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1 A. marginale and related ehrlichiae express immunoprotec
2 A. marginale encodes three proteins containing ankyrin m
3 A. marginale establishes lifelong persistence in infecte
4 A. marginale is present in the tick salivary glands befo
5 A. marginale numbers per tick increase gradually in sali
6 A. marginale T4SS proteins VirB2, VirB4-1, VirB4-2, VirB
7 A. marginale thus maintains two large, separate systems
9 ts were identified, which corresponded to 32 A. marginale subsp. centrale genotypes detected in cattl
11 oprotein M, vATPase, and ubiquitin, affected A. marginale infection in different sites of development
13 ively immunized with outer membranes against A. marginale challenge and identify three MSPs that are
14 uired for vaccine-induced protection against A. marginale and provides clear direction for developmen
15 loped strong CD4(+) T cell responses against A. marginale, MSP1a, and specific MHC class II DR-restri
16 unization, proliferated specifically against A. marginale homogenate and purified MSP1 in a dose-depe
17 smosis and is used as a live vaccine against A. marginale There has been less interest in the epidemi
20 no acid sequences are highly conserved among A. marginale strains, with identities ranging from 95 to
26 f AmOmpA and ApOmpA competitively antagonize A. marginale infection of host cells, but a monoclonal a
29 ect as few as 100 copies of 16S rRNA of both A. marginale and A. phagocytophilum in the same reaction
31 taining ankyrin motifs would be expressed by A. marginale only in tick cells and would traffic to the
32 ere confirmed to be expressed as proteins by A. marginale within infected erythrocytes, with expressi
37 eins (MSPs) between the cell culture-derived A. marginale and the bovine erythrocytic stage, currentl
40 results indicate that a genetically distinct A. marginale strain capable of superinfecting the mammal
42 Th cell epitopes among genetically distinct A. marginale strains, Th cell clones obtained prior to c
43 is that transmission of genomically distinct A. marginale strains predominates in high-prevalence are
45 that superinfection does occur with distinct A. marginale strains, as has been reported with A. margi
47 marked variation in the abilities of diverse A. marginale strains to assemble the F-actin appendages.
52 AG2 and OpAG3 were expressed by all examined A. marginale strains during the acute rickettsemia in th
53 ons are highly conserved among the expressed A. marginale variants, and similar sequences define the
54 at loss of memory T cell responses following A. marginale infection is due to a mechanism other than
55 The ratio of 16S rRNA to 16S DNA copies for A. marginale was determined to be 117.9:1 (95% confidenc
56 ervals, similar to the pattern described for A. marginale-infected cattle, while in the second patter
60 The suppressed response was specific for A. marginale, as responses to Clostridium vaccine Ag wer
63 reservoirs harbor genetically heterogeneous A. marginale and suggest that different genotypes are ma
69 E. coli were also shown to be functional in A. marginale infected cells, as determined by quantifica
70 LAG-3(+) exhausted T cells were monitored in A. marginale-challenged cattle previously immunized with
73 , these superfamily genes are transcribed in A. marginale-infected erythrocytes, tick midgut and sali
77 cterized by rickettsemic cycles in which new A. marginale variant types, defined by the sequence of t
80 Glycosylation may play a role in adhesion of A. marginale to tick cells because chemical deglycosylat
84 is not a marker for the characterization of A. marginale geographic isolates and suggest that the ge
85 a (MSP1a) and MSP1b form the MSP1 complex of A. marginale, which is involved in adhesion of the patho
87 se PCR (qRT-PCR) assays for the detection of A. marginale and A. phagocytophilum 16S rRNA in plasma-f
88 ol for the accurate and precise detection of A. marginale and A. phagocytophilum infections in cattle
89 itivity and specificity for the detection of A. marginale infection were found to be 65.2% (95% CI, 5
94 as been less interest in the epidemiology of A. marginale subsp. centrale, and, as a result, there ar
95 cells contributes to the rapid exhaustion of A. marginale-specific T cells following infection and th
97 1a, which encodes the complete msp1a gene of A. marginale under the control of human cytomegalovirus
98 ginale was evaluated by using immunoblots of A. marginale proteins separated by one- and two-dimensio
99 P1a as that found on the Virginia isolate of A. marginale in bovine erythrocytes and tick salivary gl
102 ine the genetic variations among isolates of A. marginale obtained during 2001 from infected cattle f
104 tic heterogeneity observed among isolates of A. marginale within Oklahoma could be explained by cattl
105 not conserved between different isolates of A. marginale, and at least in the isolate from Florida,
107 g the msp1aS gene, a homolog of msp1alpha of A. marginale, which contains repeats at the 5' ends that
108 ophilum, MSP2(P44), is homologous to MSP2 of A. marginale, has a similar organization of conserved an
109 ion-feeding ticks, and whether the number of A. marginale organisms per salivary gland is significant
111 PCR results indicated high occurrence of A. marginale subsp. centrale infections, ranging from 25
112 quence variants did not change on passage of A. marginale between culture, acute erythrocyte stage in
114 ombination, selection for sub-populations of A. marginale in the vertebrate host and/or PCR errors.
116 ere that the major outer membrane protein of A. marginale, MSP2, is encoded on a polycistronic mRNA.
118 two most immunodominant surface proteins of A. marginale followed by emergence of unique variants in
121 are also homologous to the MSP-2 proteins of A. marginale; thus, they were designated GE MSP-2A (45 k
123 show that the single hypervariable region of A. marginale MSP2 encodes epitopes that are immunogenic
124 esized and used to amplify msp1 sequences of A. marginale from tick cell cultures, from cattle during
126 spectrometry and tandem mass spectrometry of A. marginale proteins identified with an appendage-speci
127 nic mRNA transcript in erythrocyte stages of A. marginale and defined the structure of the genomic ex
129 of nine pseudogenes from a single strain of A. marginale provides for a combinatorial number of poss
130 ith outer membranes of the Florida strain of A. marginale resulted in protective immunity that correl
132 is persistently infected with one strain of A. marginale, infection with a second strain (superinfec
141 mals superinfected with different strains of A. marginale and hypothesized that the msp2 pseudogene r
143 pitopes conserved among different strains of A. marginale for inclusion in a nucleic acid or recombin
144 m animals infected with different strains of A. marginale reacted with different 86-kDa antigens.
145 2 functional pseudogenes from two strains of A. marginale were detected and extracted from the phi29-
147 ction does not apply to two other strains of A. marginale, and that different variants are also expre
153 hic region bound a unique MSP-2 expressed on A. marginale that was not recognized by antibody generat
155 helper (Th) cell response to these and other A. marginale antigens and to determine conservation of T
156 ut the msp2 mRNA and MSP2 protein levels per A. marginale organism increase only minimally and transi
157 number of variants required for persistence, A. marginale uses segmental gene conversion, in which ol
159 of rickettsemia that characterize persistent A. marginale infection and control of each rickettsemic
160 rotein antigenic variation during persistent A. marginale rickettsemia, were identified in the A. ovi
161 rge during cyclic rickettsemia in persistent A. marginale infection and suggest that emergent variant
164 reater percentage of infected ticks secreted A. marginale into the saliva and did so at a significant
166 (70 of 75) were infected with only a single A. marginale strain, five animals each carried two strai
167 tudy, we tested the hypothesis that specific A. marginale strains are preferentially transmitted.
168 ese data show that MSPs of erythrocyte-stage A. marginale are present on culture stages and may be st
169 s genomic expression site in Oklahoma strain A. marginale transmitted from in vitro cultures to cattl
171 athogens that generate actin filament tails, A. marginale infects mature erythrocytes, and the F-acti
173 The results support the hypothesis that A. marginale gene expression is regulated by the specifi
175 strain (low transmission efficiency) and the A. marginale St. Maries strain (high transmission effici
176 antigenic proteins, 14 are annotated in the A. marginale genome and include type IV secretion system
177 which tick cell gene expression mediates the A. marginale developmental cycle and trafficking through
182 Interestingly, the 5' structure of this A. marginale msp2 locus is conserved in the omp1 gene lo
185 ecific CD4+ T-cell clones responded to three A. marginale strains, confirming the VirB9-specific T-ce
186 lso proliferated specifically in response to A. marginale and produced high titers of gamma interfero
192 host, we tested whether the presence of two A. marginale (sensu lato) strains that differed in trans
193 gainst high-level bacteremia and anemia upon A. marginale challenge of cattle and effectively recapit
194 proportion of erythrocytes containing viable A. marginale in vitro, indicating that an antibody-indep
195 variants revealed a change in structure when A. marginale was transferred from one cell-type to anoth
198 positive samples from tropical regions where A. marginale infection is endemic identified individual
200 liferated strongly in response to both whole A. marginale homogenates and purified outer membranes, a
204 st cases, it is reported as coinfection with A. marginale without characterization of the strain.
205 ific CD4(+) T cells in cattle immunized with A. marginale outer membrane proteins or purified outer m
206 centor variabilis persistently infected with A. marginale after feeding successively on one susceptib
208 gainst erythrocyte stages, also reacted with A. marginale from cell culture and tick salivary glands.
209 marginale strains, as has been reported with A. marginale and A. marginale subsp. centrale strains.
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