ライフサイエンスコーパス: 5-HT1B receptor

1 whereas they are relatively unbiased at the 5-HT1B receptor.

2 ludes several ion channels and the serotonin 5-HT1B receptor.

3 mera (Chi22) that only weakly coupled to the 5-HT1B receptor.

4 agamma and Sf9 cell membranes containing the 5-HT1B receptor.

5 one of the serotonin-receptor subtypes, the 5-HT1B receptor.

6 velopment and by signaling and expression of 5-HT1B receptors.

7 serotonin transporter, as well as 5-HT1A and 5-HT1B receptors.

8 because several neuron types in VTA express 5-HT1B receptors.

9 region does not show any coupling ability to 5-HT1B receptors.

10 ween Galphai1 and the 5-hydroxytryptamine1B (5-HT1B) receptor.

11 excitation probably through 5-HT1A (and not 5-HT1B) receptors.

12 ses GABAergic inhibition through presynaptic 5-HT1B receptors; (2) 5-HT decreases the firing of palli

13 resses GABAergic inhibition probably through 5-HT1B receptors; (2) in the external pallidal segment,

14 agonist, partial agonist, and antagonist) on 5-HT1B receptor (5-HT1BR) occupancy and the associated h

15 ts suggest that nigral 5-HT, via presynaptic 5-HT1B receptor activation, gates the excitatory STN-->S

16 fects of serotonin1B [5-hydroxytryptamine1B (5-HT1B)] receptor activation on cocaine reinforcement we

17 s inhibitory 5-HT effect was mimicked by the 5-HT1B receptor agonist CP93129 and blocked by the 5-HT1

18 the administration to wild-type mice of the 5-HT1B receptor agonist RU24969 results in a striatal in

19 e mice, CP-93,129 (1.4 mumol/kg), a specific 5-HT1B receptor agonist, had no effect in knockout mice.

20 usion of CP 93129 (20, 40, and 80 microM), a 5-HT1B receptor agonist, increased extracellular DA conc

21 uoromethyl)phenyl]-piperazine HCl (TFMPP), a 5-HT1B receptor agonist, reduced in a dose-related manne

22 that intra-tegmental infusion of CP 94253, a 5-HT1B receptor agonist, significantly prolonged the eff

23 The 5-HT1B receptor agonists 5-methoxy-3-1,2,3,6-tetrahydro-

24 phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reaction

25 Finally, the 5-HT1B receptor agonists that blocked synaptic transmiss

26 Overexpression of 5-HT1B receptors also shifted the dose-response curve fo

27 The rat 5-HT1B receptor (also referred to as the 5-HT1D beta rec

28 of Galphai1 increase agonist binding to the 5-HT1B receptor and receptor stimulation of GTPgammaS bi

29 Furthermore, although both 5-HT1B receptor and serotonin transporters are found in

30 n pulmonary hypertension and explain how the 5-HT1B receptor and SERT are codependent in regulating S

31 Gi1 can interact with the 5-HT1B receptor and stabilize a high affinity agonist bi

32 tatin anorectic response may be modulated by 5-HT1B receptors and that a neuronal pathway from the am

33 ffinity (Ki = 17 nM) at its species homolog, 5-HT1B receptors, and at a mutant 5-HT1D beta receptor (

34 Finally, the 5-HT1B receptor antagonist NAS-181 increased the STN-tri

35 Co-infusion of the 5-HT1B receptor antagonist SB 216641 (10 microM), but no

36 microscopic immunocytochemical analysis with 5-HT1B receptor antibodies and whole-cell patch-clamp re

37 In these neurons, 5-HT1B receptors are expressed presynaptically, and thei

38 5-HT1B receptors are inhibitory GPCRs located on the pre

39 p11 increases localization of 5-HT1B receptors at the cell surface.

40 suggest that blockade and activation of VTA 5-HT1B receptors attenuates and potentiates the neuroche

41 pharmacological interventions to interrogate 5-HT1B receptor binding and function and determined bloo

42 usion and examined for 5-HT afferents to and 5-HT1B receptor-containing neuronal puncta and somata in

43 s in vivo and demonstrate that activation of 5-HT1B receptors contributes to the cellular responses e

44 ng sequence in Galphat either permitted full 5-HT1B receptor coupling to the chimera (Chi24) or only

45 ions within Chi22 (K300Q and L304E) restored 5-HT1B receptor coupling, and again the effects of the t

46 tagonistic drug characteristics and on local 5-HT1B receptor density.

47 th the structure of the 5-HT2B receptor, the 5-HT1B receptor displays a 3 angstrom outward shift at t

48 nity shift of 5-HT1A receptors compared with 5-HT1B receptors (EC50 values of 6.4 and 12.0 nM, respec

49 Simultaneous activation of 5-HT1A and 5-HT1B receptors effectively blocks L-DOPA-induced dyski

50 The 5-HT1A and 5-HT1B receptors exhibited both high- and low-affinity s

51 escending 5-HT neurons and to be mediated by 5-HT1B receptors expressed by AADC cells.

52 Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates cert

53 rinergic receptor-mediated inhibition of CHO/5-HT1B receptor function was blocked when 5-HT2A recepto

54 ion of 5-HT2A receptors had no effect on CHO/5-HT1B receptor function, although 5-HT2A receptor-media

55 Null mutant mice lacking the 5-HT1B receptor gene (5-HT1B-/-) have been developed tha

56 arch has focused on the 5-HT1A receptor, the 5-HT1B receptor has a lesser known role in modulating em

57 5-HT1B receptor immunostaining was observed associated w

58 an induce pulmonary vasoconstriction via the 5-HT1B receptor in man.

59 Here we show that serotonin 5-HT1B receptors in cholecystokinin (CCK) inhibitory int

60 as designed to assess the involvement of VTA 5-HT1B receptors in mediating the stimulatory effects of

61 Thus, increased expression of 5-HT1B receptors in NAcc efferents, probably in the term

62 viral-mediated gene transfer to overexpress 5-HT1B receptors in NAcc projections to VTA.

63 GFP injection induced elevated expression of 5-HT1B receptors in neuronal fibers in VTA and increased

64 by examining the subcellular localization of 5-HT1B receptors in the mouse SCN using electron microsc

65 For example, serotonin actions at 5-HT1B receptors in the ventral tegmental area (VTA) mod

66 als in SNr, indicating a primary role of the 5-HT1B receptors in these axon terminals.

67 that cocaine acts as an indirect agonist of 5-HT1B receptors in vivo and demonstrate that activation

68 receptor antagonist, GR127935, to antagonize 5-HT1B receptors in vivo.

69 The results suggest that activation of VTA 5-HT1B receptors increases mesolimbic DA neuron activiti

70 gic inputs that are inhibited by presynaptic 5-HT1B receptors; inhibition of excitatory synapses onto

71 s, whereas serotonin (5-HT) acting through a 5-HT1B receptor inhibits aggressive responding.

72 serotonin 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] interacts with p11.

73 results thus demonstrate that stimulation of 5-HT1B receptors is required for fenfluramine-induced an

74 To test the hypothesis that stimulation of 5-HT1B receptors is required for the anorectic effect of

75 ts are in opposition to recent findings with 5-HT1B receptor knock-out mice and may have important on

76 in inhibiting light-induced phase shifts in 5-HT1B receptor knock-out mice.

77 induced phase shifts was also examined using 5-HT1B receptor knock-out mice.

78 alterations in 5-HT afferent innervation and 5-HT1B receptor localization were observed throughout th

79 s as a result of activation of 5-HT1A and/or 5-HT1B receptors located on presynaptic terminals.

80 he circadian system by acting at presynaptic 5-HT1B receptors located on retinal axons in the SCN.

81 he lack of 5-HT2A mediated regulation of CHO/5-HT1B receptors may be due to activation of a third pat

82 reductions found in this study suggest that 5-HT1B receptors may contribute to the etiology or expre

83 5-HT1A agonist (8-OH-DPAT), indicating that 5-HT1B receptors mediate the inhibition of EPSCs.

84 residues within this domain are critical for 5-HT1B receptor-mediated G protein activation.

85 n SNr GABA neurons, indicating a presynaptic 5-HT1B receptor-mediated inhibition of glutamate release

86 ay be associated, at least in part, with the 5-HT1B receptor-mediated inhibition of VTA GABA release.

87 5-HT1B receptor-mediated presynaptic inhibition has been

88 ells, 5-hydroxytryptamine (5-HT)1B-like (CHO/5-HT1B) receptor-mediated inhibition of forskolin-stimul

89 ences aggressive behavior, a distinct set of 5-HT1B receptors modulates impulsive behavior during adu

90 as, with bLRs having greater 5-HT1A, but not 5-HT1B, receptor mRNA levels in the septum, hippocampus

91 One possibility is that 5-HT1B receptors on the terminals of GABAergic projectio

92 Our results suggest that the 5-HT1B receptor participates in the regulation of ethano

93 diates 5-HT2C receptor regulation of the CHO/5-HT1B receptor pathway.

94 idence suggests that 5-hydroxytriptamine-1B (5-HT1B) receptors play a role in modifying ethanol's rei

95 its to membranes expressing either 5-HT1A or 5-HT1B receptors shifted the majority of the receptors t

96 h serotonin receptor 1B (5-HTR1B), modulates 5-HT1B receptor signal transduction, and is required for

97 Together, these findings indicate that 5-HT1B receptor stimulation facilitates the reinforcing

98 odulating signaling through 5-HT4 as well as 5-HT1B receptors supports the concept that this protein

99 ity requires activation of nucleus accumbens 5-HT1B receptors, the blockade of which prevents social

100 act in concert to mediate the ability of the 5-HT1B receptor to couple specifically to inhibitory G p

101 of the ability of the 5-hydroxytryptamine1B (5-HT1B) receptor to discriminate between G protein heter

102 bilities of the Galphat/Galphai1 chimeras to 5-HT1B receptors using high affinity agonist binding and

103 Functional coupling to 5-HT1B receptors was assessed by 1) [35S]GTPgammaS bindi

104 e contribution of the 5-hydroxytryptamine1B (5-HT1B) receptor, we studied the induction of the immedi

105 rcing effects and voluntary intake, and that 5-HT1B receptors within the ventral tegmental area (VTA)

106 dy was designed to assess the involvement of 5-HT1B receptors within the ventral tegmental area (VTA)