ライフサイエンスコーパス: 5-HT2 receptor

1 cently been unveiled and is mediated through 5-HT2 receptor.

2 can be induced by intermittent activation of 5-HT2 receptors.

3 ors, they overlap in their agonist action at 5-HT2 receptors.

4 involved in agonist binding in the serotonin 5-HT2 receptors.

5 lower affinity than the corresponding 1a at 5-HT2 receptors, 3a and 3b had significantly greater aff

6 The role of serotonin 5-HT2 receptors (5-HT2R) in the discriminative stimulus

7 In other brain regions, 5-HT2 receptors (5-HT2R) modify synaptic transmission di

8 and developmental profile of 5-HT(1A-1D) and 5-HT2 receptors, 5-HT1A receptors, and the serotonin (5-

9 ynaptic, slow-onset inhibition attributed to 5-HT2 receptor activation exciting GABAergic interneuron

10 ith a role in facilitating tonic inhibition, 5-HT2 receptor activation increased the frequency of spo

11 at require the following: Gq-protein-coupled 5-HT2 receptor activation, new BDNF synthesis, and MEK/E

12 striatum elicited by MDMA appears to involve 5-HT2 receptor activation.

13 Episodic spinal serotonin-2 (5-HT2) receptor activation on or near phrenic motor neur

14 are primarily responsible for the effects of 5-HT2 receptor-active drugs on lordosis behavior.

15 t cholinergic interneurone firing, while the 5-HT2 receptor agonist alpha-methyl-5-HT (30 microm) mim

16 The 5-HT2 receptor agonist alpha-methyl-5-HT reduced the sAH

17 The nonselective 5-HT2 receptor agonist mCPP (0.0, 0.3, 1.0, or 3.0 mg/kg

18 Pretreatment of ganglia with the 5-HT2 receptor agonist R-(+)-dimethoxy-4-iodoamphetamine

19 Both the 5-HT2 receptor agonist, alpha-methylserotonin (100 micro

20 Recently, it has been reported that 5-HT2 receptor agonists effectively reduce intraocular p

21 Serotonin 5-HT2 receptor agonists have recently been shown to be e

22 ioral toxicity associated with non-selective 5-HT2 receptor agonists, targeting the 5-HT2C receptor m

23 a-methylserotonin, a nonselective agonist of 5-HT2 receptors, also blocked polysynaptic responses but

24 potent full agonist with selectivity for the 5-HT2 receptor and is anticipated to serve as a useful t

25 s a useful tool in exploring the role of the 5-HT2 receptor and its effector system in controlling in

26 itro at dopamine D2 and serotonin 5-HT1a and 5-HT2 receptors and in vivo for their ability to antagon

27 vary cell lines expressing each of the human 5-HT2 receptors and in vivo in animal models of obesity.

28 staminergic (H3) and serotonergic (5-HT1 and 5-HT2) receptors, and sigma binding sites.

29 A combination of a 5-HT2 receptor antagonist and TXA2 synthase inhibitor/re

30 Consistently, the 5-HT2 receptor antagonist ketanserin (10 microm) fully b

31 Similar treatment with the 5-HT2 receptor antagonist ketanserin (3 microM) had no s

32 ged increase in MPC phospho-ERK, whereas the 5-HT2 receptor antagonist ketanserin (3-[2-[4-(4-fluorob

33 Pretreatment with the select 5-HT2 receptor antagonist Ketanserin blocked DOI-induced

34 opamine receptor antagonist SCH 23390 or the 5-HT2 receptor antagonist ketanserin.

35 TXA2 on SMC proliferation was abolished by a 5-HT2 receptor antagonist, LY281067, without affecting t

36 PAG), and that such effects are blocked by a 5-HT2 receptor antagonist.

37 e reuptake inhibitor, but a potent serotonin 5-HT2 receptor antagonist.

38 ological roles of serotonin in tissues where 5-HT2 receptors are co-expressed.

39 Since 5-HT2 receptors are known to utilize protein kinase C (P

40 5-HT2 receptors are potential candidates because activat

41 sport into platelets and decreased serotonin 5-HT2 receptor binding.

42 agonists with greater affinity for D2 DA and 5-HT2 receptors, blocked the development of locomotor se

43 he rhythmic activity of olivary neurones via 5-HT2 receptors by inhibition of the T-type calcium curr

44 ory control on cholinergic interneurones via 5-HT2 receptors, by suppressing the AHPs associated with

45 These data demonstrate that 5-HT2 receptors can form functionally asymmetric heterod

46 We report that 5-HT2 receptors can form homo- and heterodimers when exp

47 cted ligands for the examined members of the 5-HT2 receptor class.

48 ation (LTF) is characterized by a persistent 5-HT2 receptor-dependent increase in respiratory motor o

49 [3H]Ketanserin binding to cortical 5-HT2 receptors did not differ among the lines, except i

50 Expression of 5-HT2 receptors did not increase binding of JCPyV to cel

51 s, supporting the physiological relevance of 5-HT2 receptor heterodimerization in vivo Accordingly, e

52 suggesting a relationship between IL-1RI and 5-HT2 receptors in the medial hypothalamus that is consi

53 anatomical relationship between IL-1beta and 5-HT2 receptors in the medial hypothalamus.

54 Furthermore, stimulation of 5-HT2 receptors increases the phosphorylation state of S

55 demonstrate that GLYX-13 does not influence 5-HT2 receptor induced head twitch response or impulsivi

56 splacement of radioligand from rat and human 5-HT2 receptors, making it one of the most potent halluc

57 This data suggests that the 5-HT2 receptor-mediated depolarization and increase in R

58 serotonergic facilitation of TRPV1 function; 5-HT2 receptor-mediated facilitation was also inhibited

59 al motoneurones as a result of activation of 5-HT2 receptors, microinjection of 5-HT2 antagonists int

60 erotonin (5-Hydroxytryptamine, 5-HT) and the 5-HT2 receptor modulate cardiovascular and autonomic fun

61 herefore, supports a pronociceptive role for 5-HT2 receptors, most likely through modulation of 5-HT2

62 In myometrium, 5-HT2 receptors not only play a role in contraction but

63 AADC cells, together with an upregulation of 5-HT2 receptors, offers a partial explanation of hyperre

64 on: indirect inhibition mediated through the 5-HT2 receptors on GABAergic interneurons and direct inh

65 ffects may also be linked to the presence of 5-HT2 receptors on the same groups of neurons in this re

66 e indole nucleus of tryptamines that bind to 5-HT2 receptor subtypes and possess LSD-like behavioral

67 tention that within the VMN, both 5-HT1A and 5-HT2 receptor subtypes contribute to the modulation of

68 The differences in the 5-HT2 receptor synaptic and behavioral responses may be

69 a greater affinity for 5-hydroxytryptamine2 (5-HT2) receptors than for D2 dopamine receptors; its eff

70 ults suggest that serotonin acts at separate 5-HT2 receptors to facilitate the acquisition and expres

71 neonatal 6-OHDA lesions involves coupling of 5-HT2 receptors to the ERK1/2/MAP Kinase cascade, a path

72 6-OHDA lesions result in a novel coupling of 5-HT2 receptors to the ERK1/2/MAP Kinase pathway, a sign

73 HT release or direct stimulation of striatal 5-HT2 receptors via the 5-HT2 agonist DOI, produced robu

74 q-coupled M3-muscarinic, thromboxane-A2, and 5-HT2 receptors was desensitized in airway smooth muscle

75 ut effect at 5-HT7 but has high affinity for 5-HT2 receptors, was also effective in attenuating the p

76 Only 5-HT2 receptors were found to support infection by JCPyV

77 leus, but became critical when alpha1 NE and 5-HT2 receptors were pharmacologically blocked.

78 cal methods to demonstrate that IL-1beta and 5-HT2 receptors were present on the same neurons within

79 These include the 5-HT2 receptor, which is further sub classified into 5-H

80 Most emphasis has been placed on 5-HT1A and 5-HT2 receptors, which inhibit and facilitate the behavi

81 whether pharmacological treatments targeting 5-HT2 receptors would alter the acquisition and expressi