ライフサイエンスコーパス: ADP-ribosyl cyclase

1 gues enzymatically using Aplysia californica ADP-ribosyl cyclase.

2 Inhibitors of either PKG or ADP-ribosyl cyclase activities did not prevent the trans

3 lturing techniques were employed to localize ADP-ribosyl cyclase activity and cADPR hydrolase activit

4 al or molecular inhibition of CD38 abolished ADP-ribosyl cyclase activity and disrupted elongation of

5 We show that CD38 expression and endogenous ADP-ribosyl cyclase activity are developmentally regulat

6 ne, a glucocorticoid, on CD38 expression and ADP-ribosyl cyclase activity in HASM cells stimulated wi

7 The ADP-ribosyl cyclase activity of osteoclastic CD38 was ne

8 CD38 is a multifunctional protein possessing ADP-ribosyl cyclase activity responsible for both the sy

9 eal-time PCR, and Western blot analysis, and ADP-ribosyl cyclase activity was assayed with nicotinami

10 ADP-ribosyl cyclase activity was determined by incubatin

11 No detectable ADP-ribosyl cyclase activity was found in neuron-enriche

12 significant augmentation of CD38 expression, ADP-ribosyl cyclase activity, and Ca2+ responses to the

13 lls, TNF-alpha augmented CD38 expression and ADP-ribosyl cyclase activity, which were attenuated by d

14 can be synthesized by a single enzyme having ADP-ribosyl cyclase activity.

15 We investigated whether ADP-ribosyl cyclase (ADPR-cyclase) in rat vascular smoot

16 lar second messenger synthesized from NAD by ADP-ribosyl cyclases (ADPR cyclases).

17 +) hydrolytic activity and lacked detectable ADP-ribosyl cyclase and ADP-ribosyltransferase activitie

18 olysis of beta-NAD(+), but also carrying out ADP-ribosyl cyclase and ADP-ribosyltransferase activitie

19 The demonstration of extracellular ADP-ribosyl cyclase and cADPR hydrolase activities assoc

20 ADP-ribosyl cyclase and cADPR hydrolase activity have be

21 ucleotide (NAD) by bifunctional enzymes with ADP-ribosyl cyclase and cADPR hydrolase activity.

22 f GDP-ribosyl cyclase activity, and both its ADP-ribosyl cyclase and the base exchange activities wer

23 antly, a family of ectocellular enzymes, the ADP-ribosyl cyclases (ARCs), has emerged as being able t

24 ADP-ribosyl cyclases are structurally conserved enzymes

25 In this study, we show that ADP-ribosyl cyclase catalyzes the cyclization of not onl

26 nthesis of a BFA-ADP-ribose conjugate by the ADP-ribosyl cyclase CD38 and (ii) covalent binding of th

27 inhibitors of cADPR hydrolysis by the human ADP-ribosyl cyclase CD38 catalytic domain (shCD38), illu

28 tinuous assay with sirtuin-1 (Sirt1) and the ADP-ribosyl cyclase CD38, the resulting steady-state kin

29 as substrate: poly(ADP-ribose) polymerases, ADP-ribosyl cyclases (CD38 and CD157), and sirtuins (SIR

30 The multifunctional ADP-ribosyl cyclase, CD38, catalyzes the cyclization of

31 viously reported that cADPR, produced by the ADP-ribosyl cyclase, CD38, controls calcium influx and c

32 We have evaluated the role of the ADP-ribosyl cyclase, CD38, in bone remodeling, a process

33 (cADPR), which is generated by an ectoenzyme ADP-ribosyl cyclase, CD38.

34 Mammalian CD38 and its Aplysia homolog, ADP-ribosyl cyclase (cyclase), are two prominent enzymes

35 talyzed by multifunctional enzymes, CD38 and ADP-ribosyl cyclase (cyclase).

36 CD38 belongs to the ADP-ribosyl cyclase family and possesses both ectoenzyme

37 CD38, which belongs to the ADP-ribosyl cyclase family, catalyzes synthesis of both

38 dependent protein kinase (PKG) activation of ADP-ribosyl cyclase for production of cADPR to activate

39 y a family of related enzymes, including the ADP-ribosyl cyclase from Aplysia california (ADPRAC) and

40 compelling evidence for a new role for CD38/ADP-ribosyl cyclase in the control of bone resorption, m

41 SAN4825, an ADP-ribosyl cyclase inhibitor that reduces cADPR and NAA

42 CD38, the best-characterized mammalian ADP-ribosyl cyclase, is postulated to be an important so

43 NADP enzymatically using Aplysia californica ADP-ribosyl cyclase or mammalian NAD glycohydrolase.

44 ADP-ribosyl cyclase synthesizes two Ca(2+) messengers by

45 series of analogs used was produced by using ADP-ribosyl cyclase to catalyze the exchange of the nico

46 Aplysia californica ADP-ribosyl cyclase tolerates even the bulky 8-phenyl-ni

47 strate properties toward Aplysia californica ADP-ribosyl cyclase were investigated.

48 Soluble and membrane-bound ADP-ribosyl cyclases were identified and both cyclized N

49 It is homologous to Aplysia ADP-ribosyl cyclase, where the crystal structure has bee