ライフサイエンスコーパス: 5-HTTLPR

1 onin transporter gene promoter polymorphism (5-HTTLPR).

2 HTT gene has a biallelic insertion/deletion (5-HTTLPR).

3 tonin transporter linked polymorphic region (5-HTTLPR).

4 ene polymorphism within the promoter region (5-HTTLPR).

5 ter-linked polymorphic region indel known as 5-HTTLPR.

6 f symptoms distinct from those influenced by 5-HTTLPR.

7 as the SLC6A4 promoter region polymorphism, 5-HTTLPR.

8 tonin transporter-linked polymorphic region (5-HTTLPR), a common functional polymorphism located in t

9 To evaluate whether 5-HTTLPR, a functional promoter polymorphism of the sero

10 ne expression levels by 15-80%, depending on 5-HTTLPR allele background and cell type.

11 reduction in FA values among low-expressing 5-HTTLPR allele carriers may contribute to biased regula

12 s with at least 1 copy of a less-transcribed 5-HTTLPR allele reported a greater increase in depressiv

13 However, the long 5-HTTLPR allele, and not the short allele or the heteroz

14 suicide and examine the relationship to the 5-HTTLPR allele.

15 association between number of low-expressing 5-HTTLPR alleles and FA values for the left frontal UF r

16 ort, we identify and characterize three rare 5-HTTLPR alleles not previously described in the human l

17 We found that although the STin2 variant and 5-HTTLPR alone did not associate with increased PTSD sym

18 inking day and percentage of days abstinent, 5'-HTTLPR and rs1042173 variants interacted significantl

19 gs indicate that the association between the 5-HTTLPR and amygdala activation is smaller than origina

20 802 European ancestry subjects genotyped for 5-HTTLPR and assessed for depression and childhood maltr

21 experimental neuroscience studies about the 5-HTTLPR and biological phenotypes relevant to the human

22 ents homozygous for the short allele (SS) of 5-HTTLPR and exposed to CA were worse at classifying neg

23 the 5-HTTLPR multimarker genotype (combined 5-HTTLPR and rs25531) were associated with significantly

24 -analyses to examine the associations of the 5-HTTLPR and STin2 polymorphisms with substance use diso

25 ong-term medical conditions, variants of the 5-HTTLPR and STin2 VNTR polymorphisms of SERT have been

26 easured by education, and two polymorphisms (5-HTTLPR and STin2 VNTR) of the serotonin transporter ge

27 The 5-HTTLPR and the STin2 VNTR, but not the rs25531, polymo

28 5-HT transporter (5-HTT) expression based on 5-HTTLPR and two additional single nucleotide polymorphi

29 rtion/deletion polymorphism in the promoter (5-HTTLPR) and a polymorphism in intron 2 are inconclusiv

30 er region of the serotonin transporter gene (5-HTTLPR) and exposure to early childhood adversities (C

31 onin protein gene (SLC6A4) promoter variant (5-HTTLPR) and risk of current PTSD in a sample of 590 pa

32 tonin transporter linked polymorphic region (5-HTTLPR) and stressful life events on an increased risk

33 an modify the associations between genotype (5-HTTLPR) and the neural mechanisms of selective attenti

34 ying, and genetic variation (alpha2A C1291G, 5-HTTLPR, and GNbeta3 C825T genotypes).

35 SLC6A4 polymorphisms STin2, 5-HTTLPR, and rs25531 were genotyped in 235 individuals.

36 tonin transporter-linked polymorphic region [5-HTTLPR]) and stressful life events (SLEs) has been ext

37 Because behaviors modulated by the 5-HTTLPR are a subset of those dependent on the VMPFC, a

38 ports the notion that allele variants of the 5-HTTLPR are associated with selective attention to nega

39 tic variants (COMT Val158Met, BDNF Val66Met, 5-HTTLPR) associated with hippocampal volume and a measu

40 a), previously behaviorally and genetically (5-HTTLPR) characterized, were monitored while they watch

41 Relevant attention bias and 5-HTTLPR data were extracted based on specific coding ru

42 However, a significant 5-HTTLPR effect on receptor binding at the 5-HT(1A) rece

43 ted that this association may be mediated by 5-HTTLPR effects on the response bias of the human amygd

44 llele, which replicates results from earlier 5-HTTLPR expression experiments.

45 enetic variant suggesting a specific role of 5-HTTLPR for the subiculum, BDNF Val66Met for CA4/dentat

46 s of life stressors (strong risk factor) and 5-HTTLPR genotype (no impact on risk) are strikingly con

47 ed published data on the association between 5-HTTLPR genotype (SS, SL, or LL), number of stressful l

48 Although the 5-HTTLPR genotype alone did not predict the onset of PTS

49 5-HTTLPR genotype and age appear to independently influe

50 There was a significant interaction between 5-HTTLPR genotype and both crime rate (odds ratio = 2.68

51 No association was found between 5-HTTLPR genotype and depression in any of the individua

52 y sample was carefully preselected regarding 5-HTTLPR genotype and SLEs.

53 atric illness, and to explore the effects of 5-HTTLPR genotype as well as amygdala reactivity on harm

54 The serotonin transporter 5-HTTLPR genotype has been found to moderate the effect

55 We found that 5-HTTLPR genotype influenced gray matter volumes of the

56 Therefore, we hypothesized that maternal 5-HTTLPR genotype influences the child's brain developme

57 Many studies have shown that 5-HTTLPR genotype interacts with exposure to stress in c

58 5-HTTLPR genotype moderates the effect of stress on brai

59 ata support the notion that variation in the 5-HTTLPR genotype modulates selective attention to negat

60 at social environment modifies the effect of 5-HTTLPR genotype on PTSD risk.

61 To examine the effects of 5-HTTLPR genotype on the reactivity of the human amygdal

62 Effect sizes of 5-HTTLPR genotype on total cortical and frontal lobe gra

63 ), a series of psychological traits, and the 5-HTTLPR genotype prior to internship and then assessed

64 The 5-HTTLPR genotype was associated with major depression b

65 The 5-HTTLPR genotype was not related to the level of 5-HTT

66 The interaction between diagnosis and 5-HTTLPR genotype was statistically significant for the

67 for which an interaction between stress and 5-HTTLPR genotype was statistically significant.

68 However, neither 5-HTTLPR genotype, amygdala reactivity, nor genotype-dri

69 Structural MRI, 5-HTTLPR genotype, and stress exposure questionnaire dat

70 epressive episode diagnosis was moderated by 5-HTTLPR genotype.

71 n among depression, platelet activation, and 5-HTTLPR genotype.

72 ltreatment and major depression according to 5-HTTLPR genotype.

73 tonin transporter-linked polymorphic region (5-HTTLPR) genotype status as a model for differences in

74 al factors, including serotonin transporter (5-HTTLPR) genotype.

75 s were stratified according to diagnosis and 5-HTTLPR genotypes and underwent TD on one test day and

76 Triallelic 5-HTTLPR genotypes were unrelated to serotonin transport

77 The authors hypothesized that 5-HTTLPR genotypes would be related to variation in spec

78 tween 5-HT(1A) receptor-specific binding and 5-HTTLPR genotypes.

79 transporter gene-linked polymorphic region (5-HTTLPR) has been associated with heightened neural act

80 ymorphism in the serotonin transporter gene (5-HTTLPR) has been reported to confer relative risk for

81 patients with rMDD, variations in triallelic 5-HTTLPR have a direct effect on regulation of regional

82 vel alleles were identified while genotyping 5-HTTLPR in a family-based attention deficit hyperactivi

83 support for genotype-specific phenotypes for 5-HTTLPR in autism based on ratings from the Autism Diag

84 Behavioral responses to TD are affected by 5-HTTLPR in patients with rMDD and controls.

85 These results imply the 5-HTTLPR in subcortical auditory speech encoding and add

86 cation may shed further light on the role of 5-HTTLPR in the development of anxiety disorders and in

87 A common regulatory variant (5-HTTLPR) in the human serotonin transporter gene (SLC6A

88 moderating effect of a genetic polymorphism (5-HTTLPR) in the serotonin transporter protein gene on t

89 interaction exists in which the S allele of 5-HTTLPR increases risk of depression only in stressed i

90 er region of the serotonin transporter gene (5-HTTLPR) influence transcription and may play a role in

91 The SLC6A4 promoter polymorphism 5-HTTLPR influences cerebral cortical gray matter volume

92 s of two functional polymorphisms of SLC6A4 (5-HTTLPR, intron 2 variable number tandem repeat [2 VNTR

93 tonin transporter-linked polymorphic region (5-HTTLPR) is associated with altered amygdala reactivity

94 e human serotonin transporter gene promoter (5-HTTLPR) is associated with anxiety and increased risk

95 In the depressed group, subjects with the 5-HTTLPR l/l genotype had significantly higher platelet

96 epressed patients, especially those with the 5-HTTLPR l/l genotype.

97 Rhesus monkeys possess a 5-HTTLPR length polymorphism similar to humans and serve

98 om these experiments demonstrate that innate 5-HTTLPR linked variation in dmPFC activity predicts psy

99 rised by the presence of the short allele of 5-HTTLPR (LL, LS, SS) and the presence or absence of exp

100 The authors previously reported that the 5'-HTTLPR-LL and rs1042173-TT (SLC6A4-LL/TT) genotypes i

101 onin transporter gene promotor polymorphism (5-HTTLPR) locus of SLC6A4 now exist.

102 beta3 TC/TT (Delta, approximately 6 kg), and 5-HTTLPR LS/SS (Delta, approximately 4.5 kg).

103 weight (both P < .002): in participants with 5-HTTLPR LS/SS with GNbeta3 TC/TT; Delta, approximately

104 As such, the 5-HTTLPR may represent a classic susceptibility factor f

105 The authors aimed to determine whether 5-HTTLPR moderates the effect of stress on brain gray ma

106 rther evidence that a genetic variant in the 5-HTTLPR moderates the link between childhood maltreatme

107 rter gene (locus, SLC6A4; variant, serotonin 5-HTTLPR) moderates risk of posthurricane PTSD and major

108 Variations in 5-HTTLPR modulate the sensitivity of patients with rMDD

109 ith increased PTSD symptoms, rs25531 and the 5-HTTLPR multimarker genotype (combined 5-HTTLPR and rs2

110 The association was most robust with the 5-HTTLPR multimarker genotype and avoidance symptoms (P

111 prior levels of child and adult trauma, the 5-HTTLPR multimarker genotype may serve as a useful pred

112 er region of the serotonin transporter gene (5-HTTLPR) offering equivocal findings.

113 lts reveal a potent modulatory effect of the 5-HTTLPR on amygdala reactivity to environmental threat.

114 directly examined the modulatory effects of 5-HTTLPR on corticolimbic circuit responses during expos

115 appear to be due to developmental effects of 5-HTTLPR on expression and not due to its direct effect

116 tatistically significant but small effect of 5-HTTLPR on left and right amygdala activity.

117 A direct effect of 5-HTTLPR on the regulation of regional cerebral metaboli

118 erotonin-transporter-linked promoter region (5-HTTLPR) on in vivo expression of serotonin transporter

119 of the serotonin transporter promoter gene (5-HTTLPR) on serotonin transporter binding using in vivo

120 an origin, were genotyped for the triallelic 5-HTTLPR polymorphism (higher expressing allele: L(A); l

121 existing data on the association between the 5-HTTLPR polymorphism and amygdala activation and ascert

122 The 5-HTTLPR polymorphism has been widely regarded as a pote

123 The 5-HTTLPR polymorphism in the promoter region of the sero

124 stronger than the effect of the well-studied 5-HTTLPR polymorphism in the serotonin transporter gene

125 The low-expression variant of the 5-HTTLPR polymorphism increased risk of posthurricane PT

126 The current study examined whether the 5-HTTLPR polymorphism is also associated with alteration

127 has been reported in humans, suggesting the 5-HTTLPR polymorphism may play a role in serotonin (5-HT

128 The low-expression variant of the 5-HTTLPR polymorphism modifies risk of postdisaster PTSD

129 Associations of the 5-HTTLPR polymorphism to clinical phenotypes appear to b

130 rs examined the relationship of a triallelic 5-HTTLPR polymorphism to stressful life events, severity

131 nalyses indicated that the "s" allele of the 5-HTTLPR polymorphism was associated with decreased risk

132 he depressed subjects were genotyped for the 5-HTTLPR polymorphism.

133 from 220 individuals were genotyped for the 5-HTTLPR polymorphism.

134 a 44-base-pair insertion or deletion in the 5-HTTLPR polymorphism.

135 ) female participants were genotyped for the 5-HTTLPR polymorphism.

136 rotonin transporter gene 5' promoter region (5-HTTLPR) polymorphism is reported to be associated with

137 erotonin-transporter-linked promoter region (5-HTTLPR) polymorphism may influence the degree of activ

138 s also failed to find an association between 5-HTTLPR polymorphisms and harm avoidance.

139 genotyped assessing biallelic and triallelic 5-HTTLPR polymorphisms.

140 erotonin-transporter-linked promoter region (5-HTTLPR), respectively.

141 The S A allele at the 5-HTTLPR/rs25531 locus is associated with increased suic

142 on increased suicidal risk was found for the 5-HTTLPR/rs25531 S A allele (p-value = 0.0046)- which di

143 that this association is primarily driven by 5-HTTLPR, rs25532 and rs16965628.

144 possibility that human females carrying the 5-HTTLPR s allele could be more vulnerable to the effect

145 Specifically, homozygous carriers of the 5-HTTLPR S' allele with a history of SLEs (S'S'/high SLE

146 Individuals with the 5-HTTLPR s/s genotype had 3-fold higher odds of PSD comp

147 possible association of the STin2 and/or the 5-HTTLPR serotonin transporter polymorphisms in adult ma

148 The hypothesis that the S allele of the 5-HTTLPR serotonin transporter promoter region is associ

149 The 5-HTTLPR short allele appeared to be additively associat

150 These findings show that 5-HTTLPR short allele carriers avoid risky and complex f

151 eat-related dmPFC activation was enhanced in 5-HTTLPR short allele carriers in sample 1 and this effe

152 analysis suggested that the presence of the 5-HTTLPR short allele decreased real life measures of fi

153 We now confirm the finding of 5-HTTLPR short allele-driven amygdala hyperreactivity in

154 gnostic Interview-Revised was found with the 5-HTTLPR short group of HTTLPR (S/L or S/S genotypes) be

155 serotonin transporter promoter polymorphism (5-HTTLPR) short allele was associated with neurovegetati

156 6 children who were all heterozygous for the 5-HTTLPR (sl) and who had mothers who were either homozy

157 tonin transporter linked polymorphic region (5-HTTLPR), stress sensitivity, and depression in humans;

158 he effects of the number of short alleles at 5-HTTLPR, the number of stressful life events, and their

159 n the promoter of the serotonin transporter, 5-HTTLPR, to the behavioral and neural responses to TD i

160 (high hurricane exposure, the low-expression 5-HTTLPR variant, low social support) were at 4.5 times

161 ) replicates research in adults showing that 5-HTTLPR variation moderates the development of depressi

162 The 5-HTTLPR was found to be associated with increased suici

163 The triallelic system of 5-HTTLPR was genotyped.

164 er region of the serotonin transporter gene (5-HTTLPR), we found that individuals possessing the shor

165 The effect sizes of 5-HTTLPR were comparable among the European, Asian, and

166 he meta-analyses support the associations of 5-HTTLPR with alcohol, heroin, cocaine, and methamphetam

167 s hemozygous for the short (s) allele at the 5-HTTLPR would be more susceptible to framing.

168 findings contribute to the ongoing debate on 5-HTTLPR x SLEs interaction and are discussed with respe

169 endocrine stress reactivity as a function of 5-HTTLPR x SLEs.