ライフサイエンスコーパス: ABCC1

1 pump P-glycoprotein (P-gp, ABCB1) and MRP1 (ABCC1).

2 idrug resistance-associated protein 1 (MRP1, ABCC1).

3 sporter multidrug resistance protein 1 (MRP1/ABCC1).

4 nt and up-regulates the expression levels of ABCC1.

5 he function of another ABC drug transporter, ABCC1.

6 etase inhibitor or shRNA led to reduction of ABCC1.

7 and ABCG2, but has no significant effects on ABCC1.

8 egulate the drug transport activity of human ABCC1.

9 ve metabolite of CPT-11) AUC is explained by ABCC1 1684T>C, ABCB1 IVS9 -44A>G, and UGT1A1*93 (P = .00

10 beta1 induced the expression of Lpcat2/4 and Abcc1/4 and down-regulated Slc10a1 and Slco1a1 in primar

11 These include ABCA2, ABCB1, ABCB6, ABCC1, ABCC2, ABCC3, ABCC4, ABCC5, ABCC10, ABCC11, ABCC1

12 ence cellular sensitivity to taxanes (ABCB1, ABCC1, ABCC2, ABCG2, CDKN1A, CYP1B1, CYP2C8, CYP3A4, CYP

13 lar miRNAs were confirmed that target ABCA1, ABCC1, ABCC5, ABCC10, and ABCE1 genes and mediate change

14 In conclusion, we provide evidence that ABCC1 acts as an anthocyanin transporter that depends on

15 1 (also known as MDR1 or P-glycoprotein) and ABCC1 (also known as MRP1) whose inhibition remains a pr

16 umps, ABCB1 (also known as MDR1 or P-gp) and ABCC1 (also known as MRP1), whose inhibition remains a p

17 encompassing the four ohnologs NDE1, MYH11, ABCC1 and ABCC6.

18 that E(2)-induced export of S1P mediated by ABCC1 and ABCG2 transporters and consequent activation o

19 MCF7/WT cells led to increased expression of ABCC1 and associated drug resistance, consistent with ex

20 up-regulates the expression and function of ABCC1 and suggest that its activation could represent an

21 action between a specific promoter region of ABCC1 and the N1(IC)-activated transcription factor CBF1

22 -binding cassette subfamily C member 1 (MRP1/ABCC1) and the PI3/AKT pathway.

23 he human multidrug resistance protein (MRP1, ABCC1) and to assess the role of the extracellular domai

24 ein (ABCB1), multidrug resistance protein 1 (ABCC1), and breast cancer resistance protein (ABCG2) pla

25 idrug resistance-associated protein 1 (MRP1, ABCC1), and breast cancer resistance protein (BCRP, ABCG

26 drug resistance (MDR) mediated by the ABCB1, ABCC1, and ABCG2 drug-efflux transporters.

27 cell surface ABC transporters such as ABCB1, ABCC1, and ABCG2 that modulate intracompartmental and in

28 ion of new fluorescent substrates for ABCB1, ABCC1, and ABCG2.

29 ells deficient in 5-lipoxygenase, Abcb1, and Abcc1, and comparison of the effects of FTY720 with thos

30 nsporters such as P-glycoprotein/ABCB1, MRP1/ABCC1, and MXR/ABCG2 seems to be a major cause of failur

31 ion of the multidrug transporters, Abcb1 and Abcc1, and through 5-lipoxygenase activity.

32 SNPs within the efflux transporter genes ABCC1 (ATP-binding cassette, subfamily C, member 1) and

33 sette (ABC) transporter superfamily, such as ABCC1, causes enhanced efflux and, thus, decreased accum

34 porter, multidrug resistance protein 1 (MRP1/ABCC1), confers resistance to a broad range of anti-canc

35 eins as well as higher activity of N1(IC) in ABCC1-expressing MDR MCF7/VP cells compared with parenta

36 t experiments using microsomes isolated from ABCC1-expressing yeast cells showed that ABCC1 transport

37 Finally, collagen-mediated up-regulation of ABCC1 expression and function also requires actin polyme

38 ctor CBF1, suggesting that the regulation of ABCC1 expression by Notch1 is mediated by CBF1.

39 s positively correlated with CD44, HAS3, and ABCC1 expression in squamous cell carcinoma datasets and

40 umulation, collagen-induced up-regulation of ABCC1 expression levels, and collagen-mediated cell surv

41 ults reveal a unique regulatory mechanism of ABCC1 expression.

42 etween multidrug resistance protein 1 (MRP1, ABCC1) expression and cellular sensitivity to mitoxantro

43 -domain multidrug resistance protein 1 (MRP1/ABCC1) extrudes a variety of drugs and organic anions ac

44 Unlike most other ABC transporters, ABCC1 has an additional membrane-spanning domain (MSD0)

45 ole of multidrug resistance protein (MRP) 1 (ABCC1) in the emergence of mitoxantrone (MX) cross-resis

46 Transport of S1P by ABCC1 influenced migration of mast cells toward antigen

47 ABCC1 is expressed in the exocarp throughout berry devel

48 knockdown studies show that up-regulation of ABCC1 is necessary for collagen-mediated reduction of in

49 idrug resistance-associated protein 1 (Mrp1; Abcc1) is expressed in sarcolemma of murine heart, where

50 sporter multidrug resistance protein 1 (MRP1/ABCC1) is responsible for the cellular export of a chemi

51 tion in ANC nadir is explained by UGT1A1*93, ABCC1 IVS11 -48C>T, SLCO1B1*1b, ANC baseline levels, sex

52 nt biochemical evidence that an ABC protein, ABCC1, localizes to the tonoplast and is involved in the

53 ous targeting of collagen/beta1 integrin and ABCC1 may be more efficient in preventing drug resistanc

54 nsport were inhibited by the human ABCB1 and ABCC1 modulator verapamil.

55 e (SUOX) expression and the drug-transporter ABCC1 (MRP1) were linked to thiopurine sensitivity, sugg

56 ease was inhibited by MK571, an inhibitor of ABCC1 (MRP1), but not by inhibitors of ABCB1 (MDR-1, P-g

57 ter proteins ABCB1 (P-gp), ABCG2 (BCRP), and ABCC1 (MRP1), which are involved in the formation of mul

58 (Mdr1) and the leukotriene C(4) transporter Abcc1 (Mrp1).

59 orters such as ABCB1/P-glycoprotein/MDR1 and ABCC1/MRP1 causes multidrug resistance in cancer chemoth

60 These findings suggest that ABCC1/MRP1 may exist and function as a dimer and that MS

61 tus of the human full-length ABC transporter ABCC1/MRP1 using several biochemical approaches.

62 cell by the ATP-binding cassette transporter ABCC1/MRP1, and is then able to initialize cascades down

63 ted for therapeutic development to sensitize ABCC1/MRP1-mediated drug resistance in cancer chemothera

64 ive function when coexpressed with wild-type ABCC1/MRP1.

65 f multidrug resistance-associated protein 1 (ABCC1/MRP1; herein referred to as ABCC1), we measured N1

66 tidrug-resistant-associated protein 1 (MRP1; ABCC1), MRP2 (ABCC2), and MRP4 (ABCC4).

67 tor (EGF-R) activation and the expression of ABCC1 multidrug transporter gene, thus contributing to t

68 is but not meiotic mapping could exclude the Abcc1 multidrug transporter, and this was confirmed furt

69 rmacological inhibitors or gene silencing of ABCC1 (multidrug resistant protein 1) or ABCG2 (breast c

70 onfirmed further by phenotypic evaluation of Abcc1 null mice.

71 1/Pgp), multidrug resistance protein 1 (MRP1/ABCC1), or multidrug resistance protein 2 (MRP2/ABCC2).

72 glutamate-cysteine ligase catalytic subunit, ABCC1, peroxiredoxin 1).

73 Using an ABCC1 promoter construct, we observed both its reduced t

74 nesis of these CBF1 binding sites within the ABCC1 promoter region attenuated promoter-reporter activ

75 Inhibition of ABCC1 reversed drug resistance of N1(IC)-overexpressing

76 With one SNP in ABCC1, rs246240, the carriage of two copies of allele 1

77 of Abcb1, SP1 receptors, 5-lipoxygenase, and Abcc1 to enhance T cell migration and homing.

78 1) and multidrug resistance protein 1 (MRP1, ABCC1) to confirm the selectivity toward BCRP.

79 nd function of the ATP-binding cassette C 1 (ABCC1) transporter, also known as multidrug resistance-a

80 rom ABCC1-expressing yeast cells showed that ABCC1 transports malvidin 3-O-glucoside.

81 protein, multidrug resistance protein (MRP1/ABCC1), transports conjugated organic anions (e.g. leuko

82 idrug resistance protein 1 (MRP1) encoded by ABCC1 was originally discovered as a cause of multidrug

83 ltidrug resistance-associated protein (MRP1, ABCC1) was identified in small cell lung cancer followed

84 protein 1 (ABCC1/MRP1; herein referred to as ABCC1), we measured N1(IC) and presenilin 1 (PSEN1), the

85 ing cassette transporters (ABCB1, ABCB4, and ABCC1) were present.

86 Moreover, down-regulation of ABCC1 with small interfering RNA, which decreased its ce

87 ABCC1 within a cluster showing linkage is a cannabinoid

88 of the inhibitory activity toward ABCB1 and ABCC1 yielded a high selectivity toward ABCG2 for the qu