ライフサイエンスコーパス: 5-HTP

1 5-HTP treatment gradually reduced the rhythmicity of the

2 Increased [11C]5-HTP influx rate was observed in the amygdala, raphe nu

3 The influx rate of [11C]5-HTP as a measure of serotonin synthesis rate capacity

4 n [SD] age, 34.7 [9.2] years) underwent [11C]5-HTP PET imaging.

5 Adjunct 5-HTP IR could not produce this therapy-like profile, pr

6 data, our mouse data suggest that an adjunct 5-HTP SR drug could safely and effectively elevate 5-HTE

7 In both lines of mice, adjunct 5-HTP SR synergized with SSRI to elevate 5-HTExt beyond

8 We tested adjunct 5-HTP SR in wild-type mice and in mice with low brain 5-

9 Small pilot trials suggest that adjunct 5-HTP can confer antidepressant response in treatment-re

10 After 5-HTP treatment, microvoltammetric measurements indicate

11 ere may be additional regulation that allows 5-HTP to accumulate to varying levels.

12 study measured the activities of L-DOPA and 5-HTP decarboxylase (DDC and 5-HTPDC) in the substantia

13 the inhibition of N-methyltransferase blocks 5-HTP-induced head twitches in betaarr2-KO mice, indicat

14 The PET tracer (11)C-5-HTP can be used for quantitative imaging of the seroto

15 Pancreatic uptake of (11)C-5-HTP in nonhuman primates was markedly decreased by inh

16 yme dopa decarboxylase, which converts (11)C-5-HTP to (11)C-serotonin and increased after inhibition

17 T tracer (11)C-5-hydroxy-l-tryptophan ((11)C-5-HTP).

18 Uptake of (11)C-5-HTP, and its specificity for key enzymes in the seroto

19 In rat, hepatic uptake of [(11)C]5-HTP correlated with the number of transplanted islets.

20 ion (66%) in the pancreatic uptake of [(11)C]5-HTP in T1D subjects was observed, and this was most ev

21 Accumulation of [(11)C]5-HTP in the pancreas of both HVs and subjects with T1D

22 tal islet graft (n = 8) underwent two [(11)C]5-HTP PET and MRI examinations 8 months apart.

23 [(11)C]5-HTP retention in the pancreas was reduced in T1D compa

24 n the beta-cell volume, implying that [(11)C]5-HTP retention is a useful noninvasive surrogate marker

25 oncept study, the ex vivo and in vivo [(11)C]5-HTP signal was compared with the number of islets tran

26 The endocrine marker [(11)C]5-HTP thus shows a correlation between hepatic uptake an

27 his was not mirrored by a decrease in [(11)C]5-HTP tracer accumulation in the pancreas.

28 The primary outcome was the [(11)C]5-HTP uptake and retention in pancreas, as a surrogate m

29 A significant accumulation of [(11)C]5-HTP was obtained in the pancreas of the HVs, with larg

30 T) marker [(11)C]5-hydroxytryptophan ([(11)C]5-HTP) for this purpose.

31 [(11)C]5-hydroxy-tryptophan ([(11)C]5-HTP) positron emission tomography of the pancreas has

32 recursor [(11)C]5-hydroxy-tryptophan ([(11)C]5-HTP).

33 5-HTP immediate release (IR) likely curtail 5-HTP IR's antidepressant potential.

34 In contrast, the morphine treatment enhances 5-HTP accumulation in dorsal raphe nucleus, cortex and c

35 with the 5-HT precursor 5-hydroxytryptophan (5-HTP) elevates 5-HTExt beyond the SSRI effect.

36 vivo of accumulation of 5-hydroxytryptophan (5-HTP) in tissue from the dorsal and median raphe nuclei

37 Accumulation of 5-hydroxytryptophan (5-HTP) in vivo, in the presence of the aromatic amino ac

38 the serotonin precursor 5-hydroxytryptophan (5-HTP) increased the intensity of serotonin immunolabeli

39 iate precursor of 5-HT, 5-hydroxytryptophan (5-HTP), in two model opisthobranch molluscs, the nudibra

40 and after injection of 5-hydroxytryptophan (5-HTP).

41 that SR delivery will substantially improve 5-HTP's drug properties, by minimizing adverse effects a

42 Sound stress increases 5-HTP accumulation in median raphe nucleus, hippocampus,

43 s indicated EcN also increases intracellular 5-HTP and reduces 5-HIAA.

44 We modeled 5-HTP SR with minipumps, 5-HTP IR with injections, and chronic SSRI with dietary

45 We modeled 5-HTP SR with minipumps, 5-HTP IR with injections, and c

46 pletely blocked the enhanced accumulation of 5-HTP, but had no effect on basal accumulation of 5-HTP,

47 , but had no effect on basal accumulation of 5-HTP, except at the highest doses of 1.0 or 3.3 nmol, w

48 The intensity of 5-HTP immunolabeling varied between cell types and was c

49 The overall intensity of 5-HTP immunoreactivity in individual ganglia agreed with

50 onergic neurons also displayed low levels of 5-HTP immunolabeling that were above background levels.

51 ssed rats had significantly higher levels of 5-HTP in cortex and midbrain compared to sham-stressed c

52 esults support the notion that production of 5-HTP is a rate-limiting step in serotonin synthesis and

53 ined effects of sound stress and morphine on 5-HTP accumulation are identical to those obtained by ea

54 y of the components of this cascade prevents 5-HTP-induced, but not N-methyltryptamine-induced, head

55 Specific 5-HTP immunoreactivity was colocalized with serotonin in

56 rapid absorption and elimination of standard 5-HTP immediate release (IR) likely curtail 5-HTP IR's a

57 HPLC measurements showed that 5-HTP is present at approximately the same level as the

58 Serotonin and 5-hydroxy-L-tryptophan (5-HTP) induce a head-twitch response in wild-type (WT) m