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1                                              AANAT activity in these cells was rhythmic in both LD an
2                                              AANAT activity is high at night in darkness, low during
3                                              AANAT expression and melatonin secretion (1) increased i
4                                              AANAT is a globular protein consisting of an eight-stran
5                                              AANAT is also found in the retina, where melatonin is th
6                                              AANAT is bound in the central channel of the 14-3-3zeta
7                                              AANAT peptides containing either T31 or S205 associate w
8                                              AANAT Thr31 phosphorylation on its own can enhance catal
9                                              AANATs from Agnathans (lamprey) and Chondrichthyes (cats
10  for accurate K D measurements of 14-3-3zeta-AANAT interaction using 14-3-3zeta fluorescently labeled
11 ivity of arylalkylamine N-acetyltransferase (AANAT) and N-acetylserotonin O-methyl transferase (ASMT)
12          Arylalkylamine N-acetyltransferase (AANAT) catalyzes the N-acetylation of serotonin, the pen
13               Serotonin N-acetyltransferase (AANAT) controls the daily rhythm in melatonin synthesis.
14  catalyzed by serotonin N-acetyltransferase (AANAT) in a reaction requiring acetyl coenzyme A (AcCoA)
15          Arylalkylamine N-acetyltransferase (AANAT) is the penultimate and key regulatory enzyme in t
16 sferase (arylalkylamine N-acetyltransferase (AANAT)) is a critical enzyme in the light-mediated regul
17 oxylase, arylalkylamine N-acetyltransferase (AANAT), and hydroxyindole-O-methyltransferase (HIOMT).
18 ivity of arylalkylamine N-acetyltransferase (AANAT), the penultimate enzyme in the melatonin pathway
19 gland by arylalkylamine N-acetyltransferase (AANAT), the penultimate enzyme in the synthesis of melat
20 tonin by arylalkylamine N-acetyltransferase (AANAT), which is predominantly expressed in the pineal g
21 g enzyme arylalkylamine N-acetyltransferase (AANAT).
22 hesis is arylalkylamine N-acetyltransferase (AANAT).
23 sferase [arylalkylamine N-acetyltransferase (AANAT)] is a key circadian rhythm enzyme that drives the
24          Arylalkylamine N-acetyltransferase (AANAT, serotonin N-acetyltransferase, EC ) plays a uniqu
25 nthesis, arylalkylamine N-acetyltransferase (AANAT; serotonin N-acetyltransferase, EC ).
26 ssion of arylalkylamine N-acetyltransferase (AANAT; the enzyme regulating melatonin synthesis) or inh
27 ssion of arylalkylamine N-acetyltransferase (AANAT; the rate-limiting enzyme for melatonin synthesis
28 sferase (arylalkylamine N-acetyltransferase, AANAT) in the pineal gland control the rhythmic producti
29 sferase (arylalkylamine N-acetyltransferase, AANAT) is a member of the GCN5 N-acetyltransferase (GNAT
30 sferase (arylalkylamine N-acetyltransferase, AANAT) mRNA in the chicken pineal gland exhibits a circa
31 ltransferase (serotonin N-acetyltransferase, AANAT, EC ) is the penultimate enzyme in melatonin synth
32 sferase (arylalkylamine N-acetyltransferase, AANAT, EC 2.3.1.87) is the first enzyme in the conversio
33 sferase (arylalkylamine N-acetyltransferase, AANAT, EC 2.3.1.87) is the penultimate enzyme in melaton
34 known as arylalkylamine N-acetyltransferase; AANAT) bound to a potent bisubstrate analog inhibitor ha
35  the dimeric 14-3-3 protein, which activates AANAT by increasing arylalkylamine affinity.
36                         The pike AANAT-1 and AANAT-2 enzymes (66% identical amino acids) exhibit mark
37       These genes are designated AANAT-1 and AANAT-2; all known AANATs belong to the AANAT-1 subfamil
38 k between Ca(2+) influx, cAMP formation, and AANAT activity in retinal cells.
39 d light in the regulation of cAMP levels and AANAT activity in photoreceptor cells.
40 arly exclusively expressed in the retina and AANAT-2 in the pineal gland.
41 nd (2) effect of local modulation of biliary AANAT expression on the autocrine proliferative/secretor
42 and acetyltransferase reactions catalyzed by AANAT.
43 lly synthesized and found to be processed by AANAT, although 20- and 60-fold less efficiently compare
44 f melatonin, is acetylated from serotonin by AANAT (arylalkylamine N-acetyltransferase).
45 ontrol melatonin production without changing AANAT protein levels.
46 lar basis of the circadian rhythm in chicken AANAT (cAANAT).
47 nzymologic behavior of GST-AANAT and cleaved AANAT was essentially identical.
48                          Within the complex, AANAT is catalytically activated and protected from deph
49                   These genes are designated AANAT-1 and AANAT-2; all known AANATs belong to the AANA
50 nthesized and fused to bacterially expressed AANAT(30-199) using expressed protein ligation.
51  a lesser extent, BDL hepatocytes) expressed AANAT.
52 y complex (sequential) kinetic mechanism for AANAT and provide a framework for inhibitor design.
53 into the active site of X-ray structures for AANAT, and in total 241 compounds were tested as inhibit
54 ptamine were also shown to be substrates for AANAT, again with reduced kcat and kcat/Km compared with
55 o have enzyme activity generally typical for AANAT family members, although the substrate preference
56  the most striking difference is that fungal AANATs lack the regulatory domains of the vertebrate enz
57 sting genetic markers, 8 known genes (GALR2, AANAT, ENVL, SFRS2, SEC14L, DNAH17, API4, and TK1), and
58 ly expressed glutathione S-transferase (GST)-AANAT fusion protein.
59              The enzymologic behavior of GST-AANAT and cleaved AANAT was essentially identical.
60 endence on the H122Q, H120Q, and H120Q/H122Q AANAT mutants, we show that His-122 (with an apparent pK
61 bed here, a cell line (1E7) expressing human AANAT (hAANAT) has been developed to study the human enz
62  lead to the design of analogs with improved AANAT inhibitory properties for in vivo applications.
63                             Large changes in AANAT activity play an important role in the daily rhyth
64                              The decrease in AANAT expression, and subsequent lower melatonin secreti
65 ys displayed prominent daily fluctuations in AANAT activity on days 5 and 6 in vitro.
66 ated in wild-type C3H/f(+/+) mice but not in AANAT-mutated C57BL/6J mice, in a circadian rhythm; TrkB
67 thesis of melatonin; a large daily rhythm in AANAT activity drives the daily rhythm in circulating me
68 re describe a regulatory/binding sequence in AANAT that encodes a cAMP-operated binding switch throug
69 l regulation involves phosphorylation on key AANAT Ser and Thr residues which results in 14-3-3zeta r
70 re designated AANAT-1 and AANAT-2; all known AANATs belong to the AANAT-1 subfamily.
71 lso generated a doubly fluorescently labeled AANAT which can be used to assess the stability of this
72 hat binding of AANAT by 14-3-3zeta modulates AANAT's activity and affinity for its substrates by stab
73 cognized high-affinity 14-3-3-binding motifs AANAT protein binds to 14-3-3zeta through pT31 or pS205.
74 ion after a duplication of the nonvertebrate AANAT gene.
75 without markedly increasing the abundance of AANAT protein or the activity of AANAT in broken cell pr
76 bundance of AANAT protein or the activity of AANAT in broken cell preparations; and, that forskolin,
77                              The activity of AANAT reflects changes in the amount and activation stat
78           Kinetic and structural analysis of AANAT has determined that one element is floppy.
79 lographic analysis, indicate that binding of AANAT by 14-3-3zeta modulates AANAT's activity and affin
80  switch from dual to single pS205 binding of AANAT to 14-3-3 changes the Km for substrates by approxi
81   Phosphorylation of T31 promotes binding of AANAT to the dimeric 14-3-3 protein, which activates AAN
82         To determine if circadian control of AANAT activity would develop in E6 cells incubated for a
83  appear to be causally related to control of AANAT activity.
84         Here, we focused on the evolution of AANAT in early vertebrates.
85 AANAT evolved from the nonvertebrate form of AANAT after the Cephalochordate-Vertebrate split over on
86  retinas from these groups express a form of AANAT that is compositionally, biochemically, and kineti
87                    The nocturnal increase of AANAT activity also involves Ca(2+) influx, as it is inh
88 nhibitors suppress the nocturnal increase of AANAT in DD, while 8Br-cAMP augments it.
89 e first druglike and selective inhibitors of AANAT.
90 l molecules that are selective inhibitors of AANAT.
91                                  Kinetics of AANAT extracted from 1E7 cells are the same as those of
92 volves changes in the steady-state levels of AANAT protein.
93       In this study the kinetic mechanism of AANAT action was studied using bacterially expressed glu
94 stulated to be important in the mechanism of AANAT based on prior x-ray structural and biochemical st
95  of light/dark and circadian oscillations of AANAT activity in cultured retinal cells prepared from 6
96                            Overexpression of AANAT in cholangiocyte cell lines decreased the basal pr
97                  In vitro, overexpression of AANAT or inhibition of miR-200b in cholangiocytes and he
98                           Phosphorylation of AANAT facilitates the binding of enzyme to 14-3-3 protei
99 ffects of single and dual phosphorylation of AANAT on acetyltransferase activity and relative affinit
100 t protein kinase-mediated phosphorylation of AANAT T31.
101                              The products of AANAT activity were identified by RP-HPLC with fluorimet
102 or its substrates by stabilizing a region of AANAT involved in substrate binding.
103 n plays a critical role in the regulation of AANAT activity and melatonin production.
104      Development of light-dark regulation of AANAT activity appears to precede the circadian clock-co
105 e ability to express circadian regulation of AANAT activity is an intrinsic property of retinal cells
106 tend our understanding of cAMP regulation of AANAT activity, because it is currently thought that thi
107 role of Ca(2+) and cAMP in the regulation of AANAT activity.
108  for E6 cells displayed prominent rhythms of AANAT activity in both LD and DD, indicative of circadia
109                This unique essential role of AANAT in vertebrate timekeeping is recognized by the mon
110 ding to 14-3-3 and the cellular stability of AANAT and are consistent with the view that Ser-205 phos
111          We have determined the structure of AANAT bound to 14-3-3zeta, an association that is phosph
112 doleamine analogs as alternate substrates of AANAT.
113                       The effect of light on AANAT activity was reversed by Bay K 8644, 8Br-cAMP, and
114 ding was also observed using humanized ovine AANAT, which has a different C-terminal sequence (Gly-Cy
115  to the three-dimensional structure of ovine AANAT catalytic core; however, an important structural e
116           These findings indicate that ovine AANAT is dual-phosphorylated.
117              scAANAT is 47% similar to ovine AANAT, but lacks the regulatory N- and C-terminal flanki
118  the dual anchoring of doubly phosphorylated AANAT via one 14-3-3zeta heterodimer.
119                                         Pike AANAT-1 is nearly exclusively expressed in the retina an
120                                     The pike AANAT-1 and AANAT-2 enzymes (66% identical amino acids)
121                                       Pineal AANAT activity increases at night in all vertebrates, re
122 -1 mRNA peaking in late afternoon and pineal AANAT-2 mRNA peaking 6 h later.
123                              Here a putative AANAT from Saccharomyces cerevisiae (scAANAT) was studie
124 e analysis revealed the presence of putative AANATs in other fungi but not in the nearly complete gen
125        During the night in darkness, retinal AANAT is phosphorylated and forms a complex with 14-3-3
126 A changes on a circadian basis, with retinal AANAT-1 mRNA peaking in late afternoon and pineal AANAT-
127      In the current study, a putative second AANAT cyclic AMP-dependent protein kinase phosphorylatio
128 x enhances melatonin production by shielding AANAT from dephosphorylation and/or proteolysis and by d
129                            Although a single AANAT gene has been found in mammals and the chicken, we
130 he middle of the subjective night suppressed AANAT activity, indicating that the enzyme activity in t
131  exposure at night, which rapidly suppresses AANAT activity, also suppressed cAMP levels.
132 tyltransferase, AA-NAT, HGMW-approved symbol AANAT; EC 2.3.1.87) is the penultimate enzyme in melaton
133             To accomplish this, a C-terminal AANAT peptide containing the phosphonodifluoromethylene
134                   This result indicates that AANAT fluctuations were light-driven and not circadian a
135               Given a previous proposal that AANAT can catalyze an alkyltransferase reaction in a con
136  and human BMAL1/MOP4 heterodimers bound the AANAT E box element and enhanced transcription.
137                           Light disrupts the AANAT/14-3-3 complex, leading to catalytic inactivation,
138 , which may represent an intermediate in the AANAT degradation process.
139               Only vertebrate members of the AANAT family have been functionally characterized.
140 es in the amount and activation state of the AANAT protein, both of which increase at night.
141  and AANAT-2; all known AANATs belong to the AANAT-1 subfamily.
142                            Formation of this AANAT/14-3-3 complex enhances melatonin production by sh
143                   When isolated from tissue, AANAT copurifies with isoforms epsilon and zeta of 14-3-
144 ta demonstrate that the binding of 14-3-3 to AANAT is regulated by light, with dramatic functional co
145                                   Similar to AANAT activity, cAMP levels fluctuate in a daily fashion
146 y, biochemically, and kinetically similar to AANATs found in bony vertebrates (VT-AANAT).
147                                          Two AANAT genes also exist in another fish, the trout.
148  and the chicken, we have now identified two AANAT genes in fish.
149                         The evolution of two AANATs may represent a strategy to optimally meet tissue
150 ferase (arylalkylamine N-ace-tyltransferase (AANAT)) catalyzes the reaction of serotonin (or tryptami
151 experiments, as compared with the unmodified AANAT.
152 flanking regions conserved in all vertebrate AANATs.
153                                     In vivo, AANAT activity in chicken retinal photoreceptor cells ex
154                   In chicken retina in vivo, AANAT is expressed in a circadian fashion, primarily in
155                          The emergence of VT-AANAT apparently involved a dramatic acceleration of evo
156 nt with the hypotheses that the advent of VT-AANAT contributed to the evolution of the pineal gland a
157 volutionary rate estimation indicate that VT-AANAT evolved from the nonvertebrate form of AANAT after
158 n of the available genomes indicates that VT-AANAT is absent from other forms of life, including the
159 ilar to AANATs found in bony vertebrates (VT-AANAT).
160 ecreased in normal and BDL rats treated with AANAT Vivo-Morpholino, compared to controls.
161         The X-ray crystal structure of Y168F AANAT bound to a bisubstrate analog inhibitor showed no
162                         Paradoxically, Y168F AANAT showed 10-fold enhanced apparent affinity for acet
163                     By analysis of the Y168F AANAT mutant, it was demonstrated that Tyr-168 contribut

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