ライフサイエンスコーパス: AIP

1 AIP does not affect long-term survival.

2 AIP inhibits IRF7 function by antagonizing the nuclear l

3 AIP is a rare disease whose recognition and understandin

4 AIP is steroid-responsive but maintaining remission cont

5 AIP neurons responding to outline shapes also responded

6 AIP-1 overexpression also reduced accumulation of Abeta

7 AIP-directed mitochondrial import of survivin did not af

8 Patients with type 1 AIP have a high relapse rate, but patients with type 2 A

9 Type 1 AIP is the pancreatic manifestation of a systemic fibroi

10 At presentation, patients with type 1 AIP were older than those with type 2 AIP (62 +/- 14 vs

11 and vital status of 78 patients with type 1 AIP who met the original HISORt criteria and 19 patients

12 In type 1 AIP, proximal biliary involvement (hazard ratio [HR], 2.

13 a mutation in Caenorhabditis elegans AIPR-1 (AIP-related-1), which causes profound increases in evoke

14 nd evaluated the inhibitory activities of 10 AIP derivatives based on a truncated AIP analogue that i

15 Types 1 and 2 AIP have distinct clinical profiles.

16 iles and long-term outcomes of types 1 and 2 AIP.

17 type 1 AIP were older than those with type 2 AIP (62 +/- 14 vs 48 +/- 19 years; P < .0001) and had a

18 Type 2 AIP affects younger patients, does not have a gender pre

19 re geared toward diagnosis of type 1; type 2 AIP can be definitively diagnosed only on pancreatic his

20 high relapse rate, but patients with type 2 AIP do not experience relapse.

21 atients with histologically confirmed type 2 AIP.

22 IP receptors AgrC and the AIPs, as AP4-24H11.AIP-4 binding recapitulates features that have been prop

23 The agonist, AIP-I, binds AgrC-I noncooperatively in a 2:2 stoichiome

24 es features that have been proposed for AgrC-AIP recognition.

25 AgrC1 loop 2 resulted in conversion of (Ala5)AIP-1 from a potent antagonist to an activator, essentia

26 e was shown by others to be essential for an AIP-1 prolongevity function.

27 Consistent with this, we show that an AIP-1 mutant lacking the predicted farnesylation site fa

28 Therefore, an AIP-Tom20 recognition contributes to cell survival in de

29 while differential recognition of AIP-1 and AIP-4 depends primarily on three amino acid residues in

30 Since AIP-1 and AIP-4 only differ by a single amino acid, we compared th

31 pon Staphylococcus lugdunensis AIP-1 (1) and AIP-2 (2) displayed respective IC50 values of 0.2 +/- 0.

32 ) of 0.95], chronic pancreatitis (0.86), and AIP (0.99).

33 Interestingly, AIRAPL and AIP-1 contain a predicted farnesylation site, which is a

34 mportant roles of both cerebellar cortex and AIP nucleus in eyeblink conditioning were seen.

35 function from thiolactone ring formation and AIP transport.

36 ctrometry and discovered that the AIP-II and AIP-III signals are 12 residues in length, making them t

37 d IRF7 is enhanced upon virus infection, and AIP potently inhibits IRF7-induced type I IFN (IFNalpha/

38 al and anterior intraparietal areas (MIP and AIP), and parietal area PEip; somatosensory areas S1 and

39 detection of early chronic pancreatitis and AIP, risk stratification and application of risk-lowerin

40 mbined group of N, chronic pancreatitis, and AIP was determined.

41 oci methylated at high frequency in PRIM and AIP but rarely in MET.

42 peptide regions important for processing and AIP secretion.

43 The parietal area AIP operated primarily in a visual mode.

44 rmed by macaque anterior intraparietal area (AIP) and hand area (F5) of the ventral premotor cortex i

45 primates are in anterior intraparietal area (AIP) and ventral premotor cortex (PMv).

46 comprising the anterior intraparietal area (AIP), ventral premotor (PMv), and primary motor cortex (

47 ocated anterior to the angular gyrus such as AIP and VIP are less medially displaced relative to maca

48 the requirements and mechanism of S. aureus AIP biosynthesis.

49 Because AIP blocks the degradation of IkappaB, its regulation is

50 An association between AIP and the human leukocyte antigen (HLA)-DRB1*0405/DQB1

51 The interaction between AIP and IRF7 is enhanced upon virus infection, and AIP p

52 ed studies confirm the intimate link between AIP production and intracellular AgrD(C) levels.

53 s a survivin 1-141 mutant that does not bind AIP was not imported to mitochondria and failed to inhib

54 grC-I caused the receptor to be activated by AIP-I nearly as well as the wild type AgrC-I receptor.

55 ormation about object properties provided by AIP.

56 with a peptide inhibitor of calcineurin (CaN-AIP); the non-selective PP1/PP2A inhibitors okadaic acid

57 ctrometric analysis identified the S. caprae AIP as an eight-residue peptide (YSTCSYYF).

58 therapeutic efficacy of synthetic S. caprae AIP was evident by a dramatic reduction in both dermonec

59 ering the activation efficacy of the cognate AIP-1.

60 ntial for receptor activation by the cognate AIP.

61 Consistently, AIP-deficient murine embryonic fibroblasts are highly re

62 led two key structural elements that control AIP-III (and non-native peptide) activity: (1) a tri-res

63 More detailed studies with the convenient AIP model indicated that CSF-1 neutralization led to a r

64 gative I-Abeta chain(-/-) (Ab0) mice develop AIP spontaneously, likely due to dysregulation of CD8(+)

65 HLA-DR*0405 transgenic Ab0 NOD mice develop AIP with high prevalence after sublethal irradiation and

66 icient NOD.CD28KO mice spontaneously develop AIP that closely resembles the human disease.

67 indicate that (1)H NMR can help to diagnose AIP attacks based on the identification of ALA and PBG.

68 groups I-IV), each of which uses a different AIP:AgrC pair.

69 wly published strategies for differentiating AIP from pancreatic cancer are available.

70 ractions [10-12] were modified by disrupting AIP function with theta-burst TMS (cTBS) [13].

71 s explain the chemical principles that drive AIP production, including uncovering a hitherto unknown

72 During AIP, delta-aminolevulinic acid (ALA) accumulates and pro

73 d analogue of the Staphylococcus epidermidis AIP-1 (3) elicited an IC50 value of 2.7 +/- 0.1 muM.

74 the minimum effective shape feature evoking AIP responses.

75 aration were significantly reduced following AIP cTBS without directly modifying corticospinal excita

76 A novel antibody for AIP has recently been identified and its performance nee

77 Diagnostic criteria for AIP are based on histology, imaging, serology, extrapanc

78 c biopsy of the bile duct was diagnostic for AIP in 88% patients.

79 tion via a thiolactone bond is essential for AIP function; therefore, recognition of the cyclic form

80 nine residues were found to be essential for AIP production and AgrB endopeptidase activity.

81 e appears to be an important risk factor for AIP on the HLA-DRB1*0405/DQB1*0401 haplotype.

82 ne in the rate of operative intervention for AIP, a steroid-responsive disease with propensity for re

83 ponsive genes and suggests that a search for AIP-dependent, AHR-responsive genes may guide us to the

84 orticoids have become a standard therapy for AIP, but the indications requiring treatment as well as

85 oid therapy improve the diagnostic yield for AIP.

86 When decoding from AIP, F5, and M1 combined, the mean accuracy was 50% (usi

87 R*0405 expression fails to protect mice from AIP, the HLA-DRB1*0405 allele appears to be an important

88 predicted well during movement planning from AIP (medial array) and F5 (lateral array), whereas M1 pr

89 tify and quantify ALA and PBG in urines from AIP patients and (2) to identify metabolites that would

90 Furthermore, AIP significantly reduced the level of glutamate-induced

91 However, little is known about how AIP contributes to the processing of grasp-related infor

92 It is unclear how AIP binding regulates AgrC activity.

93 nfavorable, and therefore, it is unclear how AIP-producing bacteria produce sufficient amounts of the

94 ning the object shape, but it is unknown how AIP neurons actually represent object shape.

95 2_844delGAG) identical to that causing human AIP and two missense mutations, c.250G>A (p.A84T) and c.

96 fe-threatening neurological attacks in human AIP and the evaluation of therapeutic strategies.

97 thologue of BC058385 was methylated in human AIP but not in primary androgen-stimulated prostate canc

98 enzyme and accumulated metabolites in human AIP.

99 We created a mouse model of human AIP by overexpressing lymphotoxin (LT)alpha and beta spe

100 is, diagnostic markers, and therapy of human AIP.

101 Preliminary characterization of the AgrC-I-AIP-I interaction suggests that ligand specificity may b

102 Here, we have identified AIP (aryl hydrocarbon receptor interacting protein) as a

103 g peptide (AIP) signals has been identified (AIP-I), and cross talk between agr systems has not been

104 Together, our study identifies AIP as a novel inhibitor of IRF7 and a negative regulato

105 reported a set of analogues of the group-III AIP that are capable of strongly modulating the activity

106 Our results implicate AIP-1 in the regulation of protein turnover and protecti

107 reversible mislocalization of ductal CFTR in AIP, the association of asymptomatic pancreatic hyperenz

108 mutagenized and screened for deficiencies in AIP production.

109 ral other antibodies have been identified in AIP against pancreas-specific antigens like trypsinogens

110 of grasp-related and spatial information in AIP and F5 suggests at least a supportive role of these

111 to identify amino acid residues involved in AIP recognition.

112 activity from many electrodes in parallel in AIP and F5 while three macaque monkeys (Macaca mulatta)

113 the most homogeneous methylation pattern in AIP and the most heterogeneous pattern in MET.

114 ghout the task, although more prominently in AIP than in F5.

115 predominantly mediate the immune reaction in AIP.

116 k-lowering strategies to prevent relapses in AIP or the development of recurrent (and possibly chroni

117 or management and prevention of relapses in AIP.

118 aze and target positions were represented in AIP and F5 and could be readily decoded from single unit

119 Whether these spatial signals in AIP and F5 also play a causal role for the planning of r

120 1 residues were defective in a later step in AIP biosynthesis, separating the peptidase function from

121 esidues glutamate 34 or leucine 41 inhibited AIP production and AgrB activity.

122 expressing the SR-targeted CaMKII inhibitor AIP, without any significant enhancement of apoptosis vs

123 , and the selective CaMKII peptide inhibitor AIP (autocamtide-2-related inhibitory peptide) (2 microm

124 To better understand inhibitory AIP-AgrC interactions, we aimed to identify the minimal

125 Non-native ligands capable of intercepting AIP:AgrC binding, and thereby QS, in S. aureus have attr

126 Interestingly, AIP of HIV-1 Env glycoproteins were found to correlate i

127 e we report that the anterior intraparietal (AIP) and the rostral ventral premotor area (F5) in the m

128 The macaque anterior intraparietal (AIP) area has been implicated in the extraction of affor

129 ng activity from the anterior intraparietal (AIP), ventral premotor (F5), and primary motor (M1) cort

130 es were distributed among four laboratories (AIP, NCS, LSPQ, and SSI).

131 2 stoichiometry, while an antagonist ligand, AIP-II, functions as an inverse agonist of the kinase ac

132 Herein, we report amide-linked AIP analogues with greatly enhanced hydrolytic stabiliti

133 logues based upon Staphylococcus lugdunensis AIP-1 (1) and AIP-2 (2) displayed respective IC50 values

134 n the AIP-encoding gene (agrD) that modifies AIP structure must be accompanied by corresponding chang

135 NOD mouse AIP was associated with severe periductal and parenchyma

136 e rescued by presynaptic expression of mouse AIP, demonstrating that a conserved function of AIP prot

137 utocamtide-2-related inhibitory peptide (myr-AIP)--but not by inhibition of the activity of protein p

138 ) blockers applied by bath (KN-93, myristoyl-AIP) or expressed selectively in the sensory neurons (AI

139 onal structural analysis of the known native AIP signals (AIPs-I-IV) and several AIP-III analogues wi

140 A limited set of non-native AIP analogs have been shown to inhibit AgrC receptors; s

141 xpressed selectively in the sensory neurons (AIP) reduced CDF, unlike their inactive analogues.

142 y resulting in the forced evolution of a new AIP group.

143 levations (>140 mg/dl) are seen in 70-80% of AIP patients and also in 5% of normal population and 10%

144 utable to higher-than-normal accumulation of AIP-III in a codY mutant strain, as determined using ult

145 emistry for the diagnosis of acute attack of AIP and identify urinary glycin as a potential marker of

146 The biosynthesis of AIP requires AgrD, the peptide precursor of AIP, and the

147 ed as a hub that shared the visual coding of AIP only temporarily and switched to highly dominant mot

148 of the severity of a chronic complication of AIP.

149 dressed this by studying the consequences of AIP "virtual lesions" on physiological interactions betw

150 have previously localized the determinant of AIP receptor specificity to the C-terminal half of the A

151 actors that contribute to the development of AIP and new therapeutic strategies.

152 le of single HLA genes in the development of AIP in transgenic mice.

153 essary and sufficient for the development of AIP.

154 identify recent advances in the diagnosis of AIP and evaluate outcomes with various diagnostic strate

155 Behaviorally, disruption of AIP was also associated with a relative loss of the gras

156 tural insights may enable the engineering of AIP cross-reactive antibodies or quorum quenching vaccin

157 (i) The expression of AIP in hepatocytes is essential to maintain high levels

158 l immune-complex deposition, and features of AIP in Ela1-LTab mice.

159 owever, when combined with other features of AIP, it can be of great diagnostic value though its util

160 y in acinar cells of mice causes features of AIP.

161 autoimmune disorder with various features of AIP.

162 were homozygous, a unique recessive form of AIP.

163 , demonstrating that a conserved function of AIP proteins is to inhibit calcium release from ryanodin

164 APL as the functional mammalian homologue of AIP-1.

165 Mammalian homologues of AIP-1 have been shown to associate with, and regulate th

166 leading us to hypothesize that induction of AIP-1 may be a protective cellular response directed tow

167 uced activation of IFN, whereas knockdown of AIP by siRNA potentiates virally activated IFN productio

168 1 protected against, while RNAi knockdown of AIP-1 exacerbated, Abeta toxicity.

169 Pancreatic and biliary manifestations of AIP mimic pancreaticobiliary cancers.

170 strong structural support for a mechanism of AIP-mediated AgrC activation and inhibition in S. aureus

171 In addition, microinjection of AIP into the PVN significantly reduced arterial blood pr

172 Misdiagnosis of AIP can result in major surgery for a steroid-responsive

173 he first naturally occurring animal model of AIP in four unrelated cat lines who presented phenotypic

174 Overexpression of AIP blocks virus-induced activation of IFN, whereas knoc

175 sgenic model, we show that overexpression of AIP-1 protected against, while RNAi knockdown of AIP-1 e

176 The pathogenesis of AIP remains unclear but a recent report noted that T hel

177 AIP requires AgrD, the peptide precursor of AIP, and the integral membrane endopeptidase AgrB.

178 ospital survey from Japan, the prevalence of AIP was estimated at 0.82 per 100,000 individuals.

179 es further described the clinical profile of AIP and its extrapancreatic manifestations.

180 ess in understanding the clinical profile of AIP but knowledge of pathogenesis remains limited.

181 ealed that while differential recognition of AIP-1 and AIP-4 depends primarily on three amino acid re

182 lycin as a potential marker of recurrence of AIP acute attacks.

183 sociations that may predispose to relapse of AIP were reported.

184 enetic screen may help to predict relapse of AIP.

185 To understand the role of AIP in adaptive and toxic aspects of AHR signaling, we g

186 A subset of AIP neurons is also activated by two-dimensional images

187 design, synthesis, and biological testing of AIP-III mimetics.

188 gress made in the diagnosis and treatment of AIP in the past year.

189 ces in the past year in our understanding of AIP.

190 driven genes show differential dependence on AIP expression.

191 This differential dependence on AIP provides evidence that the mammalian genome contains

192 ide dismutase, whereas its inhibitor KN93 or AIP abolished the arrhythmic phenotype.

193 Replacement of the P4-P2 AIP reactive loop residues in the alpha1PI exosite varia

194 G4) is a feature of autoimmune pancreatitis (AIP) and IgG4-associated cholangitis (IAC); a >2-fold in

195 isting knowledge of autoimmune pancreatitis (AIP) and to review the progress made in the diagnosis an

196 e concentrations in autoimmune pancreatitis (AIP) by restoring mislocalized CFTR protein to the apica

197 s may differentiate autoimmune pancreatitis (AIP) from pancreatic cancer in select patients.

198 Autoimmune pancreatitis (AIP) has been divided into subtypes 1 (lymphoplasmacytic

199 Autoimmune pancreatitis (AIP) is a heterogeneous autoimmune disease in humans cha

200 Autoimmune pancreatitis (AIP) is a rare and underdiagnosed fibrosclerosing inflam

201 Autoimmune pancreatitis (AIP) is an increasingly recognized clinical condition.

202 Autoimmune pancreatitis (AIP) is the pancreatic manifestation of ISD and mimics p

203 Autoimmune pancreatitis (AIP) underlies 5%-11% of cases of chronic pancreatitis.

204 or the diagnosis of autoimmune pancreatitis (AIP) with the objective of establishing a strategy to di

205 genic mechanisms of autoimmune pancreatitis (AIP), an increasingly recognized, immune-mediated form o

206 es of patients with autoimmune pancreatitis (AIP), and follow-up periods have generally been short.

207 ronic pancreatitis, autoimmune pancreatitis (AIP), and healthy controls (N).

208 allel in macaque premotor (F5) and parietal (AIP) cortices during a delayed grasping task revealed th

209 eria, agr encodes an autoactivating peptide (AIP) that is the inducing ligand for AgrC, the agr signa

210 tive inhibitors of the autoinducing peptide (AIP) activated AgrC receptor, by altering the activation

211 um sensing in which an autoinducing peptide (AIP) activates AgrC, a histidine protein kinase.

212 ine kinase detects its autoinducing peptide (AIP) ligand and generates an intracellular signal result

213 duction and sensing of autoinducing peptide (AIP) signal molecules by the agr locus.

214 s, but only one of the autoinducing peptide (AIP) signals has been identified (AIP-I), and cross talk

215 pathogen that utilizes autoinducing peptide (AIP) signals to mediate QS and thereby regulate virulenc

216 ning peptide called an autoinducing peptide (AIP) that is biosynthesized from the AgrD precursor by t

217 ted that the S. caprae autoinducing peptide (AIP) was responsible, and mass spectrometric analysis id

218 e synthesizes a cyclic autoinducing peptide (AIP) with a distinct sequence that activates its cognate

219 ctone signal called an autoinducing peptide (AIP).

220 analogues of a native autoinducing peptide (AIP-III) signal that can inhibit AgrC-type QS receptors

221 or autocamtide-2-related inhibitory peptide (AIP) inhibited NFkappaB activation in the retina.

222 sed in FRD-SR-autocamide inhibitory peptide (AIP) mice, expressing the SR-targeted CaMKII inhibitor A

223 or autocamtide-2-related inhibitory peptide (AIP) normalized the increased amplitude of NMDAR-EPSCs a

224 ed autocamtide-2-related inhibitory peptide (AIP) was used in a rat in vivo model of retinal toxicity

225 questers the secreted agr-signaling peptide (AIP).

226 In Ag-induced peritonitis (AIP), thioglycolate-induced peritonitis, and LPS-induced

227 the inferior parietal lobe such as PF, PFG, AIP, and the tip of the IPS.

228 patients with acute intermittent porphyria (AIP) and porphyria cutanea tarda (PCT).

229 patients with acute intermittent porphyria (AIP), an inherited metabolic disorder of heme biosynthes

230 Human acute intermittent porphyria (AIP), the most common acute hepatic porphyria, is an aut

231 patients with acute intermittent porphyria (AIP).

232 The Arabidopsis information portal (AIP), a resource expected to provide access to all commu

233 t to uncover the anterior intestinal portal (AIP) endoderm as a putative heart organizer.

234 d fuse above the anterior intestinal portal (AIP) to form the heart tube.

235 d tested their apoptosis-inducing potential (AIP).

236 tios of aqueous-inlet to oil-inlet pressure (AIP/OIP), yielding a linear relationship between muaq an

237 ytes (Ela1-LTab/Ccr2(-/-)) failed to prevent AIP but prevented early pancreatic tissue damage.

238 The Arctic Investigations Program (AIP) began surveillance for invasive group A streptococc

239 ) and Alaska (Arctic Investigations Program [AIP]).

240 yl hydrocarbon receptor-interacting protein (AIP), a survivin-associated immunophilin, causes embryon

241 yl hydrocarbon receptor-interacting protein (AIP), also known as ARA9 and XAP2.

242 n E3 ligases atrophin-1-interacting protein (AIP)4 and AIP5.

243 uitin ligase atrophin-1 interacting protein (AIP)4 to bind, ubiquitinate, and stabilize Amot130.

244 In import assays using recombinant proteins, AIP directly mediated the import of survivin to mitochon

245 The Cyp1b1 and Ahrr genes require AIP expression for normal up-regulation by dioxin, where

246 At rest, AIP virtual lesions did not modify PMv-M1 interactions.

247 n native AIP signals (AIPs-I-IV) and several AIP-III analogues with varied biological activities usin

248 SHG-AIP with two symmetrical spots is found to be a signatur

249 on of second-order nonlinear emitters on SHG-AIP is highlighted.

250 SHG angular intensity pattern (SHG-AIP) of healthy and proteolysed muscle tissues are simul

251 We also show that SHG-AIP provides information on the three-dimensional struct

252 be a signature of healthy muscle whereas SHG-AIP with one centered spot in pathological mdx muscle is

253 When an extracellular peptide signal (AIP-III in strain UAMS-1, used for these experiments) re

254 Since AIP-1 and AIP-4 only differ by a single amino acid, we c

255 this spontaneous pancreatic amylase-specific AIP in regulatory T cell-deficient NOD.CD28KO mice provi

256 gnificant enhancement of apoptosis vs. CD-SR-AIP mice.

257 oxidative stress but not apoptosis in FRD-SR-AIP mice, in which a CaMKII inhibitor is targeted to the

258 eractions between the cognate staphylococcal AIP receptors AgrC and the AIPs, as AP4-24H11.AIP-4 bind

259 The term 'AIP' appears to encompass at least two distinct subtypes

260 ariance explained) significantly better than AIP (6%).

261 ion of variability in trial-to-trial RT than AIP.

262 effect on trial-to-trial RT variability than AIP.

263 Results confirmed that AIP fully attenuates caspase-3 activation for at least 8

264 Our study demonstrates that AIP of HIV-1 Env and IA collectively determine CD4 loss

265 a lead-in to this study, we discovered that AIP type I could be generated in Escherichia coli throug

266 that active endodermal shortening around the AIP accounts for most of the heart field motion towards

267 d throughout the central region encoding the AIP signal.

268 , we demonstrate two important roles for the AIP protein in AHR biology.

269 n December 2011 proposed a structure for the AIP to provide a framework for the minimal components of

270 Neurons in the AIP area respond during visually guided grasping and to

271 We now invite broader participation in the AIP development process so that the resource can be impl

272 frequently associated with mutations in the AIP gene and are sometimes associated with hypersecretio

273 wered inflammatory macrophage number; in the AIP model, this reduced number was not due to suppressed

274 with each of the four amide nitrogens in the AIP-4 macrocyclic ring.

275 to retain functionality, any changes in the AIP-encoding gene (agrD) that modifies AIP structure mus

276 s challenge the current understanding of the AIP area as a critical stage in the dorsal stream for th

277 This minimization of the AIP pharmacophore also may have therapeutic relevance as

278 (ii) Expression of the AIP protein is essential for dioxin-induced hepatotoxici

279 The design of the AIP will provide core functionality while remaining flex

280 this binding motif, (R/K)R(I/A/V) (L/P), the AIP box for Asf1-Interacting Protein box.

281 lethal dose of S. aureus by sequestering the AIP signal.

282 We show that the AIP can induce cardiac identity from non-cardiac mesoder

283 ng mass spectrometry and discovered that the AIP-II and AIP-III signals are 12 residues in length, ma

284 d into four groups (I-IV) according to their AIP signal and cognate extracellular receptor, AgrC.

285 We structurally characterized all three AIP types using mass spectrometry and discovered that th

286 tabolites that would predict the response to AIP crisis treatment and reflect differential metabolic

287 T cells; we compared their susceptibility to AIP with HLA-DQ8 or HLA-DR*0401 (single) transgenic, or

288 s of 10 AIP derivatives based on a truncated AIP analogue that inhibits all four agr types.

289 AMP tumors (PRIM, late-stage primary tumors; AIP, androgen-independent primary tumors; and MET, metas

290 Unique AIP and AgrC variants exist within and between species,

291 transgenic mice can also develop unprovoked AIP, whereas HLA-DR*0401, HLA-DQ8, and HLA-DR*0405/DQ8 t

292 ial variability and movement timing, whereas AIP might be more closely linked to overall movement int

293 ructure of the AP4-24H11 Fab in complex with AIP-4 at 2.5 A resolution to determine its mechanism of

294 beta in this model, which is consistent with AIP-1 enhancing protein degradation.

295 We analyzed data from 122 individuals with AIP who were followed from 2003 to 2013 and genotyped fo

296 ns-autophosphorylation upon interaction with AIP.

297 sed in pancreatic tissues from patients with AIP, compared with controls, and expression of chemokine

298 ligands might be used to treat patients with AIP.

299 Treatment with AIP also normalized the higher frequency of NMDAR-mediat

300 serum samples from patients with and without AIP.