ライフサイエンスコーパス: ANA

1 ANA positivity was associated with the presence of the H

2 ANA presidents were more likely to be employed at ranked

3 ANA prevalence increased with age (P=0.01), and ANAs wer

4 ANA prevalence was modestly higher in African Americans

5 ANA were detected de novo in six and three subjects with

6 ANA-12-treated Tg mice developed more gut aSyn aggregati

7 ANA-3 strains lacking arcA and etrA showed minor to mode

8 ANAs and non-ANAs did not differ in Vkappa family or Jka

9 ANAs were assessed by indirect immunofluorescence.

10 The 2012 ANA Annual Meeting's President's Symposium highlighted d

11 were strongest for high-titer (>/= 1:1,280) ANA: hair, OR = 11.41 (95% CI: 1.60, 81.23); blood, OR =

12 At pH < or = 6.5 ANA induced (45)Ca(2+) uptake either in primary cultures

13 rotein revealed that, at low pH (< or =6.5), ANA could induce an elevation of intracellular free Ca(2

14 s of autoreactivity between anti-nuclear Ab (ANA)-resistant CD45E613R.B6 and ANA-permissive CD45E613R

15 e to chromatin resulting in antinuclear Abs (ANA) production in the lupus-prone NZM2410 mouse.

16 lthough the Ig H chains of anti-nuclear Abs (ANA) have been described to possess certain shared molec

17 elop high titers of IgG2a/c antinuclear Abs (ANAs) with specificity for dsDNA, ssDNA, and histones.

18 SLAM family genes, produce antinuclear Abs (ANAs).

19 s revealed the presence of anti-nuclear Abs (ANAs) in the plasma of 92% of the Tsk2/+ mice.

20 tly, hybrids of RNA and arabinonucleic acid (ANA) as well as the 2'F-ANA analogue were shown to be su

21 nucleic acid (FANA) and arabinonucleic acid (ANA) paired to RNA are substrates of RNase H.

22 Altritol-modified nucleic acids (ANAs) support RNA-like A-form structures when included i

23 four XNA chemistries, arabino nucleic acids (ANAs), 2'-fluoroarabino nucleic acids (FANAs), hexitol n

24 ifferent chemistries (arabino nucleic acids, ANA; 2'-fluoroarabino nucleic acids, FANA; hexitol nucle

25 (AHAs) or alcohol non-heightened aggressors (ANAs) during resident-intruder confrontations after self

26 Here, we examined all ANA patterns by indirect immunofluorescence for 859 rheu

27 f a particular Vkappa1 family sequence among ANAs, we proceeded to clone a novel New Zealand Black Vk

28 When ordering and interpreting an ANA test, the clinician must be familiar with the specif

29 t of ANA in consecutive patients for whom an ANA test was requested showed that, generally, those ass

30 and N-nitrosoanabasine (NAB) from anabasine (ANA).

31 nteract with the endocannabinoid anandamide (ANA) and certain inflammatory metabolites of arachidonic

32 Anastrozole (ANA) alone delivers significant disease-free survival be

33 ace area involvement (ssDNA ab, P = .01; and ANA, P = .005), and higher skin scores (ANA, P = .004).

34 The DeltacymA strains of CN-32 and ANA-3 negatively affected the reduction of Fe(III) and M

35 enate in DeltacymA strains of both CN-32 and ANA-3.

36 S-activated mouse macrophages (RAW 264.7 and ANA-1 cells) in vitro.

37 of latent TGF-beta1 protein by both A549 and ANA-1 cells, whereas unstimulated cultures of either cel

38 human lung adenocarcinoma cell line A549 and ANA-1 macrophages activated with IFN-gamma plus lipopoly

39 rved differences in life span between AA and ANA lines, prompting a utility of this animal model in a

40 var3 were markedly different between AA and ANA rats, 52% and 100%, respectively.

41 and sham-challenged segments in both AA and ANA subjects.

42 owship) in the combined and separate AAN and ANA networks.

43 n contrast, during their presidency, AAN and ANA presidents worked at a diffuse set of institutions w

44 ofessional ties of presidents of the AAN and ANA since 1948.

45 , abnormal nailfold capillaries, and ANA and ANA subsets, as well, were not related to survival.

46 y tests for antinuclear antibodies (ANA) and ANA subsets were obtained at initial presentation.

47 tored removal of developing autoreactive and ANA-expressing B cells.

48 CID patients contained more autoreactive and ANA-expressing clones, indicative of defective central a

49 -nuclear Ab (ANA)-resistant CD45E613R.B6 and ANA-permissive CD45E613R.BALB/c mice.

50 In men, abnormal nailfold capillaries, and ANA and ANA subsets, as well, were not related to surviv

51 increased ANA-specific Ab-forming cells and ANA titers.

52 nduced IL10 expression in Jurkat T cells and ANA-1 macrophages, which further suggests that the immun

53 ociations between chemical concentration and ANA positivity were observed, but only the association i

54 depressor and sympatho-inhibitory effect and ANA-12 produced the opposite response.

55 mic resolution, we demonstrate that FANA and ANA display subtle conformational differences.

56 ng the conformational boundaries of FANA and ANA residues in crystal structures of A- and B-form DNA

57 ent with this, the conformations of FANA and ANA were found to be intermediate between the A- and B-f

58 m), GIS (Gismondine, 0.45 nm x 0.31 nm), and ANA (Analcime, 0.42 nm x 0.16 nm) zeolites.

59 samples were collected from all subjects and ANA levels were measured by immunofluorescence analysis.

60 prevalence increased with age (P=0.01), and ANAs were more prevalent among females than males (17.8%

61 The prevalence of ACPAs and ANAs was higher in RA cases compared to controls (each P

62 In these experiments, groups of AHAs and ANAs self-administered 1.0 g/kg alcohol (6% w/v) or wate

63 s-sectional associations between mercury and ANAs (indirect immunofluorescence; cutoff >/= 1:80).

64 tor antagonist (the TrkB receptor antagonist ANA-12) reversed the diminished cocaine self-administrat

65 Co-treatment with the TrkB antagonist ANA-12 blocked HDACi rescue of visual function and assoc

66 laboratory tests for antinuclear antibodies (ANA) and ANA subsets were obtained at initial presentati

67 develop spontaneous antinuclear antibodies (ANA) and fatal glomerulonephritis when on the C57BL/6 ba

68 hose of an assay for antinuclear antibodies (ANA) and with the severity of the signs and symptoms.

69 Antinuclear antibodies (ANA) are important in diagnosis and follow-up of patient

70 n to the presence of antinuclear antibodies (ANA), a widely used biomarker of autoimmunity, in a repr

71 oantibodies are true antinuclear antibodies (ANA), and 50% of the ANAs are also reactive with a diver

72 e count, presence of antinuclear antibodies (ANA), presence of human leukocyte antigen (HLA-)B27, age

73 d whether they carry antinuclear antibodies (ANA).

74 rmed the presence of antinuclear antibodies (ANAs) and other autoantibodies in morphea but found they

75 questions concerning antinuclear antibodies (ANAs) in lupus involve their pathogenic potential and th

76 d elevated levels of antinuclear antibodies (ANAs) in their serum and showed evidence of escape of pr

77 by high-avidity IgG antinuclear antibodies (ANAs) that are almost certainly products of T cell-depen

78 The presence of antinuclear antibodies (ANAs) was determined using indirect immunofluorescence w

79 antibodies (ACPAs), antinuclear antibodies (ANAs), anti-tissue transglutaminase antibodies (AGTAs),

80 ase characterized by antinuclear antibodies (ANAs), including pathogenic specificities to DNA.

81 esence or absence of antinuclear antibodies (ANAs), the ANA staining patterns, and the presence or ab

82 ads to production of antinuclear antibodies (ANAs).

83 lerance and secreted antinuclear antibodies (ANAs).

84 oduction, including anti-nuclear antibodies (ANAs), frequently occur in ADA-SCID patients after treat

85 n, fever, psoriasis, antinuclear antibodies [ANA], and rheumatoid factor).

86 mosome 4 was linked to antinuclear antibody (ANA) and anti-double stranded DNA (dsDNA) antibody (Ab)

87 titers of spontaneous antinuclear antibody (ANA) in C4(-/)- mice.

88 mercury biomarkers and antinuclear antibody (ANA) positivity and titer strength.

89 female preponderance, antinuclear antibody (ANA) positivity, and certain human leukocyte antigen typ

90 bead-based assays for antinuclear antibody (ANA) testing is a new clinical option.

91 ositive patients were anti-nuclear antibody (ANA) positive.

92 one of the classical anti-nuclear antibody (ANA) staining patterns.

93 ex (SLEDAI), serology (antinuclear antibody [ANA] and anti-double-stranded (ds) DNA), complement C3 a

94 (anti-LC1), antimitochondrial, antinuclear (ANA), and antiactin antibodies (AAA) were determined at

95 NCWS or CD develop autoimmune disorders, are ANA positive, and showed DQ2/DQ8 haplotypes compared wit

96 ropic nanofluidic-filter (nanofilter) array (ANA) is a unique molecular-sieving structure for separat

97 e anisotropically patterned nanosieve array (ANA) structures.

98 rtually all patients with SLE, SSc, or SS as ANA positive.

99 ) and the American Neurological Association (ANA).

100 Circulating antinuclear autoantibodies (ANAs) typically found in autoimmune conditions, have als

101 iated with serum antinuclear autoantibodies (ANAs), T cell hyperactivity, and elevated CD4/CD8 ratios

102 Autoimmune ANA/ENA reference sera react preferentially with DS affi

103 , such as 2'F-ANA and [3.3.0]bicyclo-ANA (bc-ANA), may not be able to adopt sugar puckers that are co

104 rtheless be interpreted with caution because ANAs, despite their disease associations, can occur in h

105 NA positive, to explore associations between ANA and concentrations of dioxins, dibenzofurans, polych

106 nalogues, such as 2'F-ANA and [3.3.0]bicyclo-ANA (bc-ANA), may not be able to adopt sugar puckers tha

107 ANA patients as well as neutrophilia in both ANA and AA subjects are nonspecific consequences of bron

108 th CTDs who have antinucleolar antibodies by ANA testing, but they are not specific for SSc or the wa

109 oxide production and TNF-alpha secretion by ANA-1 macrophages.

110 e presence of abnormal nailfold capillaries, ANA, and anti-Scl-70 antibodies were related to an incre

111 nyl phenyl benzo (b)thiophene-2-carboxamide (ANA-12) into the dorsal medial NTS (dmNTS) of male Sprag

112 s and severe proteinuria without circulating ANA, anti-dsDNA, and antinucleosome Ab.

113 e eluates from these kidneys did not contain ANA, anti-dsDNA, and antinucleosome Ab, indicative of th

114 addressing the sequence strategy containing ANA in comparison with 5 years of TAM in a low- to inter

115 compared to their nonpreferring counterpart ANA line.

116 genes, notably, Vkappa ai4 among anti-dsDNA ANAs, Vkappa23-45 among anti-ssDNA ANAs, and Vkappa21-12

117 An assay panel combining anti-dsDNA, ANA, anti-MCV, EC4d, and BC4d is sensitive and specific

118 manipulation of TLR9 gene dosage eliminates ANA in CD45E613R.BALB/c mice, but confoundingly permits

119 his method has the promise to greatly expand ANA testing in clinical settings for initial patient ass

120 arabinonucleic acid (ANA) as well as the 2'F-ANA analogue were shown to be substrates of RNase H.

121 nstrate here that ANA analogues, such as 2'F-ANA and [3.3.0]bicyclo-ANA (bc-ANA), may not be able to

122 -C3'-endo RNA strand and an all-O4'-endo 2'F-ANA strand.

123 xy-2'-fluoro-beta-D-arabinonucleic acid (2'F-ANA) sugar modification not only meet these criteria, bu

124 kemia cells with fully phosphorothioated 2'F-ANA-DNA chimeras (PS-2'FANA-DNA) and compared their gene

125 Therefore, our data demonstrate that PS-2'F-ANA-DNA chimeras are efficient gene silencing molecules,

126 mRNA and protein expression, but the PS-2'F-ANA-DNA were able to accomplish this at 20% of the dose

127 In family ANA, candidate gene analysis excluded linkage to loci as

128 For ANA subjects, the postsegmental challenge count was 29,8

129 bia, Yale, and University College London for ANA presidents.

130 ctive study, serum samples were positive for ANA in 28% of subjects with NCWS, 7.5% of subjects with

131 ive study, serum samples tested positive for ANA in 46% of subjects with NCWS (median titer, 1:80), 2

132 t of splenic mononuclear cells isolated from ANA-positive Sle1ab mice with anti-IL-6 Ab or AG490, an

133 r characteristics that distinguish AHAs from ANAs, we tested additional mice for their aggression fol

134 Trk-B receptor inhibitor ANA-12, or FTY720 + ANA-12 from 1 to 4 months of age.

135 tal clusters within voids throughout the GIS-ANA transformation.

136 Vanilloids displaced [(3)H]ANA in VR1-expressing cells, suggesting competition for

137 ive antibodies including potentially harmful ANAs.

138 more than 32 million persons in the US have ANAs, and that the prevalence is higher among females, o

139 In ANA-1 murine macrophages, LPS-mediated NO synthesis decr

140 In ANA-positive individuals, cellular staining patterns wer

141 In ANA-positive individuals, nuclear patterns were seen in

142 icals of concern and should track changes in ANA and other autoantibodies over time.

143 investigations of predictors and changes in ANA prevalence over time.

144 Transcription of arcA, etrA, and crp in ANA-3 was similar in cells grown on arsenate and cells g

145 Deletion of cymA in ANA-3 also eliminated growth on and reduction of arsenat

146 There was no difference in ANA prevalence among morphea subtypes.

147 We find that BAL eosinophilia in ANA patients as well as neutrophilia in both ANA and AA

148 he iNOS promoter and iNOS gene expression in ANA-1 macrophages.

149 The current increase in ANA requests is driven by broadening the use of ANA from

150 of endotoxin (LPS)-mediated NO production in ANA-1 murine macrophages, suppression subtractive hybrid

151 cya) proteins affect arsenate respiration in ANA-3.

152 s of Cys-30 and Cys-32 with Ser) resulted in ANA-3 strains that exhibited anaerobic growth deficienci

153 rate that the two As(V) reductase systems in ANA-3 respond to different amounts and types of inorgani

154 ior alcohol intake to escalate aggression in ANAs.

155 es associated with systemic lupus, including ANA formation and T cell hyperactivity.

156 mice were strongly associated with increased ANA-specific Ab-forming cells and ANA titers.

157 on in thymic epithelial cells did not induce ANAs, and that lack of H2-O expression in bone marrow-de

158 a potent antagonist of vanilloids, inhibited ANA-induced Ca(2+) transport in both cell systems.

159 ehicle, FTY720, the Trk-B receptor inhibitor ANA-12, or FTY720 + ANA-12 from 1 to 4 months of age.

160 nt with neurotrophin receptor TrkB inhibitor ANA-12 and MEK inhibitor PD98059 attenuates the neurotro

161 zation of metal clusters containing GIS into ANA, which retained these metal clusters within voids th

162 xpression in the murine macrophage cell line ANA-1.

163 s investigated in the murine macrophage line ANA-1.

164 ith the specific assay being used to measure ANA and the differences between the various ANA assays.

165 lonal antibodies rescued from the same mice, ANAs exhibited increased utilization of VH5/7183 genes a

166 databases, one consisting of 264 monoclonal ANAs and the other consisting of 145 non-ANAs, drawn fro

167 t support the clinical testing of monoclonal ANAs as a cancer therapy, if confirmed by further experi

168 Multiple ANA modifications within the sense strand were also well

169 nal ANAs and the other consisting of 145 non-ANAs, drawn from previously published work.

170 g anti-ssDNA ANAs, and Vkappa21-12 among non-ANAs.

171 ANAs and non-ANAs did not differ in Vkappa family or Jkappa gene usag

172 opic asthmatic (AA) and atopic nonasthmatic (ANA) subjects.

173 eferring AA rats compared with nonpreferring ANA rats.

174 percent of females were ANA positive; 96% of ANA positives had a nuclear speckled staining pattern.

175 These actions of ANA were similar to the effects determined previously fo

176 y, and the designed structural anisotropy of ANA causes different-sized or charged biomolecules to fo

177 No significant associations of ANA with education, family income, alcohol use, smoking

178 significant differences in the detection of ANA by immunofluorescence and different ELISA kits.

179 redominant role of SHM in the development of ANA and underscore the importance of self-tolerance chec

180 With the exception of ANA, the autoantibody profile does not markedly vary in

181 In contrast, titers and frequencies of ANA in Cr2(-)(/)- mice, which are deficient in CR1 and C

182 However, the generation of ANA in itself is insufficient to account for the severit

183 C tolerance checkpoint and the generation of ANA-specific Ab-forming cells.

184 perillyl alcohol, suppressed the increase of ANA.

185 Measurement of ANA in consecutive patients for whom an ANA test was req

186 Furthermore, bilateral microinjection of ANA-12 into the dmNTS greatly diminished baroreflex sens

187 and after bilateral dmNTS microinjections of ANA-12.

188 -encoding genes) in the DeltaarsR2 mutant of ANA-3 were increased in cells grown under anaerobic cond

189 rns of joint involvement and the presence of ANA were influential in determining latent classes.

190 Young age of onset, presence of ANA, and elevated ESR appeared to be predictive factors

191 el of iNOS protein and nitrite production of ANA-1 cells 2-fold; however, a substantial level of NO i

192 e consistent with known toxicity profiles of ANA and TAM treatment.

193 shed structural and functional properties of ANA analogues helps settle existing controversies concer

194 the antigen- and sham-challenged segments of ANA subjects.

195 Sequencing of ANA after identical 2-year treatment with TAM in both ar

196 marate was absent in the DeltacymA strain of ANA-3.

197 The synthesis of ANA requires higher crystallization temperatures (~415 K

198 In a system of ANA-1 murine macrophages, iNOS expression and NO product

199 ffinity of FANA considerably exceeds that of ANA.

200 se progression, despite equivalent titers of ANA.

201 In vivo treatment of ANA-positive B6.Sle1ab mice with the ras pathway inhibit

202 This was particularly true of ANA modifications at or near the 3' end of the sense or

203 requests is driven by broadening the use of ANA from a test for lupus to a test for diverse autoimmu

204 egy of 2 years of TAM followed by 3 years of ANA led to small outcome and toxicity benefits.

205 TAM or 2 years of TAM followed by 3 years of ANA.

206 ntal data favoring the antitumor activity of ANAs might support the clinical testing of monoclonal AN

207 Interestingly, the L chains of ANAs exhibited differential usage of certain complementa

208 ) tolerance checkpoint in the development of ANAs in these mice is not defined.

209 The frequencies of ANAs detected by a bead-based assay are lower than those

210 The frequencies of ANAs in the sera from African American, Hispanic, and Eu

211 en carried out to elucidate the functions of ANAs in cancer patients.

212 egions appears to be a prominent hallmark of ANAs.

213 The clinical measurement of ANAs, although valuable in assessing diagnosis and progn

214 From the PheWAS, the presence of ANAs was significantly associated with a diagnosis of Sj

215 Concordance for the presence of ANAs was significantly higher in MZ twins compared with

216 The prevalence of ANAs, AHAs, and ssDNA abs in patients with morphea was 3

217 Prevalence of ANAs, AHAs, ssDNA abs in patients with morphea vs matche

218 ld-type mice demonstrated that production of ANAs requires participation of CD4(+) T cells from H2-O(

219 The pathogenic role of ANAs in autoimmunity is well studied; however, little re

220 his model allowed us to demonstrate that one ANA clone was generated by SHM after a V(H) gene replace

221 ACA was the only ANA that demonstrated a definite bimodal distribution of

222 um was negative for antinuclear antibody (or ANA), cytoplasmic antineutrophil cvtoplasmic antibody (o

223 ad no effect on aggression in either AHAs or ANAs.

224 eristics of ACA in comparison with the other ANA patterns and clinical features of ACA-positive subje

225 d significantly higher levels than the other ANA staining patterns in both RA and healthy population

226 NA opposite RNA is preferred by RNase H over ANA, and the RNA affinity of FANA considerably exceeds t

227 E613R.BALB/c mice, but confoundingly permits ANA in CD45E613R.B6 mice.

228 5% of cage-mated CAST/ei mice had a positive ANA and none of the C3H/HeJ age-matched controls were po

229 proportion of Tsk2/+ animals with a positive ANA increased slightly with age.

230 ll C4(-)(/)- females and most males produced ANA.

231 is enriched for cells expressing prototypic ANA heavy chains in these mice in a non-autoimmune backg

232 enriched with B cells expressing prototypic ANA heavy chains.

233 stent biotypes (as determined with the RapID ANA II system); however, strains were misidentified, and

234 gnificantly enhanced disease despite reduced ANA titers.

235 Remarkably, ANAs were less common in overweight and obese individual

236 As shown by recent research, ANA production is a genetically determined process in wh

237 RIIB(-/-) ANA, by converting them to antinucleolar antibodies.

238 and significant improvement in SLEDAI score, ANA, anti-ds DNA, complement, and carbon monoxide diffus

239 and ANA, P = .005), and higher skin scores (ANA, P = .004).

240 elicited increased CD4/CD8 ratios and serum ANAs, 2 cardinal Sle3-associated phenotypes.

241 epithelium-specific antinuclear antigen (SES-ANA), both pathognomonic for chronic ulcerative stomatit

242 the framework types FAU, LTA, EMT, GIS, SOD, ANA, CAN, and JBW.

243 Fe: 0.05; Fe tot: 32.1 mM) by Shewanella sp. ANA-3 (10(8) cells/mL) in the presence of different conc

244 phosphate deaminase AgaS from Shewanella sp. ANA-3 were validated in vitro using individual enzymatic

245 As a conclusion, ACA displays a specific ANA staining pattern with a bimodal distribution, and AC

246 nti-dsDNA ANAs, Vkappa23-45 among anti-ssDNA ANAs, and Vkappa21-12 among non-ANAs.

247 Values are comparable to a standard ANA test but require a total processing time of ~20min.

248 In this study using LPS-stimulated ANA-1 murine macrophages, we demonstrate that expression

249 n this study using a model of LPS-stimulated ANA-1 murine macrophages, we demonstrate that short rang

250 reduction pathways in Shewanella sp. strain ANA-3 are induced by arsenite and under anaerobic condit

251 on and activity of the Shewanella sp. strain ANA-3 arsenate respiratory reductase (ARR), the key enzy

252 ular respiration using Shewanella sp. strain ANA-3 as a model organism.

253 tion) in the bacterium Shewanella sp. strain ANA-3 specifically confers respiratory As(V) reductase a

254 In Shewanella sp. strain ANA-3, the arsenate respiration genes (arrAB) are induce

255 In Shewanella sp. strain ANA-3, utilization of arsenate as a terminal electron ac

256 arr and ars operons in Shewanella sp. strain ANA-3.

257 spiratory reduction in Shewanella sp. strain ANA-3.

258 stems are expressed in Shewanella sp. strain ANA-3.

259 bitor of STAT3 signaling pathway, suppressed ANA production in short-term culture, indicating that th

260 stant to letrozole (T+LET R), anastrozole (T+ANA R), and exemestane (T+EXE R), as well as long-term e

261 nt lines showed that LTEDaro, T+LET R, and T+ANA R cells contained a constitutively active estrogen r

262 found that StuAp response elements (A/TCGCGT/ANA/C) are located upstream of both critical development

263 onventional gel-based separation techniques, ANA offers the potential for faster separation, higher t

264 ay crystallography, we demonstrate here that ANA analogues, such as 2'F-ANA and [3.3.0]bicyclo-ANA (b

265 < or = 6.5 are consistent with the idea that ANA and other eicosanoids act as endogenous ligands of V

266 Here we report that ANA-modified siRNAs targeting the MDR1 gene can exhibit

267 Mutation reversion analyses revealed that ANA arose predominantly from nonautoreactive B cells tha

268 Our results demonstrate that ANAs and AHAs are more prevalent among patients with mor

269 The ANA consists of a two-dimensional periodic nanofilter ar

270 The ANA is physically robust and can be reused repeatedly.

271 The ANA prevalence in the US population of individuals ages

272 The ANA structures, composed of periodically patterned deep

273 bsence of antinuclear antibodies (ANAs), the ANA staining patterns, and the presence or absence of an

274 the C57BL/6 genome that are required for the ANA phenotype, further indicating the epistatic properti

275 volunteers, we compared distributions of the ANA levels.

276 lementarity-determining region (CDR3) of the ANA originate from V(D)J recombination or somatic hyperm

277 with the endogenous FcepsilonRIgamma of the ANA-1 macrophage cell line, again in an Arg(632)-depende

278 ingly, the duration of action of some of the ANA-modified siRNAs was substantially greater than that

279 Using microfluidic channels surrounding the ANA, the fractionated biomolecule streams are collected

280 levance of this observation, we utilized the ANA-l murine macrophage model of endotoxin (LPS)-mediate

281 Together with the ANA data of 9,575 healthy volunteers, we compared distri

282 antinuclear antibodies (ANA), and 50% of the ANAs are also reactive with a diverse group of antigens

283 Most intriguingly, the CDR3 regions of the ANAs exhibited alternating arginine/lysine peaks at H96,

284 basis of the observed conformations of these ANA analogues in a DNA dodecamer duplex, we have modeled

285 We demonstrate that sensitivity to ANA is modulated by strength of TLR9 signal, because str

286 n the prefrontal cortex (PFC) as compared to ANAs while the two phenotypes expressed similar levels o

287 electrochemical method for quantifying total ANA for use as a point-of-care diagnostic aid.

288 ANA and the differences between the various ANA assays.

289 versus baseline and p < 0.05 AA peak versus ANA peak).

290 cribe the fabrication of planar and vertical ANA chips and how to perform continuous-flow bioseparati

291 ination Survey (1999-2004), of whom 14% were ANA positive, to explore associations between ANA and co

292 Sixteen percent of females were ANA positive; 96% of ANA positives had a nuclear speckle

293 ts that the loss of activity associated with ANA modification of the 5'-antisense strand may be due t

294 alysis revealed that SLE was associated with ANA positivity (>/=20 units), anti-MCV negativity (</=70

295 ut not urinary, mercury were associated with ANA positivity (sample sizes 452, 1,352, and 804, respec

296 population are not strongly associated with ANA.

297 uced estimates of chemical associations with ANA in males, nulliparous females, and parous females; t

298 in regions of ethanol-naive AA compared with ANA rats.

299 Duplexes with ANA modifications at appropriate positions in both stran

300 of SLE in which all somatic mutations within ANA V regions, including those in CDR3, could be unequiv