ライフサイエンスコーパス: A. baumannii

1 A. baumannii encodes a type VI secretion system (T6SS),

2 A. baumannii expresses a variety of virulence factors, i

3 A. baumannii strain CI 79 exhibited significantly (P < 0

4 nce of the K1 capsule in a collection of 100 A. baumannii strains.

5 065 ESBL-producing Enterobacteriaceae, 1,105 A. baumannii, 888 susceptible Enterobacteriaceae, and 36

6 Thirty P. aeruginosa and 30 A. baumannii isolates previously characterized by whole-

7 results from Raman spectroscopic data for 31 A. baumannii clinical isolates labeled according to thei

8 A total of 9,334 A. baumannii isolates were detected, of which 4,484 isol

9 herapeutic role against a collection of 5477 A. baumannii and other relevant gram-negative organisms

10 exposure quadrupled the hazards of acquiring A. baumannii even after controlling for severity of illn

11 The CA values for P. aeruginosa, A. baumannii, and S. maltophilia were 94.1%, 92.7%, and

12 ssential agreement values for P. aeruginosa, A. baumannii, and S. maltophilia were 99.5%, 99.2%, and

13 t the DMC demonstrated good activity against A. baumannii (78% susceptibility), including 74% of carb

14 development of effective antibiotics against A. baumannii in an era of emerging antibiotic resistance

15 cterial activity of cycloviolacin O2 against A. baumannii.

16 ntibodies to Ata were highly opsonic against A. baumannii ATCC 17978 and showed low to moderate killi

17 oride (HCL) (only 30.2% susceptible) against A. baumannii isolates, and was significantly more active

18 MEASUREMENTS AND MAIN RESULTS: : Data on all A. baumannii isolates were clustered at the patient leve

19 inct arrangement and is well conserved among A. baumannii strains.

20 ording to the in vitro testing methods among A. baumannii isolates.

21 Tigecycline MICs among A. baumannii, carbapenem-resistant Enterobacteriaceae (C

22 Tigecycline nonsusceptibility among A. baumannii isolates was significantly more common as d

23 The presence of an A. baumannii-positive patient (underneath the plate) was

24 These data strongly support an A. baumannii DNA damage-inducible response that directly

25 from lethal infections of P. aeruginosa and A. baumannii and enhanced the activity of colistin in vi

26 more capable of disrupting P. aeruginosa and A. baumannii biofilms when compared to conventional anti

27 apenemase production among P. aeruginosa and A. baumannii Ten testing sites then evaluated the mCIM u

28 he interactions between epithelial cells and A. baumannii will help us understand early stages of inf

29 R)4-AcpP reduced viability of A. lwoffii and A. baumannii by >10(3) colony-forming units/mL at 5-8 ti

30 argeted to essential genes of A. lwoffii and A. baumannii were bactericidal and had MICs in a clinica

31 Last, we show that both A. nosocomialis and A. baumannii produce functioning CDI systems that mediat

32 y drug-resistant A. baumannii was defined as A. baumannii (genospecies 2) nonsusceptible to all drug

33 rom the extensively drug-resistant bacteria, A. baumannii.

34 t molecular mechanism of such a step between A. baumannii and the host cells remains unclear.

35 as a tigecycline MIC of >/=4 mug/ml for both A. baumannii and Enterobacteriaceae.

36 We tested the induction of hBD-2 and -3 by A. baumannii on primary oral and skin epithelial cells a

37 remic patients with pneumonia (PP) caused by A. baumannii (13 from the unicenter and 23 from the mult

38 ibed drugs for infectious diseases caused by A. baumannii.

39 ups: (1) isolates from patients colonized by A. baumannii (16 from the unicenter and 20 from the mult

40 Moreover, hBD-3 induction by A. baumannii was found to be dependent on epidermal grow

41 predisposes the human host to infections by A. baumannii and could favor the survival and adaptation

42 shown to contribute to protein secretion by A. baumannii and other pathogenic species of Acinetobact

43 The biological processes used by A. baumannii to cause disease are not well defined, but

44 i from other members of the A. calcoaceticus-A. baumannii complex and to detect antimicrobial resista

45 , and WGS on 148 Acinetobacter calcoaceticus-A. baumannii complex bloodstream isolates collected from

46 We assessed the capacity of 15 clinical A. baumannii isolates including 9 recent clinical isolat

47 E-scaffold alone decreased A. baumannii and S. aureus biofilm cell densities by (3.

48 The implications of LOS-deficient A. baumannii are far-reaching - from impacts on cell env

49 Examination of the LOS-deficient A. baumannii cell surface demonstrated that specific lip

50 lycan cell wall, was lethal to LOS-deficient A. baumannii Global transcriptomic analysis of a PBP1A-d

51 BP1A-deficient mutant and four LOS-deficient A. baumannii strains showed a concomitant increase in tr

52 e entA and entB genes are found in different A. baumannii isolates indicate that they were acquired f

53 ion that underlines the ability of different A. baumannii isolates to acquire iron using different sy

54 of 2,500 core SNPs accurately distinguished A. baumannii isolates from different clonal lineages.

55 is associated with fulminant disease during A. baumannii sepsis.

56 ng zinc sensing as a critical process during A. baumannii infection.

57 The metabolome of each A. baumannii strain was measured using liquid chromatogr

58 The released Zn enables A. baumannii to combat host-imposed Zn starvation.

59 we showed that a mutation of an established A. baumannii global virulence regulator led to marked ch

60 Following an outbreak of fatal A. baumannii infections in a cohort of relatively immuno

61 For A. baumannii, a species known to undergo rapid horizonta

62 d 100% (95% CI, 83.9 to 100; range, 100) for A. baumannii Overall, we found both the mCIM and the Car

63 evaluated, with 11 for P. aeruginosa, 14 for A. baumannii, and 2 for S. maltophilia Categorical agree

64 for growth under low-zinc conditions and for A. baumannii pathogenesis.

65 esting for colistin should be considered for A. baumannii identified from CMS-experienced patients.

66 as associated with positive air cultures for A. baumannii (11 of 21 [52.4%] vs 0 of 25 [0%]; p < 0.00

67 y significantly reduced 14-day mortality for A. baumannii bacteremia in severely ill patients.

68 tured, 12 (22.6%) had their air positive for A. baumannii.

69 S is superior to conventional techniques for A. baumannii strain typing and outbreak analysis.

70 Four A. baumannii strains from the Walter Reed Army Medical C

71 A total of fourteen A. baumannii isolates were isolated from the donors' pre

72 hich is directed against the K1 capsule from A. baumannii, was used to determine the seroprevalence o

73 encouraging results in protecting mice from A. baumannii infection, but monoclonal anti-OMP antibodi

74 evaluate the K1 capsular polysaccharide from A. baumannii as a passive immunization target.

75 inetobacter infections other than those from A. baumannii.

76 ation have been reported following fulminant A. baumannii sepsis, little is known about the protectiv

77 e killing activity against four heterologous A. baumannii strains, whereas in the absence of PMNs, an

78 need for improved surveillance to identified A. baumannii with an extensive drug resistance profile.

79 e used the results of the search to identify A. baumannii pathogens and found a beta-lactam-resistant

80 l clearance and was secondary to an impaired A. baumannii phenylacetic acid catabolism pathway, which

81 Serum resistance was abrogated in A. baumannii treated with protease inhibitors, as well a

82 h is involved in siderophore biosynthesis in A. baumannii, and identified 6-phenyl-1-(pyridin-4-ylmet

83 eability of cephalothin and cephaloridine in A. baumannii was decreased 2- to 3-fold when the ompA(Ab

84 OmpA(Ab) is the major nonspecific channel in A. baumannii.

85 it may apply to other conserved epitopes in A. baumannii.

86 and that it suppresses biofilm formation in A. baumannii.

87 S_1340) confirmed the role of this operon in A. baumannii virulence.

88 These results define a role for PAFR in A. baumannii interaction with host cells and suggest a m

89 o a maximum (8.27 +/- 0.05) log reduction in A. baumannii and (4.71 +/- 0.12) log reduction in S. aur

90 ribe the first global virulence regulator in A. baumannii.

91 te the mechanisms of polymyxin resistance in A. baumannii AB307-0294 using an in vitro dynamic model

92 r of genes essential for serum resistance in A. baumannii indicates the degree of complexity needed f

93 involved in inducible colistin resistance in A. baumannii.

94 ght additional genes identified by Tn-seq in A. baumannii resistance to killing by NHS but not by nor

95 required for intrinsic colistin tolerance in A. baumannii and underscore the importance of outer memb

96 modal response to ciprofloxacin treatment in A. baumannii is unique and quite different than the Esch

97 To establish a persistent infection,A. baumannii must overcome the detrimental effects of co

98 This study provides the first insight into A. baumannii gene expression profiles during a life-thre

99 By using isogenic A. baumannii mutants lacking expression of virulence eff

100 that the combination synergistically killed A. baumannii via time-dependent inhibition of different

101 surfaces in the rooms of patients with known A. baumannii colonization/infection, comparing two metho

102 Four major A. baumannii clonal lineages (as defined by MLST) circul

103 pathogenic Acinetobacter species, with many A. baumannii isolates harboring two distinct CDI systems

104 erial activity, in vivo efficacy against MDR A. baumannii infections and promising preclinical safety

105 mannii with the MBC of 2.0 mug/mL and an MDR A. baumannii with the MBC of 3.13 mug/mL.

106 ial agents to treat infections caused by MDR A. baumannii, and some of these agents have documented t

107 of minocycline for the treatment of many MDR A. baumannii infections and other difficult-to-treat spe

108 nificant reduction in the acquisition of MDR A. baumannii (RR, 0.28 [95% CI, .18-.43] and 0.48 [95% C

109 consisted of 252 patients with monomicrobial A. baumannii bacteremia admitted to a large teaching hos

110 Notably, A. baumannii complex bacteremia has a high mortality rat

111 the mechanisms governing the adaptability of A. baumannii to the antibiotic colistin.

112 o ECM/BM proteins, mediating the adhesion of A. baumannii cells to collagen type IV, and contributing

113 ence, biofilm formation, and the adhesion of A. baumannii to collagen type IV.

114 Aerosolization of A. baumannii in the ICUs is a concern, and its role in t

115 formed an in vivo transcriptomic analysis of A. baumannii isolated from a mammalian host with bactere

116 usly identified a surface autotransporter of A. baumannii, Ata, that bound to various extracellular m

117 nd our understanding of the genetic basis of A. baumannii serum resistance, a transposon (Tn) sequenc

118 t factors affecting the rate of clearance of A. baumannii bacteremia in critical patients.

119 e beta-lactam-resistance protein database of A. baumannii (BRPDAB).

120 lls and suggest a mechanism for the entry of A. baumannii into the cytoplasm of host cells.

121 iratory secretions), and without evidence of A. baumannii infections prior to the collection of the f

122 The evolution of A. baumannii has largely been defined by recombination,

123 The pan-genome of A. baumannii is open when the input genomes are normaliz

124 Compared with 20 other complete genomes of A. baumannii, LAC-4 genome harbors at least 12 copies of

125 1-Dox 35/1 protects from lethal infection of A. baumannii with an ED50 value of <2.0 mg/kg.

126 r movement, are activated during invasion of A. baumannii.

127 ted multidrug-resistant clinical isolates of A. baumannii that synthesize various levels of surface P

128 The lethality of A. baumannii strains depends on distinct stages.

129 a to Ata significantly reduced the levels of A. baumannii ATCC 17978 and two MDR strains in the lungs

130 Glc-NH(2)-TT significantly reduced levels of A. baumannii in the lungs or blood 2 and 24 h postinfect

131 reening of a transposon insertion library of A. baumannii ATCC 19606T resulted in the identification

132 de a useful tool for genetic manipulation of A. baumannii.

133 urgent need to understand the mechanisms of A. baumannii pathogenesis for the future development of

134 ideromycin across the outer cell membrane of A. baumannii via siderophore-uptake pathways was respons

135 n/doripenem combination on the metabolome of A. baumannii.

136 defect in dissemination in a mouse model of A. baumannii pneumonia, establishing zinc sensing as a c

137 In a murine model of A. baumannii pneumonia, TLR9(-/-) mice exhibit significa

138 Using two clinically relevant models of A. baumannii infection in mice, pneumonia and bacteremia

139 In murine models of A. baumannii pneumonia, RAGE signaling alters neither in

140 targeting outer membrane protein A (OmpA) of A. baumannii Five anti-OmpA MAbs were developed using hy

141 An outbreak of A. baumannii emerging after DCD renal transplantation wa

142 ulence differences across a diverse panel of A. baumannii clinical isolates during murine bacteremia

143 Serial in vitro passaging of A. baumannii in the presence of C8 did not cause loss of

144 ntibiotic resistance and the pathogenesis of A. baumannii.

145 eter to characterize proteotypic peptides of A. baumannii.

146 n air contamination based on the presence of A. baumannii in respiratory secretions versus absence (p

147 rticipants and evaluated for the presence of A. baumannii.

148 oval) and then evaluated for the presence of A. baumannii.

149 (ChoP)-containing outer membrane protein of A. baumannii binds to A549 cells through platelet-activa

150 Approximately one-quarter of A. baumannii protein coding genes were differentially ex

151 The increased rate of A. baumannii eradication with combination treatment coul

152 ighlighting the human species specificity of A. baumannii serum resistance.

153 d a beta-lactam-resistant clinical strain of A. baumannii using Uniprot annotations, Gene Ontology (G

154 , and carO, in clinical resistant strains of A. baumannii and differentiated them from wild-type A. b

155 12 out of 15 genetically diverse strains of A. baumannii are resistant to NHS killing.

156 that several multidrug-resistant strains of A. baumannii harbor a large, self-transmissible resistan

157 f the T6SS varies among different strains of A. baumannii, for which the regulatory mechanisms are un

158 gnosis of wild-type and resistant strains of A. baumannii, which would be useful for the medical trea

159 ng the heterologous V5 tag to the surface of A. baumannii in a trimeric form.

160 type IV and played a role in the survival of A. baumannii in a lethal model of systemic infection in

161 type IV, and contributing to the survival of A. baumannii in a mouse model of lethal infection.

162 ified 50 genes essential for the survival of A. baumannii in NHS, including already known serum resis

163 er, these results reveal that Ata is a TA of A. baumannii involved in virulence, including biofilm fo

164 laboratories for tigecycline MIC testing of A. baumannii isolates, since MICs are significantly elev

165 s allowing high efficiency transformation of A. baumannii.

166 for the significantly enhanced virulence of A. baumannii ATCC 17978 cells cultured in the presence o

167 ethanol exposure increases the virulence of A. baumannii ATCC 17978.

168 he role of Omp33 in fitness and virulence of A. baumannii by using an isogenic knockout strain defici

169 ole of Omp33 in the fitness and virulence of A. baumannii remains unknown.

170 y, mechanisms of resistance and virulence of A. baumannii.

171 important role for fitness and virulence of A. baumannii.

172 Here, to gain insight on A. baumannii antibiotic resistance mechanisms, we analys

173 Previously, strain ATCC 19606 was the only A. baumannii strain demonstrated to subsist without lipi

174 survival of mice infected with A. lwoffii or A. baumannii, even when initial treatment was delayed af

175 Here, we show that other A. baumannii strains can also survive without lipid A, b

176 n this study, the genome of an ST10 outbreak A. baumannii isolate LAC-4 was completely sequenced to b

177 nteractions were observed among 52 patients; A. baumannii was identified from healthcare worker hands

178 pathogens collected from pediatric patients; A. baumannii and P. aeruginosa were susceptible to fewer

179 characterizations show that the periplasmic A. baumannii DsbA (AbDsbA) enzyme has an oxidizing redox

180 Previous A. baumannii pan-genomic studies used modest sample size

181 ins, with 60% of the carbapenemase-producing A. baumannii isolates producing acquired OXA-type carbap

182 apenemases among the carbapenemase-producing A. baumannii strains, with 60% of the carbapenemase-prod

183 icity in identifying carbapenemase-producing A. baumannii, no assays achieved a sensitivity of greate

184 to accurately detect carbapenemase-producing A. baumannii.

185 c pathway as a key determinant in protecting A. baumannii from the bactericidal activity of NHS via t

186 Our work further demonstrates how rapidly A. baumannii can generate resistance to a last resort an

187 ignificant proportion of clinically relevant A. baumannii strains are resistant to killing by normal

188 ed killing of competing bacteria but renders A. baumannii susceptible to antibiotics.

189 of the polymyxin-susceptible and -resistant A. baumannii strains.

190 een the polymyxin-susceptible and -resistant A. baumannii strains.

191 of the polymyxin-susceptible and -resistant A. baumannii.

192 solates and analyzing a carbapenem-resistant A. baumannii (CRAB) outbreak.

193 the hazard of acquiring carbapenem-resistant A. baumannii by 5.1% (hazard ratio, 1.051; 95% CI, 1.007

194 doxycycline against 107 carbapenem-resistant A. baumannii clinical isolates.

195 bsequent development of carbapenem-resistant A. baumannii infections.

196 Presence of carbapenem-resistant A. baumannii on surveillance cultures is strongly associ

197 of whom 49 (13.5%) had carbapenem-resistant A. baumannii on surveillance cultures.

198 was the acquisition of carbapenem-resistant A. baumannii on surveillance cultures.

199 sceptibility testing of carbapenem-resistant A. baumannii strains, very major errors are rare, but ma

200 ly for the treatment of carbapenem-resistant A. baumannii.

201 = 0.0004) of acquiring carbapenem-resistant A. baumannii.

202 ) became colonized with carbapenem-resistant A. baumannii.

203 The treatment regimen for colistin-resistant A. baumannii infection associated with the lowest mortal

204 ipid A was present in all colistin-resistant A. baumannii isolates.

205 Colistin-resistant A. baumannii occurred almost exclusively among patients

206 on or colonization due to colistin-resistant A. baumannii were identified at a hospital system in Pen

207 Twenty patients with colistin-resistant A. baumannii were identified.

208 e 176 episodes of extensively drug-resistant A. baumannii bacteremia evaluated, 55 patients with a me

209 Breakthrough extensively drug-resistant A. baumannii bacteremia under steady state concentration

210 IONS: Adults with extensively drug-resistant A. baumannii bacteremia were prospectively followed from

211 of patients with extensively drug-resistant A. baumannii bacteremia, treated with colistin-carbapene

212 penem therapy for extensively drug-resistant A. baumannii bacteremia.

213 Extensively drug-resistant A. baumannii was defined as A. baumannii (genospecies 2)

214 in most (66.7%, 40 of 68) imipenem-resistant A. baumannii (genospecies 2) and also spread beyond spec

215 , rapid identification of imipenem-resistant A. baumannii complex and early initiation of appropriate

216 Imipenem-resistant A. baumannii complex bacteremia specifically showed a hi

217 reased risk of subsequent imipenem-resistant A. baumannii complex bacteremia.

218 which was correlated with imipenem-resistant A. baumannii complex but not with any specific genospeci

219 ng 73 (24.5%) infected by imipenem-resistant A. baumannii complex.

220 the identification of beta-lactam-resistant A. baumannii pathogens.

221 eatment of patients with multidrug resistant A. baumannii (MDR-AB) infections.

222 Multidrug resistant A. baumannii has risen rapidly in Vietnam, where colisti

223 n multivariate analysis, multidrug-resistant A. baumannii (odds ratio, 4.78; 95% CI, 2.14-18.45) and

224 interaction network of a multidrug-resistant A. baumannii clinical strain (AB5075).

225 on three newly isolated multidrug-resistant A. baumannii strains from Beijing using next-generation

226 eat infections caused by multidrug-resistant A. baumannii.

227 Recent reports of polymyxin-resistant A. baumannii highlight the urgent need for research into

228 olymyxin-susceptible and polymyxin-resistant A. baumannii using untargeted metabolomics.

229 on risk; however, having multidrug-resistant-A. baumannii and specific healthcare worker activities l

230 e advantage possessed by multidrug-resistant-A. baumannii in this environment and suggest possible ar

231 mutilin derivatives against a drug sensitive A. baumannii strain, new molecules (2-4) exhibit bacteri

232 are present in the genomes of all sequenced A. baumannii strains, were acquired from different sourc

233 titutions and that matched that of sequenced A. baumannii clinical Rif(r) isolates.

234 tion, we identified further mutations in six A. baumannii genes (vacJ, pldA, ttg2C, pheS and conserve

235 Among Acinetobacter species, A. baumannii and other closely related species are commo

236 cing of the first complete genome of an ST10 A. baumannii clinical strain should accelerate our under

237 1) times the risk of developing a subsequent A. baumannii infection compared with patients who remain

238 behind the global propagation of successful A. baumannii lineages.

239 d glycosylated OmpA/MotB from the "superbug" A. baumannii to help aid in the elucidation of the funct

240 f carbapenem-resistant, colistin-susceptible A. baumannii infection prior to identification of colist

241 f carbapenem-resistant, colistin-susceptible A. baumannii infection.

242 ycycline (1-Dox 35/1) kills drug susceptible A. baumannii with the MBC of 2.0 mug/mL and an MDR A. ba

243 esults in decreased survival during systemic A. baumannii infection that mirrors that of wild-type (W

244 Following systemic A. baumannii infection, TLR9(-/-) mice have significantl

245 nt bactericidal killing of all of the tested A. baumannii isolates.

246 These results demonstrate that A. baumannii employs several mechanisms to ensure bioava

247 Previously, we demonstrated that A. baumannii regulates the expression of various genes i

248 ee Acinetobacter strains, demonstrating that A. baumannii subsets produce morphologically distinct ty

249 ral and skin epithelial cells and found that A. baumannii induces hBD-3 transcripts to a greater exte

250 In addition, we found that A. baumannii is susceptible to hBD-2 and -3 killing at s

251 Taken together, these results indicate that A. baumannii ATCC 19606(T) produces three independent To

252 The A. baumannii inner membrane zinc transporter ZnuABC is r

253 The A. baumannii Kdp system has a distinct arrangement and i

254 To investigate the role of Zur during the A. baumannii response to zinc limitation, a zur deletion

255 and demonstrate a requirement for Zur in the A. baumannii response to the various zinc levels experie

256 unctional assays of a deletion mutant in the A. baumannii sensor kinase gene, A1S_0574 (termed as gac

257 indicate that although the C terminus of the A. baumannii ATCC 19606T SecA is not essential for viabi

258 he highly variable and dynamic nature of the A. baumannii genome may be the result of its success in

259 Thirteen percent of the A. baumannii isolates from this collection were seroreac

260 Thus, the mechanism regulating the A. baumannii DNA damage response is likely different fro

261 This paper demonstrates that the A. baumannii biofilm-associated protein (Bap) is necessa

262 assays and biochemical tests showed that the A. baumannii genome contains a single functional copy of

263 and research results, we concluded that the A. baumannii isolates 3R1 and 3R2 was probably transmitt

264 gether, these observations indicate that the A. baumannii NfuA ortholog plays a role in intracellular

265 For the first time, A. baumannii KdpE is shown to be crucial to pneumonia on

266 for pneumonia, bacteremia, and death due to A. baumannii.

267 ified that GacS regulates an operon novel to A. baumannii (paa operon), which is responsible for the

268 Aspects of the innate immune response to A. baumannii infection are not yet well understood.

269 e the role for TLR9 signaling in response to A. baumannii infection.

270 e in triggering systemic immune responses to A. baumannii infection.

271 why some individuals are more vulnerable to A. baumannii infection.

272 tating alternative means to prevent or treat A. baumannii infections.

273 tant (MDR), and therapeutic options to treat A. baumannii infections are very limited.

274 need to develop new antimicrobials to treat A. baumannii infections.

275 annii and differentiated them from wild-type A. baumannii strains.

276 ecause the PKF-negative mutant and wild-type A. baumannii treated with protease inhibitors produced b

277 gh and low zinc levels compared to wild-type A. baumannii.

278 Two unrelated A. baumannii clades were associated with the outbreak.

279 Upon A. baumannii expressing ChoP binding to PAFR, clathrin a

280 acquisition, particularly in hospitals where A. baumannii desiccates and tenaciously survives on equi

281 Therefore, we asked whether A. baumannii does the same through a yet undetermined DN

282 Moreover, Ata mediated the adhesion of whole A. baumannii cells to immobilized collagen type IV and p

283 ation, because the permeability of the whole A. baumannii outer membrane was also very low.

284 phages was assessed following challenge with A. baumannii strains ATCC 19606 and clinical isolates (C

285 ients known to be infected or colonized with A. baumannii.

286 ands/gloves are frequently contaminated with A. baumannii after patient care.

287 This constitutes the largest experience with A. baumannii reported to date from a single center.

288 Mice were infected with A. baumannii American Type Culture Collection 17978 usin

289 t, RAGE(-/-) mice systemically infected with A. baumannii exhibit increased survival and reduced bact

290 We enrolled 51 patients with A. baumannii bacteremia, and examined 318 sequential who

291 For critical patients with A. baumannii complex infection, ventilator-associated pn

292 nosa isolates and less reliable for use with A. baumannii isolates.

293 se results define Zur-regulated genes within A. baumannii and demonstrate a requirement for Zur in th

294 These results demonstrate that within A. baumannii, even a fairly recently derived monophyleti

295 ing and novel mAb as therapy for lethal, XDR A. baumannii infections, and demonstrate that it synergi

296 epsis and aspiration pneumonia models of XDR A. baumannii infection.

297 and rifampicin reduced the mortality of XDR A. baumannii infections compared to colistin alone.

298 on of colistin resistance in a series of XDR A. baumannii isolates recovered during therapy of infect

299 In serious XDR A. baumannii infections, 30-day mortality is not reduced

300 with life-threatening infections due to XDR A. baumannii from intensive care units of 5 tertiary car