ライフサイエンスコーパス: A2A receptor

1 he macrophage response through the adenosine A2A receptor.

2 n PC12 cells, which endogenously express the A2A receptor.

3 ly recruited to folding intermediates of the A2A receptor.

4 perone) were recovered in complexes with the A2A receptor.

5 ss by antagonizing function of the adenosine A2A receptor.

6 by sequence is most similar to the mammalian A2A receptor.

7 cy for the rat A2A receptor versus the human A2A receptor.

8 to adenosine by competitive blockade of the A2a receptor.

9 s most likely by activation of the adenosine A2a receptor.

10 ific conditional (Cre/loxP system) KO of the A2A receptor.

11 basis of the crystal structure of the human A2A receptor.

12 -resolution structure of the human adenosine A2A receptor.

13 ne had no effect owing to the absence of the A2A receptor.

14 e agonist-promoted change in mobility of the A2A receptor.

15 when PKA was activated through the adenosine A2a receptor.

16 atterns and requires activation of adenosine A2A receptors.

17 a(olf)) coupled to dopamine D1 and adenosine A2A receptors.

18 in normal mice, indicating a lack of role of A2A receptors.

19 to pharmacological stimulation of adenosine A2A receptors.

20 ine release and the subsequent activation of A2A receptors.

21 res the postdevelopmental action of striatal A2A receptors.

22 pear to be mediated by both adenosine A1 and A2A receptors.

23 d vs radioligand binding at rat brain A1 and A2A receptors.

24 l)acetyl derivative was highly selective for A2A receptors.

25 osine and activation of Gs-coupled adenosine A2A receptors.

26 (hAPP) showed increased levels of astrocytic A2A receptors.

27 Single particle tracking of the A2A receptor(1-311), which lacks the last 101 residues,

28 osine A1 receptor (915-fold versus adenosine A2A receptor; 12-fold versus adenosine A2B receptor) wit

29 caffeine (antagonist for A1Rs and adenosine A2A receptors; 4 mg/kg intraperitoneally; dissociation c

30 The adenosine A2A receptor (A(2A)R) plays a key role in transmembrane

31 receptor antagonist) and selective adenosine A2A receptor (A2A R) blockade alleviate neurodegeneratio

32 The duration of action of adenosine A2A receptor (A2A) agonists is critical for their clinic

33 s also have the highest density of adenosine A2a receptors (A2a) in the brain.

34 We previously demonstrated that adenosine A2A receptor (A2AR) agonism attenuates lung ischemia-rep

35 Adenosine A2A receptor (A2AR) agonists are known to potently atten

36 Adenosine A2A receptor (A2AR) agonists reduce invariant natural ki

37 Adenosine A2A receptor (A2AR) agonists with Toll-like receptor (TL

38 ptors present in the striatum, ie, adenosine A2A receptor (A2AR) and cannabinoid CB1 receptor (CB1R),

39 mutants and this was dependent on adenosine A2A receptor (A2AR) and tropomyosin-related kinase B sig

40 the striatum was blunted by ENT1 deletion or A2A receptor (A2AR) antagonism.

41 sion and memory deterioration, and adenosine A2A receptor (A2AR) antagonists emerge as candidate ther

42 Endogenous adenosine acting at the adenosine A2A receptor (A2AR) can modify brain injury in a variety

43 the spontaneous reconstitution of adenosine A2A receptor (A2AR) during the de novo formation of synt

44 y was to examine the regulation of adenosine A2A receptor (A2AR) gene expression during hypoxia in ph

45 We produced mice with a floxed adenosine A2A receptor (A2AR) gene, Adora2a, and show that either

46 The adenosine A2A receptor (A2AR) has long been implicated in cardiova

47 -fold upregulation of mRNA for the adenosine A2A receptor (A2AR) in WT allografts compared with WT is

48 The adenosine A2A receptor (A2AR) is a particularly interesting exampl

49 We previously used adenosine A2A receptor (A2AR) knockout (KO) mice and bone marrow t

50 uced sleep using C57BL/6Slac mice, adenosine A2A receptor (A2AR) knockout mice, and their wild-type l

51 Both D4R and A2a receptor (A2aR) mRNAs were present in photoreceptors

52 Activation of adenosine A2A receptor (A2AR) promotes fibrosis and collagen synth

53 Adenosine A2a receptor (A2aR) signaling acts as a barrier to autoi

54 tween Toll-like receptor (TLR) and adenosine A2A receptor (A2AR) signaling switches macrophages from

55 ve previously demonstrated that occupancy of A2A receptor (A2AR) stimulates collagen production, so w

56 Adenosine A2A receptor (A2AR) stimulation promotes wound healing a

57 Circulating T cells predominantly expressed A2a receptor (A2aR) transcripts.

58 ounteracting overactivation of the adenosine A2A receptor (A2AR), which is upregulated in the human f

59 oxygen-induced neural apoptosis by adenosine A2A receptor (A2AR)-dependent mechanism, as revealed by

60 synaptic transmission and enhanced adenosine A2A receptor (A2AR)-dependent synaptic plasticity as the

61 Adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R) heteromer

62 orphology, and upregulation of the adenosine A2A receptor (A2AR).

63 Activation of adenosine A2A receptors (A2AR) has been shown to antagonize the fu

64 Adenosine acting via A2a receptors (A2aR) is a potent cerebral vasodilator th

65 Adenosine A2A receptors (A2AR) modulate dopamine and glutamate sig

66 Striatal adenosine A2A receptors (A2AR) play an essential role in both etha

67 previously found that adenosine, acting via A2A receptors (A2AR) promotes wound healing and inhibits

68 lthough T cells express inhibitory adenosine A2A receptors (A2AR) that suppress their activation and

69 Cerebral adenosine A2A receptors (A2ARs) are attractive therapeutic targets

70 Adenosine A2A receptors (A2ARs) are enriched in the striatum but a

71 Adenosine A2A receptors (A2ARs) are highly expressed in the striat

72 Since adenosine A2A receptors (A2ARs) control lysosome trafficking and p

73 e memory through the antagonism of adenosine A2A receptors (A2ARs) controlling synaptic plasticity pr

74 In contrast, adenosine A2A receptors (A2ARs) did not coprecipitate or colocaliz

75 Activation of adenosine A2A receptors (A2ARs) stimulates bone formation.

76 was developed for mapping cerebral adenosine A2A receptors (A2ARs) with PET.

77 phocyte depletion or activation of adenosine A2A receptors (A2ARs) with the selective agonist 4-{3-[6

78 We recently found that adenosine A2A receptors (A2ARs), which control synaptic plasticity

79 disease through the antagonism of adenosine A2A receptors (A2ARs).

80 eactivation mechanism of the human adenosine A2A receptor (AA2AR), a member of the class A GPCRs, we

81 were modulated by dopamine D2 and adenosine A2A receptors, acting through cAMP/PKA.

82 A2a receptor activation also increased breathing in unan

83 sults suggest that the depressant effects of A2a receptor activation are due to an increase in GABA-e

84 A2a receptor activation increased phosphorylation and ne

85 Instead, adenosine A2A receptor activation of G alpha(s/olf) seems to initi

86 We demonstrate that A2a receptor activation of NR4A1-3 receptor synthesis is

87 However, the combination of adenosine A2A receptor activation with either isoflurane precondit

88 better neuroprotective effect than adenosine A2A receptor activation, isoflurane preconditioning, or

89 Through adenosine A2A receptor activation, MTX promotes reverse cholestero

90 II inhibition, but may not involve adenosine A2A receptor activation.

91 eral subdivision of the central amygdala via A2A receptor activation.

92 -induced TNF-alpha and CXCL10 production via A2A-receptor activation.

93 Accordingly, reducing adenosine A2A receptor activity in Adk(Deltabrain) mice restored n

94 Here, we show that the adenosine A2a receptor (ADORA2A) promotes hypoxia-inducible transc

95 th CGS21680, a specific agonist of adenosine A2A receptor (AdoRA2A), and ZM241385, an AdoRA2-selectiv

96 A specific A2a receptor agonist (ATL202) was used to evaluate its p

97 In contrast, the A2a receptor agonist 2-[p-(2-carboxyethyl)phenylethylami

98 es in A2A receptor KO mice and the selective A2A receptor agonist 2-p-(2-carboxyethyl)phenethyl-amino

99 own that the peripheral administration of an A2A receptor agonist 2-p-(2-carboxyethyl)phenethylamino-

100 The selective adenosine A2A receptor agonist binodenoson results in an extent an

101 a second study with the selective adenosine A2A receptor agonist binodenoson, using 1 of 4 dosing re

102 Co-administration of the A2A receptor agonist CGS 21680 over a range of doses did

103 urinoceptors by adenosine (10 microM) or the A2a receptor agonist CGS21680 (100 nM) resulted in an in

104 carboxamidoadenosine), but not the selective A2A receptor agonist CGS21680 [2-p-(2-carboxyethyl) phen

105 The A2A receptor agonist CGS21680 produced a substantial inc

106 ptor antagonist), and it was mimicked by the A2A receptor agonist CGS21680.

107 l vessel response to CGS-21680, an adenosine A2A receptor agonist, but did not alter the concentratio

108 arboxamidoadenos ine (CGS-21680), a specific A2a receptor agonist, dose-dependently inhibited, in who

109 A selective A2A receptor agonist, WRC-0470 (2-cyclohexylmethylidene-

110 Hyperemia was induced with an A2A receptor agonist.

111 The effect of D1 receptor and A2A receptor agonists on the phosphorylation of protein

112 Here we demonstrate that spinal A2a receptor agonists transactivate TrkB receptors in th

113 Thus, we hypothesized that A2a receptor agonists would elicit phrenic long-term fac

114 the regulation of K(ATP) channels via A1 and A2a receptors allows adenosine to serve over a broad ran

115 Complex formation between the A2A receptor and HSP90alpha (but not HSP90beta) and HSP7

116 induced chemotaxis by adenosine requires the A2a receptor and is mediated via up-regulation of the cy

117 The adenosine A2A receptor and PDE2, 3, 4, and 7 are important for act

118 enosine inhibits KCa3.1 in human T cells via A2A receptor and PKAI, thereby resulting in decreased T

119 These effects are mediated via the adenosine A2A receptor and protein kinase A (PKA).

120 Complex formation between the A2A receptor and SAP102 was verified by coimmunoprecipit

121 ed by genetic polymorphisms of the adenosine A2A receptors and alpha(2)-adrenergic receptors.

122 dioligand binding assays at rat brain A1 and A2A receptors and at recombinant human A3 receptors.

123 0% (P<0.01), whereas inhibition of adenosine-A2a receptors and epoxyeicosatrienoic acids had minimal

124 TP channels may be coupled to both A1 and to A2A receptors and may be stimulated to open by adenosine

125 for the carboxyl-terminal tail of adenosine A2A receptors and showing that this interaction allows p

126 transactivation pathway that uses adenosine A2a receptors and src-family kinases (SFKs).

127 another Usp family member failing to rescue A2A receptors and Usp4 failing to rescue another intrace

128 powerful immunosuppressant (mainly acting at A2A receptors) and a modulator of cell growth (mainly ac

129 se to adenosine (via activation of adenosine A2A receptors) and to further determine the signaling me

130 TrkB, adenosine A2a receptors, and SFKs associate into complexes in lipi

131 d vs radioligand binding at rat brain A1 and A2A receptors, and structure-activity relationships at v

132 e A2A receptors with caffeine or a selective A2A receptor antagonist counteracts the striatal activat

133 utamate release by perfusion of an adenosine A2A receptor antagonist in the pmNAc shell blocked the d

134 nesthetized rats pretreated with intrathecal A2A receptor antagonist injections before mASH (PaO2 = 4

135 The novel adenosine A2A receptor antagonist KW-6002 has been examined for an

136 Different doses of an adenosine A2A receptor antagonist MSX-3 [3,7-dihydro-8-[(1E)-2-(3-

137 ant (SYN115) is an oral, selective adenosine A2A receptor antagonist that improves motor function in

138 hibition was reversed by SCH58261 (selective A2A receptor antagonist), but not by MRS1754 (A2B recept

139 intrahippocampal injection of the selective A2A receptor antagonist, 4-(2-[7-amino-2- inverted quest

140 rated to be a potent and selective adenosine A2a receptor antagonist, although with limited oral bioa

141 Adenosine A2A receptor-deficient and A2A receptor antagonist-treated mice were protected from

142 57BL/6 mice, and mice treated with adenosine A2A receptor antagonist.

143 antagonist but not by a selective adenosine A2A receptor antagonist.

144 ffects were reduced by addition of adenosine A2A receptor antagonist.

145 ceptor agonist and ZM 241385 as an adenosine A2A receptor antagonist.

146 discovery of potent and selective adenosine A2A receptor antagonists bearing substituted 1-methylcyc

147 Adenosine A2A receptor antagonists provide a promising nondopamine

148 ese results suggest that selective adenosine A2A receptor antagonists represent a new class of antipa

149 he preferential presynaptic and postsynaptic A2A receptor antagonists SCH-442416 [2-(2-furanyl)-7-[3-

150 l information for the discovery of adenosine A2A receptor antagonists that have potential to treat mu

151 inhibited by Src family tyrosine kinase and A2A receptor antagonists.

152 specific alkaline phosphatase, and adenosine A2a receptors are significantly increased in diabetic ra

153 Their studies suggest that the intracellular A2A receptors are ubiquitinated, presumably because of m

154 In resting neutrophils, we found that A2A receptors are uniformly distributed across the cell

155 s effect of adenosine was mainly mediated by A2A receptors, as KCa3.1 inhibition was reversed by SCH5

156 Loss of actin stress fibers occurs via the A2a receptor at adenosine concentrations above 10 muM, w

157 ignaling via P2Y2 receptors at the front and A2a receptors at the back of cells regulate chemotaxis.

158 e results reveal that the microbiota-inosine-A2A receptor axis might represent a potential avenue for

159 ligand, showed that the number of adenosine A2A receptor binding sites was similarly increased durin

160 A2A receptor blockade accentuated hypoxia-induced depres

161 Neither A1 nor A2A receptor blockade affected the depression caused by

162 Thus, A1 receptor blockade enhances and A2a receptor blockade protects against damage to DAergic

163 DPCPX (10 microM) but remained unaffected by A2A receptor blockade with ZM241385 (10 microM).

164 In a mouse model, prior activation of A2a receptors blocked RANTES-induced recruitment of leuk

165 Here we report the crystal structure of A2A receptor bound to compound 1 (Cmpd-1), a novel A2AR/

166 wing melanoma growth in mice lacking myeloid A2A receptors, but tumor suppression mediated by CD8(+)

167 as a candidate interactor that bound to the A2A receptor C terminus.

168 Autocrine stimulation of A2a receptors causes cyclic adenosine monophosphate accu

169 We therefore examined whether adenosine A2A receptors contribute to the pathogenesis of dermal f

170 tochondrial inhibition, and whether blocking A2a receptors could protect against damage in this model

171 s show that selectively blocking presynaptic A2A receptors could provide a new pharmacological approa

172 ceptor agonists suggested the involvement of A2a receptors, data obtained with A2a receptor-deficient

173 A2A receptor deficiency led to increased numbers of allo

174 Adenosine A2A receptor-deficient and A2A receptor antagonist-treat

175 lvement of A2a receptors, data obtained with A2a receptor-deficient mice showed that the adenosine su

176 nduced dermal fibrosis model using adenosine A2A receptor-deficient wild-type littermate mice, C57BL/

177 The A2A receptor dependence of MPEP-induced motor stimulatio

178 e the effect of A2A antagonists and targeted A2A receptor depletion on the actual development of sens

179 Herein we describe adenosine A2A receptor distribution, signaling pathways, pharmacol

180 ainst tumor metastasis, indicating that host A2A receptors enhanced tumor metastasis.

181 dopamine D1 receptor-expressing or adenosine A2a receptor-expressing medium spiny neurons (MSNs) to d

182 denosine A1 receptor and decreased adenosine A2A receptor expression in the NAc.

183 the most suitable PET ligand for quantifying A2A receptor expression in the rat brain.

184 the most suitable PET ligand for quantifying A2A receptor expression in the rat brain.

185 A2A receptor expression was effectively removed from K56

186 identify a critical role for AC 5 and 7 and A2A receptors for up-regulation of AGS3 in morphine with

187 ray crystal structure of the human adenosine A2A receptor (hA2AAR), in which the allosteric sodium io

188 The adenosine A2A receptor has emerged as an attractive non-dopaminerg

189 al neuroscience, through which antagonism of A2A receptors has now entered the arena of clinical tria

190 and its dependence on both D2 and forebrain A2A receptors highlight the functional interdependence o

191 at many more proteins must interact with the A2A receptor, if the trafficking trajectory of the recep

192 Adenosine A2A receptor immunoreactivity (A2A-LI) has been localize

193 roduction after stimulation of the adenosine A2A receptor in a dose-dependent fashion.

194 Blockade of the adenosine A2A receptor in striatopallidal neurons reduces postsyna

195 f-coupled dopamine D1 receptor and adenosine A2A receptor in the brain and other organs, elucidating

196 and, thus, promoted the accumulation of the A2A receptor in the compartment with slow mobility.

197 ated by the postnatal depletion of forebrain A2A receptors in conditional (Cre/loxP system) knock-out

198 mining the role of adenosine and both A1 and A2A receptors in kainate-induced excitotoxicity.

199 Adenosine A2A receptors in striatum are selectively localized to G

200 We investigated the role of striatal A2A receptors in the locomotor stimulant and antiparkins

201 phate hydrolysis and adenosine signaling via A2A receptors in vitro.

202 ust interact with adenosine tone, via D2 and A2a receptor, in direct and indirect pathway neurons, re

203 Stimulation of A2B but not A2A receptors induced production of interleukin-8 (IL-8)

204 Moreover, the A2a receptor-induced cross-desensitization also reduced

205 These results show that adenosine A2A receptor-induced protection is most likely to be med

206 spite the safe clinical profile of adenosine A2A receptor inhibitors (A2ARi) in Parkinson disease.

207 Surprisingly, blockade of adenosine 2A (A2A ) receptors inhibits both of these responses.

208 The A2A receptor is a class A/rhodopsin-like G protein-coupl

209 The adenosine A2A receptor is a G-protein-coupled receptor (GPCR) that

210 The adenosine A2A receptor is a prototypical rhodopsin-like G protein-

211 The cerebral adenosine A2A receptor is an attractive therapeutic target for neu

212 he pharmacologic activation of the adenosine A2A receptor is protective.

213 p-cAMPS), prostaglandin E1, or the adenosine A2A receptor is sufficient to cause epsilonPKC transloca

214 entirely NO dependent while that induced by A2A receptors is largely NO dependent; dilatation may al

215 Adenosine, acting through the A1 and A2a receptors, is a critical component in the induction

216 enosine receptor antagonist and abolished in A2A receptor knockout mice.

217 NECA inhibited diabetes in A2A receptor KO mice and the selective A2A receptor agon

218 ggest that AD-linked increases in astrocytic A2A receptor levels contribute to memory loss.

219 ding analysis with [3H]CGS21680, a selective A2A receptor ligand, showed that the number of adenosine

220 erapeutic dopamine D1 receptor and adenosine A2A receptor ligands with functionally selective propert

221 Adenosine A2A receptor ligation stimulated ERK phosphorylation, an

222 -alpha production is only partly mediated by A2a receptor ligation.

223 Adenosine and its precursors, via A2A receptors, likely suppress TNF-alpha and CXCL10 prod

224 We observed that the striatal adenosine A2A receptor links adenosine tone and psychomotor respon

225 dose was related to blockade of postsynaptic A2A receptors localized in striatopallidal neurons.

226 tingly, these effects are mediated by A1 and A2a receptors located in the substantia nigra for DAergi

227 muscle arterioles, we show that ADO acts via A2A receptors located on ECs to produce vasodilation via

228 ammation through signaling via the adenosine A2A receptor may limit tissue damage but may also favor

229 ligation stimulated ERK phosphorylation, and A2A receptor-mediated collagen production by dermal fibr

230 ounds, suggesting that PKA was necessary for A2a receptor-mediated heterologous desensitization.

231 e signaling mechanisms involved in adenosine A2A receptor-mediated promotion of collagen production.

232 inhibitors of signal transduction, adenosine A2A receptor-mediated stimulation of procollagen alphaI

233 ed kinase (erk), but surprisingly, adenosine A2A receptor-mediated stimulation of procollagen alphaII

234 Since our previous study showed that A1- and A2A-receptor-mediated NO release requires activation of

235 phorylation of eNOS by PKA via the action of A2A-receptor-mediated stimulation of AC increasing cAMP.

236 To determine the location of the A1 and A2a receptors mediating these effects, CPX or DMPX was i

237 o the development of OA; targeting adenosine A2A receptors might treat or prevent OA.

238 CR techniques revealed that adenosine A1 and A2A receptor mRNA was expressed in individual nodose neu

239 Adenosine A2A receptor occupancy promoted collagen production by p

240 f CD39/CD73 on T reg cells and the adenosine A2A receptor on activated T effector cells generates imm

241 ne may be due to an inhibitory action of the A2A receptor on the neuroprotective A1 receptor.

242 ia we propose that adenosine may also act on A2A receptors on the endothelium to cause dilatation by

243 trophils were characterized, and the role of A2A receptors on the trafficking of leukocytes to the ce

244 latation by a similar process and may act on A2A receptors on the vascular smooth muscle to cause dil

245 may also be induced by direct stimulation of A2A receptors on the vascular smooth muscle.

246 es indicate that adenosine and the adenosine A2A receptor play a role in hepatic fibrosis by a mechan

247 These results demonstrate that adenosine A2A receptors play an active role in the pathogenesis of

248 genetic data provide evidence that striatal A2A receptors play an important role in the neuroplastic

249 Because both, D1 and A2A receptors, play major roles in the cellular response

250 r increasing or decreasing activity at D2 or A2A receptors prevents the aversive motivational respons

251 at interact with and retain partially folded A2A receptor prior to ER exit.

252 nflammation and tissue repair, and adenosine A2A receptors promote wound healing by stimulating colla

253 In polarized cells, A2A receptors redistributed to the back where their stim

254 (NMDA) receptors, or activation of adenosine A2A receptors resulted in reduction of the OGD and simul

255 onstrate that beta2-adrenergic and adenosine A2A receptors scramble lipids, suggesting that rhodopsin

256 reas the other half were pretreated with the A2A receptor-selective antagonist KW-6002, inducing full

257 Selective agonism of the adenosine A2A receptor should result in a similar degree of corona

258 These results indicate that adenosine A2A receptors signal for increased collagen production b

259 Treatments that blocked endogenous A2A receptor signaling impaired the polarization and mig

260 gatively regulates dopamine D1 and adenosine A2A receptor signaling in the striatum.

261 n implies that these effects are mediated by A2a receptor signaling rather than by intracellular toxi

262 Thus, ligand activation of A2a receptors simultaneously inhibits IL-12 and stimulat

263 754, ARL67156, an ecto-ATPase inhibitor, and A2A receptor siRNA, suggesting that in contrast to ATP,

264 ylase and ABCA1 was blocked by the adenosine A2A receptor-specific antagonist ZM241385.

265 (18)F-FPSCH, respectively) were developed as A2A receptor-specific PET ligands.

266 Inhibition of PANX1 blocked A2A receptor stimulation and cAMP accumulation in respon

267 t the dilatation induced by adenosine and by A2A receptor stimulation is largely dependent on KATP ch

268 A1 or A2a receptor stimulation produced partial but significan

269 The results indicate that A2A receptors strongly modulate the efficacy of glutamat

270 odulation is primarily through the adenosine A2a receptor subtype.

271 old, by stimulation of both adenosine A1 and A2A receptor subtypes located in the neuronal membrane.

272 be stimulated via either the adenosine A1 or A2A receptor subtypes.

273 s non-selective between the adenosine A1 and A2A receptor subtypes.

274 o mediate antinociception through the A1 and A2A receptor subtypes.

275 -ethylcarboxamidoadenosine from rat striatal A2A receptors, suggesting the selective enhancement of a

276 related to blockade of striatal presynaptic A2A receptors that modulate glutamatergic neurotransmiss

277 with known crystal structures: the adenosine A2A receptor, the beta2-adrenergic receptor and rhodopsi

278 ession of SAP102 precluded the access of the A2A receptor to a compartment with restricted mobility.

279 ) plays a role in olfaction, coupling D1 and A2a receptors to adenylyl cyclase, and histone H3 phosph

280 The unique action of A2A receptors to function directly as G proteins and in

281 om endothelial cells and acts on endothelial A2A receptors to produce the major part of the hypoxia-i

282 transcript was substantially diminished, and A2A receptor transcript increased, by lipopolysaccharide

283 The A2A receptor-triggered generation of intracellular cAMP

284 tissue-protecting mechanisms, with adenosine A2A receptors triggering "OFF" signals in activated immu

285 , despite having reduced potency for the rat A2A receptor versus the human A2A receptor.

286 cells, suggesting that signaling through the A2A receptor via CD73-generated adenosine is a significa

287 Among the P1 receptors, only the A2a receptor was significantly upregulated after TAC.

288 nent of the signaling pathway induced by the A2a receptor, was sufficient to desensitize RANTES-induc

289 9 small molecule agonists/antagonists of the A2a receptor were determined and found to be in agreemen

290 Affinity-tagged versions of the A2A receptor were expressed in HEK293 cells to identify

291 ern blot analysis revealed that mRNA for the A2A receptor, which is the only adenosine receptor subty

292 ery to the cell surface of newly synthesized A2A receptors, which are otherwise predominantly intrace

293 We present evidence for functional A2A receptors, which have a weak modulatory effect on th

294 and Th2 cells in vitro depended on adenosine A2A receptors, which were also required for the efficacy

295 The A2A receptor with a cytochrome b562-RIL (BRIL) fusion (A

296 vitro as antagonist ligands of cloned human A2A receptor with affinities (Ki 7.5-53 nM) comparable t

297 y, we demonstrate that blockade of adenosine A2A receptors with caffeine or a selective A2A receptor

298 monstrate the following: (1) blocking spinal A2A receptors with MSX-3 reveals mASH-induced pMF; and (

299 In contrast, a mutated A2A receptor (with (383)DVELL(387) replaced by RVRAA) wa

300 lly and is probably not due to activation of A2A receptors within the hippocampus.