ライフサイエンスコーパス: AED

1 AED coverage of cardiac arrests was defined as cardiac a

2 AED coverage of cardiac arrests was defined as historica

3 AED networks can be used as useful tools to optimize AED

4 AED reduction also predicted >/= 10-point IQ increase (p

5 AED selection requires consideration of many factors som

6 AED use statistically explained increased survival with

7 AEDs often produce adverse effects; treatment with immun

8 AEDs were used in 4515 patients (38.6%).

9 AEDs which induce the cytochrome P450 system adversely a

10 AEDs with low bioavailability and solubility (eg, oxcarb

11 ncrease for high-risk areas was from 1 to 30 AEDs and coverage from 5.7% to 51.3%, respectively.

12 included infants born to 6,777 AED-WWE, 696 AED-WWOE, and 486 no-AED-WWOE.

13 dy population included infants born to 6,777 AED-WWE, 696 AED-WWOE, and 486 no-AED-WWOE.

14 s asystole or pulseless electrical activity, AEDs were associated with a significant decrease in surv

15 ion to the location and accessibility of all AEDs linked to the emergency dispatch center as of Decem

16 needed to fully delineate the effects of all AEDs.

17 , there is controversy regarding whether all AEDs are substrates for this transporter.

18 stander, and 36% when a bystander applied an AED.

19 4) of all cardiac arrests were covered by an AED.

20 he drone network size required to deliver an AED 1, 2, or 3 minutes faster than historical median 911

21 d 100 drones would be required to deliver an AED ahead of median 911 response times by 3 minutes.

22 e an emerging technology that can deliver an AED to the scene of an out-of-hospital cardiac arrest fo

23 rrests (n=55) have occurred </=100 m from an AED with only 14.5% (n=8) being defibrillated before the

24 fined as historical arrests </=100 m from an AED.

25 ed before EMS arrival, and 289 (2.1%) had an AED applied before EMS arrival.

26 ardiac arrests within 100 m (109.4 yd) of an AED and further categorized according to AED accessibili

27 cy between drugs, FDA approval for use of an AED as monotherapy has typically been based on trials wi

28 Application of an AED in communities is associated with nearly a doubling

29 Placement of an AED in schools should be implemented with an emergency r

30 semination of on-site AEDs, foundation of an AED registry linked to emergency medical dispatch center

31 tegies, such as the ready availability of an AED, may be related to the place where the arrest occurs

32 nary resuscitation, and 30 (83%) received an AED shock.

33 focused training of lay volunteers to use an AED in high-risk public settings.

34 e attempt rates for patients treated with an AED (13 per 1000 person-years [PY]) vs patients not trea

35 -years [PY]) vs patients not treated with an AED or lithium (13 per 1000 PY).

36 der relative to patients not treated with an AED or lithium.

37 uced in the AEx (-24.4%), diet (-23.2%), and AED (-47.9%) groups by contrast to the 20.9% increase in

38 l rhythm (shockable versus nonshockable) and AED use.

39 , a predicted aspartyl protease, and another AED, LEGUME LECTIN-LIKE PROTEIN1 (LLP1), were induced lo

40 acy than currently available antiepileptics (AEDs).

41 antidepressant, other AED, or antipsychotic, AEDs were significantly protective relative to no pharma

42 By adapting APD-AED method in the case of UAE, the intensive optimum con

43 wer density and absorbed energy density (APD-AED) and response surface methodology (RSM).

44 001) for arrests in which bystanders applied AEDs.

45 e recommend that regulatory agencies approve AEDs for the treatment of specific seizure types or epil

46 ually considers spatial AED access, assuming AEDs are available 24 h a day.

47 e of strategically expanding community-based AED programs.

48 School-based AED programs provide a high survival rate for both stude

49 We investigated how volunteer-based AED dissemination affected public cardiac arrest coverag

50 o assess the independent association between AED application and survival to hospital discharge.

51 suicide and the reported association between AEDs and risk of suicide.

52 s a significant positive association between AEDs and suicidality but voted against placing a black b

53 dard monophasic defibrillators with biphasic AEDs was associated with unchanged survival after in-hos

54 Early reductions in both AED use and healthcare use were sustained long term.

55 Survival to hospital discharge by AED use, using multivariable hierarchical regression ana

56 The magnitude of this risk varies by AED exposure.

57 epileptic networks is effectively reduced by AEDs and suggest the proposed markers as useful candidat

58 all standard defibrillators were replaced by AEDs at a single institution.

59 the current study reveals that, as a class, AEDs do not increase risk of suicide attempts in patient

60 istance from a cardiac arrest to the closest AED was 281 m.

61 ge), and the average distance to the closest AED would be 262 m.

62 age and decrease the distance to the closest AED.

63 drawal, number of AEDs reduced, and complete AED withdrawal were associated with improved postoperati

64 bination category based on their concomitant AED use.

65 Receipt of continued AED treatment (n = 23) or a standardized AMTR plus AED t

66 es during year 2 of follow-up than continued AED treatment alone.

67 Participants were randomized to continued AED treatment or AMTR 2003-2007, and observed for 2 year

68 Current AED coverage was quantified by determining the number of

69 lity at the time of cardiac arrest decreased AED coverage by 53.4% during the evening, nighttime, and

70 The automated external defibrillator (AED) has improved survival after out-of-hospital VT/VF a

71 cess to an automated external defibrillator (AED) increases the chance of survival for out-of-hospita

72 0, and all automated external defibrillator (AED) locations registered with Toronto Emergency Medical

73 ntemporary automatic external defibrillator (AED) use.

74 use of an automated external defibrillator (AED), for out-of-hospital arrests.

75 able by an automatic external defibrillator (AED), implantable cardioverter-defibrillator (ICD), or w

76 rest, but automated external defibrillators (AEDs) are rarely available for bystander use at the scen

77 adopting automated external defibrillators (AEDs) for use in campus settings.

78 nation of automated external defibrillators (AEDs) has been associated with more frequent AED use, th

79 Automated external defibrillators (AEDs) improve survival from out-of-hospital cardiac arre

80 n, use of automated external defibrillators (AEDs) in community settings is limited.

81 -deployed automated external defibrillators (AEDs) in public settings suggests that this may be the m

82 lation of automated external defibrillators (AEDs) in schools has been associated with increased surv

83 er use of automated external defibrillators (AEDs) to treat out-of-hospital cardiac arrest was advoca

84 in use of automated external defibrillators (AEDs), training first responders in team-based CPR inclu

85 nation of automated external defibrillators (AEDs).

86 s in patients with epilepsy should not delay AED treatment as the risks associated with seizures far

87 tification of 12 APOPLASTIC, EDS1-DEPENDENT (AED) proteins.

88 the trade-off between the number of deployed AEDs and coverage of cardiac arrests remains unclear.

89 ion model was then developed that determined AED locations to maximize OHCA actual coverage and overc

90 ects of a hypocaloric, almond-enriched diet (AED) compared with a hypocaloric nut-free diet (NFD) on

91 29), diet (Diet n = 28), exercise plus diet (AED n = 29), or no-intervention (NI n = 29) groups.

92 , adults with concomitant use of 2 different AEDs and a recent partial-onset seizure diagnosis were s

93 ed sediment cores of West Lake of El Dorado (AED), Calion Lake (ACL), and the lagoon of Magnolia Wast

94 is the first to describe antiepileptic drug (AED) combination therapy patterns according to their mec

95 Antiepileptic drug (AED) exposure during pregnancy increases the risk of maj

96 epilepsy with or without antiepileptic drug (AED) therapy and pregnancy and perinatal outcomes.

97 tfeeding during maternal antiepileptic drug (AED) therapy may be harmful.

98 soon after failure of 2 antiepileptic drug (AED) trials is superior to continued medical management

99 To investigate antiepileptic drug (AED)-related weight changes in patients with epilepsy th

100 generic formulations of antiepilepsy drugs (AEDs) may cause clinically significant changes in plasma

101 Antiepileptic drugs (AEDs) are commonly prescribed for epilepsy and bipolar d

102 epsy patients receiving antiepileptic drugs (AEDs) are not fully controlled by therapy.

103 Antiepileptic drugs (AEDs) are the only neurotherapeutics for which regulator

104 Currently available antiepileptic drugs (AEDs) fail to control seizures in 30% of patients.

105 New antiepileptic drugs (AEDs) have been a major change in the approach to manage

106 Antiepileptic drugs (AEDs) have cognitive side effects that, particularly in

107 olling its degree using antiepileptic drugs (AEDs) is of prime importance for clinical care and treat

108 Antiepileptic drugs (AEDs) remain the primary treatment.

109 fragments of well-known antiepileptic drugs (AEDs) such as ethosuximide, levetiracetam, and lacosamid

110 y used older generation antiepileptic drugs (AEDs) suggest that they might be responsible for a numbe

111 AAs) are two classes of antiepileptic drugs (AEDs) that exhibit pronounced anticonvulsant activities.

112 effects of epilepsy and antiepileptic drugs (AEDs) used during pregnancy on fetal growth and preterm

113 Antiepileptic drugs (AEDs) were generally ineffective and in 41% were associa

114 design and discovery of antiepileptic drugs (AEDs) with fewer side effects by focusing on astroglial

115 r's disease with select antiepileptic drugs (AEDs), in low doses, is usually well tolerated and effic

116 vailability of many new antiepileptic drugs (AEDs), only around 50% of people with epilepsy will beco

117 ilepsy are resistant to antiepileptic drugs (AEDs).

118 avior related to use of antiepileptic drugs (AEDs).

119 concile the effects of anti-epileptic drugs (AEDs) on individual neurons with their network-level act

120 g ingestion of typical anti-epileptic drugs (AEDs;).

121 n body weight after and before starting each AED (together with 95% CI and p values for no difference

122 Multivariate analyses evaluated AED discontinuation risk and health care use according t

123 nd continuous efforts to introduce or extend AED programs.

124 eptic focus with a role of P-gp in extruding AEDs from the brain.

125 ubstitute rather than combine when the first AED produces an idiosyncratic reaction, is poorly tolera

126 3 and 12 months after starting, one of five AEDs.

127 udy was to develop an optimization model for AED deployment, accounting for spatial and temporal acce

128 as identified from the National Registry for AED Use in Sports.

129 The evidence for AEDs increasing risk for suicide remains mixed and is ba

130 AEDs) has been associated with more frequent AED use, the trade-off between the number of deployed AE

131 unclear why carbamazepine (CBZ), a frontline AED with a known molecular mechanism, has been reported

132 chromatography-atomic emission detector (GC-AED) was performed using the 181 nm sulfur canal.

133 Nonetheless, first-generation AEDs are still widely used.

134 Many new-generation AEDs have not been approved for monotherapy, causing dru

135 Newer generation AEDs may be preferable.

136 Older generation AEDs are associated with a panoply of metabolic abnormal

137 ed benefit; and (3) switches between generic AED formulations are safe and effective.

138 Switches between generic AED products may cause greater changes in plasma drug co

139 Most generic AED products provide total drug delivery (AUC) similar t

140 ulated switches between 595 pairs of generic AED formulations, estimated AUC(0-t) differed by >15% fo

141 Drug Administration claims that: (1) generic AEDs are accurate copies of reference formulations; (2)

142 quivalence (BE) studies for approved generic AEDs to evaluate US Food and Drug Administration claims

143 e formulations may be as variable as generic AEDs and so provide no increased benefit; and (3) switch

144 We assessed how AED accessibility affected coverage of cardiac arrests i

145 However, AED use during pregnancy is generally not associated wit

146 istics of modern AEDs, strategies to improve AED access and increase survival, ancillary treatments,

147 In AED-treated subjects, the rate of suicide attempts was s

148 were found in all three water bodies (<1% in AED and ACL; and 1.1% and 4.1% in AMW, respectively).

149 ominant PBDE input (>99% in mole fraction in AED and ACL, and 94.7% in AMW).

150 Secular trends in AED prescribing during pregnancy were examined between 1

151 We examined secular trends in AED prescribing in pregnancy and pregnancy as a determin

152 One in 5 OHCAs occurred near an inaccessible AED at the time of the OHCA.

153 first responders in team-based CPR including AED use and high-performance CPR, and training dispatch

154 Increased AED use is associated with increased survival in patient

155 the current research evidence for increased AED-related suicide risk.

156 ints with epilepsy patients, mostly inducing AED treated, are consistent and concerning, however.

157 Patients treated with inducing AEDs are at increased risk of fracture.

158 Limited AED accessibility at the time of cardiac arrest decrease

159 Limited AED accessibility decreased coverage of cardiac arrests

160 11.0%) remained on antiepileptic medication (AED).

161 lation of the U.S. and Canada (330 million), AED application by bystanders seems to save 474 lives/ye

162 ion, i.e. 70% EtOH, 30mL/g, APD of 0.22W/mL, AED of 450J/mL are able to achieve similar scale up resu

163 tained at 80% EtOH, 50mL/g, APD of 0.35W/mL, AED of 250J/mL can be used to determine the optimum cond

164 llation, technical characteristics of modern AEDs, strategies to improve AED access and increase surv

165 Moreover, AEDs have many physiologic and pharmacologic effects tha

166 rs following adequate trials of 2 brand-name AEDs.

167 vings in the time and cost of developing new AEDs.

168 Newer AEDs, many with different mechanisms of action, have inc

169 stander cardiopulmonary resuscitation but no AED, 24% (69 of 289) with AED application, and 38% (64 o

170 der cardiopulmonary resuscitation but had no AED applied before EMS arrival, and 289 (2.1%) had an AE

171 in-hospital cardiac arrest compared with no AED use (16.3% vs 19.3%; adjusted rate ratio [RR], 0.85;

172 n to 6,777 AED-WWE, 696 AED-WWOE, and 486 no-AED-WWOE.

173 10 and 136g, respectively, as compared to no-AED-WWOE.

174 FINDINGS: Prior to the introduction of novel AEDs, it was generally opined that combining traditional

175 trong determinant for the discontinuation of AED prescribing particularly for women with bipolar diso

176 alyses to compare time to discontinuation of AED prescriptions between pregnant and non-pregnant wome

177 The distribution of AED location was consistently skewed in favor of public

178 We now aimed to evaluate the effect of AED withdrawal on postoperative intelligence quotient (I

179 No adverse effects of AED exposure via breast milk were observed at age 6 year

180 y of long-term neurodevelopmental effects of AED use.

181 a significant covariation with the level of AED load and a wake-dependent modulation.

182 and in the associated research promotions of AED.

183 Rates of AED use almost tripled during the study period (21.4% to

184 Regardless of AED accessibility, 28.8% (537 of 1864) of all cardiac ar

185 t persistence was measured from the start of AED combination therapy until the end of the combination

186 Start of AED withdrawal, number of AEDs reduced, and complete AED

187 ToStop (TTS) study, we showed that timing of AED withdrawal does not majorly influence long-term seiz

188 viously identified determinants of timing of AED withdrawal.

189 quate measures of excitability and action of AEDs have been difficult to identify.

190 eizure is rescued by prior administration of AEDs, opening a new perspective for early drug intervent

191 er's disease suggest that certain classes of AEDs that reduce network hyperexcitability have disease-

192 Because head-to-head comparisons of AEDs (used in the European Union to approve drugs for mo

193 y identify neuropsychiatric complications of AEDs.

194 to identify predictors of discontinuation of AEDs in pregnancy.

195 4 US hospitals following the introduction of AEDs on general hospital wards.

196 From 2007 to 2011, the number of AEDs and the corresponding coverage of cardiac arrests i

197 access defibrillation program, the number of AEDs increased 15-fold with a corresponding increase in

198 Start of AED withdrawal, number of AEDs reduced, and complete AED withdrawal were associate

199 The higher the number of AEDs reduced, the higher was the IQ (gain) after surgery

200 Reduction of AEDs at the latest NPA significantly improved postoperat

201 ; n = 301) and analyzed whether reduction of AEDs prior to the latest NPA was related to postoperativ

202 perinatal outcomes as well as whether use of AEDs influenced risks.

203 Use of AEDs reduces suicide attempt rates both relative to pati

204 talized patients with cardiac arrest, use of AEDs was not associated with improved survival.

205 Within users of AEDs in monotherapy, the prevalence of SGA ranged from 7

206 Another older AED, valproate, is associated with the occurrence of pol

207 reasingly prescribed in pregnancy over older AEDs namely carbamazepine and sodium valproate.

208 Information on AED exposure was available in the subset of offspring fr

209 voted against placing a black box warning on AEDs for suicidality.

210 INTERPRETATION: Women on AEDs during pregnancy, whether for epilepsy or for other

211 However, only AED group significantly decreased HbA1c (-4.4%, p = 0.01

212 rt of US high schools with at least 1 onsite AED was identified from the National Registry for AED Us

213 In total, 1710 high schools with an onsite AED program were studied.

214 ge cohort of US high schools that had onsite AED programs.

215 are strongly encouraged to implement onsite AED programs as part of a comprehensive emergency respon

216 Using the spatiotemporal model to optimize AED deployment, a 25.3% relative increase in actual cove

217 orks can be used as useful tools to optimize AED placement in community settings.

218 Optimized AED deployment can increase cardiac arrest coverage and

219 tant treatment with an antidepressant, other AED, or antipsychotic, AEDs were significantly protectiv

220 The overall AED cohort showed no difference in survival to discharge

221 , 95% CI = 1.0-4.2, p = 0.001, IQ points per AED reduced).

222 eatment (n = 23) or a standardized AMTR plus AED treatment (n = 15).

223 table disabling MTLE, resective surgery plus AED treatment resulted in a lower probability of seizure

224 dily increased and has been the most popular AED prescribed in pregnancy since 2004.

225 Within the entire study population, AED use was associated with a lower rate of survival aft

226 Potential AED use was significantly improved with a spatiotemporal

227 g methodology for the discovery of potential AEDs.

228 4 despite being the most commonly prescribed AEDs in pregnancy up to 2004.

229 Prospective AED trials should include validated scales to systematic

230 Mathematical modeling can augment public AED deployment programs.

231 nequivocal funding to schools for purchasing AEDs.

232 lepsy were twice as likely to stop receiving AEDs (Hazard Ratio (HR) 2.00, 95% Confidence Interval (C

233 pregnancy were more likely to stop receiving AEDs in pregnancy.

234 regnant women with epilepsy, those receiving AEDs less regularly before pregnancy were more likely to

235 4 were within 100 m of at least 1 registered AED (23% coverage).

236 nontraumatic public OHCAs and 737 registered AED locations were identified.

237 t occurred within 100 meters of a registered AED (assumed coverage 24 h per day, 7 days per week) wit

238 urred both within 100 meters of a registered AED and when the AED was available (actual coverage).

239 ters of cardiac arrests without a registered AED within 100 m were identified.

240 rests occurring within 100 m of a registered AED.

241 location cardiac arrests and 1669 registered AEDs.

242 Of 552 registered AEDs, 9.1% (n=50) were accessible at all hours, and 96.4

243 rdiac arrests (1994-2011) and all registered AEDs (2007-2011) in Copenhagen, Denmark, were identified

244 otal of 451 OHCAs were covered by registered AEDs under assumed coverage 24 h per day, 7 days per wee

245 gust 2014) and obtained a list of registered AEDs (March 2015) from Toronto Paramedic Services.

246 The number of registered AEDs increased from 141 in 2007 to 7800 in 2012.

247 tter safety profile than clinically relevant AEDs ethosuximide, lacosamide, or valproic acid.

248 ary 2016, 17 of 50 U.S. states (34%) require AED installation in at least some of their schools; the

249 ty of U.S. states have legislation requiring AED placement in schools, and even fewer provide funding

250 t have not yet enacted legislation requiring AEDs in schools may look to neighboring states for examp

251 cardiac arrests due to nonshockable rhythms, AED use was associated with lower survival (10.4% vs 15.

252 or cardiac arrests due to shockable rhythms, AED use was not associated with survival (38.4% vs 39.8%

253 e bystander CPR and implementation of school AEDs and other public access defibrillation programs imp

254 the patient tolerates their first or second AED well, but with a suboptimal response, particularly w

255 es and 30.0% fewer drones to achieve similar AED delivery times.

256 of Danish citizens, dissemination of on-site AEDs, foundation of an AED registry linked to emergency

257 or not shockable rhythm; and 7) study site, AED application was associated with greater likelihood o

258 Current deployment usually considers spatial AED access, assuming AEDs are available 24 h a day.

259 and pregnancy as a determinant for stopping AED prescribing.

260 answers on whether to combine or substitute AEDs.

261 The findings suggest that AED combinations with different MOAs have greater effect

262 An FDA alert in 2008 raised concerns that AEDs may increase the risk of suicidal thoughts and beha

263 The AED and NFD groups experienced clinically significant an

264 The AED was applied by health care workers (32%), lay volunt

265 The AED, compared with the NFD, was associated with greater

266 Despite smaller weight loss in the AED group at 6 mo, the AED group experienced greater imp

267 Those in the AED group lost slightly but significantly less weight th

268 er weight loss in the AED group at 6 mo, the AED group experienced greater improvements in lipid prof

269 ost urban region, the 90th percentile of the AED arrival time was reduced by 6 minutes and 43 seconds

270 Since the establishment of the AED network (2007-2011), few arrests (n=55) have occurre

271 o maximize the impact of the presence of the AED.

272 hematical model can substantially reduce the AED delivery time to an out-of-hospital cardiac arrest e

273 ted the weight difference after starting the AED for each patient.

274 100 meters of a registered AED and when the AED was available (actual coverage).

275 These AEDs target mechanisms of epileptogenesis involving amyl

276 he apparent permeability (Papp) of the three AEDs in the absence or presence of P-gp inhibitors.

277 an AED and further categorized according to AED accessibility at the time of cardiac arrest.

278 and, if so, whether this is attributable to AED use.

279 Analyses were restricted to AED and lithium monotherapy.

280 imization and queuing can reduce the time to AED arrival.

281 As an alternative to AEDs, novel therapies based on cell transplantation offe

282 Prenatal exposure to AEDs in WWE and WWOE was associated with a mean lower bi

283 ify all current state statutes pertaining to AEDs in schools.

284 us (SGA) among infants exposed prenatally to AEDs when used by women with epilepsy (WWE) or women wit

285 ompared with that among infants unexposed to AEDs and born to WWOE.

286 y strategic placement but also uninterrupted AED accessibility warrant attention if public-access def

287 In women with epilepsy, using AEDs during pregnancy did not increase the risks of preg

288 In patients whose initial rhythm was VT/VF, AEDs were not associated with improvement in time to fir

289 itored and nonmonitored hospital units where AEDs were used, after matching patients to the individua

290 d by EMS personnel or bystanders and whether AEDs are applied by bystanders, the proportion of arrest

291 th Alzheimer's disease will identify whether AEDs or related strategies could improve their cognitive

292 tment options and issues influencing whether AEDs should be substituted or combined in the remainder

293 th AED application, and 38% (64 of 170) with AED shock delivered.

294 suscitation but no AED, 24% (69 of 289) with AED application, and 38% (64 of 170) with AED shock deli

295 ncreased risk of suicidality associated with AED treatment, the current study reveals that, as a clas

296 rse effects of breastfeeding associated with AED use on IQ at age 3 years, but IQ at age 6 years is m

297 fibrillator to a biphasic defibrillator with AED capability.

298 With AEDs deployed in the top 30 locations, an additional 112

299 and the interaction of anesthetic drugs with AEDs.

300 was 34% for arrests in public settings with AEDs applied by bystanders versus 12% for arrests at hom