ライフサイエンスコーパス: 7-dehydrocholesterol

1 fluids as a result of P450 7A1 oxidation of 7-dehydrocholesterol.

2 rs of ecdysone biosynthesis, cholesterol and 7-dehydrocholesterol.

3 d in skin through ultraviolet irradiation of 7-dehydrocholesterol.

4 7-Dehydrocholesterol (7-DHC) is the most oxidizable lipi

5 Children with SLOS have elevated serum 7-dehydrocholesterol (7-DHC) levels and typically have l

6 ized by diminished cholesterol and increased 7-dehydrocholesterol (7-DHC) levels.

7 nts have decreased cholesterol and increased 7-dehydrocholesterol (7-DHC) levels.

8 A mammalian analog of ergosterol, 7-dehydrocholesterol (7-DHC), accumulates in Smith-Lemli

9 n with standard, the identity of this ion is 7-dehydrocholesterol (7-DHC), an immediate dehydrogenate

10 radical chain oxidation of highly oxidizable 7-dehydrocholesterol (7-DHC), initiated by 2,2'-azobis(4

11 The mechanism of free radical oxygenation of 7-dehydrocholesterol (7-DHC), one of the biologically im

12 d adrenals produced robust transformation of 7-dehydrocholesterol (7-DHC; precursor to cholesterol an

13 d an accumulation of its metabolic precursor 7-dehydrocholesterol (7DHC) in developing tissues.

14 hether novel pathways of vitamin D3 (D3) and 7-dehydrocholesterol (7DHC) metabolism initiated by CYP1

15 in the Kandutsch-Russell pathway, converting 7-dehydrocholesterol (7DHC) to cholesterol.

16 ions in DHCR7, which impair the reduction of 7-dehydrocholesterol (7DHC) to cholesterol.

17 The vitamin D precursor, 7-dehydrocholesterol (7DHC), was significantly lower in

18 urprisingly ergosterol, a fungal sterol, and 7-dehydrocholesterol, a sterol present in elevated level

19 e potently reversed by crude lipid extracts, 7-dehydrocholesterol, and a recently identified DAF-12 s

20 In addition, we describe the metabolism of 7-dehydrocholesterol by CYP11A1 to a single product iden

21 After feeding BM 15.766, hepatic 7-dehydrocholesterol delta 7-reductase activity decrease

22 piperazin-4-yl]ethyl]-benzoic acid) inhibits 7-dehydrocholesterol delta 7-reductase activity, reduces

23 ed birth disorder caused by markedly reduced 7-dehydrocholesterol delta 7-reductase activity, the fin

24 reductase, lathosterol 5-dehydrogenase, and 7-dehydrocholesterol delta 7-reductase are down-regulate

25 tic pathway, lathosterol 5-dehydrogenase and 7-dehydrocholesterol delta 7-reductase, were measured.

26 pathway catalyzed by the microsomal enzyme, 7-dehydrocholesterol-delta 7-reductase.

27 , lovastatin, and BM 15.766, an inhibitor of 7-dehydrocholesterol delta7-reductase, and were compared

28 unable to produce cholesterol and accumulate 7-dehydrocholesterol (DHC) in serum and tissue.

29 e catalyzes the conversion of lathosterol to 7-dehydrocholesterol in the next to last step of cholest

30 old increase of the 27-hydroxy metabolite of 7-dehydrocholesterol in the plasma of children with Smit

31 The content of the vitamin D(3) precursor 7-dehydrocholesterol in the skin of obese and nonobese s

32 Solar ultraviolet B photons are absorbed by 7-dehydrocholesterol in the skin, leading to its transfo

33 in the pathway, lead to the accumulation of 7-dehydrocholesterol in tissues and fluids of SLOS patie

34 ncentrations reduced 25%, and the precursor, 7-dehydrocholesterol, increased to represent 71% of the

35 The finding that 7-dehydrocholesterol is a precursor of 7-ketocholesterol

36 7-Dehydrocholesterol is highly reactive, giving rise to

37 holesterol (k(p)= 11 +/- 2 M(-1) s(-1)), and 7-dehydrocholesterol (k(p)= 2260 +/- 40 M(-1) s(-1)).

38 d or lovastatin could reduce elevated plasma 7-dehydrocholesterol levels induced by BM 15.766.

39 ces plasma cholesterol levels, and increases 7-dehydrocholesterol levels to reproduce the biochemical

40 ls and a marked increase of serum and tissue 7-dehydrocholesterol levels.

41 The oxidation of 7-dehydrocholesterol occured with predominant formation

42 he consequences of the extreme reactivity of 7-dehydrocholesterol on human health is the focus of a c

43 The mechanism of 7-dehydrocholesterol oxidation to 7-ketocholesterol is p

44 Mutations in the gene for Delta(7)-dehydrocholesterol reductase (Delta(7)-reductase), wh

45 shed by a strong and selective inhibition of 7-dehydrocholesterol reductase (7-DHCR, EC 1.3.1.21), an

46 rol reductase (C14SR, also known as TM7SF2), 7-dehydrocholesterol reductase (DHCR7) and 24-dehydrocho

47 7-Dehydrocholesterol reductase (DHCR7) is the terminal e

48 pitz syndrome (SLOS) is caused by defects in 7-dehydrocholesterol reductase (DHCR7), an enzyme cataly

49 encoding the cholesterol biosynthetic enzyme 7-dehydrocholesterol reductase (DHCR7).

50 fferent autosomal recessive mutations of the 7-dehydrocholesterol reductase gene leading to deficient

51 Since a defect of 7-dehydrocholesterol reductase is associated with Smith-

52 1790349, located in DHCR7, the gene encoding 7-dehydrocholesterol reductase that synthesizes choleste

53 Mutations within the gene encoding 7-dehydrocholesterol reductase, the last enzyme in the p

54 sterol levels dropped 75% and the precursor, 7-dehydrocholesterol rose substantially.

55 reductase that synthesizes cholesterol from 7-dehydrocholesterol; rs6599638 in the region harboring

56 d with various sterols, only desmosterol and 7-dehydrocholesterol supported internalization.

57 76% and was associated with a marked rise of 7-dehydrocholesterol that could be almost entirely preve

58 esterol have been established, we found that 7-dehydrocholesterol (the immediate precursor of cholest

59 free radical propagation rate constants, and 7-dehydrocholesterol, the immediate biosynthetic precurs

60 nd relative plasma cholesterol, but not with 7-dehydrocholesterol, the immediate precursor, confirmin

61 aenoate (20:5), docosahexaenoate (22:6), and 7-dehydrocholesterol to be 115 +/- 7, 145 +/- 8, 172 +/-

62 y rat liver microsomes, of the conversion of 7-dehydrocholesterol to cholesta-5,8-dien-3 beta-ol is a

63 an enzyme responsible for the conversion of 7-dehydrocholesterol to cholesterol in the last step of

64 The conversion of 7-dehydrocholesterol to cholesterol is the last reaction

65 tase gene leading to deficient conversion of 7-dehydrocholesterol to cholesterol, the RSH (so-called

66 ations of DHCR7 that impair the reduction of 7-dehydrocholesterol to cholesterol.

67 olet B light we found that the conversion of 7-dehydrocholesterol to previtamin D3 was reduced in chi

68 7A1 converted lathosterol (Delta(5)-dihydro-7-dehydrocholesterol) to a mixture of the 7-keto and 7al

69 In some experiments, cholesterol or 7-dehydrocholesterol was incorporated into the lipid mix

70 Ampoules containing 7-dehydrocholesterol were exposed to a LED that emitted

71 containing 7-8 double bonds (lathosterol and 7-dehydrocholesterol) were better raft stabilizers than