ライフサイエンスコーパス: 5-formyltetrahydrofolate

1 in pemetrexed activity in growth medium with 5-formyltetrahydrofolate.

2 n a complex with uridine monophosphate and N-5-formyltetrahydrofolate.

3 he conversion of methenyltetrahydrofolate to 5-formyltetrahydrofolate.

4 nversion of 5,10-methenyltetrahydrofolate to 5-formyltetrahydrofolate.

5 was catalytically inactive and did not bind 5-formyltetrahydrofolate.

6 rolysis of 5, 10-methenyltetrahydrofolate to 5-formyltetrahydrofolate.

7 loligase (5-FCL) catalyzes the conversion of 5-formyltetrahydrofolate (5-CHO-H(4)PteGlu(n)) to 5,10-m

8 thermodynamic parameters for the binding of 5-formyltetrahydrofolate (5-CHO-H4PteGlun) and its polyg

9 With 5-formyltetrahydrofolate (5-CHO-THF) as the folate sourc

10 istant L1210 clonal variant in which MTX and 5-formyltetrahydrofolate (5-CHO-THF) influx was markedly

11 5-Formyltetrahydrofolate (5-CHO-THF) is formed by a side

12 5-Formyltetrahydrofolate (5-CHO-THF) is formed via a sec

13 5-Formyltetrahydrofolate (5-formylTHF) is the only folat

14 s of the tight-binding dimer are occupied by 5-formyltetrahydrofolate (5-formylTHF), whose N5-formyl

15 Transport of 5-formyltetrahydrofolate (5-FTHF) into primary cultured

16 dministered unnatural carbon-6 isomers, (6R)-5-formyltetrahydrofolate (5-HCO-THF) and (6S)-5,10-methe

17 he respiration of mitochondria, whereas (6S)-5-formyltetrahydrofolate (5-HCO-THF) was inactive.

18 asured by 5-methyltetrahydrofolate (5MeTHF), 5-formyltetrahydrofolate (5FoTHF), and folic acid concen

19 forms of folates - 5-methyltetrahydrofolate, 5-formyltetrahydrofolate and 10-formyltetrahydrofolate -

20 THFS) is the only enzyme known to metabolize 5-formyltetrahydrofolate and catalyzes the conversion of

21 a approximately 50% decrease in the EC50 for 5-formyltetrahydrofolate and folic acid and the MTX IC50

22 roxymethyltransferase-catalyzed formation of 5-formyltetrahydrofolate, and 5, 10-hydroxymethylenetetr

23 AR resulted in augmentation of methotrexate, 5-formyltetrahydrofolate, and 5-methyltetrahydrofolate i

24 d E45K all 1) increased carrier affinity for 5-formyltetrahydrofolate approximately 4-fold, 2) increa

25 other antifolates in HepG2 cells grown with 5-formyltetrahydrofolate at physiological pH.

26 etrahydrofolate synthase (MTHFS; also called 5-formyltetrahydrofolate cyclo-ligase; EC 6.3.3.2) activ

27 5-Formyltetrahydrofolate cycloligase (5-FCL) catalyzes t

28 We have identified the 5-formyltetrahydrofolate cycloligase gene (FTL_0724) as

29 nd how much of a physiologic dose of [(13)C5]5-formyltetrahydrofolate delivered in a pH-sensitive ent

30 of [(3)H]5-methyltetrahydrofolate and [(3)H]5-formyltetrahydrofolate (di- through heptaglutamates).

31 ed transport, subsequent pemetrexed and (6S)-5-formyltetrahydrofolate export into the cytosol was mar

32 The folate derivative 5-formyltetrahydrofolate (folinic acid; 5-CHO-THF) was d

33 thenyltetrahydrofolate is hydrolyzed to only 5-formyltetrahydrofolate if reducing agents are present

34 ahydrofolate, 5'-methyltetrahydrofolate, and 5'-formyltetrahydrofolate in human plasma.

35 oxyl group of serine and the formyl group of 5-formyltetrahydrofolate in complexes of these species w

36 In order to address the function of 5-formyltetrahydrofolate in mammalian cells, intracellul

37 rganisms, the addition of p-aminobenzoate or 5-formyltetrahydrofolate in the external medium restored

38 drolysis of 5,10-methenyltetrahydrofolate to 5-formyltetrahydrofolate in vivo, and there is no requir

39 duce large quantities of folate, and [(13)C5]5-formyltetrahydrofolate infused during colonoscopy is a

40 These results suggest that 5-formyltetrahydrofolate inhibits serine hydroxymethyltr

41 The metabolic role of 5-formyltetrahydrofolate is not known; however, it is an

42 whereas folE thyA mutants supplemented with 5-formyltetrahydrofolate (lacking pterins and depleted i

43 ydrofolate in mammalian cells, intracellular 5-formyltetrahydrofolate levels were depleted in human 5

44 sent in mouse liver and kidney does not bind 5-formyltetrahydrofolate, nor does it oligomerize with t

45 ermined the effects of depleting cytoplasmic 5-formyltetrahydrofolate on cellular folate concentratio

46 the N terminus of slr0642) enabled growth on 5-formyltetrahydrofolate or folic acid but not on 5-form

47 A in the presence and absence of glycine and 5-formyltetrahydrofolate pentaglutamate.

48 that results from the binding of glycine and 5-formyltetrahydrofolate polyglutamate, a slow tight-bin

49 s replaced with the more physiological 25 nM 5-formyltetrahydrofolate, R5 cells were 2-fold collatera

50 and was purified from the culture medium by 5-formyltetrahydrofolate-Sepharose affinity chromatograp

51 R-luciferase mRNA binds to the cSHMT.glycine.5-formyltetrahydrofolate ternary complex with an apparen

52 ahydrofolate and catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolat

53 r that catalyzes the oxidative catabolism of 5-formyltetrahydrofolate to p-aminobenzoylglutamate and

54 myltetrahydrofolate or folic acid but not on 5-formyltetrahydrofolate triglutamate, demonstrating tha

55 Folic acid was a much better substrate, and 5-formyltetrahydrofolate was a poorer substrate for tran

56 c acid, (6S)5-methyltetrahydrofolate, or (6S)5-formyltetrahydrofolate was not detected.

57 ahydrofolate, 5'-methyltetrahydrofolate, and 5'-formyltetrahydrofolate were 1250, 400, and 360 pmol/L

58 e degradation in vitro with the exception of 5-formyltetrahydrofolate, which may be a storage form of

59 ze folinic acid (also known as leucovorin or 5-formyltetrahydrofolate), whose metabolic function rema