ライフサイエンスコーパス: ANT2

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1 transcriptional regulation of both Ant1 and Ant2.

2 sues but muscle, in marked contrast to human ANT2.

3 of transcription, as hypothesized for human ANT2.

4 ion of the adenine nucleotide translocase 2 (ANT2), an inner mitochondrial membrane protein, which le

5 AT, and knockdown of the major ANT isoforms, ANT2 and ANT3, did not collapse DeltaPsi after respirato

6 ing enzyme and the ADP/ATP carrier proteins, ANT2 and ANT3.

7 The finding that the mouse Ant2 and Pem loci are tightly linked suggests that human

8 a gene implicated in Graves' disease and it, ANT2 and two others are confirmed by EST matches.

9 leotide translocase-1 and -2 genes (Ant1 and Ant2) and assigned the loci to mouse chromosomes 8 and X

10 sequenced the genomic loci of mouse Ant1 and Ant2, and compared them to the three human ANT loci.

11 aved between two extant groups, 0.ANT1 and 0.ANT2, and is distant from strains associated with the se

12 endent tyrosine phosphorylation of L1, ANT1, ANT2, and MMP14.

13 e sequence of 135 038 nt contains the entire ANT2 cDNA as well as four other candidates suggested by

14 Ant2 cosegregates with DXMit49 and DXMit50 and lies dist

15 his segment of the Hprt region as: Agtr2-Pem-Ant2-DXMit50-Lamp2-DXMit49.

16 we describe the genomic organization of the Ant2 gene and its regional map position on the X chromos

17 rmatogenesis where the sex chromosome-linked Ant2 gene is inactivated.

18 The mouse Ant2 gene, like human ANT2, has an upstream GRBOX, yet t

19 re promoters of the mouse and human ANT1 and ANT2 genes are very similar.

20 The mouse and human ANT1 and ANT2 genes showed substantial homology starting about 30

21 The mouse Ant2 gene, like human ANT2, has an upstream GRBOX, yet this element is not ass

22 e we demonstrate that targeted disruption of Ant2 in mouse liver enhances uncoupled respiration witho

23 hermore, we show that ADP/ATP translocase 2 (ANT2) interacts with Fe-S apoproteins and MMS19 in the C

24 Mouse Ant2 is strongly expressed in all tissues but muscle, in

25 hrough the mitochondrial inner membrane, and Ant2 is the predominant isoform expressed in the liver.

26 Interestingly, liver specific Ant2 knockout mice are leaner and resistant to hepatic s

27 loci are tightly linked suggests that human ANT2 may be useful as a marker for isolating the human P

28 of wild-type mice exhibited higher levels of Ant2 mRNA compared with hindlimb muscle, which may compe

29 3000 translocation breakpoint and six genes (ANT2, NDUFA1, LAMP2, OCRL, IGSF1, and HDGF) at better th

30 enetic or pharmacologic inhibition of either ANT2 or HIF-1alpha can prevent or reverse these pathophy

31 complex and that the structurally homologous ANT2 protein does not bind the complex.

32 cate that plasma membrane-localized ANT1 and ANT2 regulate L1-mediated neurite outgrowth in conjuncti

33 15kb of Ant1 sequence and 36% of the 27kb of Ant2 sequence and included SINEs, LINEs and LTR elements

34 leotide translocator (ANT) isoforms ANT1 and ANT2 that are present in the plasma membrane of mouse ce

35 Of interest, in contrast to its paralog Ant2, which is encoded by the X chromosome and ubiquitou

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