ライフサイエンスコーパス: A(2A) receptor

1 he macrophage response through the adenosine A2A receptor.

2 n PC12 cells, which endogenously express the A2A receptor.

3 ly recruited to folding intermediates of the A2A receptor.

4 perone) were recovered in complexes with the A2A receptor.

5 ss by antagonizing function of the adenosine A2A receptor.

6 s most likely by activation of the adenosine A2a receptor.

7 by sequence is most similar to the mammalian A2A receptor.

8 cy for the rat A2A receptor versus the human A2A receptor.

9 basis of the crystal structure of the human A2A receptor.

10 -resolution structure of the human adenosine A2A receptor.

11 ne had no effect owing to the absence of the A2A receptor.

12 e agonist-promoted change in mobility of the A2A receptor.

13 when PKA was activated through the adenosine A2a receptor.

14 atterns and requires activation of adenosine A2A receptors.

15 a(olf)) coupled to dopamine D1 and adenosine A2A receptors.

16 in normal mice, indicating a lack of role of A2A receptors.

17 to pharmacological stimulation of adenosine A2A receptors.

18 osine and activation of Gs-coupled adenosine A2A receptors.

19 (hAPP) showed increased levels of astrocytic A2A receptors.

20 uration of the inflammatory response via the A(2A) receptor.

21 n approaches as antagonists of the adenosine A(2A) receptor.

22 a palmitoyl moiety in the C terminus of the A(2A) receptor.

23 nhibition was mediated through the adenosine A(2A) receptor.

24 pha completely inhibits hypoxic induction of A(2A) receptor.

25 es that display functional antagonism of the A(2A) receptor.

26 e hyperaemia is partly mediated by adenosine A(2A)-receptors.

27 Single particle tracking of the A2A receptor(1-311), which lacks the last 101 residues,

28 caffeine (antagonist for A1Rs and adenosine A2A receptors; 4 mg/kg intraperitoneally; dissociation c

29 The adenosine A(2A) receptor (A(2A) R) is a potential drug target for

30 , 7, and 9 agonists, together with adenosine A(2A) receptor (A(2A)R) agonists, switch macrophages fro

31 al interaction between the G protein-coupled A(2A) receptor (A(2A)R) and the receptor tyrosine kinase

32 Adenosine A(2A) receptor (A(2A)R) blockade enhances innate and ada

33 The adenosine A(2A) receptor (A(2A)R) is a G-protein-coupled receptor

34 The adenosine A(2A) receptor (A(2A)R) is increasingly recognized as a

35 auses a 9- and 6-fold induction of adenosine A(2A) receptor (A(2A)R) mRNA in mouse pulmonary iNKT and

36 We previously reported that the adenosine A(2A) receptor (A(2A)R) specific agonist, ATL146e, decre

37 -derived adenosine, acting via the adenosine A(2A) receptor (A(2A)R), is emerging as an important neg

38 ures of the thermostabilized human adenosine A(2A) receptor (A(2A)R-GL31) bound to its endogenous ago

39 Deletion of adenosine A(2A) receptors (A(2A)ARs) has been reported to activate

40 Adenosine A(2A) receptors (A(2A)Rs) are highly enriched in the str

41 The function of striatal adenosine A(2A) receptors (A(2A)Rs) is well recognized because of

42 The adenosine A2A receptor (A(2A)R) plays a key role in transmembrane

43 receptor antagonist) and selective adenosine A2A receptor (A2A R) blockade alleviate neurodegeneratio

44 The duration of action of adenosine A2A receptor (A2A) agonists is critical for their clinic

45 We previously demonstrated that adenosine A2A receptor (A2AR) agonism attenuates lung ischemia-rep

46 Adenosine A2A receptor (A2AR) agonists are known to potently atten

47 Adenosine A2A receptor (A2AR) agonists reduce invariant natural ki

48 ptors present in the striatum, ie, adenosine A2A receptor (A2AR) and cannabinoid CB1 receptor (CB1R),

49 mutants and this was dependent on adenosine A2A receptor (A2AR) and tropomyosin-related kinase B sig

50 the striatum was blunted by ENT1 deletion or A2A receptor (A2AR) antagonism.

51 sion and memory deterioration, and adenosine A2A receptor (A2AR) antagonists emerge as candidate ther

52 the spontaneous reconstitution of adenosine A2A receptor (A2AR) during the de novo formation of synt

53 We produced mice with a floxed adenosine A2A receptor (A2AR) gene, Adora2a, and show that either

54 The adenosine A2A receptor (A2AR) has long been implicated in cardiova

55 -fold upregulation of mRNA for the adenosine A2A receptor (A2AR) in WT allografts compared with WT is

56 The adenosine A2A receptor (A2AR) is a particularly interesting exampl

57 uced sleep using C57BL/6Slac mice, adenosine A2A receptor (A2AR) knockout mice, and their wild-type l

58 Both D4R and A2a receptor (A2aR) mRNAs were present in photoreceptors

59 Activation of adenosine A2A receptor (A2AR) promotes fibrosis and collagen synth

60 Adenosine A2a receptor (A2aR) signaling acts as a barrier to autoi

61 tween Toll-like receptor (TLR) and adenosine A2A receptor (A2AR) signaling switches macrophages from

62 ve previously demonstrated that occupancy of A2A receptor (A2AR) stimulates collagen production, so w

63 Adenosine A2A receptor (A2AR) stimulation promotes wound healing a

64 Circulating T cells predominantly expressed A2a receptor (A2aR) transcripts.

65 ounteracting overactivation of the adenosine A2A receptor (A2AR), which is upregulated in the human f

66 oxygen-induced neural apoptosis by adenosine A2A receptor (A2AR)-dependent mechanism, as revealed by

67 synaptic transmission and enhanced adenosine A2A receptor (A2AR)-dependent synaptic plasticity as the

68 Adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R) heteromer

69 orphology, and upregulation of the adenosine A2A receptor (A2AR).

70 Adenosine A2A receptors (A2AR) modulate dopamine and glutamate sig

71 Striatal adenosine A2A receptors (A2AR) play an essential role in both etha

72 previously found that adenosine, acting via A2A receptors (A2AR) promotes wound healing and inhibits

73 lthough T cells express inhibitory adenosine A2A receptors (A2AR) that suppress their activation and

74 Cerebral adenosine A2A receptors (A2ARs) are attractive therapeutic targets

75 Adenosine A2A receptors (A2ARs) are enriched in the striatum but a

76 Adenosine A2A receptors (A2ARs) are highly expressed in the striat

77 Since adenosine A2A receptors (A2ARs) control lysosome trafficking and p

78 e memory through the antagonism of adenosine A2A receptors (A2ARs) controlling synaptic plasticity pr

79 In contrast, adenosine A2A receptors (A2ARs) did not coprecipitate or colocaliz

80 Activation of adenosine A2A receptors (A2ARs) stimulates bone formation.

81 was developed for mapping cerebral adenosine A2A receptors (A2ARs) with PET.

82 We recently found that adenosine A2A receptors (A2ARs), which control synaptic plasticity

83 disease through the antagonism of adenosine A2A receptors (A2ARs).

84 beta-2 adrenoreceptor (ADRB2), the adenosine A(2A) receptor (AA2AR), and the sphingosine 1-phosphate

85 eactivation mechanism of the human adenosine A2A receptor (AA2AR), a member of the class A GPCRs, we

86 were modulated by dopamine D2 and adenosine A2A receptors, acting through cAMP/PKA.

87 creases during hypoxia, we hypothesized that A(2A) receptor activation contributes to acute intermitt

88 -mediated immunosuppressive effects, because A(2A) receptor activation decreased IFN-gamma and IL-4 s

89 In summary, these data demonstrate that A(2A) receptor activation has strong inhibitory actions

90 receptor-deficient mice, we demonstrate that A(2A) receptor activation inhibits Th1- and Th2-cell dev

91 monstrated using receptor knockout mice that A(2A) receptor activation is critically required for the

92 Spinal adenosine 2A (A(2A)) receptor activation also elicits phrenic motor fa

93 A2a receptor activation also increased breathing in unan

94 A2a receptor activation increased phosphorylation and ne

95 Instead, adenosine A2A receptor activation of G alpha(s/olf) seems to initi

96 We demonstrate that A2a receptor activation of NR4A1-3 receptor synthesis is

97 However, the combination of adenosine A2A receptor activation with either isoflurane precondit

98 better neuroprotective effect than adenosine A2A receptor activation, isoflurane preconditioning, or

99 Through adenosine A2A receptor activation, MTX promotes reverse cholestero

100 II inhibition, but may not involve adenosine A2A receptor activation.

101 eral subdivision of the central amygdala via A2A receptor activation.

102 -induced TNF-alpha and CXCL10 production via A2A-receptor activation.

103 d quinpirole, suggesting that removing tonic A(2A) receptor activity enables behaviors mediated by do

104 Accordingly, reducing adenosine A2A receptor activity in Adk(Deltabrain) mice restored n

105 Here, we show that the adenosine A2a receptor (ADORA2A) promotes hypoxia-inducible transc

106 th CGS21680, a specific agonist of adenosine A2A receptor (AdoRA2A), and ZM241385, an AdoRA2-selectiv

107 l and neurochemical effects of the adenosine A(2A) receptor agonist CGS 21680 [2-p-(2-carboxyethyl) p

108 cts of intra-NAc core microinjections of the A(2A) receptor agonist, CGS 21680 (4-[2-[[6-amino-9-(N-e

109 ed whether FR rats are hypersensitive to the A(2A) receptor agonist, CGS-21680.

110 The A(2A) receptor agonist, CGS21680, inhibited osteoclast d

111 A specific A2a receptor agonist (ATL202) was used to evaluate its p

112 es in A2A receptor KO mice and the selective A2A receptor agonist 2-p-(2-carboxyethyl)phenethyl-amino

113 carboxamidoadenosine), but not the selective A2A receptor agonist CGS21680 [2-p-(2-carboxyethyl) phen

114 ptor antagonist), and it was mimicked by the A2A receptor agonist CGS21680.

115 l vessel response to CGS-21680, an adenosine A2A receptor agonist, but did not alter the concentratio

116 The effect of D1 receptor and A2A receptor agonists on the phosphorylation of protein

117 Here we demonstrate that spinal A2a receptor agonists transactivate TrkB receptors in th

118 Thus, we hypothesized that A2a receptor agonists would elicit phrenic long-term fac

119 A(2A) receptors also contributed to the adenosine augmen

120 A(2A) receptor and osteoclast marker expression levels w

121 Complex formation between the A2A receptor and HSP90alpha (but not HSP90beta) and HSP7

122 induced chemotaxis by adenosine requires the A2a receptor and is mediated via up-regulation of the cy

123 The adenosine A2A receptor and PDE2, 3, 4, and 7 are important for act

124 enosine inhibits KCa3.1 in human T cells via A2A receptor and PKAI, thereby resulting in decreased T

125 Complex formation between the A2A receptor and SAP102 was verified by coimmunoprecipit

126 ed by genetic polymorphisms of the adenosine A2A receptors and alpha(2)-adrenergic receptors.

127 0% (P<0.01), whereas inhibition of adenosine-A2a receptors and epoxyeicosatrienoic acids had minimal

128 powerful immunosuppressant (mainly acting at A2A receptors) and a modulator of cell growth (mainly ac

129 se to adenosine (via activation of adenosine A2A receptors) and to further determine the signaling me

130 mbens also contain high numbers of adenosine A(2A) receptors, and, for that reason, the behavioral an

131 A selective A(2A) receptor antagonist (MSX-3, 8 microg kg(-1), 12 mi

132 A second A(2A) receptor antagonist (ZM2412385, 7 microg kg(11), 7

133 cal treatment of ADA-deficient mice with the A(2A) receptor antagonist ZM-241385 prevented the develo

134 (PD) pathophysiology, a selective adenosine A(2A) receptor antagonist, istradefylline, shows promise

135 enzenepropanoic acid hydrochloride), and the A(2A) receptor antagonist, MSX-3 (3,7-dihydro-8-[(1E)-2-

136 Groups 2 and 4, which received the selective A(2A)-receptor antagonist ZM241385 before the third and

137 utamate release by perfusion of an adenosine A2A receptor antagonist in the pmNAc shell blocked the d

138 nesthetized rats pretreated with intrathecal A2A receptor antagonist injections before mASH (PaO2 = 4

139 Different doses of an adenosine A2A receptor antagonist MSX-3 [3,7-dihydro-8-[(1E)-2-(3-

140 ant (SYN115) is an oral, selective adenosine A2A receptor antagonist that improves motor function in

141 hibition was reversed by SCH58261 (selective A2A receptor antagonist), but not by MRS1754 (A2B recept

142 ffects were reduced by addition of adenosine A2A receptor antagonist.

143 ceptor agonist and ZM 241385 as an adenosine A2A receptor antagonist.

144 A(2A) receptor antagonists (such as caffeine) may exert

145 Adenosine A(2A) receptor antagonists are psychomotor stimulants th

146 ic role for adenosine in the skin and reveal A(2A) receptor antagonists as novel therapeutic agents f

147 nizes dopamine signaling at D2 receptors and A(2A) receptor antagonists have been tested as therapeut

148 d indirect-pathway MSNs, we demonstrate that A(2A) receptor antagonists potentiate 2-AG release and i

149 Adenosine A(2a) receptor antagonists reduce symptom severity in Pa

150 discovery of potent and selective adenosine A2A receptor antagonists bearing substituted 1-methylcyc

151 he preferential presynaptic and postsynaptic A2A receptor antagonists SCH-442416 [2-(2-furanyl)-7-[3-

152 l information for the discovery of adenosine A2A receptor antagonists that have potential to treat mu

153 inhibited by Src family tyrosine kinase and A2A receptor antagonists.

154 Adenosine, via activation of A(2A) receptors, antagonizes dopamine signaling at D2 re

155 Thus, accumbens adenosine A(2A) receptors appear to regulate behavioral activation

156 The adenosine A(2A) receptor appears required for neurotoxicity in a m

157 ults of biophysical mapping of the adenosine A(2A) receptor are presented.

158 A(2A) receptors are a major class of G-protein-coupled r

159 Adenosine A(2A) receptors are colocalized with D(2) receptors on n

160 Adenosine A(2A) receptors are preferentially expressed in rat stri

161 specific alkaline phosphatase, and adenosine A2a receptors are significantly increased in diabetic ra

162 In resting neutrophils, we found that A2A receptors are uniformly distributed across the cell

163 s effect of adenosine was mainly mediated by A2A receptors, as KCa3.1 inhibition was reversed by SCH5

164 Loss of actin stress fibers occurs via the A2a receptor at adenosine concentrations above 10 muM, w

165 ignaling via P2Y2 receptors at the front and A2a receptors at the back of cells regulate chemotaxis.

166 e results reveal that the microbiota-inosine-A2A receptor axis might represent a potential avenue for

167 Here we report the crystal structure of A2A receptor bound to compound 1 (Cmpd-1), a novel A2AR/

168 ke nitric oxide (NO) release via endothelial A(2A)-receptors, but the role for NO in exercise hyperae

169 wing melanoma growth in mice lacking myeloid A2A receptors, but tumor suppression mediated by CD8(+)

170 Moreover, activation of accumbens A(2A) receptors by local injections of CGS 21680 increas

171 as a candidate interactor that bound to the A2A receptor C terminus.

172 Our results suggest that the A(2A) receptor-C/EBPbeta axis is critical for IL-10 prod

173 Autocrine stimulation of A2a receptors causes cyclic adenosine monophosphate accu

174 In conclusion, A(2A) receptors constrain the expression of serotonin-de

175 s show that selectively blocking presynaptic A2A receptors could provide a new pharmacological approa

176 A2A receptor deficiency led to increased numbers of allo

177 Using A(2A) receptor-deficient mice, we demonstrate that A(2A)

178 efficacious in augmenting TIMP-1 release by A(2A) receptor-deficient than control macrophages.

179 eceptors confirmed that wild type and mutant A(2A) receptor differed in diffusivity and diffusion mod

180 Stimulation of accumbens adenosine A(2A) receptors disrupted performance of an instrumental

181 -MNI-444 regional uptake was consistent with A(2A) receptor distribution in the brain.

182 Herein we describe adenosine A2A receptor distribution, signaling pathways, pharmacol

183 ivity (e.g. ARL67156) and antagonists of the A(2a) receptor (e.g. ZM241385) blocked Treg-mediated imm

184 (51% +/- 8%, P > 0.05), indicating specific A(2A) receptor effects.

185 ainst tumor metastasis, indicating that host A2A receptors enhanced tumor metastasis.

186 dopamine D1 receptor-expressing or adenosine A2a receptor-expressing medium spiny neurons (MSNs) to d

187 denosine A1 receptor and decreased adenosine A2A receptor expression in the NAc.

188 the most suitable PET ligand for quantifying A2A receptor expression in the rat brain.

189 the most suitable PET ligand for quantifying A2A receptor expression in the rat brain.

190 A2A receptor expression was effectively removed from K56

191 Blockade of adenosine 2A (A(2A)) receptors facilitates dopamine D(2) receptor func

192 identify a critical role for AC 5 and 7 and A2A receptors for up-regulation of AGS3 in morphine with

193 Analysis of the A(2A) receptor gene promoter revealed a hypoxia-responsi

194 ray crystal structure of the human adenosine A2A receptor (hA2AAR), in which the allosteric sodium io

195 In addition, we demonstrate that A(2A) receptor has angiogenic potential, as assessed by

196 Antagonism of the human A(2A) receptor has been implicated as a point of therape

197 erebral ischemia, inhibition of facilitatory A(2A) receptors has profound neuroprotective effects, wh

198 nd agonist-bound structures of the adenosine A(2A) receptor have revealed much about how a ligand may

199 lly enabled homology models of the adenosine A(2A) receptor, identifying a diverse range of ligand ef

200 at many more proteins must interact with the A2A receptor, if the trafficking trajectory of the recep

201 ect to the ventral pallidum showed adenosine A(2A) receptors immunoreactivity.

202 Additional data show increased expression of A(2A) receptor in human lung tumor cancer samples relati

203 determined whether deletion of the adenosine A(2A) receptor in knockout (KO) mice protects against do

204 alpha but not HIF-1alpha regulates adenosine A(2A) receptor in primary cultures of human lung endothe

205 modulin (CaM) to the carboxy-terminus of the A(2A) receptor in the A(2A)-D(2) receptor heteromer.

206 ed on osteoclasts, we determined the role of A(2A) receptor in the regulation of osteoclast different

207 We investigated the role of A(2A) receptors in regulating T helper (Th)1- and Th2-ce

208 ested the hypothesis that adenosine A(1) and A(2A) receptors in the prefrontal cortex contribute to t

209 The results showed that adenosine A(1) and A(2A) receptors in the prefrontal cortex modulate cortic

210 roduction after stimulation of the adenosine A2A receptor in a dose-dependent fashion.

211 f-coupled dopamine D1 receptor and adenosine A2A receptor in the brain and other organs, elucidating

212 and, thus, promoted the accumulation of the A2A receptor in the compartment with slow mobility.

213 phate hydrolysis and adenosine signaling via A2A receptors in vitro.

214 s to adenosine, which dilates arterioles via A(2A) receptors, in a nitric oxide-independent manner.

215 ust interact with adenosine tone, via D2 and A2a receptor, in direct and indirect pathway neurons, re

216 immunosuppressive nucleoside, and adenosine A(2A) receptors inhibit T-cell activation.

217 e groups of anaesthetized rats the effect of A(2A)-receptor inhibition with ZM241385 on femoral vascu

218 spite the safe clinical profile of adenosine A2A receptor inhibitors (A2ARi) in Parkinson disease.

219 Surprisingly, blockade of adenosine 2A (A2A ) receptors inhibits both of these responses.

220 Thus, adenosine, acting via the A(2A) receptor, inhibits macrophage colony-stimulating f

221 These data also demonstrate that A(2A) receptor is regulated by hypoxia and HIF-2alpha in

222 The A2A receptor is a class A/rhodopsin-like G protein-coupl

223 The adenosine A2A receptor is a G-protein-coupled receptor (GPCR) that

224 The adenosine A2A receptor is a prototypical rhodopsin-like G protein-

225 The cerebral adenosine A2A receptor is an attractive therapeutic target for neu

226 he pharmacologic activation of the adenosine A2A receptor is protective.

227 p-cAMPS), prostaglandin E1, or the adenosine A2A receptor is sufficient to cause epsilonPKC transloca

228 NECA inhibited diabetes in A2A receptor KO mice and the selective A2A receptor agon

229 ggest that AD-linked increases in astrocytic A2A receptor levels contribute to memory loss.

230 erapeutic dopamine D1 receptor and adenosine A2A receptor ligands with functionally selective propert

231 Adenosine and its precursors, via A2A receptors, likely suppress TNF-alpha and CXCL10 prod

232 nd suggest the involvement of an upregulated A(2A) receptor-linked signaling pathway in NAc.

233 We observed that the striatal adenosine A2A receptor links adenosine tone and psychomotor respon

234 dose was related to blockade of postsynaptic A2A receptors localized in striatopallidal neurons.

235 muscle arterioles, we show that ADO acts via A2A receptors located on ECs to produce vasodilation via

236 Medications targeting the A(2A) receptor may have utility in the treatment of mala

237 ammation through signaling via the adenosine A2A receptor may limit tissue damage but may also favor

238 rther demonstrate the nonselective nature of A(2A) receptor-mediated immunosuppressive effects, becau

239 y is sustained, after initial activation, by A(2A) receptor-mediated signalling.

240 e signaling mechanisms involved in adenosine A2A receptor-mediated promotion of collagen production.

241 inhibitors of signal transduction, adenosine A2A receptor-mediated stimulation of procollagen alphaI

242 ed kinase (erk), but surprisingly, adenosine A2A receptor-mediated stimulation of procollagen alphaII

243 o the development of OA; targeting adenosine A2A receptors might treat or prevent OA.

244 s were to determine the effects of adenosine A(2A) receptor modulation in the NAc on cocaine seeking

245 A(2A) receptor mRNA expression in both Th1 and Th2 effec

246 in adenosine A(2A) receptor-positive but not A(2A) receptor-negative cells.

247 d preladenant may have different profiles of A(2A) receptor occupancy in humans.

248 hat tozadenant will provide a more sustained A(2A) receptor occupancy than preladenant in humans at c

249 into AMP and adenosine, which then binds to A(2a) receptors on effector T cells, suppressing their f

250 These data demonstrate a critical role for A(2A) receptors on striatopallidal medium spiny projecti

251 he adenosine so formed, acts on extraluminal A(2A) receptors on the vascular smooth muscle.

252 res independently of NO and acts directly on A(2A)-receptors on the vascular smooth muscle to cause v

253 f CD39/CD73 on T reg cells and the adenosine A2A receptor on activated T effector cells generates imm

254 es indicate that adenosine and the adenosine A2A receptor play a role in hepatic fibrosis by a mechan

255 Because both, D1 and A2A receptors, play major roles in the cellular response

256 ce a larger hyperaemia, adenosine acting via A(2A)-receptors plays a greater role in the hyperaemia a

257 endogenously generated adenosine, acting at A(2A) receptors, plays a role in toxin-induced hepatic f

258 ine can trigger a cAMP response in adenosine A(2A) receptor-positive but not A(2A) receptor-negative

259 r increasing or decreasing activity at D2 or A2A receptors prevents the aversive motivational respons

260 at interact with and retain partially folded A2A receptor prior to ER exit.

261 cently reported that activation of adenosine A(2A) receptors promotes collagen synthesis by human der

262 In polarized cells, A2A receptors redistributed to the back where their stim

263 Thus, A(2A) receptors represent a target for reducing enhanced

264 (NMDA) receptors, or activation of adenosine A2A receptors resulted in reduction of the OGD and simul

265 onstrate that beta2-adrenergic and adenosine A2A receptors scramble lipids, suggesting that rhodopsin

266 reas the other half were pretreated with the A2A receptor-selective antagonist KW-6002, inducing full

267 These results indicate that adenosine A2A receptors signal for increased collagen production b

268 Treatments that blocked endogenous A2A receptor signaling impaired the polarization and mig

269 gatively regulates dopamine D1 and adenosine A2A receptor signaling in the striatum.

270 754, ARL67156, an ecto-ATPase inhibitor, and A2A receptor siRNA, suggesting that in contrast to ATP,

271 human A(2A) adenosine receptor bound to the A(2A) receptor-specific antagonist, ZM241385, was recent

272 ylase and ABCA1 was blocked by the adenosine A2A receptor-specific antagonist ZM241385.

273 (18)F-FPSCH, respectively) were developed as A2A receptor-specific PET ligands.

274 Thus, A(2A) receptor stimulation by adenosine, a breakdown pro

275 Taken together, these findings suggest that A(2A) receptor stimulation reduces, while A(2A) blockade

276 A(2A)-receptor stimulation suppressed the development of

277 Inhibition of PANX1 blocked A2A receptor stimulation and cAMP accumulation in respon

278 odulation is primarily through the adenosine A2a receptor subtype.

279 o mediate antinociception through the A1 and A2A receptor subtypes.

280 related to blockade of striatal presynaptic A2A receptors that modulate glutamatergic neurotransmiss

281 In contrast to the wild type A(2A) receptor, the concentration-response curve for ago

282 with known crystal structures: the adenosine A2A receptor, the beta2-adrenergic receptor and rhodopsi

283 utions of endogenous adenosine and adenosine A(2A) receptors to skin fibrosis.

284 ession of SAP102 precluded the access of the A2A receptor to a compartment with restricted mobility.

285 ) plays a role in olfaction, coupling D1 and A2a receptors to adenylyl cyclase, and histone H3 phosph

286 The unique action of A2A receptors to function directly as G proteins and in

287 , despite having reduced potency for the rat A2A receptor versus the human A2A receptor.

288 cells, suggesting that signaling through the A2A receptor via CD73-generated adenosine is a significa

289 Among the P1 receptors, only the A2a receptor was significantly upregulated after TAC.

290 ta(2) adrenergic receptors and the adenosine A(2a) receptor were determined in the antagonist-bound s

291 that mice with striatum-specific deletion of A(2A) receptors were selectively impaired in habit forma

292 9 small molecule agonists/antagonists of the A2a receptor were determined and found to be in agreemen

293 Affinity-tagged versions of the A2A receptor were expressed in HEK293 cells to identify

294 ncreased in striatum after acute blockade of A(2A) receptors, which are highly expressed by striatal

295 We present evidence for functional A2A receptors, which have a weak modulatory effect on th

296 and Th2 cells in vitro depended on adenosine A2A receptors, which were also required for the efficacy

297 The A2A receptor with a cytochrome b562-RIL (BRIL) fusion (A

298 vitro as antagonist ligands of cloned human A2A receptor with affinities (Ki 7.5-53 nM) comparable t

299 monstrate the following: (1) blocking spinal A2A receptors with MSX-3 reveals mASH-induced pMF; and (

300 In contrast, a mutated A2A receptor (with (383)DVELL(387) replaced by RVRAA) wa