ライフサイエンスコーパス: ANP receptor

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1 hormone activation and the allostery of the ANP receptor.

2 e with selective deletion of the endothelial ANP receptor.

3 le because these cells only express a single ANP receptor.

4 ytic) domains of atrial natriuretic peptide (ANP) receptor-A (Npra) in postbinding events and metabol

5 cytes exists within caveolae bound to type B ANP receptors (ANP-RB, a guanylyl cyclase), we have used

6 (5 muM) that was inhibited completely by the ANP receptor antagonist anantin and a 60% increase in ne

7 Isatin, a specific ANP receptor antagonist, reversed ANP's effect.

8 NP (1 pM to 1 micromol/L), and/or isatin, an ANP receptor antagonist.

9 ated dimerized hormone-binding domain of the ANP receptor at 2.0-A resolution.

10 tures are shared among the A-type and B-type ANP receptors but not by ANP clearance receptors.

11 ences in either density or affinity of renal ANP receptors, but was abolished when accumulation of cG

12 ng domain of the atrial natriuretic peptide (ANP) receptor contains two possible dimer pairs, the hea

13 Endoglycosidase treatment of the full-length ANP receptor expressed in COS-1 cells also had no detect

14 isruption of the atrial natriuretic peptide (ANP) receptor [guanylyl cyclase-A (GC-A)] gene yields mi

15 ally, suggesting polarized expression of the ANP receptors in these cells.

16 suggest that transmembrane signaling by the ANP receptor is initiated via a hormone-induced rotation

17 The atrial natriuretic peptide (ANP) receptor is a 130-kDa transmembrane protein contain

18 ylation sites in the extracellular domain of ANP receptor (NPR-ECD) from rat expressed in COS-1 cells

19 the extracellular ANP-binding domain of rat ANP receptor (NPR-ECD) in a water-soluble form.

20 the dimerized hormone binding domain of the ANP receptor provides a first three-dimensional view of

21 support the proposed rotation mechanism for ANP receptor signaling.

22 The ANP receptor that mediates these actions is a glycosylat

23 ed by hormone binding extracellularly to the ANP receptor, thereby activating its intracellular guany

24 lding and transport of the newly synthesized ANP receptor to the cell surface, the oligosaccharide mo

25 GMP-dependent signaling cascade leading from ANP receptors to nuclear accumulation of both molecules.

26 ed member is the atrial natriuretic peptide (ANP) receptor, which is involved in blood pressure regul

27 use of a beta-cell-specific knockout of the ANP receptor with guanylate cyclase activity (betaGC-A-K

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