ライフサイエンスコーパス: A. nidulans

1 ociation of the cargo adapter HookA (Hook in A. nidulans).

2 not play an important role in endocytosis in A. nidulans.

3 We find pinA to be an essential gene in A. nidulans.

4 hich is required for proper proliferation of A. nidulans.

5 DeltanudG) at the nudG locus encoding LC8 in A. nidulans.

6 the control of mitotic spindle formation in A. nidulans.

7 gesting that DHS and PHS induce apoptosis in A. nidulans.

8 UDE, which also affects nuclear migration in A. nidulans.

9 in a single step from a cell-free extract of A. nidulans.

10 sequenced from the model filamentous fungus A. nidulans.

11 fecting the asexual to sexual spore ratio in A. nidulans.

12 tty acid metabolism and spore development in A. nidulans.

13 it must be a dimer to support the growth of A. nidulans.

14 tibiotic (PN) and a lethal mycotoxin (ST) in A. nidulans.

15 dF, a gene required for nuclear migration in A. nidulans.

16 llus spp., are clustered on chromosome IV of A. nidulans.

17 f phosphatidylserine to the Spitzenkorper in A. nidulans.

18 us, and the sterigmatocystin gene cluster in A. nidulans.

19 t signal is required for apical extension in A. nidulans.

20 AC activity is, thus, spatially regulated in A. nidulans.

21 rowth, subapical cell arrest, and mitosis in A. nidulans.

22 (cdk) activity are required for septation in A. nidulans.

23 rowth, while represses sexual development in A. nidulans.

24 ts initiation of mitosis after DNA damage in A. nidulans.

25 t protein kinase (CaMK) is also essential in A. nidulans.

26 ite fungisporin, not previously described in A. nidulans.

27 tA and drives the sexual cycle in the fungus A. nidulans.

28 and germination by interacting with VosA in A. nidulans.

29 ng asexual development and conidiogenesis in A. nidulans.

30 as an antibiotic not known to be produced by A. nidulans.

31 elf-fertilization and sexual reproduction in A. nidulans.

32 cial for governing growth and development in A. nidulans.

33 eptation to take place in a timely manner in A. nidulans.

34 ttenuated by palB and pacC mutant strains of A. nidulans.

35 ation of a stable axis of hyphal polarity in A. nidulans.

36 ce between asexual and sexual development in A. nidulans.

37 is also functional when VeA is expressed in A. nidulans.

38 TR controls splicing of the arginase mRNA in A. nidulans.

39 cleaving a putative arginine riboswitch from A. nidulans.

40 assa compared with that which has evolved in A. nidulans.

41 us, 323 to 592 for A. flavus, 131 to 143 for A. nidulans, 366 to 520 for A. niger, 330 to 462 for A.

42 tages of agreement with reference values for A. nidulans (60 to 80%).

43 spergillus species (A. flavus, A. fumigatus, A. nidulans, A. niger, A. terreus, A. ustus, and A. vers

44 solates of Aspergillus fumigatus, A. flavus, A. nidulans, A. niger, and A. terreus to caspofungin (MI

45 t cases of invasive aspergillosis (IA), with A. nidulans, A. niger, and A. ustus being rare causes of

46 ntive structural annotation improvements for A. nidulans, A. oryzae and A. fumigatus genomes based on

47 iger, A. terreus, A. versicolor, A. glaucus, A. nidulans, A. ustus, and A. sydowii.

48 In this report, we demonstrate that A. nidulans AflR (AnAflR) is a 45kDa protein that binds

49 Recently, A. nidulans AFLR was shown to bind to the motif 5'-TCGN5

50 olog of NUDE, a nuclear distribution gene in A. nidulans and a multicopy suppressor of the LIS1 homol

51 pergillus species A. parasiticus, A. flavus, A. nidulans and A. sojae was conducted.

52 ciated with the production of eicosanoids in A. nidulans and Aspergillus fumigatus provides new insig

53 gical roles of the Pin1 orthologue, PINA, in A. nidulans and evaluate the relevance of the interactio

54 d that C-terminal domains of the full-length A. nidulans and Geobacillus stearothermophilus synthetas

55 to measure tip growth rates in germlings of A. nidulans and in multinucleate hyphal tip cells, and w

56 signaling was conserved in the genetic model A. nidulans and mediated by NapA, a homolog of AP-1-like

57 gh similarity to the pantothenate kinases of A. nidulans and mouse.

58 a conserved mechanism of nuclear movement in A. nidulans and neuronal migration in the developing mam

59 stabilities of the mitochondrial genomes in A. nidulans and P. anserina.

60 tor and NIMA are coincidentally regulated in A. nidulans and suggest that the unscheduled appearance

61 Surprisingly, wild-type A. nidulans and the catA, catB, and catA/catB mutants we

62 eins control similar morphogenetic events in A. nidulans and the dimorphic yeasts, significant differ

63 how NIMA promotes chromatin condensation in A. nidulans and when expressed in other eukaryotes.

64 regulatable promoter, transferring them into A. nidulans , and expressing them.

65 ases of A. fumigatus, A. flavus, A. terreus, A. nidulans, and A. oryzae for domains conserved in NRPS

66 isolates, and 10 isolates each of A. niger, A. nidulans, and A. terreus to voriconazole, posaconazol

67 We engineered ZmLOX3 into wild-type A. nidulans, and into a DeltappoAC strain that was reduc

68 A. nidulans appears to have a particular virulence in CG

69 constitutively active and inactive forms of A. nidulans Aras to modulate hyphal morphogenesis and as

70 co-transformation and complementation of an A. nidulans areA loss-of-function mutant (areA18 argB2 p

71 entation of their mutant phenotypes using an A. nidulans autonomously replicating vector.

72 functionally unassigned transcript, stcO, in A. nidulans based on sequence homology at both nucleotid

73 heterologous markers that are selectable in A. nidulans but do not direct integration at any site in

74 egulation of sexual development, not only in A. nidulans, but also in the phylogenetically unrelated

75 lus genus as genomic analysis indicates that A. nidulans, but not A. fumigatus or A. oryzae, has lost

76 ination during transformation is possible in A. nidulans, but the frequency of correct gene targeting

77 Conidiation induction in A. nidulans by another microbial redox-active secondary

78 Therefore SVs arrive at the apex of A. nidulans by anterograde transport involving cooperati

79 This indicates that A. nidulans cells ensure accurate mitotic NPC segregatio

80 tion, and the requirement for such a role in A. nidulans cells is temperature dependent.

81 Here, we have identified the A. nidulans CLIP-170 homologue, CLIPA.

82 ve binding affinities within the cell during A. nidulans' closed mitosis, analogous to what occurs du

83 chanism by which the NPC is regulated during A. nidulans' closed mitosis.

84 ded polypeptides are 41-43% identical to the A. nidulans CRNA protein and 56-57% identical to NAR-3,

85 ion of rca-1 caused conidiation in submerged A. nidulans cultures just as was previously observed for

86 Mutations that disrupt tagging, including A. nidulans cutA and a newly characterized gene, cutB, r

87 In A. nidulans, deletion of rcoA (DeltarcoA), a recessive m

88 The A. nidulans disordered protein Spa18(Mto2) and the centr

89 SB functions as the central regulator of the A. nidulans DNA damage response, whereas MUSN promotes r

90 lization suggest that PrpA acts early in the A. nidulans DNA damage response.

91 e, we demonstrate that SepB functions in the A. nidulans DNA damage response.

92 Because A. nidulans does not secrete detectable amounts of farne

93 well as other mitotic genes, indicates that A. nidulans dynein plays a role in mitosis.

94 In A. nidulans, dynein is not apparently required for mitot

95 A total of 5.6% of A. nidulans ESTs implicate inducer-dependent cell wall d

96 Stress response genes in A. nidulans ESTs total 1039 transcripts, contrasting wit

97 These data also reveal that A. nidulans exhibits a remarkable spatial regulation of

98 The redox and structural properties of A. nidulans flavodoxin and the Asn58Gly mutant confirm t

99 e potentials and the effects of mutations in A. nidulans flavodoxin are rationalized using a thermody

100 ents of three orthorhombic forms of oxidized A. nidulans flavodoxin are reported, and salient feature

101 tudied the backbone mobility of the oxidized A. nidulans flavodoxin at pH 6.6, 303 K by 15N NMR relax

102 Asn58-Val59 peptide in crystalline wild-type A. nidulans flavodoxin rotates away from the flavin to t

103 gene appears to be a functional homologue of A. nidulans flbD and this is the first demonstration of

104 can complement the conidiation defect of an A. nidulans flbD mutant and that induced expression of r

105 We have used A. nidulans for our method development and validation du

106 Therefore, an essential function exists in A. nidulans for the Pho85-like kinase pair PHOA and PHOB

107 show here that loss of either FhipA or FtsA (A. nidulans FTS homologue) disrupts HookA-early endosome

108 in polar growth and nuclear distribution in A. nidulans, functions not yet described for its homolog

109 f A. terreus; one isolate each of A. flavus, A. nidulans, Fusarium moniliforme, and F. solani; and tw

110 We propose that GpgA is the only A. nidulans G gamma-subunit and is required for normal v

111 enomic clone and the characterization of the A. nidulans gene designated panK.

112 One mutation, an unprecedented finding in A. nidulans genetics, resulted from an insertion of an e

113 We have characterized a 60-kb region in the A. nidulans genome and find it contains many, if not all

114 Analysis of the A. nidulans genome identified a single gene named gpgA e

115 petitive DNA is nonrandomly dispersed in the A. nidulans genome, reminiscent of heterochromatic bandi

116 do not direct integration at any site in the A. nidulans genome.

117 activated form of rasA, the ras homologue in A. nidulans, germinate in the absence of an inducing car

118 Wild-type A. nidulans germinated on porcine corneas and produced h

119 We conclude that A. nidulans has components of a SIN-MEN pathway, one of

120 In this study the genetic model organism, A. nidulans, has been used to investigate the regulation

121 We also demonstrate that the single A. nidulans histone H2A gene contains the C-terminal SQE

122 The predicted SUDD proteins from A. nidulans, Homo sapiens and S. cerevisiae all share a

123 We have identified the A. nidulans homolog (nkuA) of the human KU70 gene that i

124 hen combined with mutations in scaANBS1, the A. nidulans homolog of NBS1.

125 We have investigated the role of CdhA, the A. nidulans homologue of the APC/C activator protein Cdh

126 ergillus nidulans as a key player for HookA (A. nidulans Hook) function via a genome-wide screen for

127 te host-defense pathway, the pathogenesis of A. nidulans in CGD cannot be explained.

128 play a significant role in pathogenicity of A. nidulans in p47(phox)-/- mice, and therefore raise do

129 derstanding of invasive infections caused by A. nidulans in the CGD patient and is intended to direct

130 Using A. nidulans in vivo microscopy, we show that HypA(Trs120

131 Wild-type A. nidulans inoculated intranasally caused fatal infecti

132 2 is required for mitotic NPC inheritance in A. nidulans Interestingly, the role of Nup2 during mitot

133 RNA silencing is not a significant aspect of A. nidulans IRT-RNA silencing.

134 trate that our newly identified dynein IC in A. nidulans is also localized to microtubule ends and is

135 As A. nidulans is genetically tractable, this organism shou

136 These data suggest nitrogen metabolism in A. nidulans is in part regulated in response to the intr

137 tial and positively regulates NIMA function, A. nidulans is most sensitive to a reduction in PINA con

138 model depicting regulation of conidiation in A. nidulans is presented.

139 de that the essential role(s) of myosin I in A. nidulans is probably structural, requiring little, if

140 activator protein for quinate catabolism in A. nidulans is that expected for random sequences of the

141 nazole, 0.25 (95%); voriconazole, 1 (98.1%); A. nidulans, itraconazole, 1 (95%); posaconazole, 1 (97.

142 iticus, and sterigmatocystin biosynthesis in A. nidulans, led to the cloning of 17 genes responsible

143 murine immunity contributes significantly to A. nidulans lethality.

144 isassembly under control of NIMA and Cdk1 in A. nidulans may represent a new mechanism for regulating

145 pose a complete biosynthetic pathway for the A. nidulans meroterpenoids.

146 e dramatic changes in NPC composition during A. nidulans mitosis and provides insight into how NPC di

147 up of the NPC is dramatically changed during A. nidulans' mitosis.

148 at DHS and PHS induce a type of apoptosis in A. nidulans most similar to the caspase-independent apop

149 he marginally altered phenotypes observed in A. nidulans mutants indicate the presence of effective c

150 ns wild-type isolate (A83), loss-of-function A. nidulans mutants of the palB (B7) or pacC (C6309) gen

151 isolated four extragenic suppressors of the A. nidulans nimX2(cdc2) temperature-sensitive mutation.

152 his paper we examine the interactions of the A. nidulans NUDF and NUDE proteins with components of dy

153 report that the FluG-mediated conidiation in A. nidulans occurs via derepression.

154 e (CGD) is Aspergillus fumigatus followed by A. nidulans; other aspergilli rarely cause the disease.

155 We additionally explored whether A. nidulans oxylipins affect seed LOX gene expression du

156 The amino acid sequence of A. nidulans PanK (aPanK) predicted a subunit size of 46.

157 stimulates transcription of a gene from the A. nidulans penicillin (PN) gene cluster and elevates pe

158 to enhance virulence, demonstrating that the A. nidulans pH-responsive transcription factor PacC play

159 hat, in neutropenic mice, elimination of the A. nidulans pH-responsive transcription factor PacC, blo

160 Uniquely among the A. nidulans pH-signalling pal genes, palC appears to hav

161 ome-specific library and correlation with an A. nidulans physical map, the septins are not clustered

162 Moreover, A. nidulans possesses a second likely ceramide synthase

163 on-mammalian genomes, and the discovery that A. nidulans possesses reading frames so closely homologo

164 e (ZmLOX3) could substitute functionally for A. nidulans ppo genes.

165 Here, we report the identification of A. nidulans ppoA, encoding a putative fatty acid dioxyge

166 Therefore, in A. nidulans, proteins encoded by the smo genes likely ha

167 l. (2014) describe important new findings in A. nidulans regarding the role of EBA, the master regula

168 fl bA encodes an A. nidulans regulator of G-protein signaling (RGS) domai

169 his study shows that conidial germination in A. nidulans requires protein synthesis and that the init

170 tion of the 27 polyketide synthases (PKS) in A. nidulans revealed that one highly reduced PKS (HR-PKS

171 sequencing of Aspergillus species including A. nidulans reveals that the products of many of the sec

172 The A. nidulans rtfA gene product accumulates in nuclei.

173 In A. nidulans, salt stress HOG genes, such as pbsA, hogA,

174 Since no known A. nidulans secondary metabolites could be produced by t

175 As expected, the A. nidulans septins contain the highly conserved GTP bin

176 In A. nidulans, septum formation requires the assembly of a

177 Here, we show that in A. nidulans several SPB outer plaque proteins also locat

178 lso developed procedures for deleting entire A. nidulans SM clusters.

179 Although comparable to S. pombe eMTOCs, A. nidulans sMTOCS are permanent septum-associated struc

180 hese activities may be sufficient to prevent A. nidulans spores from entering into DNA synthesis.

181 stration of functional complementation of an A. nidulans sporulation defect using a gene from an evol

182 A. nidulans stcU was shown previously to encode a ketore

183 s observation led us to hypothesize that the A. nidulans sterigmatocystin biosynthetic pathway is bra

184 P-body formation is disrupted in A. nidulans strains deleted for Edc3, an enhancer of dec

185 In vitro growth kinetics were similar for A. nidulans strains in liquid medium at pH 6.0 (P = 0.24

186 n of scarified porcine or human corneas with A. nidulans strains maintained in buffered medium until

187 GUS activity in wild-type aflR or delta aflR A. nidulans strains, we found that stc gene activation r

188 nding motif present in related proteins from A. nidulans (StuA), Candida albicans (EFGTF-1), and Sacc

189 effect on cellular physiology and ageing in A. nidulans than that of their homologs in another fungu

190 e suggest a model for dynein motor action in A. nidulans that can explain dynein involvement in both

191 hile deletion of the swoC gene was lethal in A. nidulans, the C terminus, including NLS, microtubule-

192 During asexual development, A. nidulans unexpectedly accumulates stress response and

193 clear localization signal (NLS) motif in the A. nidulans VeA amino acid sequence and demonstrated its

194 re microtubule dynamics in vivo in wild-type A. nidulans versus temperature-sensitive loss-of-functio

195 impaired in a farnesol-dependent manner when A. nidulans was co-cultivated with C. albicans.

196 The sepH gene from A. nidulans was discovered in a screen for temperature-s

197 Similar to the CGD model, catalase-deficient A. nidulans was highly virulent in cortisone-treated BAL

198 ation of the pathway metabolite scytalone in A. nidulans, we provided chemical evidence that the Pfma

199 ate the complete range of dynein function in A. nidulans, we searched for synthetic lethal mutations

200 s found to be highly homologous to stcP from A. nidulans, which has been reported earlier to be invol

201 ine a second and specific RGS-Galpha pair in A. nidulans, which may govern upstream regulation of fun

202 nown, and will then juxtapose N. crassa with A. nidulans, which, as will be described below, provides

203 Fungal strains included an A. nidulans wild-type isolate (A83), loss-of-function A.

204 combination deficient (nkuADelta) strains of A. nidulans with fusion PCR products results in high fre