ライフサイエンスコーパス: 67Ga

1 However, a notable amount of accumulation of 67Ga also occurs, both in vitro and in vivo, by a transf

2 Hodgkin's lymphoma) patients underwent both 67Ga and 201Tl scintigraphy.

3 DTPA, 131I-albumin (HSA), 99mTc-nanocolloid, 67Ga and 99mTc-gluceptate were evaluated as in vivo cont

4 ficity of 3Auger electron emitters, (111)In, 67Ga, and 125I, and to evaluate beta-particle emitters,

5 The uptake of 67Ga, both as a citrate salt and as a gallium-transferri

6 eviously that normal soft tissues accumulate 67Ga by a transferrin-dependent route, but uptake by tum

7 strongly potentiates the cellular uptake of 67Ga by a transferrin-independent process.

8 en efforts to improve oncologic imaging with 67Ga by increasing the tumor activity, or by decreasing

9 o experiments demonstrate that the uptake of 67Ga by the transferrin-independent route can be enhance

10 ls in nude mice and comparisons of uptake of 67Ga by these tumors in vivo were made.

11 No pulmonary uptake occurred on 67Ga citrate scans (18 patients) and 111In-tagged leukoc

12 in the low-grade lymphoma group compared to 67Ga citrate.

13 -methylene diphosphonate (MDP) (3-5 mCi) and 67Ga-citrate (500 microCi), were performed starting at t

14 111In-DTPA, 131I-albumin, 99mTc-nanocolloid, 67Ga-citrate and 99mTc-gluceptate with an infection Imax

15 111In-DTPA, 131I-albumin, 99mTc-nanocolloid, 67Ga-citrate and 99mTc-gluceptate.

16 In control experiments, 67Ga-citrate exhibited tumor uptake of 2.2 +/- 0.4% of t

17 led liposomes also exhibited advantages over 67Ga-citrate for detection of acute osteomyelitis.

18 c mice with 45Ti-transferrin coinjected with 67Ga-citrate for direct comparison.

19 Single-photon imaging with 67Ga-citrate has been widely used for lymphomas.

20 cterize the patterns of hilar uptake (HU) on 67Ga-citrate imaging after cyclophosphamide, doxorubicin

21 The tumor-to-muscle ratio of the 67Ga-citrate reached 6.7 at 24 h, whereas the ratio of t

22 ditional combination of three-phase bone and 67Ga-citrate scintigraphy can be replaced by a single in

23 The biodistribution of 45Ti-transferrin and 67Ga-citrate showed similar trends.

24 Ga-DF-folate, 67Ga-deferoxamine (67Ga-DF) or 67Ga-citrate was administered by intravenous injection.

25 For 67Ga-citrate, several 111In compounds, 131I-MIBG and 201

26 , whereas bone uptake increased more for the 67Ga-citrate.

27 ellular uptake of [18F]holo-transferrin and [67Ga]citrate in various conditions, and washout of label

28 5 days, at which time either 67Ga-DF-folate, 67Ga-deferoxamine (67Ga-DF) or 67Ga-citrate was administ

29 Unconjugated 67Ga-deferoxamine showed no tumor affinity.

30 me either 67Ga-DF-folate, 67Ga-deferoxamine (67Ga-DF) or 67Ga-citrate was administered by intravenous

31 The 67Ga-DF-folate conjugate showed marked tumor-specific de

32 Tumor uptake of 67Ga-DF-folate conjugate was effectively blocked by co-i

33 67Ga-labeled deferoxamine-folate conjugate (67Ga-DF-folate) to target tumor cells in vivo was examin

34 20 g tumors in 15 days, at which time either 67Ga-DF-folate, 67Ga-deferoxamine (67Ga-DF) or 67Ga-citr

35 3 %ID/g for 45Ti and 8.72 +/- 0.98 %ID/g for 67Ga [%ID/g = percentage injected dose per gram]) and re

36 escent light strongly promotes the uptake of 67Ga in the cultured cells in a time-dependent and conce

37 f nuclear medicine scanning, especially with 67Ga, in the presumptive diagnosis and clinical manageme

38 Under these conditions, uptake of 67Ga is 1000-fold greater than basal levels and 50-fold

39 Neither 201Tl or 67Ga is dependable in the evaluation of low-grade lympho

40 of photodegraded nifedipine on the uptake of 67Ga is independent of expression of the transferrin rec

41 idity, the transferrin-independent uptake of 67Ga is significant and can be augmented to exceed trans

42 The in vivo uptake of 67Ga is significantly increased in tumors in which the t

43 ect of calcium channel blockers on uptake of 67Ga, it was observed that, after exposure to light (eit

44 The ability of a 67Ga-labeled deferoxamine-folate conjugate (67Ga-DF-fola

45 ignificant transferrin-independent uptake of 67Ga occurs both in vitro and in vivo.

46 Maximal uptake of 67Ga occurs when the cells are incubated for 30 min with

47 However, a negative 67Ga scan after therapy had a significantly lower predic

48 A positive 67Ga scan at the end of therapy is rarely seen in patien

49 After treatment, the 67Ga scan remained positive in four patients and was int

50 The negative predictive value of posttherapy 67Ga scan was 83.5% for all patients; however, when calc

51 Ten of the 43 patients (23%) had 67Ga scanning as a component of their diagnostic evaluat

52 Two of those 10 patients had serial 67Ga scanning performed to assess response to antibiotic

53 All patients underwent 67Ga scans at the time of diagnosis, near the end or jus

54 mong the remaining 97 patients with negative 67Ga scans, 16 patients relapsed, including five with st

55 The predictive value of 67Ga scans, as well as newer imaging studies, should be

56 Although 67Ga scintigraphy has been extensively used to evaluate

57 The difference between 201Tl and 67Ga sensitivity in patients with low-grade lymphoma on

58 in tumors can be imaged with tracers such as 67Ga, that mimic transferrin-mediated iron uptake.

59 The high potency of 67Ga, together with its low nonspecific toxicity, caused

60 Intense renal uptake of 67Ga, typically in the clinical setting of fever, progre

61 and of soluble (ionic) iron concentration on 67Ga uptake also was determined.

62 The effect of nifedipine on 67Ga uptake as a function of time, concentration, durati

63 to reconcile the differences with respect to 67Ga uptake as a function of tumor grade and type in the

64 for evaluating the mechanism and control of 67Ga uptake have significant limitations.

65 ors are variable in gallium-avidity, whether 67Ga uptake is a transferrin-independent or dependent pr

66 ial therapy for RPMP, resolution of abnormal 67Ga uptake over time may provide an objective endpoint

67 Light-shielded nifedipine has no effect on 67Ga uptake.

68 nifedipine to improve oncologic imaging with 67Ga warrants further investigation.

69 In all 10 patients, renal uptake of 67Ga was classified as intense.

70 ficant differences were found when 201Tl and 67Ga were compared in the intermediate, high or Hodgkin'

71 delivered disintegrations per cell, 131I and 67Ga were the most potent of the radionuclides tested, w

72 If the factors that control uptake of 67Ga were understood better, then efforts to improve onc