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1 require type II PKA interaction with AKAPs (A-kinase anchoring proteins).
2 t resembled the RII-binding domains of other A Kinase Anchor Proteins.
3 F-activating protein, BIG2, which is also an A kinase-anchoring protein.
4 tide containing the PKA-binding domain of an A-kinase anchoring protein.
5 t targeted to discrete cellular locations by A-kinase anchoring proteins.
6 interactions of PKA regulatory subunits with A-kinase anchoring proteins.
7 a family of scaffold proteins referred to as A-kinase anchoring proteins.
8 [Hsp90], Hsp10), and phosphatase regulators (A-kinase anchor protein 1 [AKAP149], protein phosphatase
10 mutants where the N0 area homologous to dual A-kinase-anchoring protein-1 or the acyl-CoA signature m
12 rylatable ATR-S435A construct or deletion of A kinase-anchoring protein 12 (AKAP12) impeded platinum
14 ific variant of the scaffold protein AKAP12 (A-kinase anchor protein 12), AKAP12v2, in metastatic mel
16 sion by increased ubiquitination of AKAP121 (A-kinase anchor protein 121) leading to reduced phosphor
18 of association with IPF susceptibility near A-kinase anchoring protein 13 (AKAP13; rs62025270, odds
21 t Na(+) channels are associated with PKA and A-kinase-anchoring protein 15 (AKAP-15), and immunocytoc
23 at neuron cultures because of its binding to A kinase-anchoring protein 150 (AKAP150), a scaffold for
25 aN) are targeted to GluA1 through binding to A-kinase anchoring protein 150 (AKAP150) in a complex wi
29 lex comprising adenylyl cyclase 5/6 (AC5/6), A-kinase anchoring protein 150 (AKAP150), and protein ki
30 Dynamic sensitization of TRPV1 activity by A-kinase anchoring protein 150 demonstrates a critical r
31 Hinke et al illustrate the significance of A-kinase anchoring protein 150 in tethering protein phos
32 naling complex containing PKA and I-1 by the A-kinase anchoring protein 18 (AKAP18) facilitates this
33 hospholamban in a complex that also contains A-kinase anchoring protein-18, protein kinase type A-RII
34 change from Ile to Val in the dual-specific A kinase-anchoring protein 2 (d-AKAP2) gene, showed the
39 osophila A kinase anchor protein, Drosophila A kinase anchor protein 200 (DAKAP200), is predicted to
40 roteins (e.g. MacMARCKS, adducin, Drosophila A kinase anchor protein 200, and N-methyl-d-aspartate re
42 meostatic mechanism are under the control of A-Kinase Anchoring Protein 220 (AKAP220; product of the
48 tagonizing the interaction between TRPV1 and A kinase anchoring protein 79 (AKAP79), a scaffolding pr
49 lity in regions of intrinsic disorder within A-kinase anchoring protein 79 (AKAP79) delineates PP2B a
52 eurin inhibitory domains of Cain/Cabin-1 and A-kinase anchoring protein 79 specifically in the heart.
53 PDE1 coimmunoprecipitated with B-Raf and A-kinase anchoring protein 79, and AVP increased this in
54 ic modifications of postsynaptic scaffolding A-kinase anchoring protein 79/150 (AKAP79/150) signaling
57 e-associated protein 97 (SAP97) that contain A-kinase anchoring protein 79/150 (AKAP79/150), protein
61 ll-specific deletion of the scaffold protein A kinase anchoring protein 9 (AKAP9) and use models of i
62 scribe three alleles of the widely expressed A-kinase anchoring protein 9 (Akap9) gene, all of which
66 use sperm flagellum, AKAP82, a member of the A Kinase Anchor Protein (AKAP) family of polypeptides th
68 of cAMP-dependent protein kinase (PKA), and A kinase anchoring protein (AKAP) 121/149, one of the PK
69 ivity of these kinases was coordinated by an A kinase anchoring protein (AKAP) by demonstrating that
73 eracting protein NSF, and two members of the A kinase-anchoring protein (AKAP) family were found to b
75 ha-(KCNQ1) and beta-subunits (KCNE1) and the A kinase-anchoring protein (AKAP) Yotiao (AKAP-9), which
76 ys and mass spectrometry, we have identified A kinase-anchoring protein (AKAP)150 and the protein pho
78 -immunoprecipitations reveal proteins of the A kinase-anchoring proteins (AKAP) family, including AKA
80 a interaction with the PKC-targeting protein A-kinase anchoring protein (AKAP) 79 and interferes with
81 hatase-2B/calcineurin (CaN) scaffold protein A-kinase anchoring protein (AKAP) 79 is localized to exc
83 ylation of the AMPAR-linked scaffold protein A-kinase anchoring protein (AKAP) 79/150 is required for
85 ide (Ht31) that prevents interaction between A-kinase anchoring protein (AKAP) and PKA also enhanced
87 erases (PDE4), protein kinase A (PKA) or PKA/A-kinase anchoring protein (AKAP) interaction blocked an
89 3, has been identified by RII overlays as an A-kinase anchoring protein (AKAP) that localizes the cAM
90 Gene silencing approaches identified the A-kinase anchoring protein (AKAP) WAVE1 as an effector o
91 Furthermore, a novel approximately 150-kDa A-kinase anchoring protein (AKAP), which binds to RII, w
97 imerization domain to interact with multiple A-kinase anchoring proteins (AKAP) that localize it to d
98 tic two-step mechanism that links rut-AC1 to A-kinase anchoring proteins (AKAP)-sequestered protein k
100 e have called AKAP-Lbc, that functions as an A-kinase-anchoring protein (AKAP) and a Rho-selective gu
109 pendent protein kinase (PKA) anchored via an A-kinase anchoring protein (AKAP15), and the most rapid
112 with the AMPA receptor GluR1 subunit via the A kinase anchor protein AKAP150 is crucial for GluR1 pho
115 , PDE10A was found to be associated with the A kinase anchoring protein AKAP150 suggesting the existe
116 ere, we demonstrate the critical role of the A-kinase anchoring protein AKAP150 in PKA-dependent modu
119 hen ROMK1 channels were coexpressed with the A kinase anchoring protein AKAP79, which was cloned from
123 he pore forming alpha subunit of BKCa and an A-kinase-anchoring protein (AKAP79/150) for beta2 agonis
124 ory subunit of PKA (RIIbeta), and the 79 kDa A-kinase-anchoring-protein (AKAP79), are tightly associa
133 eriments were designed to test the idea that A kinase anchor proteins (AKAPs) tether regulatory subun
136 ubcellular localization directed by specific A kinase anchoring proteins (AKAPs) is a mechanism for c
138 of the myeloid translocation gene family of A kinase anchoring proteins (AKAPs), regulates repulsive
144 identified WAVE-1 in a screen for rat brain A kinase-anchoring proteins (AKAPs), which bind to the S
148 part by the anchoring of PKA to a family of A-kinase anchor proteins (AKAPs) positioned in close pro
163 We have investigated the possible role of A-kinase anchoring proteins (AKAPs) in protein kinase A
164 zonula occludens-1 (PDZ)-domain proteins and A-kinase anchoring proteins (AKAPs) increased receptor d
166 , whilst disruption of the binding of PKA to A-kinase anchoring proteins (AKAPs) inhibited currents t
167 Localisation of Protein Kinase A (PKA) by A-Kinase Anchoring Proteins (AKAPs) is known to coordina
174 of cAMP-dependent protein kinase A (PKA) by A-kinase anchoring proteins (AKAPs) targets PKA to disti
178 e CaV1.2 pore-forming subunit is promoted by A-kinase anchoring proteins (AKAPs) that target cAMP-dep
179 By this means, signaling scaffolds, such as A-kinase anchoring proteins (AKAPs), compartmentalize ki
180 the hydrophobic face as the binding site to A-kinase anchoring proteins (AKAPs), little attention ha
181 association of the regulatory subunits with A-kinase anchoring proteins (AKAPs), whereas a diverse f
182 ed by a class of scaffolding proteins called A-kinase anchoring proteins (AKAPs), which sequester PKA
207 upts type II PKA holoenzyme association with A-kinase-anchoring proteins (AKAPs) also inhibited BAD p
209 f PKA regulatory type II (RII) subunits with A-kinase-anchoring proteins (AKAPs) confers location, an
210 ar targeting of PKA through association with A-kinase-anchoring proteins (AKAPs) facilitates GLP-1-me
211 Localization of protein kinase A (PKA) via A-kinase-anchoring proteins (AKAPs) is important for cAM
212 proposed that PKA II compartmentalization by A-kinase-anchoring proteins (AKAPs) regulates cyclic AMP
214 ete cellular compartments through binding to A-kinase-anchoring proteins (AKAPs), RI subunits are pri
215 ty to its substrate(s) via interactions with A-kinase-anchoring proteins (AKAPs), we investigated whe
219 PKA-mediated regulation of I:(Ca), including A-kinase anchor proteins and binding of phosphatase PP2a
220 n (NHR) 3 domain, which shares homology with A-kinase anchoring proteins and interacts with the regul
221 , Wiskott-Aldrich family member WAVE-1 as an A kinase anchoring protein, and glucokinase (hexokinase
223 alpha4 integrins are type I PKA-specific A-kinase anchoring proteins, and we now find that type I
225 nel by PKA also required anchoring of PKA by A-Kinase Anchoring Proteins because it was blocked by pe
226 ce suggests that the scaffold protein muscle A-kinase anchoring protein beta (mAKAPbeta) serves as a
229 characterization of a novel sarcomeric AKAP (A-kinase anchoring protein), cardiac troponin T (cTnT).
230 We have cloned cDNA that encodes six novel A kinase anchor proteins (collectively named AKAP-KL).
235 in synaptic vesicle trafficking and an AKAP (A-kinase anchor protein) domain linked to localization o
237 tially homologous to AKAP95, a member of the A kinase-anchoring protein family, but lacks the protein
238 protein kinase and the anchoring domains of A kinase anchor proteins for general application in cons
240 s review we will focus on the description of A-kinase anchoring protein function in the regulation of
241 PKA activity or its ability to interact with A kinase anchoring proteins inhibited the activity of th
242 sphate], protein kinase A inhibitors, and an A-kinase anchoring protein inhibitor significantly block
243 and the role of auxiliary proteins (such as A kinase anchoring proteins) involved in PKA regulation.
244 PLCepsilon scaffolded to muscle-specific A kinase-anchoring protein (mAKAP), along with PKCepsilo
246 ng complex maintained by the muscle-specific A-kinase anchoring protein (mAKAP) that includes PKA, PD
247 Now we demonstrate that the muscle-selective A-kinase anchoring protein, mAKAP, maintains a cAMP sign
248 found to be scaffolded to a muscle-specific A kinase anchoring protein (mAKAPbeta) in heart and NRVM
249 DAKAP200 is a potentially mobile, chimeric A kinase anchor protein-myristoylated alanine-rich C kin
251 gs are consistent with a role for BIG2 as an A kinase-anchoring protein (or AKAP) that could coordina
252 and RSK3 anchoring using a competing muscle A-kinase anchoring protein peptide inhibited the hypertr
253 roinjecting a cell-permeable synthetic AKAP (A-kinase anchor protein) peptide into the NAc to disrupt
256 re, we show that the Rho-GTPase Rac contains A-kinase anchoring protein properties and forms a dynami
257 independent of its regulatory subunit or an A-kinase anchoring protein, providing an additional mech
258 the regulated binding of RSK3 to the muscle A-kinase anchoring protein scaffold, defining a novel ki
259 reorganize and amplify the intracellular PKA-A-kinase anchoring protein signaling network and suggest
262 ex with PI3K heterodimer and IRS-1, it is an A-kinase anchoring protein that binds the type I regulat
263 ization by a mechanism that is distinct from A-kinase anchoring proteins that interact with the regul
264 rmethylation: RAB32, a ras family member and A-kinase-anchoring protein, was methylated in 14 of 25 (
265 hat are either freely diffusible or bound to A kinase anchoring proteins, we demonstrate that the dif
266 iao is a member of a large family of protein A-kinase anchoring proteins with important roles in the
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