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1 ADH (alcohol dehydrogenase) gene expression, enzyme acti
2 ADH and its cofactor nicotinamide adenine dinucleotide (
3 ADH is caused by mutations in the low-density lipoprotei
4 ADH peptides induced the production of interferon-gamma
5 ADH-1 enhancement of response to melphalan was associate
6 ADH-1 improved responses to regional LPAM but had variab
7 ADH-1 in combination with LPAM ILI improved antitumor re
8 ADH-1 increased vascular permeability without effecting
9 ADH-1 is a cyclic pentapeptide that disrupts N-cadherin
10 ADH-41 targets Abeta in a sequence and structure-specifi
11 ADH-41 was also effective at inhibiting the seed-catalyz
12 ADH-specific peripheral T-cell responses were assessed b
13 ADH-specific T-cell responses have not been characterize
15 tabolizing enzymes alcohol dehydrogenase 1B (ADH-1B; rs1229984) and alcohol dehydrogenase 1c (ADH-1C;
17 odococcus ruber (ADH-A), whereas evo-1.1.200 ADH led to their counterpart (R)-enantiomers also with c
20 no-3,7-dideoxy-d-threo-hept-6-ulosonic acid (ADH) synthase, the product of the Mj0400 gene, catalyzes
21 arison of the enzyme with related aldolases, ADH synthase is classified as a new member of the class
22 ehydrogenase (either metagenomic ADH-150, an ADH from Sphingobium yanoikuyae (SyADH), or a variant of
25 vating mutation in this region, V836L, in an ADH patient, we studied the remaining residues in this r
30 This imbalance between gene expression and ADH activity at 10 degrees C, as well as the unexpected
31 ng that ChREBP regulates EtOH metabolism and ADH activity through its direct control of sirtuin 1 exp
33 irected to alcohol dehydrogenase (ADH), anti-ADH titers being associated with disease severity and ac
36 ial hypercholesterolemia 4 (FH4), defined as ADH in absence of mutations in these genes and thereafte
37 ment of highly homologous isoenzymes such as ADHs where multiple signature peptides can be examined b
38 ressed genes between DCIS-HN and 447 between ADH-HN, with >90% of the ADH-HN genes also present among
40 1 (E-47 cells) were exposed to ethanol, both ADH- and CYP2E1-generated products reduced STAT1 phospho
41 and bienzymatic (anchoring sequentially both ADH and aldehyde dehydrogenase) systems were tested.
45 ce that: (a) class I ADH is the medium-chain ADH that is expressed in human breast parenchyma, specif
46 IV alcohol dehydrogenase (ADH), medium chain ADHs that can catalyze oxidation of ethanol, are express
51 used the mouse hepatocyte cell line (CYP2E1/ADH-transfected HepB5 cells) or primary mouse hepatocyte
52 because inhibition of alcohol dehydrogenase (ADH) activity blunted ChREBP EtOH-induced acetylation in
53 ionships between some alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) genes and alcohol
54 e catabolism in which alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) play central role
56 betaL crystallin and alcohol dehydrogenase (ADH) and significantly less effective than wt alphaB cry
57 e dismutase (SOD) and alcohol dehydrogenase (ADH) as protein models] showed the integrity of the Zn-b
59 tigated bioanode with alcohol dehydrogenase (ADH) catalysing oxidation of glycerol and glyceraldehyde
61 ns in hepatic Class 1 alcohol dehydrogenase (ADH) expression in ethanol-fed rats correspondent with r
65 ombinant medium chain alcohol dehydrogenase (ADH) from the hyperthermophilic archaeon Aeropyrum perni
66 aimed to test whether alcohol dehydrogenase (ADH) gene variants were associated with alcohol use befo
69 l (PBMC) responses to alcohol dehydrogenase (ADH) in patients with alcohol-related cirrhosis, associa
71 ine-51 in horse liver alcohol dehydrogenase (ADH) is part of a hydrogen-bonded system that appears to
72 yde produced from the alcohol dehydrogenase (ADH) reaction was shown to improve the linearity of NAD(
73 ll extant short-chain alcohol dehydrogenase (ADH) through retroposition, provides an opportunity to e
74 the immobilization of alcohol dehydrogenase (ADH) via Nafion entrapment, with excellent analytical ch
75 mammals catalyzed by alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), flavin-containing m
76 zyme, hepatic Class I alcohol dehydrogenase (ADH), and this mechanism involves regulated CCAAT/enhanc
77 ntibodies directed to alcohol dehydrogenase (ADH), anti-ADH titers being associated with disease seve
78 nzyme family) with an alcohol dehydrogenase (ADH), applying the in situ substrate feeding product rem
79 a potent inhibitor of alcohol dehydrogenase (ADH), decreased the conversion of [3H]20-HETE to 20-COOH
80 the coenzyme bound to alcohol dehydrogenase (ADH), may facilitate hydride transfer and hydrogen tunne
81 her class I and/or IV alcohol dehydrogenase (ADH), medium chain ADHs that can catalyze oxidation of e
84 relation of maternal alcohol dehydrogenase (ADH)1B genotype (rs1229984) with these outcomes (the A a
85 zing a single enzyme, alcohol dehydrogenase (ADH)] and bienzymatic (anchoring sequentially both ADH a
86 ependent alcohol and aldehyde dehydrogenase (ADH and AldDH) enzymes for biofuel cell applications.
88 latinum) and enzymes (alcohol dehydrogenase, ADH; lactate dehydrogenase, LDH; xanthine oxidase, XOx;
92 s obtained here, DET using the PQQ-dependent ADH and AldDH still lacks high current density, while th
93 entiate between the methods used to diagnose ADH, which may be related to the size of the ADH focus.
96 roups of the CWP to adipic acid dihydrazide (ADH)-derivatized protein, and (ii) binding of the carbod
100 new architecture can up-regulate endogenous ADH activity by > 20-fold in transgenic Arabidopsis.
103 CI: 1.2, 10) more likely in mass (n = 20 for ADH and n = 20 for DCIS) than in non-mass (n = 46 for AD
104 = 20 for DCIS) than in non-mass (n = 46 for ADH and n = 97 for DCIS), compared with nonunderestimati
105 ears, met modified Simon-Broome criteria for ADH and were screened for mutations in the exons and con
111 oncentration, the antiparallel double helix (ADH) conformation was observed to be most abundant for G
112 patient-matched histologically normal (HN), ADH, and DCIS from 12 patients with estrogen receptor po
113 of a thermophilic alcohol dehydrogenase (ht-ADH): Y25A (at the dimer interface) and V260A (at the co
114 tant thermophilic alcohol dehydrogenases (ht-ADH), presenting evidence for Arrhenius prefactor values
115 Arrhenius curves previously reported for ht-ADH are proposed to arise, at least in part, from a chan
116 dynamical transition at 30 degrees C for ht-ADH, the temperature dependence of the KIE is seen to in
118 esidues in the cofactor-binding pocket of ht-ADH (Leu176 and V260) have been mutated to a series of h
119 a thermolabile psychrophilic homologue of ht-ADH, ps-A25Y, leads to a more thermostable enzyme and a
120 ogenase from Bacillus stearothermophilus (ht-ADH) has been mutated at an aromatic side chain in the a
122 ced temperature alters the ability of the ht-ADH variants to sample the catalytically relevant region
125 Autosomal-dominant hypercholesterolemia (ADH) is characterized by elevated low-density lipoprotei
126 ND- Autosomal dominant hypercholesterolemia (ADH), characterized by elevated plasma levels of low-den
127 a diagnosis of atypical ductal hyperplasia (ADH) (75 of 6,081 [1.2%]) were reviewed; these patients
128 erestimation of atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS) at magnetic res
129 djacent foci of atypical ductal hyperplasia (ADH) in eight, and well-differentiated papillary ductal
132 plasia (SH) and atypical ductal hyperplasia (ADH), are candidate precursors to ductal carcinoma in si
133 tients with autosomal dominant hypocalcemia (ADH) repressed the transcription of miR-9 and miR-374 ge
134 bjects with autosomal dominant hypocalcemia (ADH), five appear at the junction of TM helices 6 and 7
138 virtual abrogation of expression of class I ADH in invasive breast cancer suggests that the enzyme h
140 f ethanol; and (c) the expression of class I ADH is dramatically reduced or abrogated in invasive bre
141 findings provide evidence that: (a) class I ADH is the medium-chain ADH that is expressed in human b
145 eated hepatocytes, a significant decrease in ADH protein content and/or acetylation was observed.
151 Conclusion The rates of underestimation in ADH and DCIS diagnosed at MR imaging-guided vacuum-assis
152 the molecular mechanism for ethanol-induced ADH expression during the UEC pulse in adult male rats f
154 e specimens were examined for class I and IV ADH mRNA by reverse transcription-PCR, for protein by im
155 her these results indicate that class I-like ADH is conserved in zebrafish, albeit with mixed functio
156 phy of doubly substituted His51Gln:Lys228Arg ADH complexed with NAD(+) and 2,3- or 2,4-difluorobenzyl
157 le alcohol dehydrogenase (either metagenomic ADH-150, an ADH from Sphingobium yanoikuyae (SyADH), or
161 paucity of data about the molecular basis of ADH among ethnic groups other than those of European or
162 Here, we examined the molecular basis of ADH in a multiethnic patient cohort from lipid clinics i
165 hen catalyzes deamination and cyclization of ADH, resulting in DHQ, which is fed into the canonical p
166 at NPS 2143 corrects the molecular defect of ADH mutations for treatment of this disease are also dis
167 included 955331 women with 1727 diagnoses of ADH, 1058 (61.3%) of which were diagnosed by core biopsy
175 Cell-based assays to assess the effect of ADH-41 on Abeta are underway and will be presented in du
177 tly higher in cases of three or more foci of ADH (15 [28%] of 53 cases) than in cases of fewer than t
183 to ethanol vapor, the enzymatic reaction of ADH and ethanol transforms NAD(+) into NADH, which cause
186 pattern of regulation is similar to that of ADH that encodes alcohol dehydrogenase, which we have re
188 tudied the effects of insulin and ethanol on ADH gene expression in a highly differentiated rat hepat
190 en it was placed under anoxia; the two other ADH homologs encoded on the Chlamydomonas genome do not
191 We hypothesized that the novel pentapeptide (ADH-1), which disrupts N-cadherin adhesion, could sensit
192 e enhanced thermal stability of the A.pernix ADH is thought to arise primarily from increased ionic a
195 tion of OYE2 with a Prelog or an anti-Prelog ADH allowed the preparation of the secondary alcohols wi
197 lcohol dehydrogenase from Rhodococcus ruber (ADH-A), whereas evo-1.1.200 ADH led to their counterpart
200 eotide polymorphisms (SNPs) across the seven ADH genes and analyzed their association with alcoholism
203 xpression system for Sulfolobus solfataricus ADH-10 (Alcohol Dehydrogenase isozyme 10) and its use in
205 ium; (b) human breast parenchyma can support ADH-mediated oxidation of ethanol; and (c) the expressio
208 In a preclinical animal model, systemic ADH-1 given with regional melphalan demonstrated synergi
211 These data provide genetic evidence that ADH (but not SH) are often precursors to cancer and sugg
212 and atomic force microscopy (AFM) show that ADH-41 wholly suppresses the aggregation of Abeta at a s
214 two peaks in the ADH region suggesting that ADH populations are composed of two distinct conformers.
218 e-nucleotide polymorphisms (SNPs) across the ADH clusters in a global sampling of 42 populations.
220 Chaperoning abilities, as determined by the ADH assay and the betaL-crystallin heat denaturation ass
224 has the highest F(st) of the 54 SNPs in the ADH cluster, and it is significantly above the mean F(st
225 -95 and other discontinuous sequences in the ADH peptide, whereas only one sequence was targeted in a
226 spectrometry data revealed two peaks in the ADH region suggesting that ADH populations are composed
229 bium yanoikuyae (SyADH), or a variant of the ADH from Thermoanaerobacter ethanolicus (TeSADH W110A))
230 that SREBP-1 is a negative regulator of the ADH gene and may work in concert with the CCAAT/enhancer
231 s within the proximal promoter region of the ADH gene were studied by electrophoretic mobility shift
233 genes, including the two known genes of the ADH pathway, kauB and gbuA, were found to be inducible b
234 encode enzymes for the initial steps of the ADH pathway, the potential physiological functions of th
235 tOH attenuates the antiviral function of the ADH-ALDH pathway, which suggests the possibility that Et
238 mic amperometric detection of ethanol on the ADH-Nafion/NiOxNPs/GC modified electrode gives linear re
240 nd identified novel risk loci mapping to the ADH gene cluster on chromosome 4 and extending centromer
242 pecificity of nuclear protein binding to the ADH-SRE site was confirmed using antibody and UV cross-l
243 In hypophysectomized rats, in which the ADH protein increased by approximately 6-fold, the nucle
244 s C already at 10%wl in a synchrony with the ADH activity, indicating a rapid response likely due to
246 fluenza vaccination were consistent with the ADH and may have contributed to findings of low VE acros
248 three genes are tandemly arrayed within the ADH cluster on chromosome 4 and have very high nucleotid
250 nt study, we genotyped 16 markers within the ADH gene cluster (including the ADH1A, ADH1B, ADH1C, ADH
252 Further, sequence analysis shows that these ADHs form a monophyletic group along with additional fam
255 The in vivo binding status of SREBP-1 to ADH-SRE sites, as measured by the chromatin immunoprecip
256 ggest that additional loci may contribute to ADH, especially in understudied populations such as blac
266 of the V292T ADH-NAD+-pyrazole and wild-type ADH-NAD+-4-iodopyrazole ternary complexes are very simil
267 a plastidic arogenate dehydrogenases (TyrAa /ADH) encoded by two ADH genes (BvADHalpha and BvADHbeta)
269 tored in real time, show N(tz)AD(+) and N(tz)ADH to be substrates for yeast alcohol dehydrogenase and
270 e is seen as N(tz)AD(+) is converted to N(tz)ADH, reflecting a complementary photophysical behavior t
273 s with LDLR variants, those with unexplained ADH had lower levels of LDL-cholesterol (292 +/- 47 mg/d
275 Chaperone activity was determined by using ADH, insulin, and betaL-crystallin as the target protein
282 Surgical excision is recommended even when ADH involves fewer than three foci and all mammographic
283 most effective bioanode was fabricated when ADH was immobilized on gold nanoparticles (AuNPs) modifi
286 e based on cohorts that included women whose ADH was diagnosed before widespread use of screening mam
287 d with ADH is slightly lower for women whose ADH was diagnosed by needle core biopsy compared with ex
289 the risk of invasive cancer associated with ADH diagnosed using core needle biopsy vs excisional bio
291 port here that melphalan in combination with ADH-1 significantly reduced tumor growth up to 30-fold o
294 When the bioreductions were performed with ADH-A from Rhodococcus ruber overexpressed in E. coli, n
295 95% CI, 3.0%-12.8%) compared with those with ADH diagnosed via core needle biopsy (5%; 95% CI, 2.2%-8
300 Phylogenetic analysis of these zebrafish ADHs indicates that they share a common ancestor with ma
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