts via the SER-5 rece

265 These results show that 5-HT transients have strong and opposing short and long-

266 Our results suggest that 5-HT and DA extrinsic neurons target partially overlappi

267 Collectively, these findings suggest that 5-HT neurons exert a frequency-dependent, cell-type-spec

268 Several lines of evidence suggest that 5-HT transmission in the amygdala is implicated in the s

269 s, yet no overlap with ORNs, suggesting that 5-HT may modulate PNs and LNs directly but not ORNs.

270 The 5-HT-induced response was amplified by acute hyperglycae

271 (5-HT1A, 5-HT1B, 5-HT2A, and 5-HT4) and the 5-HT transporter (5-HTT).

272 is stabilized by hydrogen bonds between the 5-HT hydroxyl group and lipid headgroups and allows 5-HT

273 -HT; 5-hydroxytryptamine), into cells by the 5-HT transporter (SERT).

274 pression in the human brain by comparing the 5-HT density across the atlas with data from the Allen H

275 Although a few reports have examined the 5-HT innervation of select nuclei of the amygdala in the

276 ociated with peripheral abnormalities in the 5-HT pathway.

277 essed the ability of glucose to modulate the 5-HT response in vitro.

278 s of serotonin (5-HT) and high levels of the 5-HT metabolite 5-hydroxyindole acetic acid (5-HIAA).

279 Components of the 5-HT signalling system (5-HT, 5-HIAA, SERT) and TNF-alph

280 This new in vivo neuroimaging atlas of the 5-HT system not only provides insight in the human brain

281 HT) system, likely via its modulation of the 5-HT transporter (SERT).

282 ibit egg laying in a manner dependent on the 5-HT receptor SER-1 and the G protein GOA-1.

283 Moreover, Pet-1 directly regulates the 5-HT neuron maturation factor Engrailed 1, which suggest

284 These data demonstrate that the 5-HT abnormalities in distinct respiratory neural contro

285 tively enhanced alphavbeta3 signaling to the 5-HT system in the brain.

286 R activity, surface level of SERT, and their 5-HT uptake rates.Interestingly, no significant differen

287 d defects in platelet IR should change their 5-HT uptake rates, and this should be a leading factor f

288 There, 5-HT modulates critical neurodevelopmental processes.

289 nse of gastric-projecting vagal afferents to 5-HT, it attenuates the ability of glucose to amplify 5-

290 00A10), a multifunctional protein binding to 5-HT receptors, in layer II/III neurons of the prelimbic

291 ctrical excitability and its contribution to 5-HT release is a novel mechanism of EC cell function.

292 reduction in vasoconstrictive reactivity to 5-HT trending toward significance (P = 0.09).

293 measurements are reflective with regards to 5-HT signaling from the entire colon.

294 ith channelrhodopsin genetically targeted to 5-HT neurons.

295 Using 5-HT neuron-specific reduction of 5-HT1A autoreceptor ge

296 -type-specific control over BA circuitry via 5-HT and glutamate co-release to inhibit the BA output.S

297 nd promote roaming in fasting worms, whereas 5-HT produced by the NSM neurons acts on the MOD-1 recep

298 However, the mechanism by which 5-HT regulates BDNF signaling is unknown.

299 e the physiological mechanisms through which 5-HT neurons in the dorsal raphe nuclei modulate amygdal

300 ignificantly after stimulation of cells with 5-HT and TG.