ライフサイエンスコーパス: APC gene

1 formation with CpG --> TpG mutations in the Apc gene.

2 gene and the mutation cluster region of the APC gene.

3 s with the D1822V [corrected] variant of the APC gene.

4 gene and the mutation cluster region of the APC gene.

5 tuses bearing a heterozygous mutation in the APC gene.

6 be shown to have truncating mutations of the APC gene.

7 r this disorder by genetically modifying the Apc gene.

8 310 kD and is encoded by exons 1 - 15 of the APC gene.

9 ed due to cancer-associated mutations in the APC gene.

10 AP) coli who have germ line mutations in the APC gene.

11 ht to be associated with a disruption in the APC gene.

12 es and thereby initiated CRC by mutating the APC gene.

13 Cre-mediated bi-allelic inactivation of the Apc gene.

14 nd because much is known about the causative APC gene.

15 iduals are heterozygous for mutations in the APC gene.

16 tudied in mice that inherit mutations in the Apc gene.

17 FAP is due to mutations in the APC gene.

18 d are negative for germline mutations in the APC gene.

19 to a thymine-adenine pair (G:C-->T:A) in the APC gene.

20 contribute to the specific targeting of the APC gene.

21 alterations in key regions of the K-ras and Apc genes.

22 mutations in the adenomatous polyposis coli (APC) gene.

23 ctivation of the adenomatous polyposis coli (APC) gene.

24 mutations in the Adenomatous polyposis coli (Apc) gene.

25 mutation in the adenomatous polyposis coli (APC) gene.

26 function of the Adenomatous polyposis coli (APC) gene.

27 ressors TP53 and adenomatous polyposis coli (APC) gene.

28 e product of the Adenomatous Polyposis Coli (APC) gene.

29 RC occurs in the adenomatous polyposis coli (APC) gene.

30 mutations to the adenomatous polyposis coli (Apc) gene.

31 mutation in the adenomatous polyposis coli (APC) gene.

32 mutations in the adenomatous polyposis coli (APC) gene.

33 mutations of the adenomatous polyposis coli (Apc) gene.

34 mutations in the adenomatous polyposis coli (APC) gene.

35 The adenomatous polyposis coli (APC) gene, a member of the WNT pathway, has been shown t

36 The adenomatous polyposis coli (Apc) gene also plays an important role in regulating gen

37 he FGPs were shown to carry the same somatic APC gene alteration in 24 (96%) of 25 cases.

38 P patients showed infrequent (one of 13, 8%) APC gene alterations (P: = 0.008).

39 as no difference in the frequency of somatic APC gene alterations between FGPs with foveolar dysplasi

40 Identical APC gene alterations were found in the dysplastic and ad

41 No APC gene alterations were found in the normal epithelium

42 Somatic APC gene alterations were identified frequently (21 of 4

43 Somatic, second-hit APC gene alterations, which precede morphological dyspla

44 own that somatic adenomatous polyposis coli (APC) gene alterations are frequently present in FGPs ass

45 analyzed somatic adenomatous polyposis coli (APC) gene alterations in 41 FAP-associated FGPs (20 with

46 denomas that have homozygous mutation of the APC gene and also select against fetuses bearing a heter

47 from increased nuclear transcription of the APC gene and correlated with a concomitant increase in t

48 Min mice possess a mutation in the APC gene and display a neoplastic phenotype similar to t

49 Other RNAs are expressed from the APC gene and include one form that contains an exon upst

50 nt role for germ-line allele sequence in the APC gene and individual risk of metachronous adenomatous

51 cing and large rearrangement analysis of the APC gene and targeted sequence analysis for the 2 most c

52 hat have a chain-terminating mutation in the Apc gene and that were either wild-type for SCFA metabol

53 single-nucleotide polymorphisms (SNP) in the APC gene and the odds of developing metachronous colorec

54 C57BL/6J-Min/+ (Min/+) mouse bears a mutant Apc gene and therefore is an important in vivo model of

55 ification of the adenomatous polyposis coli (Apc) gene and are excellent models for familial cancer p

56 mutation in the adenomatous polyposis coli (Apc) gene and develop multiple adenomas throughout their

57 terations of the adenomatous polyposis coli (APC) gene and frequently demonstrate epithelial dysplasi

58 iciencies in the adenomatous polyposis coli (APC) gene and in cells stimulated with the Wnt3a ligand.

59 Mutations in the adenomatous polyposis coli (APC) gene and K-ras occur in the majority of human color

60 eficiency in the adenomatous polyposis coli (APC) gene and subsequent activation of beta-catenin lead

61 +/- mice that inherit a mutant allele of the Apc gene, and intermediate effects are seen if a single

62 oth are caused by inherited mutations in the APC gene, and management includes genetic testing, colon

63 vered in colon cancers that retain wild-type APC genes, and also in melanomas, medulloblastomas, pros

64 mutation in the adenomatous polyposis coli (APC) gene (Apc(Min/+) mice).

65 mutations in the adenomatous polyposis coli (APC) gene (APC) that are orthologous to those responsibl

66 mutation in the adenomatous polyposis coli (APC) gene; APC-knockout mice; and p53-knockout mice.

67 Somatic mutations in the APC gene are an early event in colorectal tumorigenesis,

68 Mutations in the APC gene are associated with an inherited susceptibility

69 Mutations in the adenomatous polyposis coli (APC) gene are associated with an early onset of colorect

70 ns of the human adenomatosis polyposis coli (APC) gene are associated with the development of familia

71 mutations in the Adenomatous Polyposis Coli (APC) gene are at increased risk of developing hepatoblas

72 terations of the adenomatous polyposis coli (APC) gene are common events in gastrointestinal tumor de

73 mutations of the adenomatous polyposis coli (APC) gene are initiating events in the majority of spora

74 Mutations in the adenomatous polyposis coli (APC) gene are linked to polyp formation in familial and

75 Mutations in the adenomatous polyposis coli (APC) gene are pivotal in colorectal tumorigenesis.

76 terations of the adenomatous polyposis coli (APC) gene are present in biliary tract cancers and the A

77 mutations in the adenomatous polyposis coli (APC) gene are thought to cause colon adenoma and carcino

78 ons in the human adenomatous polyposis coli (APC) gene are thought to initiate colorectal tumorigenes

79 mutations on the adenomatous polyposis coli (APC) gene as a model of FAP-related malignant cells.

80 Mice with mutations in the Apc gene, as well as in genes that modify or interact wi

81 ations at any of 15 sites on K-ras, p53, and APC genes; Bat-26, a microsatellite instability marker;

82 e germline mutation lay in the region of the APC gene between the first and second beta-catenin degra

83 ers of FAP families in which mutation of the APC gene cannot be found.

84 Germ-line mutations in the APC gene cause adenomatous polyposis coli (APC), a syndr

85 Germline mutations in the APC gene cause FAP and can now be identified by direct m

86 severe polyposis phenotype and mutations at APC gene codons 1309 and 1328.

87 The mutation cluster region in the APC gene defines a region of approximately 660 bp, in wh

88 hemistry to address barriers associated with APC gene delivery, which include cellular uptake and int

89 mutation in the adenomatous polyposis coli (Apc) gene, double heterozygous animals have increased nu

90 N-induced loss of heterozygosity, and indeed Apc gene editing was less efficient in tetraploid than i

91 The APC gene encodes a large protein with multiple cellular

92 The APC gene encodes multiple protein isoforms through a com

93 The APC gene encodes the adenomatous polyposis coli tumour s

94 The adenomatous polyposis coli (APC) gene encodes APC tumour suppressor protein, germlin

95 Similarly, mice that contain a single mutant APC gene encoding a protein truncated at residue 716 (Ap

96 variants identified within the region of the APC gene examined, suggesting that any effect from this

97 n RNA interference showed that the wild-type APC gene expression is required for DNA methylation-indu

98 cells and observing a 5-fold increase in the APC gene expression.

99 Mutations in the APC gene from codons 1310 to 2011 were the most common r

100 n the GI tract of these mice involve loss of Apc gene function in a manner very similar to that seen

101 Mouse models of FAP, in which the APC gene has been genetically inactivated, have been par

102 utely transformed on in vivo deletion of the APC gene; however, the significance of this is unclear.

103 ine sequence alteration at codon 1307 of the APC gene (I1307K) has been reported in 6-7% of the Ashke

104 cently, a germ-line missense mutation in the APC gene, I1307K, was identified that may indirectly cau

105 Sequencing of the Apc gene in a sampling of rat tumors failed to find seco

106 The prominent role of the APC gene in colorectal tumor development is well establi

107 Targeting the Apc gene in lung epithelial progenitors by Nkx2.1-cre st

108 he presence and patterns of mosaicism in the APC gene in patients with colon neoplasms not associated

109 activation of a gatekeeper gene, such as the APC gene in the colon and the CDKN2A gene in the pancrea

110 he mutation cluster region in exon 15 of the APC gene in those SPTs that did not harbor beta-catenin

111 APC genes made up 0.4 to 14.1 percent of all APC genes in the stool.

112 o inactivate the Adenomatous Polyposis Coli (Apc) gene in the murine renal epithelium.

113 beta-catenin or adenomatous polyposis coli (Apc) genes in osteoblasts.

114 denomas for germline variants throughout the APC gene, including promoter mutations.

115 mutation in the adenomatous polyposis coli (Apc) gene increased the tumor number in the GI tract and

116 ether this D1822V [corrected] variant of the APC gene is associated with colon cancer and whether its

117 Inactivation of the APC gene is considered the initiating event in human col

118 The I1307K mutation of the APC gene is found in approximately 6% of the Ashkenazi J

119 APC gene is frequently inactivated by DNA mutations.

120 In previous studies, we have shown that the APC gene is inducible and that the DNA damage-induced le

121 tant regulator in Wnt-signaling pathway, the APC gene is involved in apoptosis and cell cycle arrest.

122 The APC gene is located at chromosome band 5q23, and is dele

123 hat the CaMKII-Cre used to delete the floxed APC gene is present in efferent olivocochlear (OC) neuro

124 nt Apc(Min/+) mice, in which mutation of the Apc gene is responsible for tumor initiation.

125 ctivation of the adenomatous polyposis coli (APC) gene is a critical event in the development of huma

126 Mutation of the adenomatous polyposis coli (APC) gene is an early step in the development of colorec

127 Mutation of the adenomatous polyposis coli (APC) gene is an early step in the initiation of colon ca

128 The adenomatous polyposis coli (APC) gene is important in the etiology of colon cancer.

129 The Adenomatous Polyposis Coli (APC) gene is mutated in the majority of colorectal cance

130 Since the Adenomatous Polyposis Coli (APC) gene is mutated in the majority of human colon canc

131 mutation of the adenomatous polyposis coli (APC) gene, is characterized by development of colorectal

132 kdown and the pleiotropic effects of EB1 and APC gene knockdown.

133 BER than the cell line expressing the mutant APC gene lacking the proliferating cell nuclear antigen-

134 g a fully penetrant dominant mutation in the Apc gene, leading to the development of gastrointestinal

135 ation using polymorphic markers flanking the APC gene locus.

136 We also assessed APC gene loss of heterozygosity.

137 In the patients with positive tests, mutant APC genes made up 0.4 to 14.1 percent of all APC genes i

138 suggest that the codon 1,822 variant of the APC gene may have functional significance.

139 re not functionally equivalent, and that the APC gene may have other tumor suppressor functions besid

140 crossed with mice bearing a mutation in the Apc gene (MIN mice), and the CEA.Tg/MIN progeny develope

141 y efficacious against CRC tumors carrying an APC gene mutation between the first and second 20-amino-

142 APC gene mutation is an early alteration in most colorec

143 When an Apc gene mutation was bred into the Mlh1 mutant mice, th

144 ations (microsatellite instability (MSI) and APC gene mutation).

145 We analyzed somatic beta-catenin and APC gene mutations in 16 sporadic JNAs from nonfamilial

146 curs through induction of the Wnt pathway or APC gene mutations that cause familial adenomatous polyp

147 APC gene mutations were identified by analysis of leukoc

148 Somatic APC gene mutations were identified in 76% (59 of 78) of

149 In those CRC cells, the APC gene mutations were located within a small segment b

150 APC gene mutations were present in six of nine (67%) of

151 atients from 19 FAP kindreds with identified APC gene mutations were reviewed.

152 eas essentially never harbor beta-catenin or APC gene mutations, we have recently identified alterati

153 beta-catenin and adenomatous polyposis coli (APC) gene mutations are well established and are known t

154 Adenomatous polyposis coli (APC) gene mutations have been implicated in familial and

155 ri infection and adenomatous polyposis coli (Apc) gene mutations have been linked to gastric cancer i

156 the role of adenomatous polyposis coli gene (Apc) gene mutations in the GI tumors of Mlh1 mutant mice

157 Mutations in the adenomatous polyposis coli (APC) gene occur in the vast majority of colorectal cance

158 a mutagen-induced nonsense allele of the rat Apc gene on an inbred F344/NTac (F344) genetic backgroun

159 ve mutational analysis in this region of the APC gene on DNA extracted from 240 Italian, Finnish, and

160 tumors that are either solely mutant in the Apc gene or in combination with another colon cancer-ass

161 rigenesis, mice with the min mutation of the APC gene or with the tm1 mutation of the p53 gene were c

162 mutations of the adenomatous polyposis coli (APC) gene or the beta-catenin gene that stabilize beta-c

163 esults indicate that somatic mutation of the APC gene plays an important role in the pathogenesis of

164 The protein products of mutant APC genes present in colorectal tumors were found to be

165 So far, a clear biological function for the APC gene product has not been determined.

166 efore, C57Bl/6J(Min/+) mice with a truncated APC gene product were fed diets supplemented with cerami

167 The adenomatous polyposis coli (APC) gene product is mutated in the vast majority of hum

168 The adenomatous polyposis coli (APC) gene product mediates coordinated cell growth in th

169 ctivation of the adenomatous polyposis coli (APC) gene product, we examined protein levels and locali

170 , p120, p27, and adenomatous polyposis coli (APC) gene product.

171 (GSK-3beta), and adenomatous polyposis coli (APC) gene products interact to form a network that influ

172 This investigation shows that APC gene promoter methylation occurs in the majority of

173 However, hypermethylation in APC gene promoter was also observed in different cancers

174 thylation of the adenomatous polyposis coli (APC) gene promoter occurs in primary non-small cell lung

175 ting mutation of adenomatous polyposis coli (APC) gene reduces intestinal adenomatous polyposis via A

176 Variants in the APC gene region also were analyzed.

177 ic losses of 5q (adenomatous polyposis coli [APC] gene region) and 18q (deleted in colorectal cancer

178 A necessary role for p53 in APC gene regulation is supported by the failure of MNNG

179 A direct causal role for p53 in APC gene regulation was further evaluated by transfectin

180 The biological function of CBF in APC gene regulation was further indicated by the decreas

181 omologues or the adenomatous polyposis coli (APC) gene, respectively, are important for the developme

182 Mutations in the APC gene result in an increased propensity to develop in

183 Mutations in the adenomatous polyposis coli (APC) gene result in uncontrolled proliferation of intest

184 eliminating the function of both Drosophila APC genes simultaneously.

185 ial flexible sigmoidoscopy and two different APC gene testing approaches.

186 We assessed indications for APC gene testing, whether informed consent was obtained

187 We evaluated the clinical use of commercial APC gene testing.

188 al factors with an inherited mutation of the Apc gene that is associated with colon cancer.

189 mutation of the adenomatous polyposis coli (APC) gene that causes colorectal cancer if prophylactic

190 mutations in the adenomatous polyposis coli (APC) gene that initiate colorectal tumors theoretically

191 ne allele of the adenomatous polyposis coli (Apc) gene that is similar to most mutations observed in

192 mutations of the adenomatous polyposis coli (APC) gene that leads to colon cancer.

193 mutation in the adenomatous polyposis coli (APC) gene that results in the spontaneous development of

194 mutations in the adenomatous polyposis coli (APC) gene that underlies familial adenomatous polyposis.

195 dentified in the adenomatous polyposis coli (APC) gene that was suggested to increase cancer predispo

196 most adenomas have lost their WT copy of the Apc gene through loss of heterozygosity by homologous so

197 his alteration is believed to predispose the APC gene to a secondary mutation at the same locus, resu

198 e pigs with knockout alleles in the DAZL and APC genes to model infertility and colon cancer.

199 ctivation of the adenomatous polyposis coli (Apc) gene to accelerate intestinal tumourigenesis using

200 efective for the adenomatous polyposis coli (APC) gene to reinvestigated the identity and importance

201 nderstanding to date of how mutations in the APC gene translate into changes at the protein level, wh

202 spectrum of DNA polymerase beta in the human APC gene under PCR conditions and compared it with the s

203 Mutations in the Adenomatous Polyposis Coli (APC) gene up-regulate Wnt signaling by stabilizing beta-

204 to detect chain-truncation mutations in the APC gene using DNA or RNA from cancer cell lines as well

205 he two tumors, biallelic inactivation of the APC gene was found.

206 on cancer cell line expressing the wild-type APC gene was more sensitive to a DNA-methylating agent d

207 urements showed that RNA expression from the APC gene was not significantly altered by the presence o

208 The adenomatous polyposis coli (APC) gene was first identified as the gene mutated in an

209 ngle nucleotide polymorphisms in the CRP and APCS genes was examined by application of family-based t

210 ations in the mutation cluster region of the APC gene were detected in the four JNAs without beta-cat

211 /-)Apc1638N mice frameshift mutations in the Apc gene were suppressed by Msh3.

212 Furthermore, colorectal tumors with intact APC genes were found to contain activating mutations of

213 Microsatellites in human TGFBR2, PTEN and APC genes were placed in yeast vectors and analyzed in i

214 mutations in the adenomatous polyposis coli (APC) gene were demonstrated in 50% of dysplastic juvenil

215 heterozygous for a nonsense mutation in the Apc gene, were randomized at weaning to seven groups, in

216 cal onset group versus controls involved the APCS gene, whereas for late-onset cases, one APCS varian

217 Mutations in the adenomatous polyposis coli (APC) gene, which initiate almost all human colon cancers

218 mutation of the adenomatous polyposis coli (APC) gene, which leads to activation of the Wnt/beta-cat

219 mutations of the adenomatous polyposis coli (APC) gene, whose product is an important component of th

220 at do not test positive for mutations in the APC gene with routine testing.

221 in allele of the adenomatous polyposis coli (Apc) gene with ethylnitrosourea (ENU) results in approxi

222 deletion of the adenomatous polyposis coli (Apc) gene within the adult bladder led rapidly to coinci