ライフサイエンスコーパス: ADPR cyclase

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1 ynthesized from NAD by ADP-ribosyl cyclases (ADPR cyclases).

2 (0.2 mg/kg per day) prevented an increase in ADPR cyclase.

3 but to a much lesser degree than activity of ADPR cyclase.

4 HL-60 ADPR-cyclase and other known types of ADPR-cyclases.

5 ADPR cyclase gene resulted in an increase in ADPR cyclase activity and cADPR levels, as well as eleva

6 fferent fluorescence-based assays to measure ADPR cyclase activity in Arabidopsis and found that this

7 in an approximately Delta + 300% increase of ADPR cyclase activity in extracts from uterus, but in li

8 The higher ADPR cyclase activity in response to E2 was due to the i

9 to its nuclear receptors in vivo, increases ADPR cyclase activity in uterus.

10 ought to determine whether the low levels of ADPR cyclase activity reported in Arabidopsis are indica

11 n of atRA to rats resulted in an increase of ADPR-cyclase activity in aorta ( congruent with+60%) and

12 ne (T(3)) to rats resulted in an increase of ADPR-cyclase activity in aorta ( congruent with+89%), bu

13 m VSMCs, with anti-CD38 antibodies increased ADPR-cyclase activity; CD38 antigen was detected both in

14 Zn(2+) stimulated the activity of CD38 HL-60 ADPR-cyclase and other known types of ADPR-cyclases.

15 viously shown to contain NAD glycohydrolase, ADPR cyclase, and cADPR hydrolase activities also utiliz

16 2)-Vitamin D(3) (calciferol) stimulated VSMC ADPR-cyclase dose dependently at subnanomolar concentrat

17 atic properties distinct from "classic" CD38 ADPR-cyclase, especially sensitivity to inhibition by Zn

18 fer from the well-characterized CD38-antigen ADPR-cyclase, expressed in HL-60 cells.

19 ADPR-cyclase from VSMCs, but not CD38 ADPR-cyclase from HL-60 cells, was inhibited by ganglios

20 ADPR-cyclase from VSMCs, but not CD38 ADPR-cyclase from

21 is plants, induced expression of the Aplysia ADPR cyclase gene resulted in an increase in ADPR cyclas

22 ins with significant similarity to the known ADPR cyclases have been reported in any plant genome dat

23 3) administration of atRA and T(3) increases ADPR-cyclase in aorta in vivo.

24 The specific activity of ADPR-cyclase in membranes from VSMCs was >20-fold higher

25 ADPR-cyclase in VSMC membranes was more sensitive than C

26 We conclude the following: (1) ADPR-cyclase in VSMCs has enzymatic properties distinct

27 vity to inhibition by Zn(2+) and Cu(2+); (2) ADPR-cyclase in VSMCs is upregulated by various retinoid

28 ventricle (+18%), but atRA had no effect on ADPR-cyclases in lungs, spleen, intestinal smooth muscle

29 lates cADPR synthesis by ADP ribose cyclase (ADPR cyclase) in cultured epithelial cells.

30 We investigated whether ADP-ribosyl cyclase (ADPR-cyclase) in rat vascular smooth muscle cells (VSMCs

31 Our results suggest that activation of ADPR cyclase is an early ABA-signaling event partially i

32 esponsible for cADPR synthesis, ADP-ribosyl (ADPR) cyclase, is rapidly induced by ABA in both wild-ty

33 We report here that an ADPR cyclase purified from Aplysia californica readily c

34 agonist 9-cis-retinoic acid-upregulated VSMC ADPR-cyclase; the stimulatory effect of atRA was blocked

35 membranes was more sensitive than CD38 HL-60 ADPR-cyclase to inactivation by N-endoglycosidase F and

36 Most of the E2-stimulated uterine ADPR cyclase was associated with membranes.

37 rus, but in liver, brain, or skeletal muscle ADPR cyclase was unchanged.

38 Most importantly, VSMC ADPR-cyclase was inhibited by Zn(2+) and Cu(2+) ions; th

39 ute for cADPR synthesis or that a homolog of ADPR cyclase with low similarity might exist in plants.

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