ライフサイエンスコーパス: 9-cis-retinoic acid

1 en troglitazone was given with estradiol and 9-cis retinoic acid.

2 n the granulocytic pathway after exposure to 9-cis retinoic acid.

3 all-trans retinol, but not the stereo-isomer 9-cis retinoic acid.

4 ar diffusion barrier against fluorescein and 9-cis retinoic acid.

5 fect similar to that of triiodothyronine and 9-cis-retinoic acid.

6 transcription in response to the RXR ligand 9-cis-retinoic acid.

7 hat is activated by the vitamin A derivative 9-cis-retinoic acid.

8 of RXR were modestly enhanced by its ligand, 9-cis-retinoic acid.

9 regulates gene transcription in response to 9-cis-retinoic acid.

10 oid and similar to those for the pan-agonist 9-cis-retinoic acid.

11 hat is activated by the vitamin A metabolite 9-cis-retinoic acid.

12 rticipation of CRAD3 in the biogeneration of 9-cis-retinoic acid.

13 clear receptors for 1alpha,25(OH)(2)D(3) and 9-cis-retinoic acid.

14 to detect significant levels of all-trans or 9-cis retinoic acids.

15 roglitazone (2.7 A), felodipine (2.3 A), and 9-cis-retinoic acid (2.6 A) were determined to examine l

16 monolayers to fluorescein (20 microg/mL) and 9-cis retinoic acid (3 x 10(-4) M) were also determined.

17 We utilized [20-methyl-(3)H]-9-cis-retinoic acid ([(3)H]9-cis-RA) as a direct photoaf

18 We report that 9-cis retinoic acid (9-cis RA) and all trans retinoic ac

19 (PPs), 3,3',5-triiodo-L-thyronine (T3), and 9-cis retinoic acid (9-cis RA) induce hepatocyte prolife

20 leukemia line), because they were induced by 9-cis retinoic acid (9-cis RA) to differentiate towards

21 The effects of 13-cis RA, 9-cis retinoic acid (9-cis RA), and all-trans retinoic a

22 h efficacy and high potency equal to that of 9-cis-retinoic acid (9-c-RA).

23 a,25-dihydroxyvitamin D3 (1, 25-[OH]2D3) and 9-cis-retinoic acid (9-c-RA).

24 dy was conducted to evaluate the activity of 9-cis-retinoic acid (9-cis-RA) as an inhibitor of prosta

25 SCD mRNA expression was also increased by 9-cis-retinoic acid (9-cis-RA) as well as 4-(E-2-(5,6,7,

26 9-cis-retinoic acid (9-cis-RA) has shown potential chemo

27 In this study we demonstrate that 9-cis-retinoic acid (9-cis-RA) is a negative regulator o

28 ha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) and 9-cis-retinoic acid (9-cis-RA) ligands in the binding of

29 and synergistically activating RXRalpha with 9-cis-retinoic acid (9-cis-RA), a natural ligand binding

30 Here we have discovered that 9-cis-retinoic acid (9-cis-RA), a RXRalpha-specific liga

31 C) in combination with its obligate partner, 9-cis-retinoic acid (9-cis-RA), decreased surfactant pho

32 inding domain in the presence and absence of 9-cis-retinoic acid (9-cis-RA).

33 mediates stimulation of promoter activity by 9-cis-retinoic acid (9-cis-RA).

34 9-cis-Retinoic acid, 9-trans-retinoic acid, and MC1288,

35 olution structure of the TRalpha*T3:RXRalpha*9-cis retinoic acid (9c) ligand binding domain heterodim

36 cid (RA), all-trans retinoic acid (t-RA) and 9-cis retinoic acid (9c-RA).

37 amine the neurorestorative effect of delayed 9 cis retinoic acid (9cRA) treatment for stroke.

38 Wild-type RXR has an EC50 of 500 nM for 9-cis retinoic acid (9cRA) and an EC50 of >10 microM for

39 Two RXRalpha ligands, 9-cis retinoic acid (9cRA) and LG268, induced SUMOylatio

40 We have shown that 9-cis retinoic acid (9cRA) inhibits acinar differentiati

41 The effect of the endogenous metabolite 9-cis retinoic acid (9cRA) on allergic sensitization is

42 e chemopreventive efficacy of two retinoids, 9-cis-retinoic acid (9cRA) and 4-(hydroxyphenyl)retinami

43 tinoid X receptor (RXRalpha) is activated by 9-cis-retinoic acid (9cRA) and regulates transcription a

44 Previously, 9-cis-retinoic acid (9cRA) was defined as a potent RXR a

45 Although RXRs bind 9-cis-retinoic acid (9cRA) with high affinity, in vitro

46 is in multiple tissues, with abnormally high 9-cis-retinoic acid (9cRA), a pancreas autacoid that att

47 The all-trans-retinoic acid (atRA) isomer, 9-cis-retinoic acid (9cRA), activates retinoic acid rece

48 RXR, which is activated by 9-cis-retinoic acid (9cRA), can modulate several signali

49 XR), a nuclear receptor that is activated by 9-cis-retinoic acid (9cRA), can regulate transcription a

50 tive fashion by 22(R)-hydroxycholesterol and 9-cis-retinoic acid (9CRA), suggesting induction by nucl

51 nd RXRalpha LBDs complexed to the RXR ligand 9-cis-retinoic acid (9cRA), the PPARgamma agonist rosigl

52 The 9-cis-retinoic acid (9cRA)-inducible enhancer of the rat

53 vation of its heterodimeric partner RXR with 9-cis-retinoic acid (9cRA).

54 alpha LBD (T223-T462) with and without bound 9-cis-retinoic acid (9cRA).

55 Recently, 9-cis retinoic acid, a high affinity ligand for retinoic

56 , is affected by treatment of the cells with 9-cis retinoic acid, a treatment that activates the reti

57 In support of this hypothesis, we show that 9-cis-retinoic acid, acting through RXR, inhibits both t

58 9-cis-Retinoic acid activates retinoid X receptors, whic

59 ever, beta-apo-13-carotenone antagonized the 9-cis-retinoic acid activation of RXRalpha.

60 nes, but neither all-trans-retinoic acid nor 9-cis-retinoic acid affected reporter transcription.

61 9-cis-Retinoic acid (ALRT1057), a pan agonist retinoid t

62 g to the retinoic acid receptor (RAR), while 9-cis-retinoic acid also binds to the retinoid X recepto

63 elated retinoids all-trans-retinoic acid and 9-cis-retinoic acid also display slight agonist properti

64 The RXR agonist 9-cis-retinoic acid also increased Bcl2a1 expression, al

65 inol, as well as all-trans retinoic acid and 9-cis retinoic acid, also repressed HIV-1 long terminal

66 MO, tocopherol acetate, selenomethionine, or 9-cis-retinoic acid, although the effects on late-stage

67 with various concentrations of all-trans or 9-cis retinoic acid (an analogue of 11-cis retinoic acid

68 wing cotreatment with PPARgamma agonists and 9-cis-retinoic acid, an RXRalpha agonist.

69 glitazone and ciglitazone, is coactivated by 9 cis-retinoic acid and is inhibited by the PPARgamma an

70 The receptors for 9-cis retinoic acid and 1,25-dihydroxyvitamin D3 [1,25(O

71 inoic acid than control subjects but similar 9-cis retinoic acid and retinol levels.

72 ide evidence that potentiation of ST8SIA2 by 9-cis-retinoic acid and artificial polysialylation of ol

73 Cotreatment with 9-cis-retinoic acid and PPARgamma agonists decreased the

74 receptors (RXRs), which include the natural 9-cis-retinoic acid and synthetic analogs, are potent in

75 l to generate the retinoid X receptor ligand 9-cis-retinoic acid and/or may regenerate dihydrotestost

76 molar concentrations of the RXRalpha ligand (9-cis-retinoic acid) and PPARgamma ligands to CpG-activa

77 d receptor-alpha (RARalpha), including atRA, 9-cis-retinoic acid, and Am580, sequentially increased t

78 ted the in vitro effect of triiodothyronine, 9-cis-retinoic acid, and the retinoid X receptor-selecti

79 All-trans- and 9-cis-retinoic acid are active retinoids for regulating

80 retinoids, like all-trans retinoic acid and 9-cis retinoic acid, are known to affect proliferation a

81 -retinal into the retinoid X receptor ligand 9-cis-retinoic acid as two previously identified ALDHs w

82 In comparison, 9-cis retinoic acid at 30 mg/kg inhibited growth of esta

83 9-cis-Retinoic acid attenuates the stimulating effect of

84 iles between these lineages is distinct with 9- cis-retinoic acid being exclusively detected in Jurka

85 1, CRAD3, or RDH1, to reconstitute a path of 9-cis-retinoic acid biosynthesis in situ.

86 ver, we studied 9-cis-retinol metabolism and 9-cis-retinoic acid biosynthesis in two hepatic-derived

87 y that ALDH12 could function in a pathway of 9-cis-retinoic acid biosynthesis in vivo includes biosyn

88 , type 3), which catalyzes the first step in 9-cis-retinoic acid biosynthesis, the conversion of 9-ci

89 uggest that it could meet specific needs for 9-cis-retinoic acid biosynthesis.

90 ming growth factor beta, lipopolysaccharide, 9-cis-retinoic acid) but not others (e.g., tumor necrosi

91 id X receptor in the presence and absence of 9-cis-retinoic acid by Q(tau) analysis.

92 otene is a subject of recent interest, since 9-cis retinoic acid can apparently be formed from 9-cis

93 The structure of the 9-cis-retinoic acid complex reveals that two substrate m

94 ation and the rate of association of the RXR-9-cis-retinoic acid complex were significantly slower in

95 ent with a retinoid X receptor alpha ligand, 9-cis-retinoic acid, decreased [(3)H]thymidine incorpora

96 gth SHP to the GAL4 DNA binding domain shows 9-cis-retinoic acid-dependent interaction with a VP16-re

97 and synthetic ligands for RXRalpha including 9-cis-retinoic acid, docosahexaenoic acid, and LG100268

98 ximately 35 fmol RAR alpha/mg total protein (9-cis retinoic acid; EC50, approximately 50-100 nM).

99 nsitivity to growth inhibition by retinoids (9-cis-retinoic acid; EC50, approximately 3 nM).

100 Treatment of cells with 9-cis retinoic acid enhanced accessibility to cisplatin

101 re, PPARgamma ligands alone or combined with 9-cis-retinoic acid enhanced CpG-induced expression of C

102 9-cis-retinoic acid enhances ST8SIA2 expression, providi

103 Little is known, however, regarding 9-cis-retinoic acid formation.

104 ehydrogenase, which probably plays a role in 9-cis-retinoic acid formation.

105 iosynthesis in vivo includes biosynthesis of 9-cis-retinoic acid from 9-cis-retinol in cells co-trans

106 animals, whereas all-trans-retinoic acid and 9-cis-retinoic acid function as ligands for nuclear reti

107 of additional pathways for the generation of 9-cis-retinoic acid in specialized tissues.

108 ometric isomers, all-trans retinoic acid and 9-cis retinoic acid, in a focal model of ischemia.

109 atoma cells, whereas RXRalpha and its ligand 9-cis-retinoic acid increased MTP promoter activity by 6

110 t interacts with both RAR and RXR receptors (9-cis-retinoic acid) increases IGFBP-3 levels and suppre

111 9-cis Retinoic acid induced higher rates of apoptosis in

112 recursor protein, 22R-hydroxycholesterol and 9-cis-retinoic acid induced ABCA1 expression and increas

113 nce of a confluent RPE monolayer reduced the 9-cis retinoic acid-induced apoptosis rate (P = 0.002),

114 Cycloheximide did not inhibit 9-cis retinoic acid-induced apoptosis, but phorbol myris

115 9-cis retinoic acid inhibited the accumulation, suggesti

116 9-cis Retinoic acid is an important mediator of vascular

117 9-cis-Retinoic acid is a known biological ligand for ret

118 When the pan-agonist 9-cis-retinoic acid is bound to the receptor, only the d

119 luciferase expression by ciprofibrate and/or 9-cis-retinoic acid is dependent upon cotransfection of

120 A second molecule of 9-cis-retinoic acid is located above the proximal molecu

121 metabolism of all-trans-retinol to at-RA or 9-cis-retinoic acid is observed in these cells.

122 le transcription factor that is activated by 9-cis-retinoic acid, is a member of the superfamily of n

123 nd that, while this activity is regulated by 9-cis-retinoic acid, it is distinct from and independent

124 Like vertebrate RXRs, jRXR binds 9-cis retinoic acid (Kd = 4 x 10(-10) M) and binds to th

125 Hypoxia also diminished the 9-cis-retinoic acid-mediated activation of a reporter co

126 Addition of exogenous ligands, such as 9-cis retinoic acid or all-trans retinoic acid, expands

127 ed with either an RXR agonist (bexarotene or 9-cis retinoic acid) or vehicle (dimethylsulfoxide) for

128 owed an increased growth inhibition by ATRA, 9-cis-retinoic acid, or the synthetic retinoid 6-(5,6,7,

129 CRAD3 contributes to 9-cis-retinoic acid production in intact cells, in conju

130 involved in the first step of all-trans- and 9-cis-retinoic acid production in many tissues.

131 er as homodimers or as heterodimers with the 9-cis retinoic acid (RA) receptor (retinoid X-receptor [

132 However, 1,25(OH)(2) vitamin D(3), 9-cis retinoic acid (RA), and 13-cis RA also induced the

133 We herein show that the combination of 9-cis-retinoic acid (RA) and IFN-alpha induces marked an

134 promoter 150% of control, in the presence of 9-cis-retinoic acid (RA), whereas RXR alpha/T3R beta het

135 y RXR in the presence of its cognate ligand, 9-cis-retinoic acid (RA).

136 The 9-cis retinoic acid receptor (retinoid X receptor, RXR)

137 rization but now forms heterodimers with the 9-cis retinoic acid receptor (RXR) DBD.

138 rms active, heterodimeric complexes with the 9-cis retinoic acid receptor (RXR) on vitamin D response

139 cs through binding as a heterodimer with the 9-cis retinoic acid receptor (RXR) to enhancers in targe

140 function as homo- or heterodimers such as TR:9-cis retinoic acid receptor (RXR).

141 imer of Xenopus thyroid hormone receptor and 9-cis retinoic acid receptor (TR-RXR).

142 heterodimer of thyroid hormone receptor and 9-cis retinoic acid receptor (TR-RXR).

143 heterodimer of thyroid hormone receptor and 9-cis retinoic acid receptor (TR/RXR) to nucleosomal DNA

144 ectively bound PXR as a heterodimer with the 9-cis retinoic acid receptor alpha (NR2B1).

145 s, we demonstrated that TR alone and TR/RXR (9-cis retinoic acid receptor) can bind to the LTR in viv

146 The 9-cis retinoic acid receptor, RXR, binds DNA effectively

147 activated FXR acts as a heterodimer with the 9-cis-retinoic acid receptor (RXR) and regulates the Std

148 tor-activated receptor gamma (PPARgamma) and 9-cis-retinoic acid receptor (RXR) are required for enha

149 mily and functions as a heterodimer with the 9-cis-retinoic acid receptor (RXR).

150 s either homodimers or heterodimers with the 9-cis-retinoic acid receptor (RXR).

151 hat the heterodimers of T3 receptor (TR) and 9-cis-retinoic acid receptor bind to the TRE both in vit

152 All isoforms heterodimerise with the 9-cis-retinoic acid receptor RXR, and play an important

153 Interestingly, although the unliganded TR/9-cis-retinoic acid receptor was able to recruit corepre

154 nd PPARgamma2 alone or as a heterodimer with 9-cis-retinoic acid receptor.

155 imers of thyroid hormone receptors (TRs) and 9-cis retinoic acid receptors (RXRs) are the likely in v

156 To determine whether 9-cis retinoic acid receptors (RXRs) regulate the biolog

157 emonstrated that hADA3 directly binds to the 9-cis retinoic acid receptors alpha and beta, and functi

158 All-trans-retinoic acid receptors (RAR) and 9-cis-retinoic acid receptors (RXR) are nuclear receptor

159 The 9-cis-retinoic acid receptors (RXRalpha, RXRbeta, and RX

160 cription system by introducing TRs and RXRs (9-cis-retinoic acid receptors) into Xenopus oocytes.

161 The vitamin A metabolites all-trans- and 9-cis-retinoic acid regulate gene expression by binding

162 PBP to PPARgamma1 or retinoid-X-receptor for 9-cis-retinoic acid (RXR) is independent of their phosph

163 ,25(OH)(2)D(3) (vitamin D receptor, VDR) and 9-cis-retinoic acid (RXRalpha).

164 Treatment with AGN194204 and 9-cis-retinoic acid significantly decreased apoptosis me

165 Both AGN194204 and 9-cis-retinoic acid significantly increased luciferase a

166 Furthermore, 9-cis-retinoic acid significantly up-regulated NAADP syn

167 c acid (ATRA), retinol, retinalaldehyde, and 9-cis-retinoic acid stimulated release of (45)Ca from ca

168 In Hep G2 cells, 9-cis-retinoic acid synthesis was strongly inhibited by

169 sed as a source for 9-cis-retinol and, thus, 9-cis-retinoic acid synthesis.

170 rs via all-trans retinoic acid metabolism to 9-cis retinoic acid, the natural ligand of retinoid X re

171 Clofibrate and 9-cis-retinoic acid, the partner ligands for binding to

172 Administration of the RXR agonist 9-cis-retinoic acid to demyelinated cerebellar slice cul

173 n surrounding the TATA box in cells prior to 9-cis retinoic acid treatment, which was abolished follo

174 l-trans retinoic acid (atRA), and panagonist 9-cis-retinoic acid-upregulated VSMC ADPR-cyclase; the s

175 9-cis Retinoic acid was undetectable in either leiomyoma

176 nteraction of retinoid X receptor alpha with 9-cis-retinoic acid was studied using stopped-flow fluor

177 Both all-trans-retinoic acid and 9-cis-retinoic acid were able to elevate the expression

178 wth inhibition by all-trans-retinoic acid or 9-cis-retinoic acid, whereas RAR gamma was less effectiv

179 ed markedly after exposure to oxysterols and 9-cis-retinoic acid, which are ligands for the nuclear h

180 The compounds are capable of displacing 9-cis-retinoic acid with IC(50) values in the 10 nm and

181 a involves the stoichiometric interaction of 9-cis-retinoic acid with retinoid X receptor alpha monom

182 nd kinetic parameters of the interactions of 9-cis-retinoic acid with RXR and with a deletion mutant