ライフサイエンスコーパス: AAH

1 AAH plays a paramount role in purine metabolism in this

2 d and paraffin-embedded tissue samples of 41 AAHs and their paired lung neoplasms from 28 patients fo

3 Mutations were found in 16 (39%) of the 41 AAHs, 8 (42%) of the 18 adenocarcinomas, and none (0%) o

4 allantoinase, (2) allantoate amidohydrolase (AAH), (3) ureidoglycine aminohydrolase, and (4) ureidogl

5 Anandamide amidohydrolase (AAH) catalyzes the hydrolysis of arachidonylethanolamide

6 Adenine aminohydrolase (AAH) is an enzyme that is not present in mammalian cells

7 Of the 18 patients with both an AAH and a synchronous lung adenocarcinoma, 6 had K-ras m

8 ts demonstrated a direct interaction between AAH and Notch as well as its ligand Jagged.

9 ly, an inverse correlation was shown between AAH stereoselectivity and the brain cannabinoid receptor

10 ling that results in over-expression of both AAH and Notch.

11 isplayed low susceptibility to hydrolysis by AAH.

12 nd 23% identical to Saccharomyces cerevisiae AAH and human adenosine deaminase enzymes, respectively,

13 Leishmania donovani AAH is 38 and 23% identical to Saccharomyces cerevisiae

14 achidonylglycerol were shown to be excellent AAH substrates.

15 Functional AAH, ureidoglycine aminohydrolase, and UAH are also pres

16 20 patients with acute alcoholic hepatitis (AAH), 16 patients with stable advanced alcohol-related c

17 benefit in severe acute alcoholic hepatitis (AAH); however, this is limited by uncertainty in patient

18 Aspartyl-(asparagyl)-beta-hydroxylase (AAH) is overexpressed in various malignant neoplasms, in

19 -dependent aromatic amino acid hydroxylases (AAHs) are known from animals and microbes but not plants

20 nerated by aromatic amino acid hydroxylases (AAHs).

21 s known as atypical adenomatous hyperplasia (AAH) and bronchioloalveolar carcinoma (BAC).

22 Atypical adenomatous hyperplasia (AAH) of the prostate, a small glandular proliferation, i

23 rations in atypical adenomatous hyperplasia (AAH) of the prostate, we examined the prevalence of alle

24 ignated as atypical adenomatous hyperplasia (AAH).

25 Atypical alveolar hyperplasia (AAH) is a potential precursor lesion from which lung ade

26 To identify AAH inhibitors, hydrolysis of anandamide was also studie

27 ogenesis and prostate carcinoma are found in AAH.

28 to rationalize corticosteroid prescribing in AAH and, furthermore, justifies investigation of this no

29 ity was found to be significantly reduced in AAH compared with controls (I(max) 67[+/-4.5]% versus 95

30 nohistochemically, Dicer was up-regulated in AAH and BAC and down-regulated in areas of invasion and

31 Analysis of full-length AAH cDNAs from Pinus taeda, Physcomitrella patens, and C

32 tudy, we analyzed DNA from 25 microdissected AAH lesions for allelic imbalance as compared to matched

33 ents of AAH substrates, rat brain microsomal AAH hydrolysis of a series of anandamide congeners was s

34 ted next-generation sequencing on multifocal AAHs and different zones of histologic progression withi

35 Organisms having a functional PCD but no AAH partner include angiosperms, yeast, and various prok

36 Because these genomes often encode no AAH homologs, the annotation of their COG2154 proteins a

37 vity; six of these came from genomes with no AAH, and six were noncanonical.

38 y was dependent on pharmacologic ablation of AAH by 2'-deoxycoformycin.

39 ence of a genetic link between some cases of AAH and carcinoma.

40 allelic imbalance in 7 of 15 (47%) cases of AAH.

41 Several morphological characteristics of AAH suggest a relationship to cancer; however, no defini

42 udies underscore the paramount importance of AAH to purine salvage by L. donovani.

43 The mRNA transcript levels of AAH, insulin receptor substrate (IRS), insulin and insul

44 sing gene points to the neoplastic nature of AAH and suggests that glandular neoplasms of the lung ar

45 Overexpression of AAH led to increased levels of Notch, and co-immunopreci

46 Overexpression of AAH was detected in 87% of the HCC relative to the paire

47 This genotypic profile of AAH will allow for comparisons with well-differentiated

48 The upstream regulation of AAH and its functional role in Notch-mediated signaling

49 To delineate the structural requirements of AAH substrates, rat brain microsomal AAH hydrolysis of a

50 The functional role of AAH in relation to cell motility has been linked to incr

51 The P. taeda and P. patens AAHs were specific for Phe, required iron, showed Michae

52 nflowering plants have functional plastidial AAHs, establish an unprecedented electron donor role for

53 A survey of genomes and ESTs revealed AAH-like sequences in gymnosperms, mosses, and algae.

54 by (3)H-thymidine incorporation in 12 severe AAH patients and age-matched and sex-matched controls.

55 Ablating the single AAH gene in P. patens caused accumulation of Phe and caf

56 A requirement for soybean AAH and UAH for ureide catabolism in leaves has been dem

57 nd immunofluorescence studies confirmed that AAH is localized to the parasite cytosol.

58 Western blot analysis established that AAH is expressed in both life cycle stages of L. donovan

59 H locus in intact parasites established that AAH is not an essential gene and that Deltaaah cells are

60 Together, these data indicate that AAH enzymes in the parasite do not cause global or regio

61 Evidence suggests that AAH represents an initial step in the progression to ade

62 subtype of lung carcinoma, varies along the AAH-BAC-adenocarcinoma sequence, and might explain the o

63 ma, 4 did not harbor mutations in either the AAH or the adenocarcinoma, and 2 had mutations in both t

64 a but not in the AAH, 6 had mutations in the AAH but not in the adenocarcinoma, 4 did not harbor muta

65 utation in the adenocarcinoma but not in the AAH, 6 had mutations in the AAH but not in the adenocarc

66 addition, the transforming properties of the AAH genes were assessed by transient and stable transfec

67 Deletion of the AAH locus in intact parasites established that AAH is no

68 inolamine dehydratase, which regenerates the AAH cofactor, is also chloroplastic.

69 ed proteins form a distinct clade within the AAH family.

70 s was the same K-ras mutation present in the AAHs and adenocarcinoma of the patient.

71 carcinoma, and 2 had mutations in both their AAH and their synchronous adenocarcinoma.

72 n the transition zone, the same region where AAH lesions most often occur.

73 corticosteroid therapy seen in patients with AAH and to address the extent to which theophylline can

74 ls of endotoxin in plasma from patients with AAH caused over expression of immune inhibitory receptor

75 In addition, patients with AAH had greater numbers of interleukin 10-producing T ce

76 Fewer T cells from patients with AAH produced interferon gamma in response to lipopolysac

77 T cells from patients with AAH, but not alcohol-related cirrhosis, expressed higher

78 ponses were greatly reduced in patients with AAH, compared with controls, and patients with alcohol-r

79 mune responses are impaired in patients with AAH.

80 2, 8q22.2, and 18q12.2 from 15 patients with AAH.

81 that genetic alterations in transition zone AAH lesions may be infrequent.