ライフサイエンスコーパス: 7-hydroxystaurosporine

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1 dulator tested in clinical trials is UCN-01 (7-hydroxystaurosporine).

2 n and enhanced with the checkpoint abrogator 7-hydroxystaurosporine.

3 n, ionizing radiation, hydrogen peroxide, or 7-hydroxystaurosporine.

4 We have reported that UCN-01 (7-hydroxystaurosporine) abrogates DNA damage-induced S a

5 tor, LY294002, and an Akt inhibitor, UCN-01 (7-hydroxystaurosporine), both synergistically sensitized

6 UCN-01 (7-hydroxystaurosporine), currently in clinical trials, h

7 UCN-01 (7-hydroxystaurosporine) is a cell-cycle checkpoint abrog

8 UCN-01 (7-hydroxystaurosporine) is a potent antitumor agent that

9 Akt pathway with the chemotherapeutic agent 7-hydroxystaurosporine prevented proliferation of vGPCR-

10 Inhibition of Chk1 kinase with 7-hydroxystaurosporine (UCN-01) abrogated the checkpoint

11 The investigational anticancer agent 7-hydroxystaurosporine (UCN-01) abrogates the G2 checkpo

12 checkpoint abrogator and Chk1/Chk2 inhibitor 7-hydroxystaurosporine (UCN-01) also increases camptothe

13 1 (Chk1) in synergistic interactions between 7-hydroxystaurosporine (UCN-01) and mitogen-activated pr

14 nificantly attenuated by two PKC inhibitors, 7-hydroxystaurosporine (UCN-01) and N,N,N-trimethylsphin

15 nted by the protein kinase C (PKC) inhibitor 7-hydroxystaurosporine (UCN-01) but not by the Cdc2 inhi

16 e.g., PD184352) and the checkpoint abrogator 7-hydroxystaurosporine (UCN-01) dramatically induces apo

17 r agent and protein kinase C (PKC) inhibitor 7-hydroxystaurosporine (UCN-01) induces apoptosis indepe

18 7-Hydroxystaurosporine (UCN-01) is a selective protein k

19 endent kinase and protein kinase C inhibitor 7-hydroxystaurosporine (UCN-01) potentiates the cytotoxi

20 with regard to the efficacy of drugs such as 7-hydroxystaurosporine (UCN-01) that abrogate S and G(2)

21 e to the pharmacological agents caffeine and 7-hydroxystaurosporine (UCN-01) that inhibit the checkpo

22 The addition of the Chk1 kinase inhibitor 7-hydroxystaurosporine (UCN-01) to F-ara-A-arrested S-ph

23 bryostatin 1 and the PKC and Chk1 inhibitor 7-hydroxystaurosporine (UCN-01) were compared with respe

24 The Chk1 inhibitor, 7-hydroxystaurosporine (UCN-01), overcomes both S and G(

25 ely inhibited by checkpoint activation since 7-hydroxystaurosporine (UCN-01), the specific Chk1 inhib

26 ented by the cell-cycle checkpoint abrogator 7-hydroxystaurosporine (UCN-01), which markedly potentia

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