ライフサイエンスコーパス: AP2

1 2 of the mammalian ADAPTOR PROTEIN COMPLEX2 (AP2).

2 irst postcontrast and the unenhanced series (AP2).

3 uit the clathrin adaptor, Adaptor protein 2 (AP2).

4 cargo-selecting, clathrin adaptors, CALM and AP2.

5 or mutants were found to harbor mutations in AP2.

6 lant AP4 but not that of plant and mammalian AP2.

7 FCHo and SGIP proteins, that directly binds AP2.

8 exposing membrane and cargo binding sites on AP2.

9 m prevents clathrin recruitment by cytosolic AP2.

10 mediates its binding to the clathrin adaptor AP2.

11 ctly to DPF sequences in Dab2 that also bind AP2.

12 for LDLR endocytosis under conditions of low AP2.

13 miR156, miR172f, miR172g, miR408a, SPL6 and AP2.

14 rabidopsis MINI3, IKU2, SHB1, AGL62, FIE and AP2.

15 functional interactions between clathrin and AP2.

16 binding gene), RAV (related to ABI3/VP) and AP2.

17 114 common bean genes that coexpressed with AP2-1 and proposed these as being targets for transcript

18 have to be silenced, through miR172c-induced AP2-1 cleavage, in active mature nodules.

19 ic roots overexpressing miR172c or a mutated AP2-1 insensitive to miR172c cleavage demonstrated the p

20 A drastic decrease in miR172c and high AP2-1 mRNA levels were observed in ineffective nodules.

21 The expression of AP2-1 target showed a negative correlation with miR172c

22 ng targets for transcriptional activation by AP2-1.

23 L1 also interacted with Adaptor protein2-2A (AP2-2A), which is part of a complex that recruits cargo

24 Adaptor protein-2 (AP2), a central component of clathrin-coated vesicles (C

25 AP2, a heterotetramer of alpha, beta, mu and sigma subun

26 ay a critical role in the earliest stages of AP2 activation and CCP nucleation.

27 inding alpha-adaptin appendage domain of the AP2 adaptor as switches in a regulated, multistep matura

28 d, and the recruitment of the beta2-adaptin, AP2 adaptor complex to clathrin as well as transferrin i

29 tect arrival of the clathrin triskelions and AP2 adaptors that initiate coat assembly.

30 xpression of PPARgamma target genes, such as aP2 and adipsin.

31 wifruit gene with high levels of homology to AP2 and AP2-like genes from other plant species was iden

32 of LRP6 signalosomes via the recruitment of AP2 and clathrin and that LRP6 internalization may not b

33 lar endocytic pathway that is independent of AP2 and clathrin, activated upon ligand binding to cargo

34 nteractions with the core endocytic proteins AP2 and dynamin.

35 (ICD), responsible for the interaction with AP2 and GABA(A)R internalization.

36 sulfate and keratocan; or adipocyte markers ap2 and leptin.

37 demonstrated that ARF3 is a direct target of AP2 and partially mediates AP2's function in FM determin

38 and live imaging analysis demonstrated that AP2 and PICALM cross-link LC3 with APP-CTF.

39 cided with that of the neural crest, because AP2 and SoxE are not co-expressed in amphioxus, and beca

40 y reduces the binding efficiency of GluR2 to AP2 and subsequently decreases AMPA receptor endocytosis

41 466 is expected to decrease its affinity for AP2 and to inhibit the endocytic rate.

42 Cre lines driven by the adipocyte protein 2 (aP2) and adiponectin (Adipoq) gene promoters, as well as

43 tion of two floral homeotic genes, APETALA2 (AP2) and AGAMOUS (AG).

44 t of the clathrin-associated adaptor protein AP2) and clathrin, was disproportionately affected by th

45 ecruitment of the adaptin protein-2 complex (AP2) and ensuing receptor endocytosis.

46 clathrin adaptor protein (AP) complexes AP1, AP2, and AP3.

47 to clathrin structures with integrin beta1, AP2, and reduced amounts of Eps15.

48 ired internalization of MACs in a clathrin-, AP2-, and dynamin-dependent manner into Rab5(+)endosomes

49 pment that encode proteins with apicomplexan AP2 (ApiAP2) DNA binding domains.

50 articularly enriched within the Apicomplexan AP2 (ApiAP2) DNA-binding protein family.

51 Orthologous Apicomplexan AP2 (ApiAP2) expression has been rearranged relative to

52 P2-G, a conserved member of the apicomplexan AP2 (ApiAP2) family of DNA-binding proteins, is essentia

53 actor PfAP2-I, belonging to the Apicomplexan AP2 (ApiAP2) family, that is responsible for regulating

54 ulators of the host adaptor proteins AP1 and AP2, are essential for hepatitis C virus (HCV) infection

55 tionally, we identified the clathrin adaptor AP2 as an interacting partner of a previously uncharacte

56 cultures induced ADAM10 endocytosis through AP2 association and decreased surface ADAM10 levels and

57 We found that the ADAM10/AP2 association was increased in the hippocampi of AD pa

58 motifs in C. parvum upstream regions are not AP2 binding motifs.

59 Thus, AP2 binding to an RRR motif in the GABA(A)R beta3-subuni

60 Here, we show that the second AP2 domain in AP2 binds a non-canonical AT-rich target sequence, and,

61 Expression of native FABP4/aP2 (but not the non-fatty acid binding mutant R126Q) in

62 eptor interactions with the clathrin-adaptor AP2, but the molecular determinants of these association

63 WRINKLED1 (WRI1), a member of the APETALA2 (AP2) class of transcription factors, positively regulate

64 The AP2 clathrin adaptor complex links protein cargo to the

65 and membrane-facing in the open form of the AP2 clathrin adaptor complex.

66 This study reveals a novel role for the AP2 clathrin adaptor in promoting the abundance of GluRs

67 Clathrin/AP2-coated vesicles are the principal endocytic carriers

68 In mammals, the AP2 complex acts as the central hub of CME by docking to

69 The AP2 complex of the CME pathway is conserved in yeast, an

70 tic analysis between TWD40-2 and AP2M of the AP2 complex revealed that the roles of TWD40-2 in CME ar

71 nt of Cx43, which does not interact with the AP2 complex, and by expressing mutants that cannot be ph

72 PtdIns4,5P(2)-binding sites on the endocytic AP2 complex, providing evidence that the orientation of

73 both distinct from and cooperative with the AP2 complex.

74 subunits of the clathrin adaptor protein 2 (AP2) complex in Caenorhabditis elegans to characterize t

75 o proteins of the classic adaptor protein 2 (AP2) complex of the clathrin-mediated endocytosis (CME)

76 subunit of the endocytosis adaptor protein, AP2, complexed with Kir6.2 predicted that mu2 docks by i

77 Heterotetrameric adaptor protein 2 (AP2) complexes, which initiate clathrin-coated pit (CCP)

78 he lethality can be rescued by expression of AP2 components in the skin, which allowed us to evaluate

79 Here, we have discovered that AP1 and AP2 cotraffic with HCV particles in live cells.

80 c subunits of AMPK (AMPK-ASKO mice) by using aP2-Cre and adiponectin-Cre.

81 we show that biallelic Dicer1 deletion with aP2-Cre drives aggressive and metastatic angiosarcoma in

82 In addition, the aP2-Cre line can lead to germline recombination of floxe

83 in any other tissues examined, whereas both aP2-Cre lines resulted in recombination in endothelial c

84 ene (Fsp27(DeltaAd)) were generated using an aP2-Cre transgene with the Cre/LoxP system.

85 -fat diet (HFD)-induced obesity using female aP2-Cre(-/+)/ERalpha(fl/fl) mice (atERalphaKO).

86 on of Ptpn11/Shp2 in adipocytes, mediated by aP2-Cre, led to premature death, lack of white fat, low

87 aP2-cre-mediated GRP78 deletion leads to lipoatrophy wit

88 Angiosarcomas in aP2-Cre;Dicer1(Flox/-) mice histologically and genetical

89 s, four established cell lines from PEL (CRO-AP2, CRO-AP3, CRO-AP5, and CRO-AP6) were characterized b

90 FABP4/aP2-deficient macrophages are resistant to LPS-induced m

91 Silencing of UCP2 mRNA in FABP4/aP2-deficient macrophages negated the protective effect

92 lathrin-binding beta2 hinge and developed an AP2-dependent budding assay.

93 volved in the stabilization of Clathrin- and AP2-dependent endocytic pits.

94 emia and epilepsy, whether this occurs in an AP2-dependent manner also remains unclear.

95 via both adapter protein complex (AP)1- and AP2-dependent trafficking pathways.

96 osis of some cargoes proceeds efficiently in AP2-depleted cells.

97 inhibited Dab2-mediated LDLR endocytosis in AP2-depleted cells.

98 and a doubling of CCP/CCV diameter, whereas AP2 depletion has opposite effects.

99 These data demonstrate that FABP4/aP2 directly regulates intracellular FFA levels and indi

100 nt, whereas double mutants of nsn1 apetala2 (ap2) displayed enhanced defective floral phenotypes.

101 recognition sequence, one in each of its two AP2 DNA binding domains.

102 These proteins contain a conserved AP2 DNA-binding domain and several uncharacterized motif

103 of apicomplexa-specific proteins containing AP2 DNA-binding domains (ApiAP2s) was identified in mala

104 Although PfAP2-I contains three AP2 DNA-binding domains, only one is required for bindin

105 AP2 does not repress the transcription of AG in the inne

106 Here, we show that the second AP2 domain in AP2 binds a non-canonical AT-rich target s

107 tein binding microarrays, we established the AP2 domain of AP2IX-9 binds a CAGTGT DNA sequence motif

108 AP2 domain-containing proteins have evolved to be the ma

109 2/ERF superfamily and has a highly conserved AP2 domain.

110 PPMO directed against plant-like Apetela 2 (AP2) domain transcription factor XI-3 (AP2XI-3), not pre

111 s two DNA-binding domains referred to as the AP2 domains and its DNA recognition sequence is still un

112 We show that apicomplexan and perkinsid AP2 domains cluster distinctly from other chromalveolate

113 tein-binding specificity assays of C. parvum AP2 domains combined with motif conservation upstream of

114 C. parvum AP2 domains display reduced binding diversity relative t

115 T-rich target sequence, this work shows that AP2 domains have wide-ranging target specificities and p

116 nding motif was identified in one of the two AP2 domains of AtWRI1, which was also found to be critic

117 ariants were identified, all containing both AP2 domains, including a variant that potentially produc

118 apicomplexan transcriptional regulation, pre-AP2 domination.

119 AP2 tagged with enhanced green fluorescence (AP2-EGFP) and on lateral protrusions from immobile SUM15

120 east carcinoma cells, gene-edited to express AP2-EGFP.

121 oping coarse-grained models for clathrin and AP2, employing a Monte Carlo click interaction, to simul

122 was a major force in expanding B. distachyon AP2/EREBP (BdAP2/EREBP) family.

123 Especially AP2/EREBP and WRKY TFs may be important regulators of su

124 Except a few members, the AP2/EREBP family has not been characterized in Brachypod

125 further function analysis of stress tolerant AP2/EREBP genes in B. distachyon.

126 A total of 149 AP2/EREBP genes were identified and divided into four su

127 ethylene-responsive element binding protein (AP2/EREBP) transcription factors constitute one of the l

128 YUC8 and OCTADECANOID-RESPONSIVE ARABIDOPSIS AP2/ERF (ORA)59 independently of protein translation.

129 y network was deduced where targets, such as AP2/ERF and bHLH transcription factors and chromatin rem

130 e to low temperature, encode closely related AP2/ERF DNA-binding proteins that recognize the C-repeat

131 signals that may impact ethylene's effect on AP2/ERF family members.

132 Fs), OsEREBP1 and OsEREBP2, belonging to the AP2/ERF family were identified.

133 ion factors (TFs) in Group IX of the tobacco AP2/ERF family.

134 We isolated PsAP2 a novel AP2/ERF from Papaver somniferum which was highly upregul

135 The fast responses of four AP2/ERF genes, ERF6, RRTF1, ERF104, and ERF105, were ent

136 AP2/ERF proteins play crucial roles in plant growth and

137 ced transcription factor that belongs to the AP2/ERF superfamily and has a highly conserved AP2 domai

138 The jasmonic acid (JA)-responsive AP2/ERF transcription factor (TF), ORCA3, and its regula

139 oned the responsible gene, ERN1, encoding an AP2/ERF transcription factor.

140 sponse factors (CRFs) are a group of related AP2/ERF transcription factors that are transcriptionally

141 ion detected between MED25 and four group IX AP2/ERF transcription factors was shown to require the a

142 LE/BRANCHED FLORETLESS 1 (FZP/BFL1) encoding AP2/ERF transcription factors.

143 t with ESE1, a member of the B-3 subgroup of AP2/ERF transcription factors.

144 e, PsnSHN2, a counterpart of the Arabidopsis AP2/ERF type transcription factor, SHINE2.

145 ly of the APETALA2/ETHYLENE RESPONSE FACTOR (AP2/ERF) transcription factor ORA59, which controls the

146 er of the APETALA2/ETHYLENE RESPONSE FACTOR (AP2/ERF) transcription factor superfamily; the gene is s

147 x binding APETALA2/ETHYLENE RESPONSE FACTOR (AP2/ERF) transcription factors ERF1 or ORA59, we found t

148 encoding Apetala2/Ethylene-Response Factor (AP2/ERF)-domain transcription factors (TFs) in Group IX

149 ther transcription factor families like MYC, AP2/ERF, bZIP, etc. are enriched in OsMADS1-bound DNAs.

150 d on the expression of the six TFs families (AP2/ERF, NAC, MYB, MYB-related, bZIP and WRKY) and the m

151 se Factor 6 (CRF6) is a cytokinin-responsive AP2/ERF-family transcription factor that, through the cy

152 ent MPK6 activation leading to initiation of AP2/ERF-TF gene expression and other downstream gene tar

153 YLENE RESPONSE FACTOR transcription factors (AP2/ERF-TFs) were found to respond within 10 min after t

154 WRKY33, OCTADECANOID-RESPONSIVE ARABIDOPSIS AP2/ERF59 (ORA59), and PDF1.2 is inhibited, whereas tran

155 factors OCTADECANOID-RESPONSIVE ARABIDOPSIS AP2/ERF59 and ERF1 as well as the master regulator MYC2.

156 how that OCTADECANOID-RESPONSIVE ARABIDOPSIS AP2/ERF59- and ERF1-dependent activation of PLANT DEFENS

157 The AP2/ERFs are one of the most important family of transcr

158 a physical cluster with two uncharacterized AP2/ERFs, ORCA4 and 5.

159 iption activation motif of MED25-interacting AP2/ERFs.

160 A signaling pathway, including the APETALA2 (AP2)/ETHYLENE RESPONSE FACTOR (ERF) transcription factor

161 in mice, we have identified a population of aP2-expressing progenitors in the stromal vascular fract

162 When isolated and grown in culture, the aP2-expressing SVF cells proliferate and differentiate i

163 A LIKE1 (PtAIL1) transcription factor of the AP2 family during adventitious root formation.

164 n transcriptional processes that involve ERF/AP2 family members.

165 tion by down-regulation of the mRNA level of aP2, FAS, LPL, HSL and PLIN1.

166 n adipose Grp78-knockout mouse utilizing the aP2 (fatty acid binding protein 4) promoter-driven Cre-r

167 gulation (CRY2, PHYA), and flowering (AGL20, AP2, FLC).

168 t requires the transcriptional activation of ap2-g (PF3D7_1222600), the master regulator of sexual de

169 AP2-G expression during this 'commitment cycle' prepares

170 in a persistent infection, the expression of ap2-g is limited to a sub-population of parasites (1-30%

171 e parasite transcriptomes from a conditional AP2-G knockdown line and NF54 wild-type parasites at mul

172 rmine the transcriptional changes induced by AP2-G within this sub-population.

173 evelopment, we show that sexually committed, AP2-G(+) mature schizonts specifically upregulate additi

174 P2-SP proteins in blood stages, and identify AP2-G2 as a repressor active in both asexual and sexual

175 molecules and transcription factors such as AP2, Gbx2, Pax3 and Zic1.

176 he microRNA BLINDBEN belongs to the TOE-type AP2 gene family, members of which control flowering time

177 l as a tamoxifen-inducible Cre driven by the aP2 gene promoter (iaP2), were bred to the Rosa26R (R26R

178 d insulin signaling in the adipose tissue of aP2-GPS2 transgenic mice.

179 Thus, we speculate that AP2 has evolved as a key regulatory node to coordinate C

180 The probe AP2 has excellent ability to detect ~10(3) copies of tar

181 In contrast to G proteins and arrestins, mu-AP2 has no significant effect on the organization of the

182 l homeotic proteins containing MADS domains, AP2 has two DNA-binding domains referred to as the AP2 d

183 BP4), commonly known as adipocyte protein 2 (aP2), has been extensively used as a marker for differen

184 redox intercalating probes (AP probes: AP1, AP2) have been designed, synthesized, characterized and

185 e basis of the broad biological functions of AP2 in Arabidopsis, as well as the divergent biological

186 Thus, our results identify a new role for AP2 in extracellular calcium homeostasis.

187 o repress AG and plays an additive role with AP2 in floral organ specification.

188 elegans to characterize the in vivo role of AP2 in GluR trafficking.

189 we show that inhibition or deletion of FABP4/aP2 in macrophages results in increased intracellular fr

190 Fatty acid-binding protein 4 (FABP4 or aP2 in mice) has been identified as a key regulator of c

191 Here, we describe a role of AP2 in promoting the maintenance of floral stem cell fat

192 pendent manner, whereas it interacts with mu-AP2 in the absence of ligand or in the presence of ghrel

193 The presence of clathrin and AP2 in the LRP6 signalosomes depended on PtdIns(4,5)P(2)

194 ntify null mutations in the alpha subunit of AP2 in the nematode Caenorhabditis elegans.

195 of GluRs at synapses in vivo, and implicates AP2 in the regulation of GluR trafficking at an early st

196 P4/aP2(-/-) macrophages, as well as in FABP4/aP2 inhibitor-treated cells, but partially rescued in FA

197 as clathrin structures contain both Dab2 and AP2, integrin beta1 and transferrin localize in separate

198 PICK1-AP2 interactions are required for clustering AMPARs at e

199 fined behavior at EZs, which is dependent on AP2 interactions via this motif.

200 by a hippocampal-specific increase in PICK1-AP2 interactions, followed by PICK1-dependent lysosomal

201 e-associated proteins FCHo and SGIP1 convert AP2 into an open, active conformation.

202 When this motif is disrupted, binding to AP2 is abolished in vitro and in rat brain.

203 recruited by AP2 may be recruited by Dab2 if AP2 is absent.

204 he endocytic machinery but it is unclear how AP2 is activated on the plasma membrane.

205 AP2 is also negatively regulated by an evolutionary cons

206 cytosis, even when the major adaptor protein AP2 is depleted.

207 that PICK1 binding to the endocytic adaptor AP2 is enhanced by OGD in hippocampal, but not cortical

208 However, whether aP2 is expressed in adipogenic progenitors is controvers

209 Therefore, the expression of aP2 is not limited to mature adipocytes, but also marks

210 Coincident with the loss of FABP4/aP2 is the upregulation of the antioxidants superoxide d

211 The clathrin adaptor complex AP2 is thought to be an obligate heterotetramer.

212 acid binding protein 4 (FABP4, also known as aP2) is a cytoplasmic fatty acid chaperone expressed pri

213 Fatty acid binding protein 4 (FABP4 or aP2) is an intracellular lipid chaperone that is induced

214 APETALA2 (AP2) is best known for its function in the outer two flo

215 Assembly polypeptide 2 (AP2) is the most abundant adaptor and is pivotal to CME.

216 ing binding site in the mRNA of an APELATA2 (AP2)-like transcription factor, HvAP2.

217 gene with high levels of homology to AP2 and AP2-like genes from other plant species was identified.

218 Previous studies showed that Q encodes an AP2-like transcription factor, but the causal polymorphi

219 Conversely, ablation of the aP2 lineage greatly reduces the adipogenic potential of

220 When grafted into wild-type mice, the aP2-lineage progenitors give rise to adipose depots in r

221 The aP2-lineage progenitors reside in the adipose stem cell

222 uch as adipocyte fatty acid-binding protein (aP2), lipoprotein lipase (LPL), fatty acid synthase (FAS

223 ced mitochondrial protein oxidation in FABP4/aP2(-/-) macrophages attenuates the mitochondrial unfold

224 Consistent with a diminished mtUPR, FABP4/aP2(-/-) macrophages exhibit reduced expression of cleav

225 inflammasome activation, is ablated in FABP4/aP2(-/-) macrophages, as well as in FABP4/aP2 inhibitor-

226 the accessory proteins normally recruited by AP2 may be recruited by Dab2 if AP2 is absent.

227 These data suggest that AP2 may function as two partially independent hemicomple

228 The prototypical clathrin adaptor AP2 mediates cargo recruitment, maturation, and scission

229 of double flowers, and we found that miR172-AP2, miR156-SPLs were critical regulatory nodes contribu

230 mpared with wild-type mice, transgenic mice (aP2-MRAP) overexpressing MRAP fat specifically exhibited

231 delta-ICD increases in affinity for clathrin AP2-mu2 leading to endocytosis.

232 elta subunits with clathrin adaptor proteins AP2-mu2 revealed by coimmunoprecipitation, followed by a

233 -fatty acid binding mutant R126Q) into FABP4/aP2 null cells reduced UCP2 expression, suggesting that

234 reated cells, but partially rescued in FABP4/aP2-null macrophages when UCP2 is silenced.

235 We describe non-essential functions for AP2-O and AP2-SP proteins in blood stages, and identify

236 Furthermore, depletion of AP2 or clathrin by siRNA treatment significantly inhibit

237 ell as the divergent biological functions of AP2 orthologs in dicotyledonous plants.

238 However, it is unknown how AP2 performs these functions.

239 Using aP2-PFKFB3 transgenic (Tg) mice, we explored the ability

240 This molecular mechanism linking AP2/PICALM and AD is consistent with genetic evidence in

241 These results demonstrate that AP2 plays a broad role in flower development by controll

242 Moreover, aP2-PPARgamma response element (PPRE) interacts with bot

243 ely abolish the association of PPARgamma and aP2-PPRE.

244 pecific PPARgamma knock-out mice carrying an aP2 promoter-driven Cre recombinase transgene showed a b

245 EL (WUS) to terminate floral stem cell fate, AP2 promotes the expression of WUS.

246 The A-class gene APETALA2 (AP2) promotes sepal and petal identities in whorls 1 and

247 ytosis by increasing receptor binding to the AP2 protein of the endocytotic machinery.

248 asome, as demonstrated for the wrinkled1 ERF/AP2 protein.

249 With the AP2 protocol, the sensitivity was 0.85 (95% CI: 0.78, 0.

250 action of purified GHS-R1a with arrestin and AP2 provide a new rationale to the differences in basal

251 Knockdown of AP2 reduced autophagy-mediated APP-CTF degradation.

252 Further analysis showed that AP2 regulated the cellular levels of APP-CTF.

253 ese data offer a novel pathway whereby FABP4/aP2 regulates macrophage redox signaling and inflammasom

254 Here, we demonstrate that ablation of FABP4/aP2 regulates systemic redox capacity and reduces cellul

255 lusters allowed the construction of putative AP2 regulons across the in vitro life cycle.

256 copy the loss of AP2 subunits and found that AP2 remains inactive in fcho-1 mutants.

257 We show that AP2 represses its target genes by physically recruiting

258 direct target of AP2 and partially mediates AP2's function in FM determinacy.

259 his molecular switching mechanism can couple AP2's membrane recruitment to its key functions of cargo

260 Here we show that missense mutations of AP2 sigma subunit (AP2S1) affecting Arg15, which forms k

261 We identify five (clathrin, dynamin1, AP2, sorting nexins [SNX] SNX27, and SNX1) that increase

262 scribe non-essential functions for AP2-O and AP2-SP proteins in blood stages, and identify AP2-G2 as

263 8/TDR1 and other clade members from the same AP2 sub-family.

264 ous as the majority of them, except those of AP2 subfamily, had no intron.

265 motifs and full-length CvpA interacted with AP2 subunits and clathrin heavy chain.

266 s elegans mutants that phenocopy the loss of AP2 subunits and found that AP2 remains inactive in fcho

267 cord (VNC) of animals with mutations in the AP2 subunits APM-2/mu2, APA-2/alpha, or APS-2/sigma2.

268 h allowed us to evaluate the requirement for AP2 subunits at synapses.

269 tified 71 compensatory mutations in all four AP2 subunits.

270 ng U373 glioblastoma cells stably expressing AP2 tagged with enhanced green fluorescence (AP2-EGFP) a

271 and miR172, which target the NF-YA/HAP2 and AP2 TFs, respectively.

272 Here, we determined a structure of AP2 that includes the clathrin-binding beta2 hinge and d

273 ly regulated conformational changes activate AP2 to drive both nucleation and subsequent stabilizatio

274 ependent recruitment of the clathrin adaptor AP2 to IR.

275 Binding of the transcription factor AP2 to the BST2 promoter was attenuated by inhibition of

276 uits beta-arrestins and the clathrin adaptor AP2 to trigger PC1 internalization.

277 dormancy in kiwifruit was proposed based on AP2 transcript accumulation in axillary buds before and

278 Increased AP2 transcript accumulation was detected in the aberrant

279 d species Arabidopsis thaliana, the AP2-type AP2 transcription factor represents a major A-function p

280 e3 at the binding site for the PF3D7_1466400 AP2 transcription factor.

281 a particularly strong selective sweep at an AP2 transcription factor.

282 f a single particular var gene that involves AP2 transcription factors and lncRNAs.

283 ion upon DTT treatment revealed a network of AP2 transcription factors and their targets being activa

284 t with these profiles were the expression of AP2 transcription factors typically associated with extr

285 cells negatively regulates the expression of Ap2 transcription factors, and enhances the Wnt agonist

286 gulators of gene expression, including other AP2 transcription factors, histone-modifying enzymes, an

287 (miR172) and its conserved target APETALA2 (AP2) transcription factor in the common bean (Phaseolus

288 of ethylene response factor (ERF)/APETALA2 (AP2) transcription factors, mediated by Math-BTB/POZ (fo

289 and insulin resistance (AKT2 KO, Adiponectin aP2-transgenic), suggested that scWAT TAG Elovl6 ratio w

290 the rosid species Arabidopsis thaliana, the AP2-type AP2 transcription factor represents a major A-f

291 In turn, we demonstrate that the petunia AP2-type REPRESSOR OF B-FUNCTION (ROB) genes repress the

292 the murine fatty acid binding protein (FABP4/aP2) uncouples obesity from inflammation although the me

293 adipocyte fatty acid-binding protein (FABP4/aP2) uncouples obesity from inflammation via upregulatio

294 ed on PtdIns(4,5)P(2), and both clathrin and AP2 were required for the formation of LRP6 signalosomes

295 we show that clathrin and adaptor protein 2 (AP2) were part of the LRP6 signalosomes.

296 at the A-class organ identity gene APETALA2 (AP2), which is known to repress the C-class gene AGAMOUS

297 cal for FM maintenance, and AG and APETALA2 (AP2), which regulate FM determinacy by repression and pr

298 tiate by coordinated arrival of clathrin and AP2, which is usually detected as two sequential steps,

299 of increased WISP2 in vivo, we generated an aP2-WISP2 transgenic (Tg) mouse.

300 Pharmacologic inhibition of FABP4/aP2 with the FABP inhibitor HTS01037 also upregulated UC