ライフサイエンスコーパス: AKAP

1 AKAP palmitoylation was regulated by seizure activity in

2 AKAP-Lbc facilitates PKA phosphorylation of Shp2, which

3 AKAP-Lbc facilitates PKA phosphorylation of Shp2, which

4 AKAP-Lbc integrates PKA and Shp2 signaling in the heart.

5 AKAP-Lbc interacts with Shp2, facilitating its regulatio

6 AKAP-Lbc is a scaffold protein that coordinates cardiac

7 AKAP-Lbc-tethered PKA is implicated in cardiac hypertrop

8 AKAP-PKA disruption had minimal effects on whole-cell cA

9 AKAPs coordinate compartmentalized cAMP signaling in ASM

10 re we show that AKAP13 (also known as Brx-1, AKAP-Lbc, and proto-Lbc), a unique protein kinase A-anch

11 Protein kinase A-anchoring protein 79/150 (AKAP), residing at the plasma membrane in neurons, scaff

12 review, we summarize recent evidence for AC-AKAP complexes and requirements for compartmentalization

13 pr161 functions as a selective high-affinity AKAP for type I PKA regulatory subunits (RI).

14 H) induces the expression of an 80-kDa AKAP (AKAP 80) in ovarian granulosa cells as they mature from

15 ts used heterologous expression with AKAP15, AKAP-KL, and AKAP79 in Xenopus oocytes.

16 Although AKAPs have been recently shown to bind adenylyl cyclase

17 ly interacts with radial spoke protein 3 (an AKAP), which is located at the base of the spoke.

18 s class I ADP-ribosylation factors and as an AKAP for RIIbeta that localizes PKA signaling within cel

19 g to melanosomes and shown to function as an AKAP on mitochondria.

20 over, we show that Gpr161, functioning as an AKAP, recruits PKA RI to primary cilia in zebrafish embr

21 se results confirm that flagellar RSP3 is an AKAP and reveal that a mutation in the PKA binding domai

22 Thus, we propose that Gpr161 is itself an AKAP and that the cAMP-sensing Gpr161:PKA complex acts a

23 This is the first example of an AKAP capable of binding a small molecule.

24 ify PC2 and PDE4C as unique components of an AKAP complex in primary cilia and reveal a common mechan

25 tical role for the PKA phosphorylation of an AKAP in the functional regulation of an ion channel prot

26 el activity, and indicate the key role of an AKAP, possibly AKAP79, in the spatial organization these

27 rin in ERM-knockdown cells, expression of an AKAP-deficient mutant of radixin did not fully rescue gr

28 Here we demonstrate that an AKAP, RSP3, forms a dimeric structural scaffold in the f

29 tory subunit type I (RI) interacting with an AKAP in this process.

30 ENaC activity was unaffected by AKAP79 and AKAP-KL expression.

31 yocyte-like cells and that selective PDZ and AKAP interactions are responsible for the integration of

32 n of CSR complexes that included C, RII, and AKAP 95 constituted a functional event and was necessary

33 Depletion of PKA subunits and AKAP 95 from RSW extracts by immunoprecipitation resulte

34 tein complex formation, the PKA subunits and AKAP 95 were removed from the RSW by immunoprecipitation

35 cal hypersensitivity requires both TRPA1 and AKAP.

36 rrent concept about anchoring mechanisms and AKAPs.

37 sruption of the interactions between PKA and AKAPs decreases the nuclear accumulation of active RSK1

38 regulatory and catalytic subunits as well as AKAP 95 in the CSR-protein complexes was absolutely nece

39 Knockdown of specific membrane-associated AKAPs using RNAi identified gravin (AKAP250) as the cent

40 cat binding; however, no competition between AKAP and beta-cat binding to cadherins was detected in v

41 Thus, PDE3A in these BIG1 and BIG2 AKAP complexes may contribute to the regulation of ARF f

42 d transcription coactivator function on BIG2 AKAP-C sequence.

43 Inferring a requirement for BIG1 and/or BIG2 AKAP sequence in PKA modification of beta-catenin and it

44 that involved the binding of RIIbeta to BIG2 AKAP domains B and C.

45 -activated PKA phosphorylated BIG1 and BIG2 (AKAPs for assembly of PKA, PDE3A, and other molecules),

46 Given the important cardiac roles of both AKAP-Lbc and Shp2, we investigated the AKAP-Lbc-Shp2 int

47 ing that local control of cAMP signalling by AKAP proteins is more intricate than previously apprecia

48 physiological relevance of PKA anchoring by AKAPs in general and AKAP150 specifically in the regulat

49 and Western blotting revealed two candidate AKAPs that are known to be targeted to mitochondria, AKA

50 proteomic analyses were used to characterize AKAP expression in ASM.

51 KA anchoring are patterned after a conserved AKAP motif.

52 Proteins that contain AKAP sequences act as scaffolds for the assembly of PKA

53 We demonstrated that T cells contain AKAPs and now ask whether PKA anchoring to AKAPs via the

54 GSKIP, and ascribe a function to a cytosolic AKAP-PKA interaction as a regulatory factor in the contr

55 Our results define AKAP signaling complexes of CaV1.2 and CaV1.3 channels i

56 ed to dissect the contributions of different AKAP-targeted pools of PKA.

57 hannel phosphorylation, and we report direct AKAP-mediated alteration of channel function distinct fr

58 wn of AKAP5 or St-Ht31 treatment, to disrupt AKAP interaction with the PKA RIIbeta regulatory subunit

59 hor protein) peptide into the NAc to disrupt AKAP-dependent signaling revealed that inhibition of AKA

60 peptides AKAP-IS or Ht31 was used to disrupt AKAP-PKA interactions, and global and compartmentalized

61 depolymerize postsynaptic F-actin disrupted AKAP-cadherin interactions and resulted in loss of the A

62 A peptide inhibitor (HT31) that disrupts AKAP/PKA interactions stimulates oocyte maturation in th

63 n MAP2, indicating that MAP2 is the dominant AKAP in neurons.

64 Here, we describe a Drosophila AKAP protein, MDI that recruits a translation stimulator

65 Knockdown of the Drosophila AKAP-like scaffolding protein Nervy also reduces PDF res

66 Intrinsic targeting domains in each AKAP determine the subcellular localization of these com

67 (RSelect) sequences were obtained for eight AKAPs following competitive selection screening.

68 loss of PKA from binding sites on endogenous AKAPs.

69 Whereas several endogenous AKAPs were identified in HEK-293 cells, small interferin

70 we uncovered a novel, ubiquitously expressed AKAP, termed small membrane (sm)AKAP due to its specific

71 e examined the roles of epithelial-expressed AKAPs in regulating the epithelial Na+ channel (ENaC).

72 r, it is unclear which of the many expressed AKAPs in neurons target PKA to signaling complexes impor

73 ts in Chinese hamster ovary cells expressing AKAP-9 and either PDE4D3 or PDE4D5 isoforms revealed mod

74 in Chinese hamster ovary cells co-expressing AKAP-9, and PDE4D3, but not PDE4D5, co-immunoprecipitate

75 from cultured rat sensory neurons following AKAP siRNA transfection and from AKAP-knock-out mice had

76 of gravin behaves as a dominant-negative for AKAP gravin regulation of receptor resensitization/recyc

77 asymmetry provides greater possibilities for AKAP docking.

78 These studies uncover a role for AKAP-Lbc in which increased expression of the anchoring

79 lusitropy, thereby indicating a key role for AKAP-targeted PKA in control of heart rate and contracti

80 ory subunit (RII) can alter its affinity for AKAPs and the catalytic subunit (PKA(cat)).

81 nitially detected in a two-hybrid screen for AKAPs.

82 s following AKAP siRNA transfection and from AKAP-knock-out mice had less PKA activity, GRK2 Ser-685

83 es with AKAP mutants indicated that impaired AKAP-mediated PKA scaffolding significantly reduces DOR-

84 Using knockin mice that are deficient in AKAP-anchoring of either PKA or the opposing phosphatase

85 ated a link between genetic perturbations in AKAP and human disease in general and AKAP9 and LQTS in

86 teral membranes, and beta-cat was present in AKAP-cadherin complexes isolated from epithelial cells,

87 AMPA glutamate receptors, and the inhibitory AKAP peptide reduced the PSD content of protein kinase A

88 nd actin polymerization redistributed intact AKAP-cadherin complexes from lateral membranes to intrac

89 Here we describe an ERK1/2-interacting AKAP and suggest a mechanism by which cAMP-dependent pro

90 Gene knockdown of potential RI-interacting AKAPs expressed in alveolar macrophages revealed that AK

91 the anchoring domain (AD) of an interactive AKAP are each attached to a biologic entity, and the res

92 Consistent with its AKAP function, BIG2 was required for the cAMP-induced PK

93 ne (FSH) induces the expression of an 80-kDa AKAP (AKAP 80) in ovarian granulosa cells as they mature

94 anism by which cAMP-dependent protein kinase-AKAP binding can be modulated by the activity of other e

95 on of a palmitoylation-independent lipidated AKAP mutant in DHHC2-deficient neurons largely restored

96 Many AKAPs were discovered solely based on the AH-RIIa intera

97 Most AKAPs exhibit nanomolar affinity for the regulatory (RII

98 ASM expresses multiple AKAP family members, with gravin and ezrin among the mos

99 N-myristoylation was found to affect neither AKAP macroscopic localization nor AKAP function.

100 The neuronal AKAP MAP2B, which also interacts with CaV1.2 and CaV1.3

101 ct neither AKAP macroscopic localization nor AKAP function.

102 cues GABAergic metaplasticity and normalizes AKAP signaling in MD animals.

103 In this paper, we report a novel AKAP-dependent localization of RIalpha to distinct organ

104 Collectively, these results identify a novel AKAP-mediated biochemical mechanism that increases TRPA1

105 ing analyses revealed the molecular basis of AKAP-selective interactions and shed new light on native

106 native contact points for the side chains of AKAP peptides that allow them to adopt different binding

107 s have also been identified as components of AKAP complexes, namely AKAP79, Yotiao, and mAKAP.

108 rotein interaction domains, form the core of AKAP function.

109 Moreover, disruption of AKAP-PKA anchoring does not affect glutamatergic synapse

110 To test the importance of AKAP-mediated targeting of PKA on cardiac function, we d

111 endent signaling revealed that inhibition of AKAP signaling impaired the reinstatement of cocaine see

112 of PKA-RII localization and that movement of AKAP-PKA complexes underlies PKA redistribution.

113 basal and cAMP responsive phosphorylation of AKAP-associated substrates.

114 PKAc, and it is disrupted by the presence of AKAP peptides, mutations in the RIalpha AKAP-binding sit

115 ever, we do not understand how regulation of AKAP targeting controls AMPAR endosomal trafficking.

116 The ability of AKAPs to assemble intricate feedback loops to control sp

117 tion of rut-derived cAMP signals at level of AKAPs might serve as counting register that accounts for

118 KA binds to an amphipathic helical region of AKAPs via an N-terminal domain of the regulatory subunit

119 be tightly tethered by a novel repertoire of AKAPs, providing a new perspective on spatio-temporal co

120 This study aimed to assess the role of AKAPs in regulating global and compartmentalized beta(2)

121 inase A (PKA) is a well-recognized target of AKAPs, with other kinases now emerging as additional tar

122 protein kinase A (PKA) anchoring protein or AKAP.

123 Protein kinase A anchoring proteins or AKAPs regulate the activity of many ion channels.

124 e in the expression of AKAP150 but not other AKAPs.

125 mutants that are selective for a particular AKAP.

126 Stable expression or injection of peptides AKAP-IS or Ht31 was used to disrupt AKAP-PKA interaction

127 Disruption of the PKA-AKAP interaction is sufficient to cause a long-lasting r

128 ses onto DA neurons, suggesting that the PKA-AKAP-CaN complex is uniquely situated at GABA(A) recepto

129 of the beta(1)-AR because disruption of PKA/AKAP interactions or small interfering RNA-mediated down

130 hat Ht-31 peptide-mediated disruption of PKA/AKAP interactions prevented the recycling and functional

131 ied in testis as an A-kinase anchor protein (AKAP)- binding protein.

132 n with a protein kinase A anchoring protein (AKAP 95) and CSR-BPs participate in forming CSR-protein

133 -95, and protein kinase A-anchoring protein (AKAP) 5 in the plasma membrane in a PDZ-dependent manner

134 nd protein kinase A (PKA)-anchoring protein (AKAP) 5, which anchor the receptor in the plasma membran

135 argeting protein A-kinase anchoring protein (AKAP) 79 and interferes with ionomycin-induced transloca

136 A-kinase anchoring protein (AKAP) 79/150 is a scaffold protein found in dendritic sp

137 scaffold protein A-kinase anchoring protein (AKAP) 79/150 is required for its targeting to recycling

138 A-kinase-anchoring protein (AKAP) 79/150 organizes a scaffold of cAMP-dependent prot

139 scaffold protein A-kinase anchoring protein (AKAP) 79/150.

140 the role of BIG2 A kinase-anchoring protein (AKAP) domains in the regulation of TNFR1 exosome-like ve

141 nce in BIG2 of 3 A kinase-anchoring protein (AKAP) domains, one of which is identical in BIG1.

142 The A-kinase anchoring protein (AKAP) GSK3beta interaction protein (GSKIP) is a cytosoli

143 a unique protein kinase A-anchoring protein (AKAP) guanine nucleotide exchange region belonging to th

144 e A (PKA) or PKA/A-kinase anchoring protein (AKAP) interaction blocked an immediate return of subplas

145 ins also contain A-kinase anchoring protein (AKAP) sequences that can act as scaffolds for multimolec

146 kinase A, i.e., A kinase-anchoring protein (AKAP) sequences.

147 I overlays as an A-kinase anchoring protein (AKAP) that localizes the cAMP-dependent protein kinase (

148 Yotiao is an A-kinase-anchoring protein (AKAP) that recruits the cyclic AMP-dependent protein kin

149 PH3 is a protein kinase A-anchoring protein (AKAP) that scaffolds the cAMP-dependent protein kinase h

150 s identified the A-kinase anchoring protein (AKAP) WAVE1 as an effector of OxPL action in vitro.

151 (KCNE1) and the A kinase-anchoring protein (AKAP) Yotiao (AKAP-9), which recruits protein kinase A)

152 component of the A-kinase-anchoring protein (AKAP)-Lbc complex.

153 t of the protein kinase A anchoring protein (AKAP)-Lbc complex.

154 covered that the A-Kinase Anchoring Protein (AKAP)-Lbc is upregulated in hypertrophic cardiomyocytes.

155 in (RSP) 3 is an A-kinase anchoring protein (AKAP).

156 have identified A kinase-anchoring protein (AKAP)150 and the protein phosphatase calcineurin as bind

157 folding molecule A-kinase anchoring protein (AKAP)79/150 targets both the cAMP-dependent protein kina

158 ious work showed A-kinase-anchoring protein (AKAP)79/150-mediated protein kinase C (PKC) phosphorylat

159 the channels by A-kinase anchoring protein (AKAP)79/150.

160 ffolding protein A-kinase-anchoring protein (AKAP)79/150.

161 orchestrated by A kinase-anchoring protein (AKAP)79/150.

162 that a specific A-kinase anchoring protein, AKAP-Lbc, is a major contributor to the formation of the

163 t with multiple A-kinase anchoring proteins (AKAP) that localize it to different parts of the cell.

164 inks rut-AC1 to A-kinase anchoring proteins (AKAP)-sequestered protein kinase A at the level of Kenyo

165 A-kinase-anchoring proteins (AKAPs) are a canonical family of scaffold proteins known

166 A-kinase anchoring proteins (AKAPs) are a family of scaffolding proteins that target

167 A-kinase anchoring proteins (AKAPs) are scaffolding molecules that coordinate and int

168 A-kinase anchoring proteins (AKAPs) are well known for their ability to scaffold prot

169 A kinase anchoring proteins (AKAPs) assemble and compartmentalize multiprotein signal

170 A-kinase anchoring proteins (AKAPs) bind and target PKA to various subcellular locati

171 ) subunits with A-kinase-anchoring proteins (AKAPs) confers location, and catalytic (C) subunits phos

172 A-kinase anchoring proteins (AKAPs) contain an amphipathic helix (AH) that binds the

173 A-kinase anchoring proteins (AKAPs) coordinate cell signaling events.

174 A-Kinase Anchoring Proteins (AKAPs) ensure the fidelity of second messenger signaling

175 PKA) by protein kinase A-anchoring proteins (AKAPs) facilitates local protein phosphorylation.

176 A-kinase anchoring proteins (AKAPs) function to target protein kinase A (PKA) to spec

177 A-kinase anchoring proteins (AKAPs) have emerged as a converging point of diverse sig

178 A-kinase anchoring proteins (AKAPs) have emerged as important regulatory molecules th

179 tors of protein kinase A anchoring proteins (AKAPs) implicated PKA regulatory subunit type I (RI) int

180 in proteins and A-kinase anchoring proteins (AKAPs) increased receptor diffusion, indicating that the

181 Protein kinase A-anchoring proteins (AKAPs) influence fundamental cellular processes by direc

182 A-kinase anchoring proteins (AKAPs) influence the spatial and temporal regulation of

183 nding of PKA to A-kinase anchoring proteins (AKAPs) inhibited currents through ARC channels, and bloc

184 ase A (PKA) via A-kinase-anchoring proteins (AKAPs) is important for cAMP responsiveness in many cell

185 nase A (PKA) by A-Kinase Anchoring Proteins (AKAPs) is known to coordinate localised signalling compl

186 A-kinase anchoring proteins (AKAPs) localize PKA to AMPARs leading to enhanced phosph

187 A-kinase anchoring proteins (AKAPs) mediate the intracellular localization of PKA and

188 A kinase-anchoring proteins (AKAPs) organize compartmentalized pools of protein kinas

189 Protein kinase A-anchoring proteins (AKAPs) participate in the formation of macromolecular si

190 Protein kinase A-anchoring proteins (AKAPs) play important roles in the compartmentation of c

191 cAMP signaling, A-kinase anchoring proteins (AKAPs) provide a molecular mechanism for cAMP compartmen

192 Protein kinase A-anchoring proteins (AKAPs) provide spatio-temporal specificity for the omnip

193 A-kinase anchoring proteins (AKAPs) recruit signaling molecules and present them to d

194 A-kinase anchoring proteins (AKAPs) represent a family of structurally diverse protei

195 A-kinase anchoring proteins (AKAPs) spatially constrain phosphorylation by cAMP-depen

196 A-kinase-anchoring proteins (AKAPs) target PKA to glutamate receptor and ion channel

197 A kinase-anchoring proteins (AKAPs) target PKA to specific microdomains by using an a

198 A-kinase anchoring proteins (AKAPs) tether the cAMP-dependent protein kinase (PKA) to

199 is promoted by A-kinase anchoring proteins (AKAPs) that target cAMP-dependent protein kinase (PKA) t

200 ffolds, such as A-kinase anchoring proteins (AKAPs), compartmentalize kinase activity and ensure subs

201 Protein kinase A anchoring proteins (AKAPs), defined by their capacity to target the cAMP-dep

202 ough binding to A-kinase-anchoring proteins (AKAPs), RI subunits are primarily diffuse in the cytopla

203 ng with protein kinase A anchoring proteins (AKAPs), the present study was undertaken to identify the

204 1.2 channels by A-kinase anchoring proteins (AKAPs).

205 caffolds called A kinase anchoring proteins (AKAPs).

206 nase A bound to A-kinase anchoring proteins (AKAPs).

207 s substrates by A-kinase-anchoring proteins (AKAPs).

208 y controlled by A-kinase anchoring proteins (AKAPs).

209 subunit, R, to A-kinase-anchoring proteins (AKAPs).

210 ase A (PKA) and A-kinase anchoring proteins (AKAPs).

211 compartments by A-kinase anchoring proteins (AKAPs).

212 ssociation with A-kinase anchoring proteins (AKAPs).

213 f RSK1 with A-kinase PKA anchoring proteins (AKAPs).

214 ry subunit with A-kinase anchoring proteins (AKAPs).

215 ediated through A-kinase anchoring proteins (AKAPs).

216 on with protein kinase A anchoring proteins (AKAPs).

217 ling partner by A-kinase anchoring proteins (AKAPs).

218 ) subunits with A-kinase anchoring proteins (AKAPs).

219 lecules such as A-Kinase Anchoring Proteins (AKAPs).

220 E) 4D3 binds to A kinase-anchoring proteins (AKAPs).

221 o two prominent A kinase-anchoring-proteins (AKAPs).

222 otein kinase A-anchoring family of proteins (AKAPs), which target the cAMP-dependent protein kinase (

223 Kinases A and C (PKA and PKC, respectively), AKAP facilitates phosphorylation and sensitization of TR

224 ed to cellular substructures, whereas PKA-RI-AKAP complexes have remained largely undiscovered.

225 e of AKAP peptides, mutations in the RIalpha AKAP-binding site, or knockdown of AKAP11.

226 nteractions and shed new light on native RII-AKAP interactions.

227 Many PKA-RII-AKAP complexes are heavily tethered to cellular substruc

228 We postulate that radial spokes use the RIIa/AKAP module to regulate ciliary and flagellar beating; a

229 n of PKA stimulates the formation of a SAP97-AKAP/PKA-GluA1 protein complex leading to synaptic deliv

230 n and characterization of a novel sarcomeric AKAP (A-kinase anchoring protein), cardiac troponin T (c

231 le for cTnT as a dual-specificity sarcomeric AKAP.

232 mAKAP (muscle-selective AKAP) localizes PKA and its substrates such as phosphodi

233 KA is also found in the N termini of several AKAP-binding proteins unrelated to PKA as well as a 24-k

234 Several AKAPs have been identified in oocytes including one at 1

235 Several AKAPs have been shown to accelerate, amplify, and specif

236 ly expressed AKAP, termed small membrane (sm)AKAP due to its specific localization at the plasma memb

237 helical motif from D-AKAP2, a dual-specific AKAP, bound to the RIIalpha D/D domain.

238 ng protein (SKIP) is a truly type I-specific AKAP.

239 melanophores, Rab32 is a melanosome-specific AKAP that is essential for regulation of melanosome tran

240 of PKA in neurons and the roles of specific AKAPs are poorly understood.

241 studies show that cTnT is a dual specificity AKAP, interacting with both PKA-regulatory subunits type

242 endosomes, enlargement of dendritic spines, AKAP recruitment to spines, and potentiation of AMPAR-me

243 e sub-structures, in concert with the static AKAP-regulatory subunit interface, generates a solid-sta

244 by microinjecting a cell-permeable synthetic AKAP (A-kinase anchor protein) peptide into the NAc to d

245 s that can regulate cocaine relapse and that AKAP proteins may contribute to relapse vulnerability by

246 PKA and Shp2 signaling in the heart and that AKAP-Lbc-associated Shp2 activity is reduced in hypertro

247 PKA and Shp2 signaling in the heart and that AKAP-Lbc-associated Shp2 activity is reduced in hypertro

248 egy in rat hippocampal slices, we found that AKAP is required for NMDA receptor-dependent long-term d

249 Overall, our data indicate that AKAP-Lbc integrates PKA and Shp2 signaling in the heart

250 Our data indicate that AKAP-Lbc integrates PKA and Shp2 signaling in the heart

251 Here, we show that AKAP function is required for DCC-mediated activation of

252 s, and RNA interference techniques show that AKAP-Lbc couples activation of protein kinase D (PKD) wi

253 It was shown that AKAP 95 as well as RII formed a direct linkage with CSR

254 These findings suggest that AKAP scaffolds PKA to increase plasma membrane targeting

255 addition, our observations demonstrate that AKAPs serve not solely as stationary anchors in cells bu

256 In summary, these data suggest that AKAPs interact with both PKA and PDE in T lymphocytes an

257 cellular systems, and evidence suggests that AKAPs play an important role in cardiac signaling.

258 The AKAP gravin is a scaffold for protein kinases, phosphata

259 ze Sema-1a-PlexA-mediated repulsion, and the AKAP binding region of Nervy is critical for this effect

260 opy contributions to the binding between the AKAP protein HT31 with the D/D domain of RII alpha-regul

261 Here we show that both the AKAP function of GSKIP, i.e. its direct interaction with

262 noline-sulfon-amide 2HCl), as well as by the AKAP inhibitory peptide Ht31.

263 present study was undertaken to identify the AKAP involved in PKA-mediated phosphorylation of the bet

264 ne kinase Src plays an essential role in the AKAP gravin-mediated receptor resensitization and recycl

265 both AKAP-Lbc and Shp2, we investigated the AKAP-Lbc-Shp2 interaction in the heart.

266 Mapping the AKAP binding site in cadherins identified overlap with b

267 se effector protein MyRIP is a member of the AKAP family.

268 Immunoprecipitaiton of the AKAP from rat brain extract found that the PP1 catalytic

269 ion against RIalpha in the N terminus of the AKAP helix, the hydrophobic groove discriminates against

270 Here, we report that palmitoylation of the AKAP N-terminal polybasic domain targets it to postsynap

271 Here, we have studied the effects of the AKAP Yotiao on the function of the I(Ks) channel that ha

272 rin interactions and resulted in loss of the AKAP, but not cadherins, from synapses.

273 Here we test the hypothesis that the AKAP WAVE1 is required during mammalian fertilization, a

274 f beta-catenin by GSKIP is specific for this AKAP as AKAP220, which also binds PKA and GSK3beta, did

275 process, inhibition of Shp2 activity through AKAP-Lbc-anchored PKA is a previously unrecognized mecha

276 process, inhibition of Shp2 activity through AKAP-Lbc-anchored PKA is a previously unrecognized mecha

277 FICANCE: Inhibition of Shp2 activity through AKAP-Lbc-anchored PKA is a previously unrecognized mecha

278 Thus, AKAP-Lbc synchronizes PKA and PKC activities in a manner

279 ibitory peptide derived from a human thyroid AKAP, prevents both the short- and the long-term facilit

280 n AKAPs and now ask whether PKA anchoring to AKAPs via the RIIalpha regulatory subunit is necessary f

281 ctivity regulation that relies on binding to AKAPs and consequent modulation of the enzyme activation

282 Inhibition of protein kinase A binding to AKAPs by Ht-31 peptide reduces ASIC currents in cortical

283 We show that blockade of PKA binding to AKAPs in the nucleus accumbens shell of Sprague-Dawley r

284 that competes with PKARIalpha for binding to AKAPs, decreased the amount of PP2Ac in the RSK1 complex

285 The anchoring of PKA to AKAPs (A kinase-anchoring proteins) creates compartmenta

286 Disruption of the binding of RII to AKAPs by Ht31, an inhibitory peptide derived from a huma

287 d the effects of disrupting PKA targeting to AKAPs in the heart by expressing the 24-amino acid regul

288 , little is known about how PKA targeting to AKAPs is regulated in the intact cell.

289 serine 96 on RII regulates PKA targeting to AKAPs, downstream substrate phosphorylation and calcium

290 ated by the anchoring of RIIbeta to BIG2 via AKAP domains B and C.

291 ase 1, is recruited to the I(Ks) channel via AKAP-9 and contributes to its critical regulation by cAM

292 d DOR desensitization is directed by PKA via AKAP scaffolding.

293 , but not PDE4D5, co-immunoprecipitated with AKAP-9.

294 Moreover, overexpression studies with AKAP mutants indicated that impaired AKAP-mediated PKA s

295 ic anchoring of PKA through association with AKAPs plays an important role in the regulation of AMPA

296 uce LTF require type II PKA interaction with AKAPs (A-kinase anchoring proteins).

297 We show that PKA interaction with AKAPs is essential for two sequential steps in the matur

298 ain meiotic arrest in immature oocytes, with AKAPs implicated as critical mediators but poorly unders

299 wn that blocking the interaction of PKA with AKAPs disrupts its subcellular location and prevents LTP

300 he A kinase-anchoring protein (AKAP) Yotiao (AKAP-9), which recruits protein kinase A) and protein ph