ライフサイエンスコーパス: APC protein

1 -deleted beta-catenin poorly colocalize with APC protein.

2 clusters and the absence of linear arrays of APC protein.

3 acids (aa) each in the central region of the APC protein.

4 tations in the microtubule-binding domain of APC protein.

5 expression of an N-terminal fragment of the APC protein.

6 pc in the mouse that yields complete loss of Apc protein.

7 epeats in the mutation cluster region of the APC protein.

8 ntestinal tumors that show loss of wild-type Apc protein.

9 ry for optimal nuclear import of full-length APC protein.

10 e the nuclear localization signals (NLSs) in APC protein.

11 th an Apc mutation that yields no detectable APC protein.

12 functionally distinct from the conventional APC protein.

13 ength APC, but not with mutant SW480 or HT29 APC proteins.

14 nvolve the cytoskeletal or adhesive roles of APC proteins.

15 eric coiled coil with mutant and full-length APC proteins.

16 cadherin or the adenomatous polyposis coli (APC) protein.

17 n, axin, and the Adenomatous Polyposis Coli (APC) protein.

18 in also binds to adenomatous polyposis coli (APC) protein, a cytosolic protein that is the product of

19 n that binds the adenomatous polyposis coli (APC) protein, a tumour suppressor.

20 phase cells, the adenomatous polyposis coli (APC) protein accumulates on a small subset of microtubul

21 Loss of functional APC protein activates the Wnt signal transduction pathwa

22 associated with adenomatous polyposis coli (APC) protein, an oncosuppressor, is implicated in the re

23 increased stability of beta-catenin bound to APC protein and E-cadherin, compared with full-length be

24 ates the dynamics of beta-catenin binding to APC protein and E-cadherin.

25 APC protein and GSK-3beta bind beta-catenin, retain it i

26 ity to bind to E-cadherin, alpha-catenin, or APC protein and to serve as a substrate for tyrosine kin

27 anges in beta-catenin binding to cadherin or APC protein, and the ensuing effects on cell morphology

28 P interacts with adenomatous polyposis coli (APC) protein, and is stabilized in both APC-mutated huma

29 Apc (Apc(+/+)) or with heterozygous loss of Apc protein (Apc(1638N)).

30 cally normal enterocytes bearing a truncated Apc protein (Apc(Min/+)) migrated more slowly in vivo th

31 fied carboxyl-terminal basic domain of human APC protein (APC-basic) bound directly to and bundled ac

32 onal fragment of adenomatous polyposis coli (APC) protein (APC-25) complexes with beta-cat, reduces b

33 During normal development, APC proteins are essential negative regulators of Wnt si

34 activation by beta-catenin and suggest that APC proteins are required for the regulation of Wnt tran

35 These results suggest that APC proteins are required not only for the activity of t

36 The truncated APC proteins are, in general, stable and almost certainl

37 cells (expressing wild-type beta-catenin and APC proteins) are more sensitive to apoptosis induced by

38 A truncated APC protein associated with familial and sporadic colore

39 ta show that the adenomatous polyposis coli (APC) protein associates with the mitotic spindle and tha

40 umulation of the adenomatous polyposis coli (APC) protein at the plus ends of leading-edge microtubul

41 The adenomatous polyposis coli (APC) protein, axin, and glycogen synthase kinase 3beta f

42 The APC protein binds to the cellular adhesion molecule beta

43 functional redundancies existing between the Apc proteins both in normal homeostasis and in tumorigen

44 cleavage of beta-catenin, gamma-catenin, and APC protein, but not alpha-catenin or E-cadherin.

45 ctions have been assigned to the multidomain APC protein, but the cellular effects of APC expression

46 Many functions have been proposed for APC proteins, but these have often rested on dominant-ne

47 teracts with the adenomatous polyposis coli (Apc) protein, but the functional significance of this in

48 Conversely, knocking down of endogenous APC protein by small interfering RNA (siRNA) blocked VPA

49 Cells were exposed for 1 minute to APC, protein C zymogen, or mutant Ser360Ala-APC, and [Ca

50 ed markedly increased expression of insulin, aPC/protein C, endothelial protein C receptor, and matri

51 tion of NH2-terminal deleted beta-catenin in APC protein clusters and the absence of linear arrays of

52 ta-catenin distribution between cadherin and APC protein complexes and the functions of these complex

53 including nucleoli, whereas the cytoplasmic APC protein concentrated at the leading edge of migratin

54 APC protein-containing membranes are actively involved i

55 ession status of adenomatous polyposis coli (APC) protein determines the relative sensitivity of colo

56 Redistribution of APC protein did not depend on continual nuclear export.

57 match repair and adenomatous polyposis coli (APC) proteins, diet, inflammatory processes, and gut mic

58 We also tested the hypothesis that truncated APC proteins found in tumors are dominant negative.

59 Loss of APC protein function results in increased intracellular

60 The adenomatous polyposis coli (APC) protein functions as a negative regulator of the Wn

61 on of the full-length, approximately 320-kDa APC protein, further establishing that the two intrinsic

62 Together, these data indicate that APC protein has a role in directed cell migration.

63 he widely used Min mouse in which the mutant Apc protein has zero 20AARs.

64 nofluorescence microscopy placed full-length APC protein in both the nucleus and the cytoplasm.

65 l deletions also colocalize prominently with APC protein in clusters at the tips of plasma membrane p

66 l fractionation to determine the location of APC protein in epithelial cells.

67 intestinal architecture and the presence of APC protein in intestinal epithelial cells.

68 treatment rather than a general role of the APC protein in the mitotic spindle checkpoint.

69 APC proteins in both vertebrates and Drosophila contain

70 ried out the first assessment of the role of APC proteins in brain development, simultaneously inacti

71 des new insights into functions of truncated APC proteins in cancer.

72 ryos as a model, we investigated the role of APC proteins in CIN.

73 thers subsequently showed that the truncated APC proteins in colorectal tumors usually retain a total

74 1 bound and sequestered wild-type and mutant APC proteins in extracts of human colon cancer cell line

75 ing in this process in C. elegans similar to APC proteins in other systems.

76 ole of wild-type adenomatous polyposis coli (APC) protein in native epithelia is poorly understood.

77 cipitates of full-length, but not truncated, APC protein include a mitosis-specific kinase activity i

78 pathways consistent with the function of the APC protein, including apoptosis, cell adhesion, cell mo

79 ation and indicate that dynamic beta-catenin-APC protein interactions are critical for regulating cel

80 e biochemical activities associated with the APC protein is down-regulation of transcriptional activa

81 on of beta-catenin binding to E-cadherin and APC protein is important in controlling epithelial cell

82 Although APC protein is located in both the cytoplasm and the nuc

83 APC protein is located in both the cytoplasm and the nuc

84 d beta-catenin associated with the wild-type APC protein is recruited to the SCF(beta-TrCP) complex,

85 The analysis of the normal roles of APC proteins is complicated by the presence of two APC f

86 Loss of the adenomatous polyposis coli (APC) protein is a common initiating event in colon cance

87 Adenomatous polyposis coli (APC) protein is a large tumor suppressor that is truncat

88 The adenomatous polyposis coli (APC) protein is an important tumour suppressor in the co

89 The adenomatous polyposis coli (APC) protein is implicated in the majority of hereditary

90 The adenomatous polyposis coli (APC) protein is inactivated in most colorectal tumours.

91 The adenomatous polpyposis coli (APC) protein is mutated in most colorectal tumours.

92 S-containing transcript encoded an alternate APC protein isoform, we generated and affinity-purified

93 onventional APC, at least one of the four BS-APC protein isoforms also interacts with beta-catenin.

94 In the intestine, APC protein levels increase at the crypt/villus boundary

95 We show that APC protein localizes mainly to clusters of puncta near

96 The carboxyl-terminal third of APC protein mediates direct interactions with microtubul

97 cleavage of beta-catenin, gamma-catenin, and APC protein might contribute to paclitaxel-induced apopt

98 We have previously suggested that the APC protein might modulate the frequency of mutations, s

99 are present in biliary tract cancers and the APC protein modulates levels of beta-catenin, we evaluat

100 the two intrinsic APC NESs are necessary for APC protein nuclear export.

101 both beta-cat and Axin, we hypothesize that APC proteins play an additional role in destructosome as

102 g cell migration is exerted by the truncated APC protein present in the Min/+ mouse.

103 modification for the APC TSG, because mutant APC proteins probably retain some function and the two h

104 ause loss of the C-terminal functions of the APC protein - probably involved in microtubule binding,

105 shifts resulting in nonfunctional, truncated APC protein products.

106 This subcellular distribution of APC protein requires microtubules, but not actin filamen

107 Loss of functional APC protein results in the accumulation of beta-catenin.

108 s, simultaneous reduction in both Drosophila Apc proteins results in the global nuclear accumulation

109 ticoagulant response to activated protein C (APC):protein S in modified prothrombin time assays, the

110 hat the activities of the chimera and of the APC.protein S complex are equivalent because the active

111 ght of the fluorescein in the membrane-bound APC.protein S complex would be 84 A above the surface.

112 ioning it close to the 84 A observed for the APC.protein S complex.

113 ls correlated with anticoagulant response to APC/protein S (r = 0.47, P = 0.035), but not with activa

114 In normal plasma, added HDL enhanced APC/protein S anticoagulant activity in modified prothro

115 3)Cer) can enhance anticoagulant activity of APC/protein S by mechanisms that are distinctly differen

116 V for the inactivation of factor VIII by the APC/protein S complex.

117 The addition of human FV to the APC/protein S inactivation mixture increases by approxim

118 dase treatment reduced plasma sensitivity to APC:protein S in parallel with GlcCer reduction.

119 ified proteins, inactivation of factor Va by APC:protein S was enhanced by GlcCer alone and by GlcCer

120 plasma in the presence, but not absence, of APC:protein S, which suggests that GlcCer or Gb3Cer can

121 s that APC alleles with 5' mutations produce APC protein that down-regulates beta-catenin, inhibits b

122 the first Axin-binding SAMP repeat, yielding Apc proteins that are predicted to be deficient in desta

123 The deltaN89beta-catenin accumulated on the APC protein to a level 10-fold over that of wild-type be

124 dscape for aptamers binding allophycocyanin (APC) protein via a novel Closed Loop Aptameric Directed

125 The nuclear APC protein was concentrated in discrete subnuclear regi

126 In addition, wild-type Apc protein was detected by immunohistochemistry in all

127 When wild-type APC protein was expressed using an inducible expression

128 onation, which demonstrated that full-length APC protein was located in both the membrane/cytoskeleta

129 Full length Apc protein was not detected in the tumor cells from Min

130 parental cysts, adenomatous polyposis coli (APC) protein was localized in linear arrays and in punct

131 Mutant APC proteins were purified and characterized for their i

132 n activity when compared with tumors lacking Apc protein, which could lead to context-dependent inhib

133 petition for the adenomatous polyposis coli (APC) protein, which in other systems has been shown to p

134 Colocalization of APC protein with rRNA confirmed a nucleolar localization

135 of these novel open reading frames predicts APC proteins with different amino-terminal domains and t

136 plicing of APC leads to alternative forms of APC proteins with potentially unique functions in growth

137 e interaction of adenomatous polyposis coli (Apc) protein with the plus ends of microtubules.